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All Journal E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Anatomy Journal Indonesian Andrology and Biomedical Journal
Made Oka Negara
Departemen Andrologi, Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Post-Preparation Total Motile Sperm Count in Infertile Men and The Success Rate of Intrauterine Insemination at Rumah Sakit Kasih Ibu Denpasar in 2022 Wibawa, I Kadek Sadam; I Gusti Ngurah Pramesemara; I Made Oka Negara; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 5 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i1.53777

Abstract

Background: Every married couple hopes to have children, but not all can fulfil that desire. A married couple finds themselves unable to achieve pregnancy after 12 months of regular unprotected sexual intercourse, which can be called infertility. Infertility can also occur in men. In dealing with infertility, intrauterine insemination (IUI) is a cost-effective and non-invasive Assisted Reproductive Technology (ART) procedure. The condition of male infertility can be detected through semen analysis. One of the parameters in semen analysis is the total motile sperm count (TMSC). Objective: This research seeks to establish the relationship between post-preparation TMSC and the success rate of the IUI procedure. Methods: This research adopts a descriptive-analytical design employing a cross-sectional methodology. Non-probability sampling was utilized as the sampling technique, and the data analyzed were secondary data from the medical records of male patients aged 25 to 45 years old diagnosed with infertility. The subjects had undergone IUI at Rumah Sakit Kasih Ibu Denpasar from January 1 to December 31, 2022. Results: From the 35 obtained samples, 12 individuals (34.3%) had a post-preparation TMSC of ≥10 í— 106, while 23 individuals (65.7%) had a post-preparation TMSC of <10 í— 106. The success rate of the Intrauterine Insemination (IUI) procedure was 17.1%, with 4 couples (33.3%) having a post-preparation TMSC of ≥10 í— 106 and 2 couples (8.7%) with a post-preparation TMSC of <10 í— 106. The Fisher's Exact test carried out has obtained a result (p=0.151), while the value of the odds ratio (OR) obtained (OR=5.250) Conclusion: Based on statistical analysis, it can be concluded that there is no significant association between post-preparation TMSC in infertile men and the success rate of IUI procedures (p > 0.05). The odds ratio (OR) obtained is 5.250 (95% CI 0.799-34.496).
The Association of E-Cigarettes with Hypogonadism in Adult Men in Denpasar Djuanda, Louis Felix; I Gusti Ngurah Pramesemara; I Made Oka Negara; Jaqueline Sudiman; Faisal Yusuf Azhari
Indonesian Andrology and Biomedical Journal Vol. 5 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i2.65652

Abstract

Background : A decrease in testosterone level can cause a set of symptoms forming a clinical syndrome called hypogonadism. One of the factors that is known to disrupt testosterone levels is smoking habits. Currently, the use of e-cigarettes as an alternative product to conventional cigarettes is increasing rapidly in many countries, including Indonesia. The amounts of harmful substances in e-cigarette aerosols are similar to the smoke produced by conventional cigarettes, but the health hazards of e-cigarettes are still not well known. Objective : This study was conducted to determine the relationship between e-cigarettes and hypogonadism in adult men in the city of Denpasar. Method: This study uses a descriptive-analytical method in the form of a cross-sectional study. The research sample consisted of 49 e-cigarette users collected using consecutive sampling techniques. The data were then analyzed using SPSS® version 26. Results : Based on the research obtained from the ADAM score from a total of 49 samples, the prevalence of hypogonadism is higher in the group of people who smoked e-cigarettes, about 35,3%. Overall, this study found a fairly high prevalence of hypogonadism (26.5%) in Denpasar. The chi-square test shows a p-value of 0,032 and a prevalence ratio (PR) of 5.294. Conclusions : Active use of e-cigarettes showed a significant association with the incidence of hypogonadism experienced by adult men in Denpasar. Based on the PR calculation, the risk of hypogonadism in active e-cigarette users was 5.294 times higher than that of adult men who were not active e-cigarette users.
The Effect of Waste Cooking Oil Administration on Spermatogenic Cells in Male Mice (Mus musculus) Sari, Dewa Ayu Candranita Kerthy; I Made Oka Negara; I Gusti Ngurah Pramasemara
Indonesian Andrology and Biomedical Journal Vol. 6 No. 2 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v6i2.81306

