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All Journal HAYATI Journal of Biosciences Microbiology Indonesia Medical Journal of Indonesia Journal of Biomedicine and Translational Research Narra J Proceedings of the International Conference on Nursing and Health Sciences

Amin Soebandrio

Departemen Mikrobiologi Klinik Fakultas Kedokteran, Universitas Indonesia

Author-ID : 383481

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

Published : 9 Documents Claim Missing Document

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Articles

Resistance pattern of Mycobacterium tuberculosis to first-line antituberculosis drugs Sudiro, Tjahjani M.; Soebandrio, Amin; Prawoto, Prawoto; Sudarmono, Pratiwi
Medical Journal of Indonesia Vol 9, No 3 (2000): July-September
Publisher : Faculty of Medicine Universitas Indonesia

[no abstract available]

Development of Elisa for rapid detection of anti-dengue antibody Soebandrio, Amin
Medical Journal of Indonesia Vol 1, No 2 (1992): April-June
Publisher : Faculty of Medicine Universitas Indonesia

[no abstract available]

The H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia. Result from this study revealed that in several cases, waterfowl species could become the source of H5N1 infections in human. We found that the one of six viruses used in this study probably was a fi NI LUH PUTU INDI DHARMAYANTI; FERA IBRAHIM; . DARMINTO; AMIN SOEBANDRIO
HAYATI Journal of Biosciences Vol. 18 No. 2 (2011): June 2011
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.18.2.82

The H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia. Result from this study revealed that in several cases, waterfowl species could become the source of H5N1 infections in human. We found that the one of six viruses used in this study probably was a first antigenic shift virus in Indonesia. This study shows that the AI viruses isolated from birds around humans infected by H5N1 virus has specific characteristics namely the presence of several amino acid substitutions especially on the M1 and M2 proteins. The substitutions are similar in most of H5N1 human cases in Indonesia.

Amantadine Resistant of Indonesian H5N1 Subtype Influenza Viruses During 2003-2008 NI LUH PUTU INDI DHARMAYANTI; FERA IBRAHIM; AMIN SOEBANDRIO
Microbiology Indonesia Vol. 4 No. 1 (2010): April 2010
Publisher : Indonesian Society for microbiology

The M2 protein of 146 avian influenza (AI) viruses data available in public database (NCBI), including 20 AI isolates used in this study, were sequenced at the M2 protein to find out the probability of mutation and the increase of resistance to amantadine after more than 5 years of their circulation in Indonesia. The results showed that during 2003-2008, around 62.58% (92/147) AI viruses in Indonesia have showed resistance to amantadine and 10 of them have dual mutations at V27A and S31N.

The Genetic Drift of Indonesian Avian Influenza A H5N1 Viruses During 2003-2008 NI LUH PUTU INDI DHARMAYANTI; GINA SAMAAN; FERA IBRAHIM; RISA INDRIANI; . DARMINTO; AMIN SOEBANDRIO
Microbiology Indonesia Vol. 5 No. 2 (2011): June 2011
Publisher : Indonesian Society for microbiology

The avian influenza A H5N1 outbreaks started in 2003 and Indonesia introduced a vaccination campaign in 2004 to control the disease. In 2007, anecdotal reports about reduced vaccine effectiveness were received from commercial farmers. This paper describes the evolution of viruses in Indonesia up till 2008 and focus on viruses from vaccinating farms reporting vaccine failure were compared to viruses isolated from outbreak areas with no vaccination program. Result of the study revealed that viruses from vaccinated chickens had more extensive mutation at the HA molecule compared to chicken and other avian species without vaccination. Substitutions occurred at the HA gene level as well as at NA, M1 and NS1 genes. Viruses isolated and characterized form 2008 vaccinated flocks had substitutions that were unique and different with the old viruses. The recommendation arising from this study to the avian influenza disease control program in Indonesia is that continuous monitoring of genetic character of viruses and the vaccine seed strain should be updated periodically and matched with the virus circulated in the field.

