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All Journal Global Medical and Health Communication Jurnal Biomedika dan Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Widyasari Kumala
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Motility Indole Urease as An Alternative Diagnostic Method for Identifying Helicobacter pylori Infection Widyasari Kumala; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 2, NUMBER 2, August 2001
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2220015-7

Abstract

Background: The prevalence of Helicobacter pylori (H. pylori) infection in the world is quite high, especially in developing countries.  Usually the patient shows no specific symptoms and chronic gastritis therefore becomes chronically infected. The complication of the infection is the development of peptic ulcer, which is a predisposing factor for gastric carcinoma. Early diagnosis is an important step to avoid these complications by providing immediate accurate therapy. Methods: In this study, the CLO, MIU (Motility Indole Urease) tests and culture were conducted on 131 biopsy samples of the stomach antrum mucous tissue taken from chronic dyspepsia patients from several hospitals in Jakarta. In the CLO test, biopsy tissue was put in a small well agar to be incubated at room temperature. In the MIU test the biopsy tissue sample was submerged in the small MIU tube agar with a depth of approximately 2/3 rds from the surface, and then incubated at room temperature. Another piece of biopsy tissue was cultured micro-aerophylically.  The CLO and MIU tests are considered positive if the color changes from yellow to red, and are considered negative if there is no color change within 24 hours. Results: Compared to culture, the CLO test demonstrated 38% sensitivity, 96% specificity, 94% positive predictive value and 52% negative predictive value, whereas the Results of the MIU test aga inst culture method showed 76% sensitivity,   89% specificity, 88% positive predictive value, and   78% negative predictive value. Conclusion: The MIU test that showed high sensitivity and specificity, and thus could be further developed as an alternative diagnostic method for H. pylori infection.    Keywords: MIU,CLO, H. pylori infection
Bacteriological and Antibiotic Susceptibility Profile of Urinary Tract Infection among Online Motorcycle Drivers in Jakarta, Indonesia Effendi, Ida; Robertus, Thomas; Samira, Jihan; Devita, Arleen; Kumala, Widyasari; Bella, Isa
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.12311

Abstract

Urinary tract infection (UTI) is a bacterial infection that contributes significantly to morbidity rates. UTI is a health concern due to multidrug-resistant (MDR) organisms. Therefore, the profile of bacteria and antibiotic susceptibility patterns are very important to know in order to make the best treatment choice. Working as an online motorcycle (ojol driver) carries a risk of urinary tract infections. Online drivers are assumed to often hold their urination for short or long periods. The descriptive study with a cross-sectional design was conducted to obtain the prevalence of urinary tract infections, bacteria profile, and antibiotic susceptibility in urine specimens collected from Jakarta ojol drivers in September 2022–Maret 2023. Of 98 midstream urine specimens, 17 samples are considered to have UTI (17.34%). The identification of the 17 isolates shows that the microorganisms' distribution was more likely to be caused by gram-positive than gram-negative bacteria (70.60%). The causative bacteria were coagulase-negative Staphylococcus (17.65%), Escherichia coli (11.76%), and Enterococcus faecalis (11.76%). Our results showed that the prevalence of urinary tract infections in ojol drivers is high with the distribution of the causative organisms by coagulase-negative Staphylococcus, Escherichia coli, and Enterococcus faecalis and still showed good susceptibility to narrow-spectrum antibiotics such as cotrimoxazole.
Pengaruh ekstrak biji pala (Myristica fragrans Houtt) sebagai antibakteri terhadap pertumbuhan Pseudomonas aeruginosa Fiadwita Nia Ifriana; Widyasari Kumala
Jurnal Biomedika dan Kesehatan Vol 1 No 3 (2018)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2018.v1.172-178

Abstract

LATAR BELAKANGPseudomonas aeruginosa merupakan bakteri negatif-gram yang menjadi penyebab tersering infeksi di lingkungan Rumah Sakit yang dikenal dengan istilah infeksi nosokomial. Saat ini penggunaan antibakteri dari bahan alami mulai dikembangkan. Di seluruh dunia, ratusan tanaman dapat digunakan dalam pengobatan tradisional sebagai pengobatan untuk infeksi bakteri. Biji buah pala (Myristica fragrans Houtt) mengandung minyak atsiri, saponin, terpenoid, flavonoid, yang diketahui berpotensi sebagai antibakteri. Maka dari itu penulis ingin mengetahui aktivitas antibakteri pada biji pala (Myristica fragrans Houtt) terhadap pertumbuhan bakteri Pseudomonas aeruginosa. METODEDesain penelitian ini adalah eksperimental sesungguhnya (True Experimental) laboratorium in vitro, menggunakan metode difusi cakram, dengan menggunakan sampel ekstrak biji pala (Myristica fragrans Houtt) dan bakteri Pseudomonas aeruginosa. Terdapat 4 kelompok perlakuan dan 2 kelompok kontrol. Zona hambat yang terbentuk akan diukur menggunakan penggaris. Analisis data dengan menggunakan SPSS versi 22. HASILHasil penelitian menunjukkan ekstrak biji pala (Myristica fragrans Houtt) dapat menghambat pertumbuhan bakteri Pseudomonas aeruginosa, hal ini dibuktikan dengan terbentuknya zona hambat pada kertas cakram. Zona hambat yang terbentuk bervariasi, semakin tinggi konsentrasi ekstrak maka semakin luas zona hambat yang terbentuk. KESIMPULANEkstrak biji pala (Myristica fragrans Houtt) dapat menghambat pertumbuhan Pseudomonas aeruginosa dengan kategori lemah.
Co-Authors Abdul Aziz Rani Abdul Aziz Rani Bella, Isa Devita, Arleen Effendi, Ida Fiadwita Nia Ifriana Robertus, Thomas Samira, Jihan