Abstract

Background : The high consumption of fried foods in Indonesia leads to the common practice of repeatedly using cooking oil, transforming it into waste cooking oil (in Indonesian called “minyak jelantah). This oil undergoes chemical changes that generate compounds like reactive oxygen species (ROS), which are known to induce oxidative stress and are implicated in male infertility by disrupting spermatogenesis. Objective : This study aimed to investigate the effect of waste cooking oil administration on the number of spermatogenic cells (spermatogonia, primary spermatocytes, and spermatids) in the testes of male mice (Mus musculus). Methods : This experimental study used a post-test-only control group design. Fourteen male BALB/c mice were randomly divided into a control group (n=7), administered 0.2 ml/day of aquades, and a intevention group (n=7), administered 0.2 ml/day of waste cooking oil (palm oil heated 8 times at 180°C) for 36 days via oral sonde. After the intervention period, the mice were euthanized, and their testes were extracted for histological preparation with Hematoxylin-Eosin (H&E) staining. The number of spermatogenic cells was counted under a microscope across four fields of view. Data were analyzed using an Independent T-test. Results : Consecutively mean number of the spermatogonia, prymary spermatocyte and spermatids in the control group are 51,98 ± 1,60; 64,50 ± 2,14; 81,31 ± 3,04. Meanwhilem, Consecutively mean number of the spermatogonia, prymary spermatocyte and spermatids in the intervention group are 28,93 ± 3,20; 39,31 ± 3,57; 45,25 ± 3,97. Which mean, the mean number of spermatogenic cells was significantly lower in the intervention group compared to the control group Conclusion : The administration of waste cooking oil significantly reduces the population of spermatogenic cells including spermaogonia, prymary spermatocyte, and spermatid cells in male mice, indicating a detrimental effect on spermatogenesis. Keywords : Waste Cooking Oil, Spermatogenic Cells, Spermatogenesis, Oxidative Stress.
The Association Between Insomnia and Erectile Dysfunction Among Udayana University Hospital Employees in 2025 Putu Anindita Wira Cahyani; I Made Oka Negara; I Gusti Ngurah Pramesemara; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 7 No. 1 (2026): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v7i1.84686

Abstract

Background : Erectile dysfunction is the inability to achieve or maintain an erection sufficient for sexual activity. Insomnia is a sleep disorder that commonly occurs in individuals of productive age and may impact physiological functions of the body, including erectile function. Objective : This study aimed to determine the association between insomnia and erectile dysfunction among male employees of Udayana University Hospital. Methods : This analytical study was conducted with a cross-sectional design. The research respondents were obtained through purposive sampling and comprised 42 male employees aged 28–40 years. Data were collected using the Insomnia Severity Index (ISI) questionnaire to assess insomnia, and the International Index of Erectile Function-5 (IIEF-5) to assess erectile function. The collected data were then processed and analysed using SPSS 27 software. Results : Results indicated that 35.8% of respondents experienced insomnia, whereas 45.3% of respondents experienced erectile dysfunction. The chi-square test showed that males with insomnia had a four-fold higher risk of experiencing erectile dysfunction compared to those without insomnia (p=0.038). Conclusion : There is a significant association between insomnia and erectile dysfunction among male employees of Udayana University Hospital. Keywords : Insomnia, erectile dysfunction, IIEF-5 questionnaire, ISI questionnaire
Co-Authors Djuanda, Louis Felix Faisal Yusuf Azhari Geitha Puspita Darmi I Gusti Ayu Widianti I Gusti Made Aman I Gusti Ngurah Pramasemara I Gusti Ngurah Pramesemara I Wayan Weta Ida Ayu Dewi Dhyani Ida Ayu Gde Wahyudevi Dharmika J. A. Pangkahila Jaqueline Sudiman Jivitha Munusamy Made Ayu Rusanti Ni Nyoman Ayu Dewi Putu Anindita Wira Cahyani Putu Prathiwi Kemala Putri Sosiawan Sari, Dewa Ayu Candranita Kerthy Tifania Melucha Miguel Leong Wibawa, I Kadek Sadam Wimpie I Pangkahila Yukhi Kurniawan Yukhi Kurniawan Yukhi Kurniawan