Growth Characteristics of Chikungunya Virus Isolate from Indonesia in Various Human Cell Lines in vitro Oktaviani Naulita Turnip; OKTAVIANI N. TURNIP; RAHMA F. HAYATI; RIZKA ALAWIYAH; BENEDIKTUS YOHAN; DIONISIUS DENIS; ANOM BOWOLAKSONO; AMIN SOEBANDRIO; R. TEDJO SASMONO
Microbiology Indonesia Vol. 13 No. 1 (2019): March 2019
Publisher : Indonesian Society for microbiology

Chikungunya (CHIK) fever, a febrile illness caused by Chikungunya virus (CHIKV) infection, is one of mosquito-borne viral diseases affecting people living in the tropical and subtropical regions in the world. The pathogenesis of the disease is yet to be completely unraveled, and research on CHIK has been conducted by employing various methods, including using cell lines to investigate the biological characteristics of CHIKV in vitro. To assess the suitability of human cell line model for CHIK study, various human cell lines including A549, Huh7, and HepG2 were infected with CHIKV and assayed for their susceptibility to infection. The MTT and plaque assay methods were performed to measure cell viability and virus growth kinetics, respectively. Fluorescence-activated Cell Sorting (FACS) and immunofluorescence assay were performed to measure the proportion of infected cells in the system and their morphological visualization. Both A549 and Huh7 human cell lines showed stable high cell viability upon infection while CHIKV growth kinetics were significantly lower in these cells compared to Vero-CCL81, a monkey cell line that is routinely used in other arboviruses research. Interestingly, we observed significantly different results in HepG2 human cell line, in which cell viability and CHIKV growth kinetics were significantly higher. FACS and immunofluorescence assay confirm the higher infection rate of CHIKV in HepG2 than A549 human cell line. We concluded herethat human hepatocytes HepG2 cell line was susceptible to Asian Genotype of CHIKV and proposed as an alternative cell for the in vitro CHIKV studies to the commonly used A549 and Vero cells.

Association Between Sensory Profile and Daily Functioning in Children with Autism Anindya, Isti; Soebandrio, Amin; Ariyanto, Ibnu Agus; Sekartini, Rini; Wiguna, Tjhin; Sari, Novika Purnama
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.2787

In the diagnostic criteria outlined in the DSM-5-TR (APA, 2022) Autism is characterized by hyper- or hyporeactivity to sensory input or unusual interest. Children with Autism encounter challenges in processing sensory information, leading to difficulties in regulating responses to specific sensations and stimuli. Meanwhile, behaviours such as repetitive motor movements, running, aggression, and self-harming have been correlated with sensory processing disorders. Furthermore, some daily functioning that are often disrupted due to sensory processing disorders are sleeping, eating, and social activities. Therefore in this study, we aim to examine association between sensory profile and daily functioning in children with Autism. We collected data from parents of children aged 2-5 years with Autism (N = 96) and non Autism (N = 94) in Indonesia for three months (September-December 2023). Parents filled out five types of instruments (CARS-P, FISH, BAMBI, SCQ, and SSP) and sociodemographic data. The results of this study showed a significant difference between autistic and non-autistic groups in their daily functioning (p < 0.001). In autistic group, we found a significant relationship between sensory profiles and eating behavior (p < 0.001); and social communication skills (p < 0.001). In the non-autistic group, only sensory profile was corelated to eating behavior (p < 0.001). Primary results indicate that, the sensory profile is closely related to eating behavior and social communication skills in autistic children.

Role of ACE2 and TMPRSS2 polymorphisms on COVID-19 outcome and disease severity in adult patients: A prospective cohort study in a tertiary hospital, Indonesia Yunita, Rina; Wahyuni, Arlinda S.; Sinaga, Bintang YM.; Yamamoto, Zulham; Soebandrio, Amin; Kusumawati, R. Lia; Sembiring, Rosita J.; Pandia, Pandiaman
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.919

