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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Gici Jurnal Keuangan dan Bisnis Odonto dental journal
Dahlia Herawati
Faculty Of Dentistry, Universitas Gadjah Mada, Yogyakarta
Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health

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The difference of saline and sterile water for tetracycline hydrochloride solvents in cementum demineralization Shinta Ferronika; Ahmad Syaify; Dahlia Herawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 1 (2016): March 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (29.184 KB) | DOI: 10.20473/j.djmkg.v49.i1.p5-9

Abstract

Background: The root cementum demineralization is an important step in regenerative periodontal therapy to smear layer removal on the root surface. Smear layer on the root surface becomes a barrier of the new attachment between periodontal tissues with the root surface. The use of tetracycline capsules as root surface demineralizing agent cannot be applied directly on the root surface and solvents such as saline or sterile water are needed. Purpose: The aim of this study was to determine differences between sterile water and saline solvent for tetracycline HCl (tetra HCl) as a cementum demineralization. Method: In this study the specimens were divided into three groups: a control, tetra HCl dissolved in saline, and tetra HCl dissolved in sterile water. Application using burnishing method for 3 minutes. Samples were dehydrated with ethanol series of 30% to 100%. Results of the root demineralization observed by scanning electron microscopy (SEM). Statistical analysis was performed using the Kruskal-Wallis followed by a Mann-Whitney nonparametric test. Result: Upon statistical analysis showed that the sterile water as a solvent of tetra HCl is more effective in smear layer removal and collagen structure exposure in the cementum. Conclusion: Tetra HCl dissolved in sterile water was found to be the best root cementum demineralization agent.
Combining 10% propolis with carbonated hydroxyapatite to observe the RANKL expression in a rabbit’s alveolar bone Nungky Devitaningtyas; Ahmad Syaify; Dahlia Herawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 4 (2020): December 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i4.p212-216

Abstract

Background: Periodontitis causes an increased receptor activator level in the nuclear factor-κβ ligand (RANKL), which is one of the inflammatory mediators that plays a role in osteoclastogenesis. The open flap debridement (OFD) technique is the preferred treatment when accompanied by regenerative periodontal treatment using guided tissue regeneration (GTR) and guided bone regeneration (GBR). Carbonated hydroxyapatite is a GBR material that serves as a scaffold and has strong osteoconductive properties for bone regeneration. Propolis is natural product that can decrease osteoclastogenesis in periodontitis by decreasing the RANKL expression. Purpose: To investigate the RANKL expression after open flap debridement by applying carbonated hydroxyapatite to 10% propolis in the alveolar bone of rabbits. Methods: Nine induced-periodontitis rabbits (Oryctolagus cuniculus) were divided into three treatment groups of Group A OFD, Group B OFD followed by the application of carbonated hydroxyapatite, and Group C OFD followed by application of 10% propolis-carbonated hydroxyapatite. Each group was selected one to euthanised on the seventh, 14th and 28th day, respectively, and prepared using histology slides. The data was analysed using a two-way ANOVA followed by a post-hoc LSD test (p<0.05). Results: The RANKL expression in each group showed significant differences (p=0.00; p<0.05) on the seventh, 14th and 28th day. The post-hoc LSD test showed that the RANKL expression in the treatment group with carbonated hydroxyapatite-10% propolis had significant differences (p<0.05) in the intergroup analysis at different time points. Conclusion: Combining 10% propolis with carbonated hydroxyapatite in OFD treatment can decrease the RANKL expression in a rabbit’s alveolar bone.
Association between periodontal disease and prostate cancer Nur RAS. Aji; Dahlia Herawati
Journal of Dentomaxillofacial Science Vol. 4 No. 1 (2019): (Available online: 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.241 KB) | DOI: 10.15562/jdmfs.v4i1.755

Abstract

Objective: The aim of this literature review was to study the underlying mechanisms of the association between Periodontal disease and Prostate Cancer.Methods: This study is literature review study, pubmed searching was used to find scientific article about association of periodontal disease and Prostate CancerResults: Study about the Association between Periodontal disease and Prostate cancer by 12-year Longitudinal Cohort Study in South Korea using  Multivariate  Cox proportional Hazard Regression Analysis Periodontal Disease show a significantly and positively association with Prostrate Cancer. There may exist shared underlying genetic factors that increase the risk of both periodontal disease and cancers. Periodontitis might be associated with increased cancer risk, particularly with hematological, breast and prostate cancers. Direct correlation between periodontal disease and prostrate cancer is still unclear. It was hyphotesized that microorganisms involved in chronic periodontitis may directly induce mutations in the tumor-suppresor genes and proto-oncogenes or alter the signalling pathways that in turn stimulates cancer growthConclusion: Periodontal disease may associate to prostate cancer by mutation induction in tumor-suppresor genes.
Effect of advanced-platelet rich-fibrin combined with rosuvastatin application after open flap debridement of infrabony pocket Tissa Rahadianti; Dahlia Herawati; Kwartarini Murdiastuti
Majalah Kedokteran Gigi Indonesia Vol 7, No 2 (2021): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.53419

