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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan CEMERLANG :Jurnal Manajemen dan Ekonomi Bisnis Jurnal Kedokteran Hewan International Journal Of Public Health International Journal of Health and Medicine
Yusni Yusni
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Aktivitas Polifenol Teh Hijau (Camellia sinensis (L) O. Kuntze) Sebagai Imunomodulator melalui Respons Supresi Imunoglobulin E (IgE) pada Rinitis Alergika Yusni, -; Husni T. R,, Teuku; Achmad, Tri Hanggono
Majalah Kedokteran Bandung Vol 47, No 3 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (665.857 KB)

Abstract

Rinitis alergika adalah kondisi inflamasi mukosa nasal yang diakibatkan oleh interaksi antara alergen dan imunoglobulin E (IgE). Imunomodulator merupakan bagian terpenting dalam pengobatan rinitis alergika dan salah satu tanaman obat yang mempunyai aktivitas imunomodulator adalah teh hijau (Camellia sinensis L.) terutama polifenol. Tujuan penelitian adalah menganalisis aktivitas polifenol teh hijau sebagai imunomodulator pada pasien rinitis alergika. Penelitian ini dilaksanakan dari bulan Juni–Desember 2011 di laboratorium Fisiologi Fakultas Kedokteran Unsyiah Banda Aceh dan pemeriksaan IgE dilakukan di laboratorium swasta. Desain penelitian adalah quasi experimental dengan rancangan pretest-posttest with control group. Subjek penelitian adalah 12 pasien rinitis alergika, yaitu 6 orang sebagai kelompok kontrol (diberikan plasebo) dan 6 orang sebagai kelompok perlakuan (diberikan kapsul polifenol teh hijau 2x350 mg/hari, selama 14 hari). Analisis data menggunakan uji normalitas, uji homogenitas, dan uji-t (p<0,05). Hasil penelitian menunjukkan kadar imunoglobulin E sesudah pemberian perlakuan pada kelompok perlakuan lebih rendah dibanding dengan kelompok kontrol (1.475,2±940,7 vs 494,3±366,5 IU), namun tidak bermakna (p=0,05). Simpulan pemberian polifenol teh hijau  menurunkan sekresi IgE, namun tidak bermakna dan membutuhkan penelitian lebih lanjut.  [MKB. 2015;47(3):160–66]Kata kunci: Imunoglobulin E, imunomodulator, polifenol teh hijau (Camellia sinensis L.), rinitis alergika Activity of Green Tea (Camellia sinensis (L) O. Kuntze) Polyphenols as Immunomodulator through Response of Suppression Immunoglobulin E (IgE) in Allergic RhinitisAbstractAllergic rhinitis is an inflammatory condition of the nasal mucosa caused by  interactions between allergens and immunoglobulin E (IgE). Immunomodulatory is an important part of the treatment of allergic rhinitis. One of the medicinal plants that have immunomodulatory activities is green tea (Camellia sinensis L.), specifically polyphenols. The purpose of this study was to analyze the activity of green tea’s polyphenols as an immunomodulator in patients with allergic rhinitis. This study was conducted in  June to December 2011 in the laboratory of Physiology, Faculty of Medicine Unsyiah with the IgE examinations conducted in private laboratories. This study is a pretest-postest quasi experimental study with control group design. Subjects were 12 patients with allergic rhinitis;  6 people were included in the control group (placebo) and 6 in the treatment group (green tea’s polyphenols 2x350 mg/day, for 14 days). Analysis of the data was performed using the  normality test, homogeneity test, and t-test (p<0.05). The results showed that the levels of immunoglobulin E after the administration of green tea’s polyphenols in the treatment group was lower than the control group (1.475.2±940.7 vs 494.3±366.5 IU), but not significantly (p=0.05). In conclusion, the administration of green tea’s polyphenols can insignificantly decrease the secretion of IgE. Hence, further research is required. [MKB. 2015;47(3):160–66]Key words: Allergic rhinitis, immunoglobulin E,  immunomodulator, green tea’s polyphenols (Camellia sinensis L.)DOI: 10.15395/mkb.v47n3.596
ANALISIS KEBUTUHAN TENAGA KEPERAWATAN BERBASIS BEBAN KERJA DENGAN METODE WORKLOAD INDICATOR STAFF NEED (WISN) DI INSTALASI GAWAT DARURAT (IGD) RUMAH SAKIT IBU DAN ANAK PROVINSI ACEH Nadia Fajri; Yusni Yusni; Said Usman; Irwan Syahputra; Nurjannah Nurjannah
Jurnal Kesehatan Vol 13 No 2 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i2.16304