Coronavirus disease 2019 (COVID-19) has led to a significant number of infections and deaths worldwide, yet its pathogenesis and severity remain incompletely understood. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2), play crucial roles as receptors and molecules responsible for the virus's entry into host cells, initiating the infection process. Their polymorphisms have been extensively studied in relation to COVID-19 severity. The aim of this study was to examine the association of ACE2 (rs2074192) and TMPRSS2 (rs12329760) polymorphisms with COVID-19 outcome and severity. A prospective cohort study was conducted in 2022 at Haji Adam Malik Hospital, Medan, Indonesia. We randomly recruited hospitalized adult patients with COVID-19, confirmed by real-time polymerase chain reaction (RT-PCR). The baseline demographic data, disease severity, underlying disease, comorbidities, and COVID-19 vaccination status were collected. The single-nucleotide polymorphism (SNP) was assessed using TaqMan SNP genotyping assay, and the levels of TMPRSS2 and ACE2 proteins were measured using enzyme-linked immunosorbent assay (ELISA). A total of 151 COVID-19 patients were recruited and there were significant associations between age and severity with mortality outcomes. The age, kidney and lung diseases, and vaccination status were associated with severity levels. The results showed the CC genotype of ACE2 had the highest proportion, followed by TT and CT genotypes among patients, while CT was the most prevalent genotype, followed by CC and TT for TMPRSS2. This study did not find a significant association between ACE2 and TMPRSS2 genetic variants with disease severity and outcome but highlighted a specific association of TMPRSS2 SNP with mortality within the group. In addition, ACE2 concentration was significant different between mild-moderate and severe-critical COVID-19 groups (p=0.033).

Detection of Pathogenic Leptospira in Sputum of Leptospirosis Patient with Pulmonary Hemorrhage. Handayani, Farida Dwi; Novipuspitasari, Lisa; Ahmed, Ahmed; Safari, Dodi; Hidajat, Muhammad Choirul; Soebandrio, Amin; Gasem, Muhammad Hussein
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.28259

Background: The pathogenic Leptospira species is the causative agent of leptospirosis, an endemic zoonotic disease in Indonesia. Misdiagnosis of the disease frequently occurs, as confirmatory diagnosis confined to highly specialized laboratories. As well, the pulmonary involvement of leptospirosis with hemoptysis is scarcely reported.Case Presentation: A 49 years-old male patient was admitted to the district hospital with acute febrile illness and a history of traveling to a malaria-endemic area in Borneo, Indonesia. Based on a chest X-ray result, the patient was clinically suspected to have pulmonary tuberculosis. However, the clinical manifestations of leptospirosis i.e. conjunctival suffusion, calf pain, and oliguria were present, and later hemoptysis was also reported. A clinical diagnosis of leptospirosis with pulmonary involvement was proposed. Immunochromatographic test (ICT)-rapid test for vivax/falciparum malaria and Ziehl-Neelsen (ZN) staining of sputum for tuberculosis results were both negative. Microscopic Agglutination Test (MAT), the IgM anti-Leptospira rapid test (lateral flow assay), and PCR amplification of both conventional and real-time (qPCR) were performed using various samples (serum, urine, and sputum). The MAT of acute single serum sample and rapid test were negative. Intriguingly, the PCR showed positive results in sputum and urine samples but not in the serum sample, highlighting the usefulness of leptospiral molecular detection to confirm further diagnosis.Conclusion: Molecular detection of pathogenic Leptospira in sputum samples can be considered for confirmatory diagnosis of leptospirosis patients with pulmonary hemorrhage. Likewise, the urine sample can be used as an option in the examination of severe leptospirosis.

Co-Authors . DARMINTO . DARMINTO Ahmed, Ahmed Amarila Malik Anindya, Isti Anis Karuniawati ANOM BOWOLAKSONO Ariyanto, Ibnu Agus Aulia Rizki BENEDIKTUS YOHAN DIONISIUS DENIS Farida Dwi Handayani Fera Ibrahim Gasem, Muhammad Hussein GINA SAMAAN Hidajat, M Choirul Kambang Sariadji Kusumawati, R. Lia NI LUH PUTU INDI DHARMAYANTI NI LUH PUTU INDI DHARMAYANTI Ni Luh Putu Indi Dharmayanti Novipuspitasari, Lisa Oktaviani Naulita Turnip Pandia, Pandiaman Pratiwi Pujilestari Sudarmono Prawoto Prawoto R. TEDJO SASMONO RAHMA F. HAYATI Rina Yunita Rini Sekartini RISA INDRIANI RIZKA ALAWIYAH Safari, Dodi Sari, Novika Purnama Sembiring, Rosita J. Sinaga, Bintang YM. Sunarno Sunarno Tjahjani M. Sudiro Tjhin Wiguna Wahyuni, Arlinda S. Yamamoto, Zulham

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