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All Journal Medicina Sport and Fitness Journal E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Sari Pediatri Majalah Kesehatan FKUB ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) Cermin Dunia Kedokteran
Ida Sri Iswari
Department Of Clinical Pathology, Faculty Of Medicine, Udayana University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Efek Anti-hiperkolesterolemik Ekstrak Etanol Daun Cnidosculus aconitifolius terhadap Pembentukan Lesi Aterosklerosis Arteri Koroner pada Tikus Wistar Jantan yang Diberi Diet Aterogenik (Rattus norvegicus): Hasil Penelitian Saraswati, Ni Ketut Rake Putri; Iswari, Ida Sri; Sumadi, I Wayan Juli
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1336

Abstract

Introduction: Foods high in cholesterol increase the production of free radicals and inflammation, and may also trigger the formation of atherosclerotic lesions. Cnidosculus aconitifolius or tree spinach leaves were known to have antioxidant and anti-inflammatory activities. This study was to determine the effect of Cnidosculus aconitifolius on blood cholesterol level and coronary artery atherosclerotic lesions formation using a rat model. Methods: A randomized post-test-only control group of 30 male Wistar rats (Rattus norvegicus), aged 2-3 months, randomly divided into 3 groups: standard control was given regular food; negative control was given an atherogenic diet; and the treatment group was given an atherogenic diet + Cnidosculus aconitifolius leaf ethanol extracts. The treatment lasted 44 days. Data was analyzed with OneWay ANOVA and Kruskal-Wallis test. Results: The total cholesterol and LDL levels were significantly lower in the treatment group compared to the control group (p<0.001). A decrease of atherosclerotic lesion scores in the treatment group compared to the control (p=0.010) was also observed. Conclusion: Cnidosculus aconitifolius leaf ethanol extracts have an anti-hypercholesterolemic effect, hence the potential to prevent the formation of atherosclerotic lesions in the coronary arteries of hypercholesterolemic Wistar rats.
Respon Otonomik Jantung yang Buruk pada Pasien Diabetes Melitus Paska Infark Miokard Akut Gede Bagus Gita Pranata; Ketut Badjra Nadha; Ida Sri Iswari
WMJ (Warmadewa Medical Journal) Vol 1 No 1 (2016): Mei 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.1.8.30-41

Abstract

Diabetes mellitus (DM) dengan penyakit kardiovaskular sangat erat kaitannya. Pada beberapa penelitian telah dihubungkan antara diabetes mellitus dengan respon otonomik denyut jantung yang buruk, sedangkan hubungan diabetes mellitus dengan respon otonomik denyut jantung yang buruk pada pasien paska IMA masih belum ada. Pemulihan denyut jantung (HRR) dan denyut jantung istirahat (resting HR) merupakan alat investigasi yang baik,  terpercaya, dan mudah diukur dalam mengevaluasi pengaturan otonomik jantung dan sebagai faktor prediktor kuat untuk  semua kasus  mortalitas pada orang dewasa yang sehat maupun pada seseorang dengan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui bahwa diabetes mellitus tipe 2 sebagai faktor yang memperburuk denyut jantung saat istirahat,  terhadap pemulihan denyut jantung setelah uji latih treadmill pada pasien pasca infark miokard,  serta merupakan variabel penting sebagai faktor prediktor kejadian morbiditas dan mortalitas pada pasien dengan  paska infark miokard akut. Pada analisis bivariat ditemukan pasien dengan diabetes mellitus tipe 2 dan tanpa diabetes mellitus tipe 2 berbeda secara bermakna dalam memperburuk respon otonomik denyut jantung (denyut jantung saat istirahat dan denyut jantung pemulihan) pada pasien paska IMA (p<0,01). Pada analisis multivariat tidak ditemukan adanya pengaruh faktor umur, jenis kelamin, riwayat keluarga, dislipidemia, hipertensi, merokok, aktifitas fisik, dan penyekat beta terhadap respon otonomik denyut jantung yang buruk pada pasien DM paska IMA (p>0,05).Kata kunci: Diabetes mellitus tipe 2, Infark miokard akut, denyut jantung saat istirahat, denyut jantung pemulihan, treadmill. [Relationship Between Type 2 Diabetes Mellitus and Poor Heart Rate Autonomic Response In Post IMI Patients]. Diabetes mellitus (DM) and cardiovascular disease are very closely related. Several studies have shown the link of diabetes with poor heart rate autonomic response, whereas data on the relationship of diabetes mellitus with poor heart rate autonomic response in post AMI patients are still not available. Heart rate recovery (HRR) and resting heart rate (resting HR) is an investigative tool that is both reliable and easy to measure in evaluating the cardiac autonomic regulation and as a strong predictor factor for allcauses of mortality in healthy adults as well as in ones with cardiovascular disease. This study aimed to determine that type 2 diabetes mellitus is a factor that worsens heart rate at rest worsens recovery heart rate after treadmill exercise test in patients with post myocardial infarction, and that it is an important variable factor as predictor for incidence of morbidity and mortality. The bivariate analysis showed that patients with type 2 diabetes mellitus and those without type 2 diabetes mellitus differed significantly in worsening the autonomic response of the heart rate (heart rate at rest and recovery heart rate) in post-AMI patients (p<0.01). Multivariate analysis didn’t find any relationship of the other variables i.e. age, gender, family history, dyslipidemia, hypertension, smoking, physical activity, and beta blockers with poor heart rate autonomic response in post-AMI diabetic patients (p>0.05).Keywords: Type 2 diabetes mellitus, acute myocardial infarction, heart rate at rest, heart rate recovery, treadmill.
Co-Authors Agus Eka Darwinata Anak Agung Gde Putra Wiraguna Arisandy Achmad Bagus Ngurah Putu Arhana Cynthia Sofyanti Sugiharto Dady Iskandar Delly Dahlia Desak Made Wihandani Gede Bagus Gita Pranata Gede Bagus Gita Pranata Gede Bagus Gita Pranata, Gede Bagus Gita Gusti Ayu Dianti Violentina Hayyu Kusumaningtyas I Dewa Made Sukrama I Dewa Putu Sutjana I Gusti Made Aman I Ketut Badjra Nadha I Ketut Suada I Komang Kari I Made Gustama Heryawan I Made Jawi I Made Reza Pramudya I Putu Adiartha Griadhi I Putu Gede Septiawan Saputra I Wayan Juli Sumadi Ida Ayu Santhi Pertiwi Manuaba Ida Bagus Subanada Indramawan Setyojatmiko J. A. Pangkahila Ketut Erna Bagiari, Ketut Erna Ketut Rina, Ketut Komang Januartha Putra Pinatih Kusumajaya, I Gusti Bagus Ari Adi Luh Putu Ratna S Made Agus Hendrayana Muhammad Ali Imron Ni Made Adi Tarini Ni Nengah Dwi Fatmawati Ni Nyoman Sri Budayanti Ni Putu Siadi Purniti Ni Wayan Winarti Noviana Indrawati Olivia Julita Paramyta, I Gusti Ayu Cintya Putu Yoska Arya Harindana Saraswati, Ni Ketut Rake Putri Shalihaty Emy Sugijanto - Susy Purnawati Wimpie I Pangkahila Yuliana Tjua