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All Journal HAYATI Journal of Biosciences Jurnal Pengolahan Hasil Perikanan Indonesia Bionatura Microbiology Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology JURNAL BIOLOGI INDONESIA AGRIKAN Jurnal Ilmiah Agribisnis dan Perikanan Akuatik: Jurnal Sumberdaya Perairan PROSIDING SEMINAR NASIONAL AGRIBISNIS Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan JURNAL PANGAN
LINAWATI HARDJITO
Departemen Teknologi Hasil Perairan, FPIK, IPB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Veterinary

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Journal : Microbiology Indonesia

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Ethnomedicinal Plant Terong Pungo (Solanum sp.) LINAWATI HARDJITO
Microbiology Indonesia Vol. 2 No. 2 (2008): August 2008
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5454/mi.2.2.2

Abstract

The leaf of terong pungo Solanum sp. had been used traditionally in Aceh to treat toothache and relieve pain. Based on traditional knowledge, this research was conducted to examine the biological activities of its extract as an antibacterial agent and topoisomerase-I inhibitor. The topoisomerase-I inhibitor is one of the target molecules for anticancer compounds. In addition, it is also a target molecule for antimicrobial compounds. The antibacterial activity was examined using disc diffusion assay against Staphylococcus aureus and Escherichia coli isolated from medical patients. Topoisomerase-I inhibitor activity was determined using the method reported by TopoGEN, and its toxicity was examined against Artemia salina. Chloroform, ethyl acetate, and methanol treatments yielded crude extracts of 1.44, 1.20, and 2.69%, respectively. The chloroform extract exhibited neither antibacterial nor topoisomerase-I inhibitor activities, while the ethylacetate and methanol extracts at a concentration of 300 μg/paper disk positively inhibited the growth of both target bacteria or enzyme activity of topoisomerase-I at a concentration of 50 μg ml-1. The ethylacetate extract showed better activity against target bacteria and was chosen for further investigation. The results suggest that the crude extract showed antibacterial and topoisomerase-I inhibitor activity. Identification of the isolated active fraction indicated that it contained a steroidal alkaloid compound. This investigation revealed that the leaf of terong pungo contains biologically active compounds of pharmacological relevance.
The Influence of Oil Concentration, Nitrogen and Phosphorus Composition on Crude Oil Biodegradation by Epyzim and Mixed Cultures of Pseudomonas aeruginosa and Arthrobacter simplex ERLIZA NOOR; LINAWATI HARDJITO
Microbiology Indonesia Vol. 2 No. 3 (2008): December 2008
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.721 KB) | DOI: 10.5454/mi.2.3.10

Abstract

Biological methods have gained attention as an alternative treatment for oil degradation in pollution remediation. External and internal factors have a great influence on crude oil biodegradation. This experiment studied the effect of oil concentrations and ratios of Ammonium and Phosphate on oil degradation in mixed cultures of local strains of Pseudomonas aeruginosa and Arthrobacter simplex. The oil degradation ability of this mixed culture was compared to the dormant culture of Epyzim. The increase of oil concentration, from 1, 3, 5 and 10% (w/v), significantly lowered the ability of both cultures to degrade the oil i.e from 83 % for 1% oil concentration to 64% for 10% oil concentration using local strains. The local strains showed better capability compare to the dormant culture. Medium composition was designed by three levels of ammonium concentration (7.6, 37.9 and 75.8 mg l-1) and two levels of phosphate concentration (2.0 and 9.9 mg l-1). The ratio of ammonium to phosphate of 3.8:1.0 in the growth media has resulted the maximum level of oil degradation, i.e 83% and 88%, for dormant and local cultures respectively. The results suggest a potential usage of local microorganisms in degrading crude oil-polluted water.
Co-Authors . Chairita . Ernawati . Santoso ALBERTA RIKA PRATIWI Asadatun Abdullah DAHRUL SYAH Daniel R. Monintja Desniar - - Dohami Wina Harianja Ella Salamah Endang Srieatimah - Erliza Noor Fatimah Abdillah JOHN HALUAN Joko Santoso Lailati, Nispi Lailati, Nispi Lely Okmawaty Anwar LILY MARIA GORETTI PANGGABEAN M. Fedi A. Sondita MAGGY T WIJAYA Maggy Thenawidjaja Suhartono MARIA BINTANG Panggabean, Lily Panggabean, Lily Pipih Suptijah Putri, Ryana Tammi Rita Marsuci Harmain Shabarni Gaffar - Sitkun Deni Winarti Zahiruddin