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The Role of p53 Gene In Molecular Pathogenesis of Oral Squamous Cell Carcinoma Nabilla, Firyal; Hadikrishna, Indra; Yusuf, Harmas Yazid
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.9906

Introduction: Oral squamous cell carcinoma is the most common malignant tumor in oral and originates from the epithelial tissue. Carcinoma formation is a genetic process that triggers changes in cell morphology and behavior. Abnormalities in cell cycle control, regulated by p53 among these factors. This study was conducted to examine the role of p53 and p53-related proteins in the formation of oral squamous cell carcinoma. Review: p53 is a component of the genome associated with the development of cancer in humans. Several studies have suggested that p53 is an important antitumor weapon. In the cell cycle, p53 is recognized if there is a cell mutation or the presence of an oncogene, and delays the cell cycle to prevent cells from becoming cancerous. The level of p53 will increase and react by arresting the cell cycle, directing cells to repair or undergo apoptosis. If p53 does not function, the cell cycle carrying damaged genetic material continues and is unable to undergo apoptosis. As a result, cells continue to proliferate with genetic abnormalities that can lead to malignancy. Conclusion: Loss of p53 function can cause random mutations, chromosomal changes, and aneuploidy, which drive the growth of cancer cells to a malignant state. Analysis of changes at the molecular level can be a major diagnostic tool to guide treatment and identify changes associated with oral squamous cell carcinoma.

AMELOBLASTOMA INCIDENCE IN CHILDREN : A SCOPING REVIEW Yolanda Pratiwi; Williyanti Suwondo; Harmas Yazid Yusuf
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.30735

Ameloblastoma is a benign tumor originating from odontogenic epithelial, slow growth and locally invasive. Ameloblastoma rarely occurred in children. Ameloblastoma in Western countries was estimated around 8.7 – 15%, meanwhile in Asia African countries the incidence was around 14.6 – 25%. This study aims to discover the incidence of ameloblastoma in children. This is a literature review study using scoping review approach and applying PRISMA ScR (Preferred Reporting Items for Systematic Reviews and Meta Analyses-Scoping Review) approach on searches utilizing Boolean Operators on databases PubMed, Science Direct, Sage Journals, and EBSCOhost with pre-arranged keywords using PCC framework, with keywords “((Ameloblastoma) AND (Pediatric) OR (Ameloblastoma) AND (Children))”. Total 11 articles eligible in this study. Ameloblastoma incidence in children was about 10 – 15%, where 11 – 18% occurred in children aged 14.7-year-old. The highest mean age was reported in Jordan with mean 16.0-year-old, while the lowest mean age was in Argentine with mean 10.8-year-old. The Incidence of ameloblastoma in children was about 10-15% based on eleven articles that have been identified using different sample collection techniques.

Treatment of bilateral ankylosis of the temporomandibular joint with temporalis superficial fascia interpositional flap Yusuf, Harmas Yazid; Kasim, Alwin; Karasutisna, Tis
Padjadjaran Journal of Dentistry Vol 19, No 1 (2007): March 2007
Publisher : Universitas Padjadjaran

Ankylosis of the temporomandibular joint (TMJ) involves fusion of the mandibular condyle to the base of the skull. Trauma and infection are the leading causes of ankylosis. A case of true bilateral ankylosis of the temporomandibular joint is presented. A 21-year-old male patient had a multiple bone fractures history at the age of 13 due to a sports injury. A TMJ injury might not be detected at that time resulting in a progressive restriction of his mouth opening. He presented with almost complete lack of mobility of the mandible. Surgical treatment was a resection of the ankylotic bone mass, interposition temporalis superficial fascia flaps, and early mobilization and aggressive physiotherapy. The functional results showed good remarks.

Characteristics of Mandibular Oral Squamous Cell Carcinoma at Oral and Maxillofacial Surgery Department Hasan Sadikin General Hospital, January 2017 – 2023 Limanthara, Khriztie; Yusuf, Harmas Yazid; Arumsari, Asri; Putri, Dian Maifara
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.30-38

