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All Journal Jurnal Kedokteran Brawijaya
Putra, Nataniel Hadi
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Medicine & Pharmacology

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The Effect of Anti-Tuberculosis Drugs (ATT) Routine on Blood Profiles and Nutritional Status of Children at Ulin Hospital, Banjarmasin Khairiyadi, Khairiyadi; Sitompul, Putriana Br.; Putra, Nataniel Hadi; Panghiyangani, Roselina
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.5

Abstract

Tuberculosis (TB) is an infectious disease caused by the rod-shaped bacterium Mycobacterium tuberculosis (M. TB). TB primarily affects the lung parenchyma (pulmonary TB), but the bacterium can also infect other organs, leading to extrapulmonary TB. Anti-Tuberculosis Drugs (ATT) are a crucial component of TB treatment. However, the use of ATT is associated with side effects, the most common being anaemia and thrombocytopenia. This study aims to determine the effect of ATT on routine blood profiles and the nutritional status of pediatric patients with pulmonary TB and glandular TB at Ulin Regional Hospital, Banjarmasin. This analytical observational study employed a cross-sectional design. A total of 52 pediatric patients with pulmonary TB and glandular TB at Ulin Regional Hospital, Banjarmasin, were selected using a non-probability total sampling approach. The Wilcoxon test revealed a significant effect of ATT therapy on nutritional status, as indicated by a p-value of 0.000. ATT therapy results in changes in routine blood profiles and significant improvements in the nutritional status of pediatric patients with pulmonary TB and glandular TB. The significant changes in the routine blood profile are haemoglobin level and monocytes level which increased after ATT therapy. The average leukocytes, neutrophils, lymphocytes and Erythrocyte Sedimentation Rate (ESR) level decreased significantly after ATT therapy, while Platelet counts remained unchanged.
Neonatal Sepsis Caused by Pseudomonas putida in NICU at Tertiary Hospital in South Kalimantan Andayani, Pudji; Hartoyo, Edi; Pasaribu, Munawaroh; Marhaeni, Wulandewi; Yunanto, Ari; Putra, Nataniel Hadi; Himawan, Gratianus Billy; Salim, Monica Anggriana; Halim, Pricilia Gunawan
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Pseudomonas putida is a Gram-negative bacterium that can cause nosocomial infections, particularly in neonates. This study aimed to identify the characteristics of neonates with P. putida infection, the antibiotics administered, and the treatment outcomes during a P. putida outbreak. This descriptive study collected data from the medical records of neonates diagnosed with neonatal sepsis admitted to Ulin Hospital, Banjarmasin, between August and October 2022. Data collected included patient characteristics, clinical profiles, laboratory results, antibiotic therapy, P. putida antibiotic sensitivity results, and bacterial culture results from samples taken in the NICU during the outbreak period. Fourteen neonates (6.5%) had positive P. putida during the outbreak of blood cultures, including 13 neonates born at Ulin Hospital and one referred from another health facility. Neonates with P. putida infection exhibited leukopenia, thrombocytopenia, and elevated CRP levels. After obtaining the culture results and antibiotic sensitivity tests, the choice of antibiotics was adjusted based on the bacteria's sensitivity. The antibiotics found compelling during treatment included ciprofloxacin, cefepime, tazobactam, gentamicin, a combination of ciprofloxacin and amikacin, and a combination of piperacillin. Most of the clinical and laboratory characteristics improved following treatment, but three neonates unfortunately died during hospitalization. Overall, there were clinical and laboratory improvements after administering antibiotics according to the culture-based antibiotic resistance results.
Co-Authors ary yunanto Edi Hartoyo Halim, Pricilia Gunawan Himawan, Gratianus Billy Khairiyadi Khairiyadi Marhaeni, Wulandewi Pasaribu, Munawaroh Pudji Andayani, Pudji Roselina Panghiyangani Salim, Monica Anggriana Sitompul, Putriana Br.