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Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity Patuti, Deece; Yusuf, Harmas Yazid; Hernowo, Bethy Suryawathy
Padjadjaran Journal of Dentistry Vol 22, No 2 (2010): July 2010
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol22no2.26873

Introduction: CD10 can also facilitate the ability of tumour metastasis by its ability to invade blood vessel walls.Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity. Methods: This study was preceded by collecting data on squamous cell carcinoma of the oral cavity in the medical record and paraffin blocks in the Anatomy Pathology section of 15 samples with enlarged regional lymph nodes and 15 samples without enlargement of regional lymph nodes. Then two preparations were made, the first preparation was stained with Hematoxylin Eosin (HE) to establish the diagnosis and determine the histopathological gradation, then count the number of eosinophils, and the other development was smeared with CD10. Outward immunohistochemistry uses the Labelled streptavidin biotin immunoperoxidase complex (LSAB) method using the Starr Trek Universal HRP Detection system. (Biocare Medical, USA). The primary antibody used was CD10 (Novocastra Laboratories Ltd, Newcastle upon Tyne, UK) with a dilution of 1:25 - 1: 50. Results: There was no statistically significant correlation between CD10 and enlargement of the lymph node regionally tested statistically using the Spearman rank test rs = -0.236, meaning that the increase in CD10 immunoexpression is inversely proportional to the enlargement of regional lymph node, but the correlation is not statistically significant The results of the analysis using the Spearman rank test found significance of p = 0.043 (significant) with a correlation strength of 37.2% Conclusion: There was no correlation between CD10 and enlargement of the lymph node regionally and correlation strength eosinophil distribution in squamous cell carcinoma of the oral cavity without regional lymph node enlargement.

Correlation of odontogenic infection severity score with C-reactive protein levels on patients with odontogenic infection in Dr Hasan Sadikin General Hospital Bandung Prihandana, Ariyaka Niastya; Yusuf, Harmas Yazid; Nurwiadh, Agus; Lismayanti, Leni
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.21252

Introduction: Head and neck infections commonly caused by spreading odontogenic infection, which able to cause a local and systemic manifestation, from mild to severe complications according to its severity. Assessment of the severity of odontogenic infections is essential to determine the prognosis, assessed through local and systemic parameters. Laboratory examination used to examine the biological marker that indicates the ongoing infection. C-reactive protein (CRP) is a protein synthesised by hepatocytes in response to the body's inflammatory process, including odontogenic infection. This study was aimed to analyse the severity score of odontogenic infections using the CRP levels in patients with odontogenic infections. Methods: An analytic study with a cross-sectional approach was conducted on 30 patients of Dr Hasan Sadikin General Hospital Bandung diagnosed with odontogenic infections, determined by calculations according to Hosmer and Lemeshow. Assessment of the severity score in odontogenic infections and quantitative CRP levels with the Dimension tool was conducted afterwards. Correlation between odontogenic infection severity score and CRP levels was analysed using regression and correlation tests. Results: From 30 subjects, there was found 33.3% with mild severity score, 63.3% moderate score and 3.3% severe score. The mean of the CRP level was significantly increased according to the odontogenic severity scoring category. All research subjects who were examined showed that there was a very strong and significant correlation (p-value<0.05) between the severity of odontogenic infections and CRP levels in odontogenic infection patients with a correlation coefficient r=0.84 (p=0.001). Conclusion: There is a positive correlation between the CRP levels and the severity score of odontogenic infection. The higher the CRP levels, the odontogenic infection will be more severe. Therefore, the CRP level might be considered an additional biomarker in supporting the severity of odontogenic infection in clinical practice.

