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All Journal VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Syiah Kuala E-Bisnis : Jurnal Ilmiah Ekonomi dan Bisnis Jurnal Ilmu Kimia Universitas Brawijaya Bulletin of Chemical Reaction Engineering & Catalysis The Journal of Pure and Applied Chemistry Research Jurnal Ilmiah Administrasi Publik JURNAL ILMU PEMERINTAHAN Indonesian Journal of Chemistry Jurnal Menara Ekonomi : Penelitian dan Kajian Ilmiah Bidang Ekonomi Jurnal Kolaboratif Sains Bulletin of Chemical Reaction Engineering & Catalysis
Masruri Masruri
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Curative Activity of Isolated Fraction from Spathodea campanulata Beauv Stem Bark on Rats Exposed to Benzopyrene Masruri Masruri; Mohamad Lutfillah; Ady Sumaryanto; Rurini Retnowati; Aulanni'am Aulanni'am
Journal of Tropical Life Science Vol. 4 No. 3 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.04.03.01

Abstract

This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA) on rats cancer model exposed with benzopyrene, and the histology of its lung. The secondary metabolite of the stem bark fraction consisted of alkaloids, flavonoids-phenolic, terpenoid and steroid compounds. The isolated fraction contained of these metabolites significantly indicate bioactivity by reducting of malondialdehyde (MDA) level, and also histology appearance of the lung tissue prepared from the benzopyrene-exposed rat indicated a curative activity.
In Silico Screening of Syzygium myrtifolium Flavonoid Compoinds as Anti-bacterial Activity: In Silico Screening of Syzygium myrtifolium Flavonoid Compounds Nelsy Dian Permatasari; Jatmiko Eko Witoyo; Masruri; Sudarminto Setyo Yuwono; Simon Bambang Widjanarko
Journal of Tropical Life Science Vol. 12 No. 3 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.03.02

Abstract

Bacterial infection and antibiotic resistance are popular issues nowadays. Several pre[1]vious reports performed antibacterial screening activities involving natural herbs and synthetic drugs. Alanine racemase and transglycosylase are essential proteins for peptidoglycan membrane synthesis in bacteria and an alternative target for antibacterial performance. This study identified six flavonoid compounds in Syzygium myrtifolium to perform the antibacterial activity. In silico study was conducted for modelling flavonoids – protein complexes. Five flavonoids from S. myrtifolium were taken out of he canonical smiles from the PubChem database and modelled three-dimensional structure using ChemDraw and molView. Targeted protein, alanine racemase and transglycosylase were downloaded from Protein Data Bank with ID 4WR3 and 1SLY. Ligands and proteins were interacted by Molegro virtual Docker 5.0 and visualized by Discovery studio version 21.1.1. Five flavonoids showed inhibition with alanine racemase and transglycosylase in the same active sites of control and sodium benzo[1]ate. According to the binding energy, calopiptin performed the lowest binding energy value in alanine racemase complexes, while 2-Propanone, 1,3-bis(5-nitro-2-furanyl) showed the lowest value of four other flavonoids at transglycosylase complexes. The type of interactions were electrostatic, hydrogen bonds, hydrophobic interactions and unfavorable ones. Low binding energy and varied interaction types indicated tight of ligand-protein interaction. In summary, five flavonoids inhibited alanine racemase and transglycosylase, and the peptidoglycane membrane synthesis in bacteria might be inferred.
Co-Authors Abdillah Sani Ady Sumaryanto Alyaa Farrah Dibha Amini, Helda Wika Amini, Rekfa Wika Arda Rista Lestari Arie Srihardyastutie Aulann'iam Aulann'iam Aulanni'am Aulanni'am Bambang Ismuyanto Barlah Rumhayati Barlah Rumhayati Dasrul Dasrul Denis Al Karoma Dian Mulyani Dodyk Pranowo Eka Novitasari Eria Anggraini Fadillah Utami Prasetyaningtyas Fadlilah, Lilik Nur George Towar Ikbal Tawakkal Irfan Hanafi Arif Jatmiko Eko Witoyo Kintan Ulyantiputeri Lailatul Rohmah M. Abdi Dzil Ikhram W. Moh. Farid Rahman Moh. Farid Rahman Moh. Zakiy Fiddin Mohamad Lutfillah Mohammad Farid Rahman Mohammad Farid Rahman Momodou Salieu Sowe Momodou Salieu Sowe Mukesh Sharma Nelsy Dian Permatasari Noval Dwi Wijaya Nur Ikhtiarini Nuraini Uswatun Chasana Prasetyo Adi Prima Yulianti Rana Ayu Ning Tyas Rekfa Wika Amini Retno Indriatie Rizal Nur Alfian Rizki Wahyu Aji Wibowo Rurini R Rurini R Rurini Retnowati Shoja Ismela SIMON BAMBANG WIDJANARKO Siti Mariyah Ulfa Siti Nurul Afifah Solo, Anna Apriani Maniuk Suci Susanti Sudarminto Setyo Yuwono Tutik Setianingsih Warsito Warsito Wawan Sobari Widia Edy Kuncoro Widodo Widodo Yuga Adi Pranata