Abstract

AbstractBackground: The problem of shortage of medical personnel must be considered properly, whether it really requires additional manpower due to excessive workloads which will affect the quality provided or the amount of unproductive time spent by HR while on duty. This also happened at the Aceh Province Mother and Child Hospital, there are plans to increase the number of staff carried out at the Mother and Child Hospital who need to use workload calculations, the reality on the ground is that the planning of medical personnel in RSIA is only based on the request of the work unit and the comparison of calculations between the number of medical personnel with BOR, LOS and others or because of the increase in the class of the hospital and the lack of qualifications of each type of medical staff. Objective: to analyze the need for workload-based nursing personnel using the Workload Indicator Staff Need (WISN) method in the Emergency Departments (ED) Mother and Child Hospital, Aceh Province. Research Methods: This research is a descriptive study, using a work sampling method, namely all the activities of nurses who served in the IGD RSIA Aceh Province as respondents who were examined every time for four days. The population in this study were all nurses in the Emergency Departments (ED) of the Aceh Province Hospital in 2020 totaling 19 people, the samples in this study were all nurses in the Emergency Departments (ED) with a total sampling of 19 people. The calculation of the need for nurses using the WISN method. Results: the workload of health workers in RSIA Aceh Province can be seen from the details / job descriptions of the job, the amount of time required for each task, the time for completing tasks is a multiplication of the workload with the norm of time and the number of hours of effective working time. Besides being influenced by the number of workers, the workload of health workers can also be influenced by the number of patients and the conditions of the workplace environment. Conclusion: the results of the WISN calculation show that the health personnel at RSIA Provini Aceh still lacks 1 nurse in the ED. The shortage of health workers will have an impact on the high workload of health workers in each sector.
GROWTH INHIBITION AND INDUCTION OF APOPTOSIS IN MCF-7 AND T47D BREAST CANCER CELL LINES BY ETHANOL EXTRACT OF SEURAPOH (Chromolaena odorata) LEAVES Hanifah Yusuf; Reno Keumalazia Kamarlis; Yusni Yusni
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (641.485 KB) | DOI: 10.21157/j.ked.hewan.v14i3.17227

Abstract

This study aims to determine the growth inhibition and apoptosis induction of MCF-7 and T47D cancer cells by ethanol extract of Chromolaena odorata leaves. A post-test with control group design was used in this study. The extract was made by maceration with 80%ethanol and the tested concentrations used were 7.80 µg/mL-500 µg/mL with standard drug doxorubicin ranged from 1.56 µg/mL-100 µg/mL.The growth inhibition was determined by the MTT colorimetry method, apoptosis induction by double staining using acridine orange-ethidiumbromide, and the existence of apoptosis was proven immunocytochemically through the expression of Bcl-2 proteins. The results showed that the growth inhibition of MCF-7 was 100.29%-28.19% and T47D was 100.37%-16.01%. The IC50 values of MCF-7 was 327.34 µg/mL and T47D was 135.16 µg/mL. The presence of apoptosis was marked by finding the morphological change of cells such as dead, necrosis, and chromatin condensation cells. This suggests that interventions with ethanol extract of Chromolaena odorata leaves can induce apoptosis that has been proven by reducing the expression of Bcl-2 proteins.
Future Financial Decisions Influencing Factors Irwan Moridu; Nurcahya Hartaty Posumah; Fitriani Fitriani; Asri Ady Bakri; Yusni Yusni
CEMERLANG : Jurnal Manajemen dan Ekonomi Bisnis Vol. 3 No. 2 (2023): CEMERLANG : Jurnal Manajemen dan Ekonomi Bisnis
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/cemerlang.v3i2.1155

Abstract

This study aims to pinpoint the variables that affect how people make financial decisions in the future. Future financial decisions, saving choices, and trust in banking institutions are the three variables we use in this study. 197 junior high school teachers from the Bandung region participated in the study. Multivariate Regression is the analytical approach used, and it can be used to assess the influence of independent variables on dependent variables. The results demonstrate a strong positive relationship between current saving decision variables and future financial decision variables. Similar to this, varying levels of trust in financial organisations have a lot of favourable effects. These findings imply that people have a greater propensity to save when they are motivated to do so. People who have confidence in financial institutions will manage their money prudently going forward.
The Influence of Peer Education on the Coverage of Clean and Healthy Living Behavior in Kutacane 3 Public Middle School Students Rizki Ardika; Said Usman; Yusni Yusni; Nasrul Zaman; Irwan Saputra
International Journal of Health and Medicine Vol. 2 No. 3 (2025): July : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i3.451

