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All Journal Jurnal Sain Veteriner SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Biomedicine and Translational Research Bioscientist : Jurnal Ilmiah Biologi
Farida Dwi Handayani
Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit Salatiga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Veterinary

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Surveillance of pathogenic Leptospira among rodents and small mammals in enzootic areas of plague in Pasuruan Indonesia Febriani, Siti Amanah; Dhanti, Kurnia Ritma; Kurniawan, Kurniawan; Ristiyanto, Ristiyanto; Junaedi, Arief; Sukowati, Caecilia Hapsari Ceriapuri; Handayani, Farida Dwi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.37499

Abstract

Leptospirosis is a globally significant yet often overlooked zoonotic infection. Several regions in Indonesia are endemic for leptospirosis, including East Java. Pasuruan a region located in the East Java province of Indonesia, has been recognized as an enzootic area of plague infection. However, the presence of other rodent-borne diseases has not been reported. This study aims to detect the presence of pathogenic Leptospira in rats and small mammals in the enzootic plague area of Pasuruan in Indonesia. This study belongs to the type of observational analytic research with a cross-sectional study design. Simple random sampling was conducted to trap a total of 119 forms 107 rats and 12 small mammal kidneys were analyzed molecularly (PCR) to detect Leptospira bacteria with the LipL32 gene as the target. The study revealed that 7.6% (9/119) of rats in the enzootic areas of plague (Sedaeng, Tosari, Surorowo, Petren, Pakis Bincil, Kutukan) were found to carry Leptospira DNA, indicating a significant difference between infection rates per region (p < 0.0001).  Rattus tanezumi was identified as the Leptospirosis reservoir in settlements habitats with a percentage of 13.2%, Rattus tiomanicus was detected at 28.6% in forest habitats, and Rattus exulans was found at 4.4% in both habitats. The findings in our study, it is crucial for the community to increase awareness of the spread of rodent-borne diseases, including Leptospirosis.
Detection of Pathogenic Leptospira in Sputum of Leptospirosis Patient with Pulmonary Hemorrhage. Handayani, Farida Dwi; Novipuspitasari, Lisa; Ahmed, Ahmed; Safari, Dodi; Hidajat, Muhammad Choirul; Soebandrio, Amin; Gasem, Muhammad Hussein
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.28259

Abstract

Background: The pathogenic Leptospira species is the causative agent of leptospirosis, an endemic zoonotic disease in Indonesia. Misdiagnosis of the disease frequently occurs, as confirmatory diagnosis confined to highly specialized laboratories. As well, the pulmonary involvement of leptospirosis with hemoptysis is scarcely reported.Case Presentation: A 49 years-old male patient was admitted to the district hospital with acute febrile illness and a history of traveling to a malaria-endemic area in Borneo, Indonesia. Based on a chest X-ray result, the patient was clinically suspected to have pulmonary tuberculosis. However, the clinical manifestations of leptospirosis i.e. conjunctival suffusion, calf pain, and oliguria were present, and later hemoptysis was also reported. A clinical diagnosis of leptospirosis with pulmonary involvement was proposed. Immunochromatographic test (ICT)-rapid test for vivax/falciparum malaria and Ziehl-Neelsen (ZN) staining of sputum for tuberculosis results were both negative. Microscopic Agglutination Test (MAT), the IgM anti-Leptospira rapid test (lateral flow assay), and PCR amplification of both conventional and real-time (qPCR) were performed using various samples (serum, urine, and sputum). The MAT of acute single serum sample and rapid test were negative. Intriguingly, the PCR showed positive results in sputum and urine samples but not in the serum sample, highlighting the usefulness of leptospiral molecular detection to confirm further diagnosis.Conclusion: Molecular detection of pathogenic Leptospira in sputum samples can be considered for confirmatory diagnosis of leptospirosis patients with pulmonary hemorrhage. Likewise, the urine sample can be used as an option in the examination of severe leptospirosis.
Insidensi Ortohantavirus pada Inang Reservoir di Kota Semarang, Jawa Tengah Septiyani, Rani Dwi; Dhanti, Kurnia Ritma; Kurniawan, Kurniawan; Mulyono, Arief; Handayani, Farida Dwi
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.11591

Abstract

Orthohantavirus is an RNA virus that causes Hemorrhagic Fever with Renal Syndrome (HFRS) and Hantavirus Pulmonary Syndrome (HPS). Humans can become infected with orthohantaviruses by inhaling virus particles from the urine, saliva, and feces of infective reservoir hosts. Small mammals from the orders Rodensia, Eulipotyphla, and Chiroptera are the main reservoirs of orthohantaviruses. This study aims to detect and calculate the incidence of orthohantavirus in reservoir hosts in Semarang City. The research was conducted descriptively analytically with a cross-sectional study design. The research population was all mice and shrews in the research location (Gayamsari and Tlogosari subdistricts), and the samples were caught mice and shrews (84). The research was carried out in May-September 2023. Orthohantavirus detection was carried out using the Nested PCR test (pre denaturation, denaturation, annealing and extension). A total of 84 individuals were captured, consisting of Rattus novergicus, Rattus tanezumi and Suncus murinus. Orthohantavirus in this study was successfully detected in Rattus norvegicus. The results of the study showed that the incidence of orthohantavirus in Gayamsari Village was (11.1%), Tlogosari Village (2.78%), and the overall total was (2.38%). It is necessary to control mice to prevent transmission of orthohantavirus.
Kepadatan dan Dominasi Pinjal pada Beberapa Jenis Tikus dan Habitat di Daerah Enzootik Pes di Kabupaten Pasuruan, Jawa Timur Cahyaningrum, Winda Rahma; Wardani, Dita Pratiwi Kusuma; Ristiyanto, Ristiyanto; Almanfaluthi, Muhammad Luthfi; Handayani, Farida Dwi
Jurnal Sain Veteriner Vol 42, No 2 (2024): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.95362

Abstract

Fleas are hemophagous insects that spread the Yersinia pestis bacteria that causes bubonic plague through the bites of infected fleas. The purpose of this study was to determine the density, dominance, and infestation of larvae in several types of rodents and habitats in the Pes enzootic area. This research was conducted in May–June 2023 in Pasuruan Regency, East Java. The data analysis method used was descriptif. Samples of rat fleas were taken from rats captured in residential, garden, and forest habitats. The results showed that six species of small mammals were captured, namely, the Muridae family consisting of Niviventer fulvescens, Rattus exulans, Rattus tanezumi, and Rattus tiomanicus; the Erinaceidae family, namely Helomys suillus; and the Soricidae family, namely Suncus murinus, with the highest trap success in residential habitats by 10.9% and the highest density of rats in residential and garden habitats. The larval species obtained were Xenopsylla cheopis and Stivalius cognatus, with the highest flea infestation in the rat species Rattus exulans female (300%) and Rattus tanezumi female (64.2%).
Co-Authors Ahmed, Ahmed Amin Soebandrio Arief Mulyono Cahyaningrum, Winda Rahma Dhanti, Kurnia Ritma Febriani, Siti Amanah Gasem, Muhammad Hussein Hidajat, M Choirul Junaedi, Arief Kurniawan Kurniawan Muhammad Luthfi Novipuspitasari, Lisa Ristiyanto Ristiyanto Safari, Dodi Septiyani, Rani Dwi Sukowati, Caecilia Hapsari Ceriapuri Wardani, Dita Pratiwi Kusuma