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All Journal AL KAUNIYAH Jurnal Kesehatan Andalas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Astrid Teresa
Universitas Palangka Raya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Public Health Social Sciences

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Pengaruh Hormon Androgen terhadap Ekspresi Gen CD52 di Epididimis Mencit (Mus musculus) Silvani Permatasari; Dwi Ari Pujianto; Astrid Teresa
Jurnal Kesehatan Andalas Vol 9, No 2 (2020): Online June 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1224

Abstract

Androgen has an important role in regulation epididymal sperm maturation  Epididymal sperm maturation is occurs via interactions between sperm and proteins secreted by epididymal genes that are specifically expressed in a region-specific manner. Mice CD52 exhibited expression in all regions in epididymis. However, the regulation of its expression by androgen is needed to be known as a gene candidate that involved in sperm maturation. Objective: This study was aimed to analyze regulation of mice CD52 expression by androgen and a bioinformatics analysis was performed to predict functional domains of CD52. Methods: bioinformatics analysis using Motif Scan. For experiment, mice divided into 5 groups. The groups were control was injected ethanol 0,1 mL/day and others groups were  3, 5, 10, and 15 day used a androgen receptor antagonist, flutamide that dilute in ethanol at a dose of 50 mg/kg/day. And then quantitative real-time RT-PCR was used to analyse expression of CD52 and it’s normalized to Beta actin. Result: CD52 contained a two potential phosphorylation sites for protein kinase C and casein kinase II, N-myristoylation, and N-glycosylation that showed CD52 is secretory protein and predict it’s attached to sperm membrane. Expression of CD52 was decrease about 93% than control. Conclusion: CD52 expression depend on androgen.Keywords:  androgen; epididymis; sperm maturation; expression of CD52
Pemanfaatan Tanaman Obat Keluarga sebagai Minuman Penguat Imunitas Tubuh di RT 04 Kelurahan Bereng Pulang Pisau Silvani Permatasari; Ervi Audina Munthe; Astrid Teresa; Fraulein Aryati
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No 3 (2022): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v7i3.2723

Abstract

WHO has declared COVID-19 a pandemic. Increasing body immunity is crucial for defense against infectious diseases. The immune system is influenced by several factors, including diet, environmental factors, lifestyle, age, stress, and hormones. Utilizing medicinal plants can make traditional drinks that are useful for increasing body immunity. The Ministry of Health Letter Statement No. HK.02.02/IV.2243/2020 concerning the Utilization of Traditional Medicines for Health Maintenance, Disease Prevention, and Health Care are attached with ingredients to increase body resistance. The community of RT 04 Bereng Village has a large area to grow family medicinal plants (TOGA) such as ginger, lemongrass, turmeric, Curcuma, and lime. These spices contain curcuminoid compounds which function as immunostimulators in boosting the immune system. In addition, herbs such as ginger, ginger, turmeric, and lemongrass contain high enough antioxidants so that they can ward off free radicals in our bodies. This service aims to provide information about processing TOGA into traditional drinks that can increase body immunity during the COVID-19 pandemic. This activity has stages of delivering education through pocketbooks, direct practice processing drinks from TOGA, and giving TOGA seeds. The results of this community service are in the form of herbal drinks, which are expected to increase the community's immunity; then can improve knowledge and skills in processing TOGA, especially in the neighborhood of RT 04 Kelurahan Bereng.
Uji Efektivitas Gel Hand Sanitizer Ekstrak Daun Sembung (Blumea balsamifera) Sebagai Antimikroba Silvani Permatasari; Dewi Klarita Furtuna; Astrid Teresa; Syarpin Syarpin; Widya Krestina
Al-Kauniyah: Jurnal Biologi Vol 16, No 1 (2023): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v16i1.22831

