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All Journal e-Journal Pustaka Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) Medfarm: Jurnal Farmasi dan Kesehatan Pharmademica: Jurnal Kefarmasian dan Gizi Farmasis: Jurnal Sains Farmasi
Afifah Machlaurin, Afifah
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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Potensi Penggunaan Obat yang Tidak Tepat pada Peresepan Pasien Geriatri Rawat Jalan di RSD dr. Soebandi Jember Berdasarkan Beers Criteria (Potentially Inappropriate Medication Based on Beers Criteria in Geriatric Outpatients of dr. Soebandi District Hosp Yeni Rahmawati Negara; Afifah Machlaurin; Ema Rachmawati
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inappropriate medication in geriatric is a serious problem because of its high morbidity, mortality, and healthcare costs. Beers Criteria 2012 is the compilation drugs that potentially inappropriate on geriatric patients. The objective of this study was to observe the percentage of inappropriate medication in geriatric outpatients prescription.This study used observational descriptive and retrospective design. The study showed that 69 patients (18.30%) from 377 patients prescribed with 92 inappropriate medication, 20 medication with strong and high quality evidence to be avoided based on Beers Criteria 2012. Amitriptyline was the most prescribed potentially inappropriate agents of 17 events. Keywords: geriatric, beers criteria,outpatients
Hubungan antara Profilaksis Kotrimoksazol dan Prevalensi Toksoplasmosis pada Pasien HIV Positif di Jember (The Association Between Prophylactic Cotrimoxazole and the Prevalence Toxoplasmosis in HIV-Positive Patients in Jember) Elly Febry Taufany; Afifah Machlaurin; Prihwanto Budi Subagijo
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6613

Abstract

Human immunodeficiency virus (HIV) is a virus that causes acquired immune deficiency syndrome (AIDS). HIV is a high mortality disease and the number of patients is increasing recent days. Based on dr. Soebandi Jember Hospital report in 2015, there were 1,492 HIV patients and 455 people received antiretroviral (ARV) therapy. Toxoplasmosis is one of opportunistic infections commonly found in HIV patients in central nervous system. WHO has issued guidelines for the use of cotrimoxazole as prophylaxis in HIV positive people. The purpose of this study was to determine the relationship between cotrimoxazole prophylaxis and the incidence of toxoplasmosis. This research was a case control study with retrospective approach and used chi-square analysis. The results showed that most patients were male (57%), 20-29 years in age (50%), and 41-60 kg in weight (64%). Based on the CD4 level, most HIV patients were less than 350/mm3 (96%) and total lymphocite count (TLC) also less than 1,200/mm3 (42%). There were 1 patient from 76 patients with cotrimoxazole prophylaxis and 7 patients from 52 patient without cotrimoxazole prophylaxis who developed toxoplasmosis. Based on chi-square analysis, cotrimoxazole prophylaxis reduce the incidence of toxoplasmosis in HIV positive (p-value 0,004). Keywords: HIV/AIDS, prophilaxis therapy of cotrimoxazole, toxoplasmosis infection
Survei Pengetahuan dan Pilihan Pengobatan Jerawat di Kalangan Mahasiswa Kesehatan Universitas Jember (A Survey on Knowledge and Treatment Options of Acne Vulgaris Among Health Science Students of Universitas Jember) Antonius Nugraha Widhi Pratama; Maulina Hari Pradipta; Afifah Machlaurin
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i2.5871

Abstract

Acne vulgaris is a common disorder that may impact physically and psychologically. It can be treated either using appropriate self-medication or medical assistance. This present study aimed to explore the knowledge of acne vulgaris and its treatment ofchoice among health science students of Universitas Jember. Data were collected using a 44 item questionnaire. A total of 193 respondents from Faculty of Pharmacy (34 students), Faculty of Public Health (59 students), Faculty of Dentistry (27 students), Faculty of Medicine (29 students), and School of Nursing (44 students) participated in the study after giving their consents. All respondents have had acne at some points of their life. The average level of knowledge was 17.3 ± 3.6 (max score 30) and there was astatistically significant difference of means (p=0.002) among the respondents, based on their faculties. Self-medication (n=49; 58%) was more prefered than medical assistance (n=35; 41.7%). This study showed the need to increase awareness among young peopleto practice appropriate self-medication.Keywords: acne vulgaris, knowledge, treatment options
Pengaruh Faktor Klinik dan Pengobatan terhadap Keberhasilan Terapi Tuberkulosis pada Pasien HIV–TB di Jember (The Influences of Selected Clinical Factors and Treatment on Tuberculosis Therapy Outcome among HIV-TB Patients in Jember) Nuraini Agustin; Afifah Machlaurin; Prihwanto Budi Subagio
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i2.5861

