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All Journal Biomedika Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Raudatul Patimah
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Tanti Azizah Sujono; Raudatul Patimah; Ratna Yuliani
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i2.253

Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SABUN HANDWASH DARI EKSTRAK KELAKAI (Stenochlaena palustris (BURM.F) BEDD.) Rahmawati Rahmawati; Raudatul Patimah; Herda Ariyani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 6 No 2 (2023): March
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

ABSTRAK Meningkatnya penyebaran kasus Covid-19 saat ini menjadikan kebiasaan mencuci tangan menggunakan sabun sebagai salah satu kewajiban untuk menekan penyebarannya. Pemanfaatan tanaman herbal sebagai bahan aktif sabun handwash sering dilakukan. Penelitian ini bertujuan untuk memanfaatkan tanaman Kelakai (Stenochlaena palustris (Burm.f) Bedd.) sebagai bahan aktif dalam formulasi sabun handwash dan diuji aktivitas antibakterialnya terhadap bakteri Escherichia coli. Tanaman Kelakai dimaserasi dengan etanol 70% dan dilakukan skrinning fitokimia terhadap ekstrak yang dihasilkan. Ekstrak Kelakai kemudian diformulasikan dalam sabun handwash dan diuji aktivitas antibakteri dengan metode dilusi menggunakan media Nutrien Broth dan dilanjutkan dengan uji penegasan menggunakan media Nutrien Agar. Hasil randemen ekstrak dari Kelakai adalah sebesar 12,07%. Ekstrak etanol Kelakai menunjukkan adanya kandungan fenolik, flavonoid, saponin, terpenoid, steroid, alkaloid dan tanin. Konsentrasi Hambat Minimum (KHM) formulasi sabun handwash ekstrak Kelakai teramati pada konsentrasi 30%. ABSTRACT The growth of Covid-19 cases currently, generating the importance of washing hands with soap to suppress its spread. Herbal plants utilization as active ingredients in handwash soap is often carried out. This study aims to utilize Kelakai (Stenochlaena palustris (Burm.f) Bedd.) as an active ingredient in handwash soap formulations and evaluate its antibacterial activity against Escherichia coli bacteria. Kelakai was macerated using 70% ethanol and extract Kelakai was subjected to phytochemical screening. Kelakai extract was then formulated in handwash soap and evaluated for antibacterial activity with dilution method using Nutrien Broth and followed by a confirmation test using Nutrient Agar. The yield of the extract from Kelakai was 12.07%. The ethanol extract of Kelakai showed the presence of phenolics, flavonoids, saponins, terpenoids, steroids, alkaloids and tannins. The Minimum Inhibitory Concentration (MIC) of the Kelakai extract handwash soap formulation was observed at a concentration of 30%.
PENGOLAHAN SELULOSA MIKROKRISTAL GRADE FARMASI DARI BEBERAPA BAGIAN TANAMAN TERATAI PUTIH (Nymphaea nouchali Burm. F.): PREPARASI & UJI KUALITATIF SERBUK Lestari, Yulianita Pratiwi Indah; Raudatul Patimah; Yuspa; Muhammad; Rahmalisa Hafifah; Soraya Aldeina; Siti Mursyidah; Putri Amelia; Hikmah Fitriani; Maulinda Nur Pramudyas Primia Setyaningrum
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.26873

