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All Journal Medicina E-Jurnal Medika Udayana Jurnal Administrasi Bisnis Jurnal Kesehatan Prima ISM (Intisari Sains Medis) : Jurnal Kedokteran Ophthalmologica Indonesiana
Ni Made Laksmi Utari
Bagian Ilmu Kesehatan Mata Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Medicina

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ASTAXANTHIN MENURUNKAN KADAR VASCULAR ENDOTHELIAL GROWTH FACTOR, TUMOR NECROSIS FACTOR ALPHA, INTERLEUKIN-6, DAN NITRIC OXIDE PADA NONPROLIFERATIVE DIABETIC RETINOPATHY RINGAN: UJI KLINIS TERKENDALI Laksmi Utari, Ni Made; Putrawati T, AA Mas; Pertami Dewi, Ida Ayu; Sedani, Ni wayan
Medicina Vol 45 No 1 (2014): Januari 2014
Publisher : Medicina

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Abstract

Diabetic Retinopathy (DR) merupakan komplikasi mikrovaskular pada Diabetes Mellitus (DM) dan penyebab kebutaan paling sering pada usia produktif. Hiperglikemia menyebabkan terjadinya reaksiinflamasi dan stres oksidatif  dalam patogenesis DR dipaparkan oleh beberapa peneliti, namun peran antioksidan dalam mengurangi progresifitas DR masih menjadi perdebatan. Penelitian ini bertujuanuntuk mengetahui pemberian astaxanthin 8 mg dapat menurunkan kadar Vascular Endothelial Growth Factor (VEGF), Tumor Necrosis Factor-alpha (TNF-á), Interleukin-6 (IL-6) dan Nitric Oxide (NO) padapenderita Non Proliferative Diabetic Retinopathy (NPDR) ringan. Penelitian clinical trial dengan perluasan Randomized, Double Blinded, Placebo-Control, Pre and Posttest Group Design ini dilaksanakanpada bulan Juli 2013 - Desember 2013 di Poliklinik Mata RSUP Sanglah Denpasar Bali. Jumlah sampel yang memenuhi kriteria eligibilitas sebanyak 40 pasien NPDR ringan terbagi menjadi 20 pasien  sebagai kelompok perlakuan yang diberikan astaxanthin 8 mg dan 20 pasien NPDR ringan yang diberikan plasebo sebagai kelompok kontrol. Pengambilan sampel darah vena untuk pemeriksaan dilakukan sebelum dan setelah pemberian astaxanthin 8 mg serta plasebo selama 4 minggu. Perbedaan kadar rerata VEGF, TNF-á, IL-6 dan NO dianalisis dengan uji-t jika distribusi data normal dan uji Mann-whitney jika distribusi data tidak  normal. Hasil penelitian ini diharapkan dapat memberikaninformasi mengenai hubungan VEGF, TNF-á, IL-6, dan NO dalam perkembangan NPDR ringan serta manfaat pemberian astaxanthin dalam perkembangan NPDR ringan. [MEDICINA 2014;45:31-37]
THE PREVALENCE OF ANEMIA, KNOWLEDGE, AND NUTRIENT CONSUMPTION AMONGST PREGNANT WOMEN IN PUSKESMAS TAMPAKSIRING I, GIANYAR, BALI Aryani, Putu; Laksmi Utari, Ni Made
Medicina Vol 43 No 2 (2012): Mei 2012
Publisher : Medicina

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Abstract

According to the pregnant women’s registration data in Puskesmas Tampaksiring I, there were three cases of anemia in June 2007, which were occurred among the poor and less educated pregnant women. Therefore, the goals of this study were to determine the prevalence of anemia, knowledge and the nutrient consumption among pregnant women in Tampaksiring, Gianyar. The study was conducted from July 2007 to September 2007, used cross-sectional descriptive quantitative method. Data was collected by structured interview using questionaire and haemoglobin examination using the Sahli Method. A sample of 45 pregnant woman were choosen from the register in Puskesmas Tampaksiring. Results of the studies showed that 80% of the sample were suffering from anemia. The knowlegde of the sample about nutrition was divided into three categories, namely “good level of knowledge” (13.3%), “sufficient knowledge” (62.2%), and “insufficient knowledge” (24.4%). The consumption patterns did not support the iron and folic acid needs of these women. It was found that most of the sample’s diet contained more vegetables than fish or meat, which are known to be good sources of iron and folic acid. In addition, during pregnancy, they continued to drink coffee and tea, which inhibit the absorption of iron in small intestine. For nutritional intake during pregnancy, we found that levels of protein, vitamins A and  C were above the standard although intake of energy, calcium, Fe and vitamin B were below the recomended daily amounts.
Co-Authors AA Mas Putrawati T, AA Mas Anak Agung Ayu Sukartini Djelantik Anak Agung Surya Nirmala Dewi Ari Andayani Ayu Surasmiati, Ni Made Christine Natalia Gunawan CLARA VALENTINA Dendy Pranata Purba Eka Sutyawan, I Wayan I Gusti Ayu Ratna Suryaningrum I Made Sudarmaja I Wayan Eka Sutyawan Ida Ayu Pertami Dewi, Ida Ayu KETUT PRAMANA ADIPUTRA L.P. Suryantini Septia Dewi Made Agus Kusumadjaja Made Ayu Hapsari Dwi Ambarini Ni Luh Putu Nurindah Sukmawati Ni Made Ayu Surasmiati Ni wayan Sedani, Ni wayan Putu Aryani Putu Yuliawati REFAYANTI, NI MADE ERNITA Rima Febry Lesmana SAPHIRA EVANI