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Hervina
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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Topical Gel Formulated With Ziziphus Spina-Christi Leaf Extract Decreases Lymphocyte Infiltration in Gingival Incision Wounds I Gusti Ayu Dewi Haryani; Hervina; Made Talitha Suryaningsih Pinatih; Lee Youngwoo
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.12200

Abstract

Introduction: Gingival wounds are injuries in the oral cavity that may be caused by various factors such as trauma, infection, and periodontal disease. The wound healing process involves the activation of multiple immune cells, including lymphocytes. Lymphocytes are one of the three main types of phagocytic cells in the immune system and play a vital role in both innate and adaptive immunity, being widely distributed throughout body tissues. One potential alternative material that may accelerate wound healing is the leaf of Ziziphus spina-christi L. (Arab Bidara), which is known to contain several secondary metabolites, including alkaloids, flavonoids, saponins, steroids, and lipids, with wound-healing properties. This study is to investigate the effect of Arab Bidara leaf extract gel on lymphocyte count in gingival incision wounds of male Wistar rats (Rattus norvegicus). Materials and methods: This study was a randomized posttest-only control group experimental design. A total of 30 male Wistar rats were divided into three groups: a control group receiving Gengigel®, a placebo group, and a treatment group administered Arab Bidara (Ziziphus spina-christi L.) leaf extract gel. The gel was applied topically in the oral cavity for six consecutive days. Observations were conducted on days 3 and 5. Results and Discussion: The results showed an increase in lymphocyte count on day 3 and a significant decrease in lymphocyte count on day 5 in the treatment group. Conclusion: It can be concluded that the administration of Arab Bidara leaf extract gel has an effect on reducing lymphocyte count and is effective in accelerating gingival wound healing.
Co-Authors A.A.Istri Yogi Nareswari Dewi Anak Agung Ngurah Subawa Dewa Made Wedagama Dewi Farida Nurlitasari Dwis Syahriel Gusti Ayu Yohanna Lily Haris Nasutianto I GUSTI AYU ARI AGUNG I Gusti Ayu Dewi Haryani I Gusti Ngurah Gede Swarga Prawira I.G.A Dewi Haryani Lee Youngwoo Made Talitha Suryaningsih Pinatih Ni Kadek Ari Astuti Ni Luh Putu Sri Maryuni Adnyasari Ni Putu Idaryati Ni Wayan Arni Sardi Patriliani Angeli Sangkur