Abstract

Open flap debridement (OFD) is an invasive therapy for chronic periodontitis with pocket 5 mm or more. However, it is difficult to achieve regeneration and new attachment with this therapy. Periodontitis starts to add growth factors and local drugs delivery as host modulation therapy. Advanced-PRF (A-PRF) contains more growth factor than PRF which plays a role in promoting fibroblast proliferation, reepithelization, extracellular matrix production, and endothelial cell migration. 1.2% rosuvastatin gel (RSV) is a local delivery drug with a pleiotropic effect that can modify host response to promoting BMSCs, BMP-2, OPG, ALP, RANKL, and osteoblasts. This study aimed to examine the effect of the application of A-PRF+RSV in OFD therapy of which the parameters were probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The study samples consisted of 24 periodontal pockets which were divided into 2 groups of 12 pockets each, namely A-PRF+RSV for group 1 and PRF+RSV for group 2. Clinical evaluations were carried out on baseline, day-30, and day-90 for PD and RAL, and on baseline and day -90 for alveolar bone height. Data of PD and RAL reduction were analyzed with non-parametric test Mann-Withney, while data of reduction of alveolar bone height were analyzed with parametric Independent-T test. Group 1 obtained a statistically more significant result in reducing PD, RAL, and alveolar bone height compared to group 2 (p<0.05) To conclude, the application of A-PRF and 1.2% rosuvastatin gel in OFD procedure promotes a higher PD and RAL reduction and alveolar bone height increase than the application of PRF coupled with 1.2% rosuvastatin gel.
PENGARUH ORIENTASI DAN VOLUMETRIK GLASS FIBER NON DENTAL TERHADAP KEKUATAN PERLEKATAN GESER FIBER REINFORCED COMPOSITES UNTUK SPLINTING PERIODONTAL Dedi Sumantri; Siti Sunarintyas; Dahlia Herawati
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 2, Nomor 1, Juni 2015
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.474 KB) | DOI: 10.33854/JBDjbd.5

Abstract

Fiber Reinforced Composite (FRC) menggunakan E-glass fiber dental dalam bidang kedokteran gigi telah banyak diaplikasikan secara klinis, salah satunya dalam aplikasi splinting periodontal. Ketersediaan E-glass fiber dental di Indonesia masih terbatas dengan harga relatif mahal. Terdapat glass fiber non dental di Indonesia yang banyak digunakan bidang teknik, dengan harga terjangkau. Tujuan dari penelitian ini untuk mengetahui pengaruh orientasi dan volumetrik glass fiber non dental terhadap kekuatan perlekatan geser FRC pada splinting periodontal. Bahan penelitian berupa glass fiber non dental yang terdiri dari tiga jenis yaitu glass fiber mats (LT, China), glass fiber roving (CMAX, China), dan glass fiber woven roving (HJ, China), serta E-glass fiber dental (Fiber-Splint, Polidentia SA, Switzerland). Objek dibagi menjadi 8 kelompok, masing-masing kelompok terdiri atas 4 sampel. Kelompok I (kontrol) tanpa penambahan glass fiber non dental, kelompok II E-glass fiber dental 2,8 vol%, dan kelompok III - VIII terdiri dari glass fiber non dental mats, glass fiber non dental roving, dan glass fiber non dental woven roving, dengan fraksi volumetrik 2,8 dan 5,4 vol%. Seluruh sampel direndam dalam air destilasi selama 24 jam pada suhu 37o C. Pengujian kekuatan perlekatan geser menggunakan Universal Testing Machine. Data dianalisis menggunakan ANAVA dua jalur, uji t dan LSD. Hasil penelitian menunjukkan rerata kekuatan perlekatan geser (MPa) terendah pada kelompok tanpa fiber (kontrol) (8,95 ± 0,95) dan tertinggi pada 5,4 vol% glass fiber non dental woven roving (14,11 ± 0,35). Hasil analisis ANAVA dua jalur menunjukkan variabel orientasi dan volumetrik glass fiber non dental memberikan pengaruh signifikan (p<0,05). Uji post hoc LSD dan uji t menunjukkan perbedaan signifikan (p<0,05) pada seluruh kelompok perlakuan untuk variabel orientasi dan volumetrik. Kesimpulan penelitian ini adalah orientasi dan volumetrik glass fiber non dental memberikan pengaruh terhadap peningkatan kekuatan perlekatan geser FRC.
The Effectiveness of injectable platelet-rich fibrin and bone graft addition to open flap debridement for infrabony pocket therapy Rizka Dindarini; Dahlia Herawati; Sri Pramestri Lastianny
Majalah Kedokteran Gigi Indonesia Vol 8, No 1 (2022): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.63600

