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All Journal Global Medical and Health Communication Paediatrica Indonesiana Jurnal Biomedika dan Kesehatan
Robertus, Thomas
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Bacteriological and Antibiotic Susceptibility Profile of Urinary Tract Infection among Online Motorcycle Drivers in Jakarta, Indonesia Effendi, Ida; Robertus, Thomas; Samira, Jihan; Devita, Arleen; Kumala, Widyasari; Bella, Isa
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.12311

Abstract

Urinary tract infection (UTI) is a bacterial infection that contributes significantly to morbidity rates. UTI is a health concern due to multidrug-resistant (MDR) organisms. Therefore, the profile of bacteria and antibiotic susceptibility patterns are very important to know in order to make the best treatment choice. Working as an online motorcycle (ojol driver) carries a risk of urinary tract infections. Online drivers are assumed to often hold their urination for short or long periods. The descriptive study with a cross-sectional design was conducted to obtain the prevalence of urinary tract infections, bacteria profile, and antibiotic susceptibility in urine specimens collected from Jakarta ojol drivers in September 2022–Maret 2023. Of 98 midstream urine specimens, 17 samples are considered to have UTI (17.34%). The identification of the 17 isolates shows that the microorganisms' distribution was more likely to be caused by gram-positive than gram-negative bacteria (70.60%). The causative bacteria were coagulase-negative Staphylococcus (17.65%), Escherichia coli (11.76%), and Enterococcus faecalis (11.76%). Our results showed that the prevalence of urinary tract infections in ojol drivers is high with the distribution of the causative organisms by coagulase-negative Staphylococcus, Escherichia coli, and Enterococcus faecalis and still showed good susceptibility to narrow-spectrum antibiotics such as cotrimoxazole.
Perbandingan Respons Antibodi setelah Vaksinasi COVID-19 antara Individu dengan dan tanpa Komorbiditas Bella, Isa; Khariri, Khariri; Hartanti, Monica Dwi; Sisca, Sisca; Thabit, Jihan Samira; Effendi, Ida; Devita, Arleen; Robertus, Thomas
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background Vaccination is a Crucial public health strategy for reducing the transmission of viral infections and protecting populations from severe illness. COVID-19 vaccines have played a significant role in decreasing the incidence and mortality rates linked to the virus. However, immune responses to vaccination may differ among individuals, especially those with comorbidies that could alter immune function. This study aimed to compare antibody responses in adults with and without comorbidities, 18 months after receiving the COVID-19 vaccine. Methods This was a cohort study with two sampling time points: before vaccination and 18 months after vaccination. The study was conducted in Yogyakarta, Indonesia. Data were collected through self-administered questionnaires and venous blood sampling. Antibody titers were measured to evaluate the humoral immune response in participants with and without comorbidities. Results Before vaccination, the highest proportion of positive antibody titers was found among females (40.2%), individuals aged 18–44 years (44.7%), those with a senior high school education (48.1%), and individuals with normal body weight (44.3%). A Comparison of antibody levels at baseline and 18 months after vaccination between groups with and without comorbidities showed no statistically significant difference, with a p-value of 0.992.   Conclusions Although no significant difference was found in antibody responses between individuals with and without comorbidities, comorbid conditions may still influence immune response depending on their type and severity. These findings suggest the need for further research to examine the specific effects of various comorbidities on long-term vaccine-induced immunity.
Microbial profiles and antimicrobial resistance patterns in neonatal intensive care units: an analysis of the impact of the COVID-19 pandemic in Indonesia Santi, Theresia; Robertus, Thomas; Dewanto, Naomi Esthernita Fauzia; Hidayat, Feronica Kusuma; Hidayat, Ferry; Sungono, Veli; Jo, Juandy
Paediatrica Indonesiana Vol. 66 No. 2 (2026): March 2026
Publisher : Indonesian Pediatric Society

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Background Neonatal sepsis requires prompt antimicrobial treatment. A lack of information on patterns of antibiotic resistance among the bacteria across hospitals hinders the treatment. The COVID-19 pandemic contributed to changes in neonatal infection patterns and antimicrobial resistance.  Data describing these changes remain scarce in Indonesia. Objective To determine the spectrum of pathogens and their antibiotic resistance patterns among Indonesian neonates with sepsis, prior and during the COVID-19 pandemic. Methods This retrospective study  was done to examine patterns of pathogens and antibiotic resistance in neonates admitted to the neonatal intensive care units (NICUs) at Siloam Hospital Kebon Jeruk and Lippo Cikarang for 6 years, i.e., January 2018 to December 2020 (“Prior/Early COVID-19 Pandemic” or first phase) and January 2021 to December 2023 (“Mid/Late COVID-19 Pandemic” or second phase). The inclusion criteria were newborns with suspected or proven sepsis who underwent microbiological specimen collection for the assessment of antimicrobial resistance. We compared patterns of isolated pathogens and their antibiotic resistance of neonates with sepsis in two private hospitals, prior and during the COVID-19 pandemic. Results There were more participants in the first phase than in the second phase (44 vs. 33, respectively), resulting in more pathogenic isolates in the former than the latter phase (43 vs. 23, respectively). There were more Gram-negative bacteria detected than Gram-positive bacteria, although a reduction of several Gram-negative bacterial species from the order of Enterobacterales (including Klebsiella pneumoniae and Escherichia coli) was detected in the second phase. The resistance of Enterobacterales to gentamicin and third-generation cephalosporins was substantially increased in the second phase. Conclusion Despite an overall decline in isolate numbers, the observed increase in antibiotic resistance among Enterobacterales in the second phase may reflect suboptimal stewardship and indiscriminate use of broad-spectrum antibiotics during the COVID-19 pandemic. This highlights the growing challenge of antimicrobial resistance in neonatal sepsis management in Indonesia.
Co-Authors Bella, Isa Devita, Arleen Dewanto, Naomi Esthernita Fauzia Effendi, Ida Ferry Hidayat Hidayat, Feronica Kusuma Juandy Jo Khariri Khariri Monica Dwi Hartanti, Monica Dwi Samira, Jihan Sisca Sisca, Sisca THABIT, JIHAN SAMIRA Theresia Santi, Theresia Veli Sungono Widyasari Kumala