Abstract

Human imunodeficiency virus (HIV) is an infectious diseases that become an international problem. Since 1980s, there was an increase in morbidity and mortality due to tuberculosis (TB) infection in high HIV prevalence areas. The success of therapy is very important in the treatment of HIV-TB patients. The purpose of this study was to determine the factors that influence the success therapy in HIV-TB patients. This research was a cross sectional study with retrospective approach and used chi square analysis. The result showed that most patients were male (62.1%) and most were 25-34 years in age (42.3%). Most HIV-TB patients were 41-50 kg in weight (56.9%). They had CD4 level range of 50-199/mm3 and total lymphocyte count (TLC) less than 1,200/mm3 (58.6%). Most HIV-TB received therapy TB category 1 that was 55.2%, and antiretroviral (ARV) combination of TDF+3TC+EFV (91.8%). Based on chi square analysis, body weight, CD4 level, and TLC affected the success therapy (P value 0.022, 0.003, 0.028), whereas age and gender didn't (P value 0.222, 0.905). On the other hand, the variation therapy of TB and HIV didn't affect the success therapy either (P value 0.943, 0.718).Keywords: HIV-TB, antiretroviral, tuberculosis therapy
Analisis Efektivitas Biaya Penggunaan Antibiotik terhadap Pasien Sepsis Pediatrik di Rawat Inap RSD dr. Soebandi Kabupaten Jember pada Tahun 2014 (Cost effectiveness Analysis of Antibiotics in Hospitelized Pediatric Sepsis Patients at RSD dr. Soebandi Je Nurul Faridah; Afifah Machlaurin; Prihwanto Budi Subagio
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Antibiotics play an importent role in sepsis therapy. Inappropiate antibiotic theraphy leads to resistance of antibiotic resulting increase length of stay (LOS), mortality, and higher cost. The purpose of this study was to determine the most effective empirical antibiotic based on cost effectiveness analysis (CEA) in pediatric patients with sepsis at RSD dr. Soebandi in 2014. This study observed medical and payment records retrospectively. From 152 patient analyzed, 51 patients included and 136 patients were excluded because of the antibiotic theraphy less than three days, the age more than 18 years old and the data was not complete. The effectiveness parameter of this study were length of stay (LOS), length of stay antibiotic related (LOSAR) and 28-days mortality. According to this study, ampicillin sulbactam plus amikacin combination had shorter LOS (13,82 days) than other antibiotics. However monotheraphy ampicillin sulbactam had shorter LOSAR (7.13 days) and lower 28-days mortality (50.00%). The total cost and antibiotic cost analysis showed that ampicillin sulbactam plus amikacin combination was cheaper than other antibiotics (Rp 5,130,000.00 ± 500.00). Based on CEA and quadrant analysis ampicilin sulbactam combination plus amikacin was the most cost effective with low cost and high effectiveness (quadrant II) than other antibiotic.   Keywords: cost effectiveness, antibiotic, sepsis
Evaluasi Penggunaan Antibiotik pada Pasien Diare Menggunakan Metode ATC/DDD di Puskesmas Kalisat Kabupaten Jember Rachmawati, Ema; Husnun, Khoiriyah Haifa; Machlaurin, Afifah; Norcahyanti, Ika; Christianty, Fransiska Maria; Aryani, Dhita Evi
FARMASIS: Jurnal Sains Farmasi Vol 5 No 1 (2024): Farmasis: Jurnal Sains Farmasi Vol 5. No. 1 (2024)
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v5i1.8777