Abstract

Various biomaterials have been utilized as additional material to help tissue regeneration in the open flap debridement (OFD) procedure. Platelet-rich fibrin (PRF) is an autologous platelet concentrate that contains many growth factors (GFs) and generally used as an additional biomaterial in OFD. However, PRF has several weaknesses, such as its consistency, which is hard to mix with another biomaterial, and its abundant sediment of regenerative cells resulted from high-speed centrifugation. Injectable Platelet Rich Fibrin (I-PRF) is one of the PRF derivatives that contain more regenerative cells. Due to the low-speed centrifugation, I-PRF has a liquid form. Certain GFs were also found in I-PRF, such as PDGF, TGF-β1, VEGF, IGF, EGF dan COL-Ia. In this study, we measured probing depth (PD), relative attachment level (RAL), and bone height as the healing parameter, to see the effectiveness of I-PRF addition and bone graft in the OFD for infrabony pocket as the aim of this study. Twenty (20) periodontal pockets were chosen (PD= 5-7 mm) and divided into OFD+I-PRF+bone graft (bg) group (group I) and OFD+PRF+bg group (group II) equally. The clinical evaluation was measured at the baseline, day-30, and day-90. Results showed that PD (p= 0.022) and RAL (p= 0.008) significantly increased in group I (PD 2.80 ± 0.42; RAL 2.50 ± 0.52) compared to group II (PD 2.10 ± 0.73; RAL 2.00 ± 0.67); however, there was no significant difference in the bone height (p= 0.194). Taken together, our data revealed that I-PRF+bg induces soft tissue regeneration in infrabony pocket treatment.
Aplikasi Platelet Rich Fibrin dan Gel Rosuvastatin 1.2% sebagai Perawatan Adjuvan pasca Open Flap Debridement pada Periodontitis Stage III Grade B pada pasien dengan kondisi premenopause Nur Rahman Ahmad Seno Aji; Tissa Rahadianti; Dahlia Herawati
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 8, No 1 (2022)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.77575

Abstract

Periodontitis merupakan penyakit inflamasi jaringan pendukung gigi yang menimbulkan gangguan mastikasi, permasalahan estetika serta fonasi. Gangguan-gangguan permanen akibat periodontitis telah terbukti mempengaruhi kualitas hidup secara negatif. Periodontitis terjadi karena proses dysbiosis mikroorganisme rongga mulut dan respon inang yang inadekuat yang menyebabkan inflamasi persisten sehingga timbul destruksi jaringan periodontal. Berdasarkan tingkat keparahan dan kecepatan progresinya, periodontitis diklasifikasikan dalam stage dan grade tertentu. Periodontitis stage III Grade B merupakan kondisi penyakit periodontal tahap lanjut yang umumnya disertai poket infraboni dan kegoyangan gigi. Kondisi sistemik seperti hormon berpengaruh pada jaringan periodontal. Menjelang menopause terjadi perubahan hormon progesterone dan estrogen yang mempengaruhi integritas dan kesehatan jaringan periodontal. Modifikasi perawatan berupa penambahan bahan adjuvan pasca bedah periodontal berpengaruh positif pada periodontitis yang disertai kondisi premenopause. Platelet Rich Fibrin (PRF) merupakan salah satu olahan konsentrat platelet yang mampu menyediakan faktor pertumbuhan pada area operasi. Gel Rosuvastatin (RSV) 1,2% merupakan obat dari golongan statin yang memiliki efek pleiotrofik dan dapat berperan sebagai agen host modulation therapy (HMT) untuk mengendalikan inflamasi di jaringan periodontal. Artikel ini menyajikan sebuah alternatif perawatan fase korektif dengan aplikasi PRF dikombinasikan dengan gel rosuvastatin pada periodontitis stage III grade B sehingga diharapkan terjadi regenerasi jaringan periodontal.
In vitro evaluation of coenzyme Q10 on primary fibroblast culture Herawati, Dahlia
Majalah Kedokteran Gigi Indonesia Vol 9, No 1 (2023): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.80158

