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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Veteriner Current Biochemistry Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Warta IHP (Warta Industri Hasil Pertanian) Pharmascience FITOFARMAKA: Jurnal Ilmiah Farmasi Indonesian Journal of Applied Research (IJAR) Borneo Journal of Pharmacy
Husnawati, .
Department Of Biochemistry, Faculty Of Mathematics And Natural Sciences, IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Industrial & Manufacturing Engineering Medicine & Pharmacology Veterinary

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Journal : Current Biochemistry

 1 
Effectiveness of Gnetum gnemon Peel Extract as an Antihyperuricemic in White Rats Rattus norvegicus Akhmad Endang Zainal Hasan; Husnawati Husnawati; Chintia Ayu Puspita; Agus Setiyono
Current Biochemistry Vol. 7 No. 1 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.1.3

Abstract

Melinjo (gnetum gnemon) peel extract is believed to have potential as antihyperuricemic agent, however, in vivo assays have yet to be conducted to prove the antihyperuricemic activity. The objectives of this research were to analyze antihyperuricemic activity of melinjo peel extract in Sprague Dawley male white rat. A total of 24 rats were divided into 6 groups, which are a normal, positive, and negative group, 70% ethanolic extract of melinjo peel dose 450 mg/kg BW (ET I) and dose 900 mg/kg BW (ET II), and water extract of melinjo peel dose 93.35 mg/kg BW (EA). The results show that antihyperuricemic potency of 70% ethanolic extract of melinjo peel (ET1 and ET2) was more effective than allopurinol dose 90 mg/kg BW with a percentage decrease of 50% and 54%. Ethanol extract of melinjo peel was able to reduce uric acid levels to be in the range of normal values (<5 mg / dL). Bodyweight gain of rats given ethanol extract of melinjo peel dose 450 mg/kg BW had values that were close to the normal group. Melinjo peel extract contained flavonoid, tannins, saponin, and triterpenoid.
The Spray of Pegagan Leaf Extract as an Antifungal of Vulvovaginal Candidiasis: A Narrative Review Santi Nuraeni; Safira Rahmadanti; Aldi Fadilah; Husnawati
Current Biochemistry Vol. 7 No. 2 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.2.5

Abstract

Vulvovaginal Candidiasis (VVC) is a type of infection caused by the fungus Candida spp. The treatment of candidiasis usually uses antifungal drugs on Candida albicans. Pegagan (Centella asiatica (L.) Urban) is one of wild plants that have been used by the community as a drug. The content of secondary metabolite compounds found in pegagan, such as triterpenoids, alkaloids, flavonoids, and saponins can act as antifungal agents. A literature review in the form of national, international journals and digital books originated from various sites is carried out online. The result of the narrative analysis shows that the ethanol extract of pegagan leaves with a concentration of 75 x 103 ppm can inhibit the growth of C. albicans by up to 17.5 mm. The results of the toxicity prediction with three parameters shows that the active compounds of pegagan leaves are weak inhibitors, non-carcinogenic and in the toxicity test, it at most belongs to category III. Other than that, the spray formulation with a concentration of 1% (w/w) of pegagan leaf extract is found to be safe and non-irritant to skin.
The Potency of Senggani (Melastoma malabathricum L) Leaves in Repair of Pancreatic Beta Cells for Diabetes Mellitus Patients: A Narrative Review Galuh Rizal Prayoga; Aziz Syamsul Huda; Syndilona Br Sitepu; Husnawati
Current Biochemistry Vol. 7 No. 2 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.2.3

Abstract

Diabetes mellitus is often caused by damage to pancreatic beta cells which play a role in secreting insulin in the body. Damage to pancreatic beta cells causes the body to lack insulin. Dipeptidyl peptidase-4 (DPP-4) is a peptidase enzyme complex located on the surface of the cell membrane. Inhibition of the DPP4 enzyme will increase blood GLP-1 levels and induce regeneration of pancreatic beta cells. Senggani leaf (Melastoma malabathricum) boiled water is believed by the people of the Ciamis area to be used as a diabetes medicine. There have been many studies and reviews related to Senggani (Melastoma malabathricum) and its potential. This review focuses on the discussion of Senggani as an antidiabetic by analyzing the reduction in glucose levels and the repair ability of pancreatic beta cells. The results of the literature study that show that senggani leaves have the ability to reduce blood glucose levels and repair activity of pancreatic beta cells through the DPP-4 enzyme inhibition mechanism supported by molecular docking simulation data. There are 12 active compounds that have a binding site similarity above 50% with the comparison compound vildagliptin. Rutin is the best active compound which has a 100% similarity of the binding site. Based on in vivo research and toxicity analysis on the admetsar database, senggani leaf extract and active compounds of senggani leaves have low toxicity, making it safe to be used as antidiabetic herbal preparations.
Characterization and Bioactivity Test of Pectin from Musa balbisiana Peel Extracted using Various Acid Solvents Husnawati Husnawati; Ika Yuni Astutik; Laksmi Ambarsari
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.1

Abstract

Banana (Musaceaea) is one of the highest production fruits in Indonesia, which amounted to 7,162,685 tons in 2017. Banana peel waste produced can reach 40% of the total production of fresh bananas. Kepok banana peel contains a lot of nutrients and pectin. Pectin levels in banana peel ranged from 1.92% to 3.25% of dry weight. This study aims to characterize pectin from kepok banana peel (Musa balbisiana) extracted using nitric acid, citric acid, and HCl and screening potential of pectin bioactivity based on LC50 values. The highest pectin yield was obtained from extraction using pH 4 citrate buffer which was 3.68 ± 1.23%. In general, the characteristics of the best pectin from kepok banana peel are pectin extracted with HNO3 pH 4 with methoxyl degree 3.74 ± 0.34%, galacturonate content 87.64 ± 8.36%, and esterification degree 24.24 ± 0.098%. Based on the LC50 value the pectin extraction results can be classified into two, namely commercial pectin and pectin HCl pH 1.5 which is low bioactivity (LC50 > 100 ppm), and pH 4 HNO3 pectin and pH 4 citrate buffer pectin which has high bioactivity (LC50 ≤ 30 ppm). Keywords: Cytotoxicity, galakturonat, kepok banana pectin, methoxyl
Co-Authors Agus Setiyono Akhmad Endang Zainal Hasan Aldi Fadilah Amrista Fanzani Kananga Aziz Syamsul Huda Bambang Pontjo Priosoeryanto Chintia Ayu Puspita Danty Oktiana Prastiwi DIMAS ANDRIANTO Elgiani Yassifa Yulia Nur Insari Eny Ida Riyanti Faisal Rahman Galuh Rizal Prayoga Gina Oktaviani Sabrina Hanif Alamudin Manshur Hasim Hasim Hasim Hasim Heddy Julistiono Ika Yuni Astutik Imelia Dewi Irmanida Batubara LAKSMI AMBARSARI Latifah Kosim Darusman Mega Safithri Muhammad Farhan Muhammad Irfansyah Pradika Nurliani Bermawie Ratna Puspita Safira Rahmadanti Santi Nuraeni Siti Wachidatun Zulaikha Slamet Hamzah Sri Wahyuni Syndilona Br Sitepu Tohru Mitsunaga Tommy Abrar Yonathan Arderian Mantik Zulfikar Muchammad