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All Journal Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology AL KAUNIYAH Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Biotechnology Panrita Abdi - Jurnal Pengabdian pada Masyarakat BIOPROSPEK BIOEDUSCIENCE Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Abditani : Jurnal Pengabdian Masyarakat
Retno Aryani
Jurusan Biologi FMIPA Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Veterinary Other

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Subchronic Toxicity Test of Indian Almond (Terminalia catappa) Leaves Water Extract on The Liver Histology of Mice (Mus musculus) Nugroho Rudy; Ni Cening Sri Puspa; Retno Aryani; Widha Prahastika; Rudianto Rudianto; Hetty Manurung
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/425173

Abstract

Background: Indian almond (Terminalia catappa) is used as an alternative medicine by the community to treat various diseases. However, limited research has been conducted on the subchronic toxicity of Indian almond water extracts on the liver. Present study aimed to determine the subchronic toxic effects of Indian almond leaf water extract on the liver histology of mice and to evaluate the safe dose of Indian almond leaf water extract with various doses (125, 250, 500, 750 and 1000 mg/kg). Methods: In total of 33 male mice were randomly divided into 11 groups, each group consisting of three mice as replication. For 30 days, mice in five treatment groups were orally treated every day with water extracts of green Indian almond leaf while other five groups were given water extracts of brown Indian almond leaves and compare with control group. At the end of day 30, all mice were sacrificed, and hepar was taken out for histological preparations. The histopathological changes in the liver was observed and assessed based on histological damage in the term of degeneration and necrosis. Results: The administration of green and brown Indian almond water extract at doses of 125, 250, 500, 750 and 1000 mg / kg BB showed a toxic effect on the liver of mice. The toxic effect was due to the high doses, causing a cell swelling damage and increased liver necrosis. Conclusion: Indian almond leaf water extract can cause toxic effects on the liver of mice at the doses implemented.
Co-Authors Andy Nurcahyono Apri Pauci Florentino Ari Susandy Sanjaya, Ari Susandy Christiano Jhonson Didit Suprihanto Hetty Manurung Imam Rosadi Iyut Jaya Toimsar Iyut Toimsar L. Hartanto Nugroho Lariman Lariman Monica Kusneti Muhammad Fauzi Arif Ni Cening Sri Puspa Nugroho Rudy Nurul Fadila Pudji Astuti Rahma Suci Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudianto Rudy Agung Nugroho Rudy Nugroho Soekarti Moeljopawiro Sukarti Moeljopawiro Widha Prahastika Widha Prahastika Windi Rosiana Dewi Wulan Iyhig Ratna Sari Yanti Puspita Sari Yanti Sari