Background: Oral cancer is a highly prevalent cancer with a high incidence rate around the globe. Squamous cell carcinoma accounts for 90–95% of cases of oral cancer. With a tendency to spread rapidly, it primarily affects the palate, mandible, lower lip, tongue, and floor of the mouth The elevated frequency of occurrences emphasizes the necessity for a study to investigate the attributes of mandibular squamous cell carcinoma, particularly within the Oral and Maxillofacial Surgery Department at Hasan Sadikin General Hospital in Bandung.Method: This study adopts a retrospective descriptive approach, utilizing secondary data from medical records from patients diagnosed with mandible squamous cell carcinoma from January 2017 to 2023, based on histopathological examination results.Result: Over 48-year-olds are the most common age group affected by mandible squamous cell carcinoma, accounting for 69% of cases. Males account for 51% of cases. Bandung, West Java, has the highest incidence, with 16 cases. Treatment mainly consists of surgery and chemotherapy/radiotherapy, with the mandibular corpus being the most frequent site, affecting 84% of cases.Conclusion: There were 45 patients diagnosed with mandibular squamous cell carcinoma at Hasan Sadikin General Hospital in Bandung between January 2017 - January 2023. The data was analyzed based on the age, gender, domicile, therapy, and specific location within the mandible in order to determine the distribution of these cases.

Management of Drug Induced Gingival Overgrowth (Digo) in a Patient with Cerebral Palsy Type Spastic Quadriplegia: A Case Report Sari, Anggun Tri; Sylvyana, Melita; Yazid Yusuf, Harmas
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 1 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i1.3912

Drug Induced Gingival Overgrowth (DIGO) can be defined as local or general enlargement of the gingival tissue that occurs as a side effect of certain drugs such as immunosuppressive drugs, anticonvulsants and calcium channel blockers. Epilepsy is known to be closely related to cerebral palsy; 15-60% of children with cerebral palsy report having epilepsy requiring anticonvulsant drugs as routine therapy. When gingival enlargement occurs, it interferes with normal oral hygiene practices and can interfere with masticatory function. Gingival hyperplasia can be treated by stopping or changing drugs. In more severe cases, surgical treatment is required. A 6 year old boy patient with a history of epilepsy and cerebral palsy came with complaints of lumps in the gums of the right and left lower jaw. The patient started taking epilepsy medication about 3 years after being diagnosed with epilepsy. After about 1.5 years of taking epilepsy drugs, the patient experienced enlargement of all of his maxillary and mandibular gingiva. The patient was consulted to the Oral and Maxillofacial Surgery Department of Hasan Sadikin General Hospital, on intra-oral examination we found there was gingival enlargement that covered almost the entire tooth surface, the treatment plan was carried out by a surgical procedure in stages under general anesthesia. The results obtained after surgery showed that the shape of the gingiva was normal and the patient's masticatory function had improved. In cases where there is overgrowth of the gingiva to cover the entire tooth surface, surgical procedure is a standard procedure to restore the normal shape of the gingiva.

Characteristics of Mandibular Oral Squamous Cell Carcinoma at Oral and Maxillofacial Surgery Department Hasan Sadikin General Hospital, January 2017 – 2023 Limanthara, Khriztie; Yusuf, Harmas Yazid; Arumsari, Asri; Putri, Dian Maifara
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.30-38

Background: Oral cancer is a highly prevalent cancer with a high incidence rate around the globe. Squamous cell carcinoma accounts for 90–95% of cases of oral cancer. With a tendency to spread rapidly, it primarily affects the palate, mandible, lower lip, tongue, and floor of the mouth The elevated frequency of occurrences emphasizes the necessity for a study to investigate the attributes of mandibular squamous cell carcinoma, particularly within the Oral and Maxillofacial Surgery Department at Hasan Sadikin General Hospital in Bandung.Method: This study adopts a retrospective descriptive approach, utilizing secondary data from medical records from patients diagnosed with mandible squamous cell carcinoma from January 2017 to 2023, based on histopathological examination results.Result: Over 48-year-olds are the most common age group affected by mandible squamous cell carcinoma, accounting for 69% of cases. Males account for 51% of cases. Bandung, West Java, has the highest incidence, with 16 cases. Treatment mainly consists of surgery and chemotherapy/radiotherapy, with the mandibular corpus being the most frequent site, affecting 84% of cases.Conclusion: There were 45 patients diagnosed with mandibular squamous cell carcinoma at Hasan Sadikin General Hospital in Bandung between January 2017 - January 2023. The data was analyzed based on the age, gender, domicile, therapy, and specific location within the mandible in order to determine the distribution of these cases.

