Article Per Year (5 Year)
p-Index From 2021 - 2026
0.778
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya Sari Pediatri Jurnal Ilmiah Kedokteran Wijaya Kusuma
Marhaeni, Wulandewi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Effects of Vitamin D Supplementation on Pediatric Tuberculosis Clinical, Radiological, and Laboratory Outcomes Khairiyadi, Khairiyadi; Hadi Putra, Nataniel; Marhaeni, Wulandewi; Himawan, Indra Widjaja; Panghiyangani, Roselina
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.4

Abstract

Tuberculosis is a systemic infectious disease caused by Mycobacterium tuberculosis. Pediatric tuberculosis patients often have reduced immunity due to malnutrition. Vitamin D supplementation improves host cell antimicrobial immune response, improving clinical outcomes. A study in Iran found that intramuscular cholecalciferol administration improved tuberculosis patients' outcomes, including weight gain and arm circumference when administered alongside tuberculosis therapy for 6 or 9 months. This study focuses on oral cholecalciferol for pediatric tuberculosis patients, analyzing its effects on clinical improvement, radiological features, laboratory findings, and its impact on weight gain, height, and vitamin D levels. The chi-square test was used to analyze the effect of vitamin D on the improvement of fever (p=0.638), cough (p=1.00), nutritional status (p=0.388), radiological features (p=0.510), decrease in leukocytes (p=1.00), lymphocytes (p=0.262), monocytes (p=0.575), and increase in vitamin D levels (p=0.149). The Mann-Whitney test was used to analyze the effect of vitamin D on the average increase in weight gain (p=0.392), height (p=0.044), vitamin D levels (p=0.770), and the average decrease in leukocytes (p=0.260), lymphocytes (p=0.055), and monocytes (p=0.687). The confidence level is 95%. Most clinical, radiographic, and laboratory outcomes in pediatric TB patients did not significantly change when vitamin D therapy was used. However, it markedly increased the patients' development, indicating possible advantages for these individuals.
Hubungan Jumlah Trombosit dan Kadar Hematokrit dengan Severitas Infeksi Dengue Prasetyo, Okky; Hartoyo, Edi; Sanyoto, Didik Dwi; Marhaeni, Wulandewi; Muljanto, Selli
Sari Pediatri Vol 27, No 5 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.5.2026.329-37

