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All Journal Medfarm: Jurnal Farmasi dan Kesehatan
Poerwahyuningrum, Neny
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Chemistry Medicine & Pharmacology Public Health

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Impact of Side Effects on Adherence in Drug-Resistance Tuberculosis Treatment at RSD dr. Soebandi Jember Poerwahyuningrum, Neny; Fajrin, Fifteen Aprilla; Rahardjo, Angga Mardro; Prasetyowati, Irma; Arwi, Khoiriyatul Muhlishoh; Machlaurin, Afifah
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.537

Abstract

Tuberculosis (TB) is the leading cause of death from infectious disease worldwide. Patient adherence to treatment is crucial for therapy which side effects of tuberculosis treatment are a significant factor affecting compliance. This study aims to analyze the impact of side effects from anti-tuberculosis drugs on the medication adherence of Drug Resistant Tuberculosis patients (DR-TB) at RSD dr. Soebandi in Jember. This study was a retrospective cohort observational that included 245 DR-TB patients register at the dr. Soebandi Hospital from January 2021-December 2023. The electronic medical records, web-based tuberculosis information systems (SITB), and data filling sheets was used. The Proportion of Days Covered (PDC) method was used to evaluate the medication adherence. Data analysis was conducted in SPSS 27.0. Ten patients were excluded due to HIV comorbidities, resulting a final sample of 235 patients. The findings revealed that 53.6% of patients were non-adherence. The three most common types of side effects were gastrointestinal (43.4%), musculoskeletal (29.8%) and skin-related side effects (16.6%). The multivariate logistic regression showed that adherence was significantly reduced by the presence of side effects (aOR: 0,153; 95%CI 0,052-0,448), the number of side effects >2 types (aOR: 0,290; 95%CI 0,101-0,837), and the musculoskeletal-related side effects (aOR: 0,441; 95%CI 0,201-0,972).
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Wardhani, Firdha Aprillia; Poerwahyuningrum, Neny
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
Co-Authors Anggraeni, Linda Suci Arwi, Khoiriyatul Muhlishoh Fajrin, Fifteen Aprilla Irma Prasetyowati Khrisna Agung Cendekiawan Kintoko Kintoko Machlaurin, Afifah Rahardjo, Angga Mardro Sapto Yuliani Wardhani, Firdha Aprillia