Abstract

Obat memiliki kebermanfaatan yang penting dalam pelayanan kesehatan yang dapat digunakan dalam meningkatkan derajat kesehatan masyarakat. Namun, industri farmasi di Indonesia masih sangat tergantung dengan bahan baku impor. Proses ekstraksi biasanya menghasilkan residu (ampas ekstraksi) berupa serbuk simplisia yang tidak digunakan lagi (limbah padat organik). Pemanfaatan residu hasil ekstraksi pada tanaman teratai putih masih sangat minim, sehingga residu dari hasil ekstraksi tanaman ini dapat diolah menjadi bahan baku pembuatan selulosa mikrokristal. Penelitian ini bertujuan untuk mendapatkan selulosa mikrokristal dari beberapa bagian pada tanaman teratai putih, kemudian dilakukan pengujian kualitas serbuk dengan Avicel PH 101 sebagai bahan baku pembanding. Berdasarkan hasil penelitian, bagian dari tanaman teratai putih yang memiliki kandungan α-selulosa dengan rendemen tertinggi adalah pada bagian tangkai bunga dengan rendemen sebesar 29,02% terhadap serbuk simplisia, diikuti dengan bagian tangkai daun sebesar 22,41%, bagian bunga sebesar 18,72%, dan paling rendah bagian daun yaitu sebesar 7,70%. Selulosa mikrokristal dengan rendemen tertinggi diperoleh oleh bagian daun dengan persentase rendemen sebesar 97%, diikuti dengan bagian tangkai daun sebesar 89%, bagian bunga sebesar 88%, dan rendemen terendah oleh bagian tangkai bunga dengan persentase sebesar 83%. Sifat fisik dari serbuk selulosa mikrokristal teratai putih baik pada daun, tangkai daun, bunga, maupun tangkai bunga, menunjukkan kemiripan karakteristik dengan Avicel® PH 101 sebagai baku pembanding, meliputi reaksi warna, organoleptis, kelarutan, dan pH. Berdasarkan penelitian yang telah dilakukan, kualitas serbuk selulosa mikrokristal dari beberapa bagian tanaman teratai putih (bunga, tangkai bunga, daun, dan tangkai daun) memiliki kemiripan dengan baku pembandingnya, yaitu Avicel® PH 101.
PEMANFAATAN TERATAI PUTIH SEBAGAI BAHAN BAKU PEMBUATAN SELULOSA MIKROKRISTALIN MENGGUNAKAN HIDROLISIS ENZIMATIK DARI RAYAP Coptotermes sp. Lestari, Yulianita Pratiwi Indah; Mi'rajunnisa; Raudatul Patimah; Rizka Mulya Miranti; Tuty Mulyani
Jurnal Ilmiah Manuntung Vol 10 No 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.742

Abstract

Microcrystalline cellulose is still imported by the Pharmaceutical Industry in Indonesia even though Indonesia has large natural resources but they have not been utilized optimally. Microcrystalline cellulose can be obtained from residue (extraction dregs) in the lotus plant extraction process, namely in the form of simplicia powder which will not be used again (organic solid waste). This research aims to obtain microcrystalline cellulose from several parts of the white lotus plant (Nymphaea nouchali Burm. F.) using the enzymatic hydrolysis method using cellulase from the termite Coptotermes sp., then the quality of the powder will be tested and compared with Avicel PH 101. Each part The white lotus is extracted, then the residue is delignified to obtain α-cellulose, then hydrolyzed with crude extract from Coptotermes sp termite cellulase. so that microcrystalline cellulose is obtained which will then be characterized and compared with the commercial version, namely Avicel® PH 101. The highest yield of microcrystalline cellulose is found in leaves with a yield of 95.3%, followed by leaf stalks 89.3%, flower stalks 75.7%, and the yield lowest in interest with a percentage of 74%. The physical characteristics in the form of color reaction, organoleptics, solubility and pH of white lotus microcrystalline cellulose powder show similarities with the comparison standard. It can be concluded that microcrystalline cellulose powder from several parts of the white lotus plant can be an alternative in obtaining cellulose raw materials from natural sources.
Co-Authors Herda Ariyani Hikmah Fitriani Maulinda Nur Pramudyas Primia Setyaningrum Mi'rajunnisa Muhammad Putri Amelia Rahmalisa Hafifah Rahmawati Rahmawati Ratna Yuliani Rizka Mulya Miranti Siti Mursyidah Soraya Aldeina Tanti Azizah Sujono Tuty Mulyani Yulianita Pratiwi Indah Lestari Yuspa