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All Journal The Journal of Experimental Life Sciences (JELS) Biotropika Jurnal Pembangunan dan Alam Lestari Advance Sustainable Science, Engineering and Technology (ASSET)
Agung Pramana Warih Marhendra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience

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Journal : Biotropika

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Effect of Aqueous Basil Extract (Ocimum sanctum) on Monosodium Glutamate-Induced Mice Sperm Aris Soewondo; Sri Rahayu; Agung Pramana Warih Marhendra; Nurul Shafa Paramita; Anaqoh Roudhotul Jannah Winarso
Biotropika: Journal of Tropical Biology Vol. 13 No. 2 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.02.01

Abstract

This study aims to analyse the protective effect of aqueous extract of basil leaves (Ocimum sanctum) on the sperm quality of monosodium glutamate (MSG)-induced mice. This study used 30 male mice (aged 4-5 weeks old and weighing 25-35 grams), which were then randomly divided into five groups: P0 (healthy male mice), P1 (male mice induced with 4mg/kg BW MSG), P2, P3, P4 (male mice induced with MSG and given aqueous extract of basil leaves (O. sanctum) 300mg/kgBB, 500mg/kgBB, 700mg/kgBB for 14 days). At the end of treatment, all mice will be sacrificed and cauda epididymis was isolated. The obtained semen was analysed for sperm quality, including motility, viability, concentration, and spermatozoa abnormalities. Data analysis used one-way ANOVA and continued with the Duncan test using SPSS for Windows. In this study, the administration of 700mg/kg BW aqueous extract of basil leaves (O. sanctum) could improve sperm quality by increasing motility, viability, and concentration of sperm and also alter the sperm abnormality of MSG-induced mice.
The Effect of Starfruit Leaf Extract (Averrhoa bilimbi) on the Histology of Testes in Mice (Mus musculus) Exposed to Monosodium Glutamate (MSG) Savira Ayunda Rakhmanira; Huda, Zainul; Rohmah, Meisya Putri Maulida; Sri Rahayu; Aris Soewondo; Agung Pramana Warih Marhendra
Biotropika: Journal of Tropical Biology Vol. 13 No. 3 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.03.09

Abstract

This study analysed the effect of starfruit leaf extract (SL) on the testicular histology of mice exposed to MSG. This study used 25 male mice with a body weight of 25-30 grams and an age of 3-4 weeks. Mice were grouped into five groups: K(-) (healthy male mice), K(+) (male mice induced with MSG 4 mg/gBW), P1, P2, and P3 (male mice induced with MSG and SL extract (A. bilimbi) 250mg/kgBW, 500mg/kgBW, 750mg/kgBW for 21 days). Following the completion of the treatment, the mice were euthanised via cervical dislocation, and the testicular organs were collected. The left testicular organ was used for histological observation of the testes, with parameters including the percentage of spermatogenic cells, Leydig cells, seminiferous tubule diameter, and germinal epithelium thickness. The right testicular organ and SL extracts were tested for antioxidant activity using the DPPH method. Data was analysed using the SPSS program with one-way ANOVA and Mann-Whitney tests. These results indicate that the administration of SL extract at a dose of 750 mg/kgBB can increase testicular weight, seminiferous tubule diameter, germinal epithelium thickness, number of spermatogenic cells, and Leydig cells due to MSG exposure.  The results of the testicular antioxidant capacity test showed the highest %inhibition of 45.65% at the first dose.
Co-Authors Agus Suhadi Anandita, Septian Ragil Anaqoh Roudhotul Jannah Winarso Ardyah Ramadhina Irsanti Putri Aris Soewondo Diana Arfiati Firlina Laila Putri Gatot Ciptadi Gladys Agnescia Sumampouw HUDA, ZAINUL Jefri Permadi Juwita Ratna Dewi Maharani Pertiwi K. Nasirudin, Mohamad Nia Kurniawan Nurul Shafa Paramita Rohmah, Meisya Putri Maulida Savira Ayunda Rakhmanira Shofi Nur Aliyah SRI RAHAYU