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All Journal Jurnal Kedokteran Brawijaya Sari Pediatri
Khairiyadi Khairiyadi
RSUD Ulin Balikpapan
Health Professions Medicine & Pharmacology

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Ekspresi dan Aktivasi Reseptor Glukokortikoid serta Ekspresi Heat Shock Protein- 90 pada Sel Limfosit Penderita Sindrom Nefrotik Idiopatik Khairiyadi, Khairiyadi; Subandiyah, Krisni; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 25, No 3 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.895 KB) | DOI: 10.21776/ub.jkb.2009.025.03.5

Abstract

Glucocorticoid receptors (GR) have an important role in the resistance of steroid therapy . Previous studies showed  significant  difference  activation  and  expression  of  GR  between  Steroid  Resistant  Nephrotic Syndrome (SRNS) and Steroid Sensitive Nephrotic Syndrome (SSNS), however the other studies showed contrastive result. Previous studies also revealed Hsp-90 had an important  role in  GR activation. The aim of this study was to determine the differences expression and activation of GR and also Hsp-90 expression in lymphocytes  cytoplasm  and  nucleus  between  SRNS  and  SSNS  patients.  A  Cross-sectional  study  was conducted  to  40  children  (20  SRNS  and  20  SSNS  patients).  Double  stainning  immunocytochemistry  of lymphocytes  was  performed.  The  GR  expression  and  activation  were  determined  by  counting  amount  of lymphocytes  that  express GR and Hsp-90 among 200 under light  microscope with 1000x magnification. The differences  of  activation  and  activation  of  GR  and  Hsp-90  in  cytoplasm  and  nucleus  were  analyzed  with independent t-test and the correlation was analyzed with Pearson correlation.
Perbedaan Kadar Vitamin D, Tinggi Badan, dan Status Gizi pada Anak Palsi Serebral dengan dan Tanpa Epilepsi di Rumah Sakit Umum Daerah Ulin, Banjarmasin Amelia Mc, Sitti; Bakhriansyah, Muhammad; Ringoringo, Harapan Parlindungan; Khairiyadi, Khairiyadi; Hidayah, Nurul
Sari Pediatri Vol 26, No 4 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.4.2024.212-7

Abstract

Latar belakang. Kurangnya pajanan sinar ultraviolet akibat keterbatasan gerak, efek samping obat antiepilepsi, dan kurangnya asupan diet dapat menyebabkan defisiensi vitamin D serta memengaruhi status gizi dan tinggi badan pasien palsi serebral. Tujuan. Mengetahui perbedaan kadar vitamin D, tinggi badan dan status gizi pada pasien anak palsi serebral dengan dan tanpa epilepsi di Rumah Sakit Umum Daerah BanjarmasinMetode. Penelitian ini merupakan penelitian potong lintang. Sampel terdiri dari 35 pasien dengan palsi serebral tanpa epilepsi dan 35 pasien dengan epilepsi. Kami melakukan pengukuran kadar vitamin D, tinggi badan dan status gizi. Analisis data dilakukan dengan uji chi-square untuk mengetahui perbedaan kadar vitamin D dan status gizi antara kedua kelompok. Uji Mann-Whitney dilakukan untuk mengetahui perbedaan tinggi badan antara kedua kelompok.Hasil. Berdasarkan data kadar vitamin D, tidak didapatkan perbedaan bermakna antara kedua kelompok (p=1,000). Namun, terdapat perbedaan tinggi badan yang bermakna antara kedua kelompok (p=0,032). Terkait status gizi, tidak didapatkan perbedaan bermakna antara kedua kelompok (p=0,473).Kesimpulan. Tidak terdapat perbedaan bermakna dalam kadar vitamin D dan status gizi antara kelompok anak palsi serebral yang memiliki epilepsi dan yang tidak. Namun, terdapat perbedaan bermakna dalam tinggi badan antara kelompok tersebut.
Effects of Vitamin D Supplementation on Pediatric Tuberculosis Clinical, Radiological, and Laboratory Outcomes Khairiyadi, Khairiyadi; Hadi Putra, Nataniel; Marhaeni, Wulandewi; Himawan, Indra Widjaja; Panghiyangani, Roselina
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.4

Abstract

Tuberculosis is a systemic infectious disease caused by Mycobacterium tuberculosis. Pediatric tuberculosis patients often have reduced immunity due to malnutrition. Vitamin D supplementation improves host cell antimicrobial immune response, improving clinical outcomes. A study in Iran found that intramuscular cholecalciferol administration improved tuberculosis patients' outcomes, including weight gain and arm circumference when administered alongside tuberculosis therapy for 6 or 9 months. This study focuses on oral cholecalciferol for pediatric tuberculosis patients, analyzing its effects on clinical improvement, radiological features, laboratory findings, and its impact on weight gain, height, and vitamin D levels. The chi-square test was used to analyze the effect of vitamin D on the improvement of fever (p=0.638), cough (p=1.00), nutritional status (p=0.388), radiological features (p=0.510), decrease in leukocytes (p=1.00), lymphocytes (p=0.262), monocytes (p=0.575), and increase in vitamin D levels (p=0.149). The Mann-Whitney test was used to analyze the effect of vitamin D on the average increase in weight gain (p=0.392), height (p=0.044), vitamin D levels (p=0.770), and the average decrease in leukocytes (p=0.260), lymphocytes (p=0.055), and monocytes (p=0.687). The confidence level is 95%. Most clinical, radiographic, and laboratory outcomes in pediatric TB patients did not significantly change when vitamin D therapy was used. However, it markedly increased the patients' development, indicating possible advantages for these individuals.
The Effect of Anti-Tuberculosis Drugs (ATT) Routine on Blood Profiles and Nutritional Status of Children at Ulin Hospital, Banjarmasin Khairiyadi, Khairiyadi; Sitompul, Putriana Br.; Putra, Nataniel Hadi; Panghiyangani, Roselina
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.5

Abstract

Tuberculosis (TB) is an infectious disease caused by the rod-shaped bacterium Mycobacterium tuberculosis (M. TB). TB primarily affects the lung parenchyma (pulmonary TB), but the bacterium can also infect other organs, leading to extrapulmonary TB. Anti-Tuberculosis Drugs (ATT) are a crucial component of TB treatment. However, the use of ATT is associated with side effects, the most common being anaemia and thrombocytopenia. This study aims to determine the effect of ATT on routine blood profiles and the nutritional status of pediatric patients with pulmonary TB and glandular TB at Ulin Regional Hospital, Banjarmasin. This analytical observational study employed a cross-sectional design. A total of 52 pediatric patients with pulmonary TB and glandular TB at Ulin Regional Hospital, Banjarmasin, were selected using a non-probability total sampling approach. The Wilcoxon test revealed a significant effect of ATT therapy on nutritional status, as indicated by a p-value of 0.000. ATT therapy results in changes in routine blood profiles and significant improvements in the nutritional status of pediatric patients with pulmonary TB and glandular TB. The significant changes in the routine blood profile are haemoglobin level and monocytes level which increased after ATT therapy. The average leukocytes, neutrophils, lymphocytes and Erythrocyte Sedimentation Rate (ESR) level decreased significantly after ATT therapy, while Platelet counts remained unchanged.
Co-Authors Amelia Mc, Sitti Bakhriansyah, Muhammad Hadi Putra, Nataniel Harapan Parlindungan Ringoringo, Harapan Parlindungan Himawan, Indra Widjaja Krisni Subandiyah Loeki Enggar Fitri Marhaeni, Wulandewi NURUL HIDAYAH Putra, Nataniel Hadi Roselina Panghiyangani Sitompul, Putriana Br.