The Role of p53 Gene In Molecular Pathogenesis of Oral Squamous Cell Carcinoma Nabilla, Firyal; Hadikrishna, Indra; Yusuf, Harmas Yazid
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.9906

Introduction: Oral squamous cell carcinoma is the most common malignant tumor in oral and originates from the epithelial tissue. Carcinoma formation is a genetic process that triggers changes in cell morphology and behavior. Abnormalities in cell cycle control, regulated by p53 among these factors. This study was conducted to examine the role of p53 and p53-related proteins in the formation of oral squamous cell carcinoma. Review: p53 is a component of the genome associated with the development of cancer in humans. Several studies have suggested that p53 is an important antitumor weapon. In the cell cycle, p53 is recognized if there is a cell mutation or the presence of an oncogene, and delays the cell cycle to prevent cells from becoming cancerous. The level of p53 will increase and react by arresting the cell cycle, directing cells to repair or undergo apoptosis. If p53 does not function, the cell cycle carrying damaged genetic material continues and is unable to undergo apoptosis. As a result, cells continue to proliferate with genetic abnormalities that can lead to malignancy. Conclusion: Loss of p53 function can cause random mutations, chromosomal changes, and aneuploidy, which drive the growth of cancer cells to a malignant state. Analysis of changes at the molecular level can be a major diagnostic tool to guide treatment and identify changes associated with oral squamous cell carcinoma.

Treatment of bilateral ankylosis of the temporomandibular joint with temporalis superficial fascia interpositional flap Yusuf, Harmas Yazid; Kasim, Alwin; Karasutisna, Tis
Padjadjaran Journal of Dentistry Vol 19, No 1 (2007): March 2007
Publisher : Universitas Padjadjaran

Ankylosis of the temporomandibular joint (TMJ) involves fusion of the mandibular condyle to the base of the skull. Trauma and infection are the leading causes of ankylosis. A case of true bilateral ankylosis of the temporomandibular joint is presented. A 21-year-old male patient had a multiple bone fractures history at the age of 13 due to a sports injury. A TMJ injury might not be detected at that time resulting in a progressive restriction of his mouth opening. He presented with almost complete lack of mobility of the mandible. Surgical treatment was a resection of the ankylotic bone mass, interposition temporalis superficial fascia flaps, and early mobilization and aggressive physiotherapy. The functional results showed good remarks.

Characteristics of Mandibular Oral Squamous Cell Carcinoma at Oral and Maxillofacial Surgery Department Hasan Sadikin General Hospital, January 2017 – 2023 Limanthara, Khriztie; Yusuf, Harmas Yazid; Arumsari, Asri; Putri, Dian Maifara
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.30-38

Background: Oral cancer is a highly prevalent cancer with a high incidence rate around the globe. Squamous cell carcinoma accounts for 90–95% of cases of oral cancer. With a tendency to spread rapidly, it primarily affects the palate, mandible, lower lip, tongue, and floor of the mouth The elevated frequency of occurrences emphasizes the necessity for a study to investigate the attributes of mandibular squamous cell carcinoma, particularly within the Oral and Maxillofacial Surgery Department at Hasan Sadikin General Hospital in Bandung.Method: This study adopts a retrospective descriptive approach, utilizing secondary data from medical records from patients diagnosed with mandible squamous cell carcinoma from January 2017 to 2023, based on histopathological examination results.Result: Over 48-year-olds are the most common age group affected by mandible squamous cell carcinoma, accounting for 69% of cases. Males account for 51% of cases. Bandung, West Java, has the highest incidence, with 16 cases. Treatment mainly consists of surgery and chemotherapy/radiotherapy, with the mandibular corpus being the most frequent site, affecting 84% of cases.Conclusion: There were 45 patients diagnosed with mandibular squamous cell carcinoma at Hasan Sadikin General Hospital in Bandung between January 2017 - January 2023. The data was analyzed based on the age, gender, domicile, therapy, and specific location within the mandible in order to determine the distribution of these cases.

Characteristics of Mandibular Oral Squamous Cell Carcinoma at Oral and Maxillofacial Surgery Department Hasan Sadikin General Hospital, January 2017 – 2023 Limanthara, Khriztie; Yusuf, Harmas Yazid; Arumsari, Asri; Putri, Dian Maifara
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.30-38