Abstract

Low awareness of students about PHBS allows for a lack of knowledge obtained by students due to the lack of information obtained. Therefore, health education is important to be encouraged. One strategy that can be used in providing health education to students is peer education. To determine and analyze the effect of peer education on the scope of Clean and Healthy Living Behavior in students. The type of research used in this study is quasi-experimental, with a pretest-posttest control group design. Data analysis using variate and bivariate tests. The subjects of this study were students of Class VII-A and Class VII-B of SMP Negeri 3 Kutacane in the 2024/2025 Academic Year. The research instrument used was a test sheet. The results of the Mann-Whitney test showed a significant increase in students' understanding of each indicator including PHBS, except for the indicator of not smoking, although there was an increase but it was not statistically significant. This can be seen based on the average value of the experimental class at the time of the posttest which was greater when compared to the pretest, with a value of p = <0.05, while for the non-smoking indicator the value of p => 0.05. These results indicate the influence of health education with the peer education method on the understanding of the scope of PHBS in experimental class students. Peer Education is able to improve students' understanding of the scope of PHBS better, compared to students who do not receive peer education intervention.
The Effect of Health Education on Improving Knowledge About Anemia Among Adolescent Girls in MTsN VI Pidie Khaira Maulina; Yusni Yusni; Said Usman; Irwan Saputra; Nasrul Zaman
International Journal of Public Health Vol. 2 No. 2 (2025): June : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i2.453

Abstract

Anemia remains one of the leading public health issues among adolescent girls in Indonesia, including in Pidie District. Insufficient iron intake and low awareness and knowledge of anemia are major contributors to its high prevalence. Health education is recognized as an effective strategy to improve adolescents’ understanding of anemia.Objective: This study aimed to assess the effect of health education on increasing knowledge about anemia among adolescent girls at MTsN VI Pidie, Pidie District.Methods: A quantitative approach with a quasi-experimental design (one-group pretest-posttest) was employed. A total of 30 first-grade female students from MTsN VI Pidie were selected through purposive sampling. The intervention involved the delivery of health education on anemia via an educational video. Knowledge levels were measured before and after the intervention using pretest and posttest questionnaires. Data were analyzed using the Wilcoxon signed-rank test and paired t-test.Results: The analysis showed a statistically significant improvement in the participants’ knowledge following the intervention. The average posttest scores were notably higher than the pretest scores, indicating a positive effect of the health education intervention (p < 0.05).Conclusion: Digital media-based health education is effective in enhancing knowledge about anemia among adolescent girls. This approach is recommended for broader implementation in adolescent health promotion programs, particularly in the prevention of anemia
KAJIAN KEMAMPUAN SELEDRI (Apium graveolens Linn.) SEBAGAI HERBAL ANTISTRES PADA TIKUS WISTAR (Rattus norvegicus) Y, Yusni; Puteh, Ibrahim
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2626

Abstract

Tujuan penelitian ini adalah mengetahui, mengkaji, dan menganalisis potensi seledri sebagai herba antistres dan imunomodulator dengan cara menghambat sekresi kortisol plasma pada tikus Wistar (Rattus norvegicus) yang diinduksi kejutan listrik. Penelitian ini merupakan penelitian eksperimental laboratoris, pre and postest with control group design. Sampel yang digunakan adalah 13 ekor tikus Wistar yang dibagi dalam 3 kelompok: P0, kelompok kontrol (kejutan listrik); P1, kejutan listrik + ekstrak seledri 0,14 mg; dan P2, kejutan + ekstrak seledri 0,72 mg. Kejutan listrik dan ekstrak seledri masing-masing diberikan selama 7 hari. Kadar kortisol diukur menggunakan metode enzyme-linked immunosorbent assay (ELISA). Analisis data menggunakan uji analisis varian satu arah. Hasil penelitian menunjukkan bahwa nilai rata-rata kadar kortisol serum kelompok P0 sebelum dan setelah diberikan perlakuan mengalami peningkatan, sedangkan kelompok P1 dan P2 mengalami penurunan (P0= 1,88 vs 3,65; P1= 4,59 vs 2,63 dan P2= 3,00 vs 2,99). Pemberian ekstrak seledri cenderung menurunkan kadar kortisol serum meskipun secara statistik tidak berbeda secara signifikan (P>0,05). Disimpulkan bahwa ekstrak seledri belum sepenuhnya berperan sebagai herbal antistres pada tikus Wistar yang mengalami stres.
Co-Authors Asri Ady Bakri Fitriani Fitriani HANIFAH YUSUF Ibrahim Puteh, Ibrahim Irwan Moridu Irwan Saputra Irwan Syahputra Khaira Maulina Nadia Fajri Nasrul Zaman Nurcahya Hartaty Posumah Nurjannah Nurjannah Reno Keumalazia Kamarlis Rizki Ardika Said Usman Said Usman Teuku Husni T. R,, Teuku Tri Hanggono Achmad