Abstract

Latar belakang. Infeksi dengue masih menjadi masalah kesehatan utama dengan angka kejadian yang terus meningkat, terutama pada -anak. Pemeriksaan hematologi sederhana seperti kadar hematokrit dan jumlah trombosit berpotensi digunakan sebagai indikator awal severitas dengue. Tujuan. Menilai hubungan kadar hematokrit dan jumlah trombosit dengan severitas infeksi dengue, serta membandingkan sensitivitas dan spesifisitas keduanya sebagai prediktor dini severe dengue. Metode. Penelitian observasional analitik retrospektif dilakukan pada 119 pasien anak dengan infeksi dengue di RSUD Ulin Banjarmasin periode Januari 2023–Desember 2024. Analisis data menggunakan uji Chi-square, Spearman, serta kurva ROC. Hasil: Hemokonsentrasi ditemukan pada 33,6% pasien dan menunjukkan hubungan signifikan dengan severitas dengue (p=0,009; r=0,233). Hematokrit memiliki sensitivitas 100%, spesifisitas 69%, dan area di bawah kurva/AUC 0,762. Trombositopenia ditemukan pada 77,3% pasien dan juga berhubungan signifikan (p=0,019; r=0,227), dengan sensitivitas 100%, spesifisitas 12,2%, dan AUC 0,799. Hemokonsentrasi terbukti sebagai indikator dini kebocoran plasma, sedangkan trombositopenia efektif sebagai parameter eksklusi severe dengue, tetapi tidak cukup spesifik bila digunakan secara tunggal. Kesimpulan. Hematokrit dan trombosit berhubungan dengan tingkat keparahan infeksi dengue pada anak. Pemeriksaan hematologi sederhana ini dapat menjadi alat skrining dini untuk mengidentifikasi risiko severe dengue, sehingga membantu klinisi dalam menentukan tatalaksana lebih cepat dan tepat.
Neonatal Sepsis Caused by Pseudomonas putida in NICU at Tertiary Hospital in South Kalimantan Andayani, Pudji; Hartoyo, Edi; Pasaribu, Munawaroh; Marhaeni, Wulandewi; Yunanto, Ari; Putra, Nataniel Hadi; Himawan, Gratianus Billy; Salim, Monica Anggriana; Halim, Pricilia Gunawan
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Pseudomonas putida is a Gram-negative bacterium that can cause nosocomial infections, particularly in neonates. This study aimed to identify the characteristics of neonates with P. putida infection, the antibiotics administered, and the treatment outcomes during a P. putida outbreak. This descriptive study collected data from the medical records of neonates diagnosed with neonatal sepsis admitted to Ulin Hospital, Banjarmasin, between August and October 2022. Data collected included patient characteristics, clinical profiles, laboratory results, antibiotic therapy, P. putida antibiotic sensitivity results, and bacterial culture results from samples taken in the NICU during the outbreak period. Fourteen neonates (6.5%) had positive P. putida during the outbreak of blood cultures, including 13 neonates born at Ulin Hospital and one referred from another health facility. Neonates with P. putida infection exhibited leukopenia, thrombocytopenia, and elevated CRP levels. After obtaining the culture results and antibiotic sensitivity tests, the choice of antibiotics was adjusted based on the bacteria's sensitivity. The antibiotics found compelling during treatment included ciprofloxacin, cefepime, tazobactam, gentamicin, a combination of ciprofloxacin and amikacin, and a combination of piperacillin. Most of the clinical and laboratory characteristics improved following treatment, but three neonates unfortunately died during hospitalization. Overall, there were clinical and laboratory improvements after administering antibiotics according to the culture-based antibiotic resistance results.
Correlation Serum Ferritin and Peroxidative Index with Pulmonary Function Pediatric Beta Thalassemia Major Kusumaningtyas, Prabandari; Khairiyadi, Khairiyadi; Suhartono, Eko; Marhaeni, Wulandewi; Hidayah, Nurul
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i2.4362

Abstract

Background: Beta thalassemia major is a genetic disorder that leads to abnormal hemoglobin production, requiring regular blood transfusions. A common complication is iron overload, which potentially damaging vital organs including the lungs. Oxidative stress due to iron overload is suspected to impair pulmonary function via lipid peroxidation. Objective: This study aims to analyze the correlation between serum ferritin levels and the peroxidative index with pulmonary function in pediatric patients with beta thalassemia major undergoing routine transfusions at RSUD Ulin Banjarmasin. Methods: This study was an analytical observational study with a cross-sectional approach involving children aged 6–18 years. Measured parameters included serum ferritin, peroxidative index (H2O2 to catalase ratio), and pulmonary function spirometry (FEV1/FVC ratio). Result: The Pulmonary dysfunction was identified in 68.85% of subjects, predominantly restrictive (65.57%). Mean ferritin level was 5,423.23±3,139.96 µg/L and mean peroxidative index was 46.42±66.38. There was no statistically significant correlation between serum ferritin (p = 0.239) or peroxidative index (p = 0.147) with pulmonary function. Conclusion: Although elevated ferritin and peroxidative index were observed, no significant association was found with pulmonary dysfunction. Monitoring these parameters may aid in early detection and management of pulmonary complications in thalassemia.
Co-Authors ary yunanto Edi Hartoyo Eko Suhartono Hadi Putra, Nataniel Halim, Pricilia Gunawan Himawan, Gratianus Billy Himawan, Indra Widjaja Khairiyadi Khairiyadi Kusumaningtyas, Prabandari Muljanto, Selli NURUL HIDAYAH Pasaribu, Munawaroh Prasetyo, Okky Pudji Andayani, Pudji Putra, Nataniel Hadi Roselina Panghiyangani Salim, Monica Anggriana Sanyoto, Didik Dwi