Background: Oral cancer is a highly prevalent cancer with a high incidence rate around the globe. Squamous cell carcinoma accounts for 90–95% of cases of oral cancer. With a tendency to spread rapidly, it primarily affects the palate, mandible, lower lip, tongue, and floor of the mouth The elevated frequency of occurrences emphasizes the necessity for a study to investigate the attributes of mandibular squamous cell carcinoma, particularly within the Oral and Maxillofacial Surgery Department at Hasan Sadikin General Hospital in Bandung.Method: This study adopts a retrospective descriptive approach, utilizing secondary data from medical records from patients diagnosed with mandible squamous cell carcinoma from January 2017 to 2023, based on histopathological examination results.Result: Over 48-year-olds are the most common age group affected by mandible squamous cell carcinoma, accounting for 69% of cases. Males account for 51% of cases. Bandung, West Java, has the highest incidence, with 16 cases. Treatment mainly consists of surgery and chemotherapy/radiotherapy, with the mandibular corpus being the most frequent site, affecting 84% of cases.Conclusion: There were 45 patients diagnosed with mandibular squamous cell carcinoma at Hasan Sadikin General Hospital in Bandung between January 2017 - January 2023. The data was analyzed based on the age, gender, domicile, therapy, and specific location within the mandible in order to determine the distribution of these cases.

Potential Recurrence of Odontogenic Keratocyst Post-Surgery, Rapid Review Widyandhika, Cindy Widyandhika Ayu; Anggraini, Jamas Ari; Yusuf, Harmas Yazid
Journal of Syiah Kuala Dentistry Society Vol 8, No 1 (2023): June 2023
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v8i1.33454

Background: Odontogenic keratocyst is one of the most frequent cysts found in the jaw. Odontogenic keratocyst, or OKC, is a benign but locally aggressive cyst with a higher recurrence rate than other odontogenic cysts after surgical treatment. The OKC recurrence rate is reported to be around 2.5% to 62.5%. Objective: This rapid review analyzes the most frequent recurrence potential factors after surgical procedures. Material and Methods: Articles search by using a combination of the keywords "odontogenic keratocyst" "keratocystic odontogenic tumor," "potential," "probability," "recur," "relapse, "recurrence" in three databases; PubMed, ScienceDirect, and Google Scholar. Article inclusion criteria include articles that have data on the recurrence of odontogenic keratocyst after surgical treatment; in the English language; issued within the last 10 years (2012-2022); and using observational research with all types of study designs (cohort, cross-sectional, and case-control). This study used the PRISMA protocol (Preferred Reporting Items for Systematic Review and Meta-Analysis). Results: Thirteen articles with an observational study design were included in this rapid review, consisting of thirteen articles with retrospective cohort design. This study recorded two hundred fifty-three cases of recurrence out of 1263 cases of OKC, with a mean follow-up period of 53.6 months. Recurrences were found more often in male patients than female patients (1.58:1), especially in the third and fourth decades of age. The multilocular form of the lesion (n = 52), especially on the mandible, was more common than the unilocular form of the lesion (n = 83). Teeth preserved in the sites of involvement caused incomplete cyst removal and increased the risk of recurrence. Conclusion: This rapid review showed that the percentage of potential OKC recurrences ranged from 7.1% to 45%, with an average recurrence rate of 22.5%. The presence of a daughter or satellite cyst and residual teeth or teeth preserved in the lesion area that was not removed in the form of a large multilocular cyst affects the potential for recurrence.

Characteristics of Oral Hemangioma and Vascular Malformation Cases: A Study at Hasan Sadikin General Hospital, 2019-2023 Rachmavita, Yashinta; Yusuf, Harmas Yazid; Sylvyana, Melita
Jurnal Health Sains Vol. 5 No. 4 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i4.1255

This observational retrospective study conducted at Hasan Sadikin General Hospital (RSHS) in Bandung from January 2019 to February 2023 aimed to characterise oral hemangiomas and vascular malformations. Out of 52 medical records analysed, infantile hemangioma was the most common type (17%), typically presenting between ages 13 to 24 years. Predominantly located around the lip, tongue, and buccal mucosa, it seldom caused bleeding or pain, with women being more affected. Treatment often involved sclerotic agent injections. Venous malformations accounted for 58% of vascular malformations, showing similar age of presentation and distribution as hemangiomas, and were also treated with sclerotic agents. Accurate diagnosis and tailored treatment are crucial due to the diverse nature of these anomalies. Early detection using imaging techniques like ultrasound and CT angiography is imperative, given the potential impact on patients, including pain, swelling, and cosmetic concerns, particularly in the head and neck area. However, treatment approaches vary based on factors such as type and size, necessitating further research to refine diagnostic and therapeutic strategies and optimise patient outcomes.

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