Abstract

Pendahuluan: Diare merupakan masih menjadi masalah utama di seluruh dunia dan menjadi penyebab tingginya angka kesakitan dan kematian di segala usia. Sebagian besar kasus diare disebabkan oleh virus bersifat self limiting disease. Namun sayangnya, diare menjadi salah satu penyakit yang rentan menyebabkan overuse dan misuse dari penggunaan antibiotik. Hal tersebut berpotensi meningkatkan resiko terjadinya resistensi antibiotik. Surveilans pola peresepan antibiotik merupakan bagian penting dalam pengendalian resistensi antibiotik dan perlu dilakukan secara secara rutin dari waktu ke waktu. Tujuan: Melakukan evaluasi penggunaan antibiotik pada pasien diare di Puskesmas Kalisat Kabupaten Jember tahun 2021 menggunaakan metode ATC per DDD serta melihat kesesuiaan pemilihan antibiotik berdasarkan PPK tahun 2017. Metode: Penelitian ini merupakan penelitian cross sectional dengan metode retrospektif. Pengambilan data dilakukan terhadap 55 rekam medis pasien diare rawat jalan di Puskesmas Kalisat Kabupaten Jember tahun 2021 yang memenuhi kriteria. Data penggunaan antibiotik dihitung nilai sesuai indikator DDD per 1000 pasien per hari, Drug Utilization (DU) 90 persen serta kesesuaian dengan PPK 2017. Hasil: Karakteristik responden menunjukkan jumlah pasien diare perempuan lebih banyak dibanding pasien laki-laki (63,64 persen vs 36,36 persen). Persentase diare terbanyak terjadi pada kelompok usia 18-25 tahun dan 36-45 tahun dengan persentase masing-masing sebesar 21, 82 persen serta diagnosis paling banyak adalah gastroenteritis akut (GEA) yaitu sebesar 67,27 persen. Total penggunaan antibiotik pada pasien diare sebesar 5,98 DDD per 1000 pasien per hari dengan antibiotik yang sering diresepkan adalah kotrimoksazol dengan nilai 3,59 DDD per 1000 pasien per hari dan menyusun 60,13 persen dari segmen DU 90 persen. Persentase kesesuaian penggunaan antibiotik pada pasien GEA sebesar 94,59 persen. Sedangkan untuk pasien dengan diagnosis disentri, persentase kesesuaian penggunaan antibiotik didapatkan sebesar 38,88 persen. Kesimpulan: Kotrimoxazol paling tinggi diresepkan dalam terapi diare di Puskesmas Kalisat Kabupaten Jember dan menunjukkan persentase 60,13 persen dalam segmen DU 90 persen, sehingga perlu adanya evaluasi terkait ketepatan penggunaan sebagai upaya untuk mengendalikan jumlah peresepan antibiotik tersebut guna mencegah resiko resistensi  antibiotik.
Comparative Economic and Clinical Utility of Adding Candesartan for Hypertension Management Fitria, Najmiatul; Nguyen, Thang; Machlaurin, Afifah; Al Rizka, Nabila; Ayu Juwita, Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.111-117.2024

Abstract

Introduction: Antihypertensive drugs require high costs because they are used over a long period. Therefore, consideration is needed in drug selection requirements, effectiveness, and price. This study aimed to see the beneficial results of hypertension therapy and the non-medical costs incurred by patients using cost-utility analysis (CUA). Method: This research was a prospective study. The incremental Cost-Utility Ratio (ICUR) of antihypertensive treatment was calculated using cost-utility data obtained through EQ-5D-5L questionnaires from outpatients at Universitas Andalas Hospital in January- March 2023 who met the inclusion and exclusion criteria. The costs used were from a patient perspective, consisting of direct medical and non-medical costs. This study compared standard treatment (amlodipine) with the addition of candesartan. Results: The number of respondents in this study was 67, consisting of 23 respondents (34.33%) using amlodipine alone and 44 respondents (65.67%) using the amlodipine-candesartan combination. The ICUR value obtained was IDR7,318,674/QALY. The difference in the average utility value of the amlodipine-candesartan combination with amlodipine alone is -0.02, and the difference in cost is -IDR12,224. Based on the cost-utility diagram, the amlodipine-candesartan combination group is included in the southwest quadrant (quadrant III), which illustrates that the cost required for the amlodipine-candesartan combination group is lower than the cost of the amlodipine single treatment group and the outcome is also not better (slightly lower or the same). Conclusion: It was recommended to prioritize using amlodipine alone for hypertension management, as it provides similar outcomes to the amlodipine-candesartan combination while incurring lower costs.
Impact of Side Effects on Adherence in Drug-Resistance Tuberculosis Treatment at RSD dr. Soebandi Jember Poerwahyuningrum, Neny; Fajrin, Fifteen Aprilla; Rahardjo, Angga Mardro; Prasetyowati, Irma; Arwi, Khoiriyatul Muhlishoh; Machlaurin, Afifah
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.537

