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All Journal JURNAL KIMIA SAINS DAN APLIKASI INDONESIAN JOURNAL OF PHARMACY Makara Journal of Science
Soleh Kosela
Departemen Kimia, Universitas Indonesia, Kampus Baru Depok, 16424
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology

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MACARANGIN, A GERANYLATED FLAVONOID AND ANTICANCER ACTIVE COMPOUND ISOLATED FROM ETHYL ACETAT FRACTION OF Macaranga gigantifolia LEAVES Darmawan, Akhmad; Suwarso, Wahyudi P.; Kosela, Soleh; Kardono, Leonardus B.S.; Fajriah, Sofa
INDONESIAN JOURNAL OF PHARMACY Vol 26 No 1, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.678 KB) | DOI: 10.14499/indonesianjpharm26iss1pp52

Abstract

Macaranga known locally as mahang-mahangan has uniquely ecological function, and also became a part of traditional medicine in Indonesia. Macaranga genus also known as a sources of terpenoid and phenolic (flavonoid) compounds which have biological activity as antioxidant and anticancer (cytotoxicity).There are few phytochemical investigations have been done on M. gigantifolia species. As a part of our continuing research of isolation anticancer compound from natural product, a geranylated flavonoid compound (macarangin) has been isolated from ethyl acetate fraction of Macaranga gigantifolia leaves using chromatography methods. The isolated compund (isolat MG) was elucidated to gain the chemical structure based on spectroscopic data (LC-MS and FT-NMR). Cytotoxicity test of this compound was tested against MCF 7 cell lines, showed that macarangin has a potential activity with IC50 value 119.12μg/mL. Key words: Macarangin, geranylated  flavonoid, Macaranga gigantifolia, MCF 7 cell lines.
Senyawa Naringenin 7, 3’, 4’ -Trimetil Eter dari Daun Tanaman Pacar Cina (Aglaia Odorata Lour) Kusrini, Dewi; Kosela, Soleh; Chairul, Chairul
Jurnal Kimia Sains dan Aplikasi Vol 2, No 2 (1999): Volume 2 Issue 2 Year 1999
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5339.871 KB) | DOI: 10.14710/jksa.2.2.67-72

Abstract

Senyawa Naringenin, 7, 3’, 4', - trimetil eter berhasil diisolasi dari fraksi n-heksana ekstrak daun Pacar cina. Senyawa tersebut diisolasi dengan cara kolom kromatografi (KK) dan kromatografi cair kinerja tinggi (KCKT) serta ditentukan struktur molekulnya dengan menggunakan metode spektroskopi.
SENYAWA TRITERPENOID DARI EKSTRAK N-HEKSANA KULIT BATANG TANAMAN Garcinia benthami Elya1, Berna; Kosela, Soleh; Muhammad, Muhammad
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

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Abstract

Triterpenoids compounds from N-hexane extract of the stem bark of Garcinia benthami. Two triperpenoids compounds, i.e. friedelin (1) and 3β-hydroxy-lanosta-9(11),24-dien-26-oic acid (2) were isolated from the n-hexane extract of the stem bark of Garcinia benthami. The structures of these compounds were elucidated by IR, MS,1 H-NMR and 13C-NMR spectroscopy and by comparison of their spectroscopic data with those reported data from the literature.
Co-Authors Akhmad Darmawan Atiek Soemiati Berna Elya Chairul Chairul Dewi Kusrini Leonardus B.S. Kardono Muhammad Hanafi Muhammad Muhammad Sofa Fajriah Wahyudi P. Suwarso, Wahyudi P.