Abstract

AbstrakHand sanitizer merupakan salah satu bahan antiseptik yang yang praktis agar tubuh terhindar dari penyakit yang disebabkan oleh mikroorganisme. Hand sanitizer berbasis alkohol digunakan berlebihan dan terus menerus dapat mengakibatkan iritasi pada kulit. Kandungan yang terdapat dalam bahan alami sebagai alternatif pengganti alkohol antara lain flavonoid dan terpenoid yang terdapat di daun sembung (Blumea balsamifera). Penelitian ini bertujuan untuk mengetahui efektivitas gel hand sanitizer dari ekstrak daun sembung pada berbagai konsentrasi. Serbuk daun sembung diekstraksi secara maserasi menggunakan etanol 70%, kemudian dibuat gel dengan konsentrasi 10%, 15%, dan 20% ditambah carbopol 940, TEA, serta metil paraben. Sediaan gel hand sanitizer dievaluasi melalui uji organoleptis, pH, dan homogenitas selama 4 minggu. Setelah itu, dilakukan pengujian daya antiseptik dan aktivitas antimikroba terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans. Sediaan gel hand sanitizer ekstrak daun sembung memiliki konsistensi kental, warna hijau kehitaman, aroma khas daun sembung, homogenitas baik, dan nilai pH 6. Sediaan ini juga memiliki daya antiseptik yang baik mampu mengurangi jumlah koloni hingga 95% sama dengan sediaan gel berbasis etanol. Sediaan gel konsentrasi 20% memiliki zona hambat yang sangat kuat terhadap S. aureus dan C. albicans, serta kuat melawan E. coli. Gel hand sanitizer ekstrak Blumea balsamifera menunjukkan aktivitas antimikroba dan dapat digunakan menjadi kandidat agen antimikroba organik alami.Kata kunci: Antimikroba; Antiseptik; Ekstrak Blumea balsamifera; Hand sanitizer  AbstractHand sanitizer is one of antiseptic so that our body avoids diseases caused by microorganism. Hand sanitizer based on ethanol using continuously can cause skin irritation. The secunder metabolit contained in herbal as an alternative to hand sanitizer based ethanol contained flavonoid and terpenoid, are found in sembung leaves (Blumea balsamifera). The aim of this study is to determine the effectiveness of hand sanitizer gel from sembung leaf extract at various concentrations. Sembung leaf was extracted by maceration using 70% ethanol, and then gel was made with concentrations of 10%, 15%, and 20% plus carbopol 940, TEA, methyl paraben. The hand sanitizer gel preparation was evaluated through organoleptic, pH, and homogeneity tests for 4 weeks. After that, antiseptic activity and antimicrobial activity were tested against Staphylococcus aureus, Escherichia coli, and Candida albicans. The hand sanitizer gel preparation of sembung leaf extract has a thick consistency, blackish green color, a distinctive aroma of sembung leaves, good homogeneity, and a pH value of 6. The gel with a concentration of 20% had a very strong zone of inhibition against S. aureus and C. albicans, also strong against E. coli. Blumea balsamifera extract hand sanitizer gel exhibits antimicrobial activity and can be used as a candidate natural organic antimicrobial agent.
Uji Efektivitas Gel Hand Sanitizer Ekstrak Daun Sembung (Blumea balsamifera) Sebagai Antimikroba Silvani Permatasari; Dewi Klarita Furtuna; Astrid Teresa; Syarpin Syarpin; Widya Krestina
Al-Kauniyah: Jurnal Biologi Vol 16, No 1 (2023): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v16i1.22831

Abstract

AbstrakHand sanitizer merupakan salah satu bahan antiseptik yang yang praktis agar tubuh terhindar dari penyakit yang disebabkan oleh mikroorganisme. Hand sanitizer berbasis alkohol digunakan berlebihan dan terus menerus dapat mengakibatkan iritasi pada kulit. Kandungan yang terdapat dalam bahan alami sebagai alternatif pengganti alkohol antara lain flavonoid dan terpenoid yang terdapat di daun sembung (Blumea balsamifera). Penelitian ini bertujuan untuk mengetahui efektivitas gel hand sanitizer dari ekstrak daun sembung pada berbagai konsentrasi. Serbuk daun sembung diekstraksi secara maserasi menggunakan etanol 70%, kemudian dibuat gel dengan konsentrasi 10%, 15%, dan 20% ditambah carbopol 940, TEA, serta metil paraben. Sediaan gel hand sanitizer dievaluasi melalui uji organoleptis, pH, dan homogenitas selama 4 minggu. Setelah itu, dilakukan pengujian daya antiseptik dan aktivitas antimikroba terhadap Staphylococcus aureus, Escherichia coli, dan Candida albicans. Sediaan gel hand sanitizer ekstrak daun sembung memiliki konsistensi kental, warna hijau kehitaman, aroma khas daun sembung, homogenitas baik, dan nilai pH 6. Sediaan ini juga memiliki daya antiseptik yang baik mampu mengurangi jumlah koloni hingga 95% sama dengan sediaan gel berbasis etanol. Sediaan gel konsentrasi 20% memiliki zona hambat yang sangat kuat terhadap S. aureus dan C. albicans, serta kuat melawan E. coli. Gel hand sanitizer ekstrak Blumea balsamifera menunjukkan aktivitas antimikroba dan dapat digunakan menjadi kandidat agen antimikroba organik alami.Kata kunci: Antimikroba; Antiseptik; Ekstrak Blumea balsamifera; Hand sanitizer  AbstractHand sanitizer is one of antiseptic so that our body avoids diseases caused by microorganism. Hand sanitizer based on ethanol using continuously can cause skin irritation. The secunder metabolit contained in herbal as an alternative to hand sanitizer based ethanol contained flavonoid and terpenoid, are found in sembung leaves (Blumea balsamifera). The aim of this study is to determine the effectiveness of hand sanitizer gel from sembung leaf extract at various concentrations. Sembung leaf was extracted by maceration using 70% ethanol, and then gel was made with concentrations of 10%, 15%, and 20% plus carbopol 940, TEA, methyl paraben. The hand sanitizer gel preparation was evaluated through organoleptic, pH, and homogeneity tests for 4 weeks. After that, antiseptic activity and antimicrobial activity were tested against Staphylococcus aureus, Escherichia coli, and Candida albicans. The hand sanitizer gel preparation of sembung leaf extract has a thick consistency, blackish green color, a distinctive aroma of sembung leaves, good homogeneity, and a pH value of 6. The gel with a concentration of 20% had a very strong zone of inhibition against S. aureus and C. albicans, also strong against E. coli. Blumea balsamifera extract hand sanitizer gel exhibits antimicrobial activity and can be used as a candidate natural organic antimicrobial agent.
Co-Authors Dewi Klarita Furtuna Dwi Ari Pujianto Ervi Audina Munthe Fraulein Aryati Permatasari, Silvani Syarpin Syarpin Widya Krestina