Abstract

Tuberculosis (TB) is the leading cause of death from infectious disease worldwide. Patient adherence to treatment is crucial for therapy which side effects of tuberculosis treatment are a significant factor affecting compliance. This study aims to analyze the impact of side effects from anti-tuberculosis drugs on the medication adherence of Drug Resistant Tuberculosis patients (DR-TB) at RSD dr. Soebandi in Jember. This study was a retrospective cohort observational that included 245 DR-TB patients register at the dr. Soebandi Hospital from January 2021-December 2023. The electronic medical records, web-based tuberculosis information systems (SITB), and data filling sheets was used. The Proportion of Days Covered (PDC) method was used to evaluate the medication adherence. Data analysis was conducted in SPSS 27.0. Ten patients were excluded due to HIV comorbidities, resulting a final sample of 235 patients. The findings revealed that 53.6% of patients were non-adherence. The three most common types of side effects were gastrointestinal (43.4%), musculoskeletal (29.8%) and skin-related side effects (16.6%). The multivariate logistic regression showed that adherence was significantly reduced by the presence of side effects (aOR: 0,153; 95%CI 0,052-0,448), the number of side effects >2 types (aOR: 0,290; 95%CI 0,101-0,837), and the musculoskeletal-related side effects (aOR: 0,441; 95%CI 0,201-0,972).
Evaluasi Pengobatan pada Pasien Geriatrik Rawat Inap dengan Stroke di RS Elizabeth Situbondo Periode November 2022‒Agustus 2023 Norcahyanti, Ika; Firandi, Adelia; Mauladi, Zainol Ihsan; Machlaurin, Afifah
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.102

Abstract

Potentially Inappropriate Medicines (PIMs) cause a significant issue, particularly when dealing with elderly patients. Aging in the elderly results in a decline in physiological body functions, impacting the response to medications. Furthermore, aging leads to decreased elasticity of blood vessels, increasing the risk of cardiovascular diseases such as stroke. The management of stroke requires special attention to minimize the risk of complications and enhance recovery opportunities. This study aims to analyze patient profiles, treatment profiles, and evaluate the treatment based on the Beers Criteria 2019. It is a retrospective descriptive study using a cross-sectional research design and purposive sampling technique for sample selection. The study sample includes elderly patients diagnosed with stroke who were hospitalized at RS Elizabeth Situbondo. Patient medical record data was collected through a specifically designed Data Collection Sheet (DCS) to evaluate drug utilization in these patients. The research findings indicate that the patients are predominantly male (53.2%), aged 60-69 (62.3%), and have a Length of Stay of 1-6 days (84.4%). All patients have payment status through BPJS. The treatment profile involves the administration of medications for stroke management, with ticagrelor as the primary drug (66.2%) and citicoline as the most commonly prescribed supplementary drug (97.4%). Treatment evaluation identified 193 events of drug use that potentially met the 2019 Beers Criteria. The highest category was potentially inappropriate drugs (134 events), with pantoprazole being the most commonly used drug (71 events).
Co-Authors Al Rizka, Nabila Antonius Nugraha Widhi Pratama Arwi, Khoiriyatul Muhlishoh Aryani, Dhita Evi Dian Ayu Juwita Elly Febry Taufany Ema Rachmawati Fajrin, Fifteen Aprilla Firandi, Adelia Fransiska Maria Christianty Husnun, Khoiriyah Haifa Ika Norcahyanti Irma Prasetyowati Mauladi, Zainol Ihsan Maulina Hari Pradipta Najmiatul Fitria Nguyen, Thang Nuraini Agustin Nurul Faridah Poerwahyuningrum, Neny Prihwanto Budi Subagijo Prihwanto Budi Subagio Rahardjo, Angga Mardro Yeni Rahmawati Negara