Abstract

Chronic inflammation in periodontitis results in continuous production of Reactive Oxygen Species (ROS), so the levels are excessive, causing destruction of the gingiva, periodontal ligament, and alveolar bone through a variety of mechanisms including DNA damage and the formation of proinflammatory cytokine. One way to prevent periodontal tissue damage caused by excessive ROS formation is by administering antioxidants. Coenzyme Q10 is a powerful antioxidant that is beneficial for inhibiting free radicals to prevent the progression of periodontal tissue destruction and accelerate healing processes. The purpose of this study was to evaluate the fibroblast proliferation of the combination of Coenzyme Q10 and vegetable glycerin compared to PerioQ. Materials used were made of original Coenzyme Q10 dissolved in glycerin that was prepared in a ratio of 2:8 and 1:9, and Perio Q as the control. Each group consisted of six samples (n = 6). Primary fibroblasts were derived from healthy gingival tissue. Observations on day-1, -3, and -5 using MTT assay at a wavelength of 550nm. Statistical analysis used a Two-Way ANOVA test followed by a Post Hoc test.  The experiment showed the absorbance values were high in all the groups, the highest value was on day 3, namely Coenzyme Q10 at a concentration of 2:8, followed by Coenzyme Q10 at a concentration of 1:9, and PerioQ. The statistical tests showed significant differences in the 3 groups (p < 0.05). It is concluded that Coenzyme Q10 in 1:9 and 2:8 concentrations were both as viable as Perio Q towards primary gingival fibroblast culture. 
PENGARUH BAURAN PEMASARAN TERHADAP KEPUTUSAN PEMBELIAN DI KOPI SINGGAH BOGOR Herawati, Dahlia
Jurnal Gici Jurnal Keuangan dan Bisnis Vol 16 No 1 (2024): Jurnal Keuangan dan Bisnis
Publisher : Sekolah Tinggi Ilmu Ekonomi GICI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58890/jkb.v16i1.267

Abstract

One industry that is still growing today is the food and beverage industry. This industry is a promising business because the market potential of the food and beverage business is very large because food and drink are basic human needs, so it will create extraordinary demand. Like the Bogor Singgah Coffee shop beverage business which until now has survived in the development of the business world with a level of intense competition, this business was founded because of people's passion and love for coffee, especially if you look at the way individuals allocate money and time which can describe lifestyle also occurs in the phenomenon of drinking coffee in a coffee shop which has recently been spreading. The purpose of this study was to determine and analyze the effect of the marketing mix on purchasing decisions at Kopi Singgah Bogor. The type of research used is survey research with a research method in the form of data collection using a questionnaire. The data analysis model used is simple linear regression analysis. The sample selection was carried out by purposive sampling. The sample amounted to 80 respondents. The regression test results show that 69.7% of purchasing decision factors can be explained by product, price, location, and promotion indicators while the remaining 30.3% is is explained by other factors not examined in this study. The t test results show that the marketing mix variable shows the results of the tcount analysis (13.520) where the ttable (1.665), so the marketing mix variable has a positive and significant effect on purchasing decisions at Kopi Singgah Bogor.
Frenectomy Using Z-Plasty Technique in Case of Aberrant Frenum on Aesthetic Zone Wildan, Muhammad Nabeel; Herawati, Dahlia
Journal of Indonesian Dental Association Vol 7 No 2 (2024): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v7i2.1180

Abstract

Background: Aberrant frenum can cause many problems such as central diastema, food impaction, dental caries, and aesthetic problems. This case can be handled with frenectomy, which is Z-Plasty technique can be used to treat thick and wide frenulum associated with papillary penetrate and central diastema. Case Report: A 17 years old girl was referred from orthodontist to Department of Periodontics, RSGM UGM Prof. Soedomo Yogyakarta for treatment of maxillary labial frenulum. Intra-oral examination revealed a diastema on the maxillary central incisor of 2.5 mm and frenulum attachment extended to the palatine papilla. In this case, collaborative perio-ortho treatment was carried out, frenectomy with Z-Plasty technique done to correct thick frenulum and fixed orthodontic treatment to correct central diastema after completion of periodontal treatment. Evaluations are carried out every 7 days for the first 2 weeks then at 3 and 6 months after periodontal procedure. Conclusion: Frenectomy using Z-Plasty technique was able to correct wide and thick frenulum that extends to the palatine papilla. Good wound healing, minimal scarring and color matching the surrounding tissue, and perio-ortho collaboration treatment was successfully carried out with satisfactory results according to the patient's wishes.
Co-Authors Ahmad Syaify Ahmad Syaify, Ahmad Andy Yok Siswosaputro Ariska Ratih Damayanti Christopher Imantaka Suwondo Deassy Anggraeni Dedi Sumantri Etty Cahya Pertiwi Fitri Yuniawati Kwartarini Murdiastuti Nungky Devitaningtyas Nungky Devitaningtyas Nunuk Purwanti Nur Rahman Ahmad Seno Aji Nur RAS. Aji Oktarina, Dyah Ayu Mira Pramudita Kusuma Wardani Rezmelia Sari Rizka Dindarini Rizky Nurcahyanti Shinta Ferronika Siti Sunarintyas Sri Kadarsih Sri Kadarsih Soejono Sri Pramestri Lastianny, Sri Pramestri Sudibyo Sudibyo Suryono Suryono Tissa Rahadianti Tissa Rahadianti Wayan T Artama Wayan T Artama Wildan, Muhammad Nabeel