Potential Recurrence of Odontogenic Keratocyst Post-Surgery, Rapid Review Widyandhika, Cindy Widyandhika Ayu; Anggraini, Jamas Ari; Yusuf, Harmas Yazid
Journal of Syiah Kuala Dentistry Society Vol 8, No 1 (2023): June 2023
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v8i1.33454

Background: Odontogenic keratocyst is one of the most frequent cysts found in the jaw. Odontogenic keratocyst, or OKC, is a benign but locally aggressive cyst with a higher recurrence rate than other odontogenic cysts after surgical treatment. The OKC recurrence rate is reported to be around 2.5% to 62.5%. Objective: This rapid review analyzes the most frequent recurrence potential factors after surgical procedures. Material and Methods: Articles search by using a combination of the keywords "odontogenic keratocyst" "keratocystic odontogenic tumor," "potential," "probability," "recur," "relapse, "recurrence" in three databases; PubMed, ScienceDirect, and Google Scholar. Article inclusion criteria include articles that have data on the recurrence of odontogenic keratocyst after surgical treatment; in the English language; issued within the last 10 years (2012-2022); and using observational research with all types of study designs (cohort, cross-sectional, and case-control). This study used the PRISMA protocol (Preferred Reporting Items for Systematic Review and Meta-Analysis). Results: Thirteen articles with an observational study design were included in this rapid review, consisting of thirteen articles with retrospective cohort design. This study recorded two hundred fifty-three cases of recurrence out of 1263 cases of OKC, with a mean follow-up period of 53.6 months. Recurrences were found more often in male patients than female patients (1.58:1), especially in the third and fourth decades of age. The multilocular form of the lesion (n = 52), especially on the mandible, was more common than the unilocular form of the lesion (n = 83). Teeth preserved in the sites of involvement caused incomplete cyst removal and increased the risk of recurrence. Conclusion: This rapid review showed that the percentage of potential OKC recurrences ranged from 7.1% to 45%, with an average recurrence rate of 22.5%. The presence of a daughter or satellite cyst and residual teeth or teeth preserved in the lesion area that was not removed in the form of a large multilocular cyst affects the potential for recurrence.

Characteristics of Oral Hemangioma and Vascular Malformation Cases: A Study at Hasan Sadikin General Hospital, 2019-2023 Rachmavita, Yashinta; Yusuf, Harmas Yazid; Sylvyana, Melita
Jurnal Health Sains Vol. 5 No. 4 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i4.1255

This observational retrospective study conducted at Hasan Sadikin General Hospital (RSHS) in Bandung from January 2019 to February 2023 aimed to characterise oral hemangiomas and vascular malformations. Out of 52 medical records analysed, infantile hemangioma was the most common type (17%), typically presenting between ages 13 to 24 years. Predominantly located around the lip, tongue, and buccal mucosa, it seldom caused bleeding or pain, with women being more affected. Treatment often involved sclerotic agent injections. Venous malformations accounted for 58% of vascular malformations, showing similar age of presentation and distribution as hemangiomas, and were also treated with sclerotic agents. Accurate diagnosis and tailored treatment are crucial due to the diverse nature of these anomalies. Early detection using imaging techniques like ultrasound and CT angiography is imperative, given the potential impact on patients, including pain, swelling, and cosmetic concerns, particularly in the head and neck area. However, treatment approaches vary based on factors such as type and size, necessitating further research to refine diagnostic and therapeutic strategies and optimise patient outcomes.

Prevalence of odontogenic cysts in oral and maxillofacial surgery department of hasan sadikin general hospital: 2 years retrospective study Laksmitarani, Niken; Yusuf, Harmas Yazid; Adiantoro, Seto
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Odontogenic cysts are cysts arising from the odontogenic epithelium. According to the World Health Organization in 2017, classification of odontogenic cysts are classified into cysts originating from inflammatory and developmental processes. Most cystic lesions of the oral and maxillofacial cavity are of odontogenic origin and have higher incidence than other body parts. This study to explain about prevalence of odontogenic cyst in RSUP Hasan Sadikin in 2019-2020 .Method: This study was a retrospective study that included 30 patients diagnosed with odontogenic cysts during 2019-2020. The data taken in each patient were age, gender, location of predilection, investigations, diagnosis, management, and recurrence of cases of odontogenic cysts.Result: A total of 15 patients had developmental odontogenic cysts and 15 had inflammatory odontogenic cysts. Most developmental cysts were 12 patients with dentigerous cysts, Odontogenci Keratocyst in 2 patients, and calcifying odontogenic cyst in 1 case. Inflammatory cysts were dominated by 15 patients with radicular cysts.Conclusion: Prevalence of odontogenic cyst was found more in female, with radicular cyst and location in the maxilla

CHARACTERISTIC OF AMELOBLASTOMA IN ORAL AND MAXILLOFACIAL SURGERY AT HASAN SADIKIN HOSPITAL : 2 YEARS RETROSPECTIVE STUDY Tanusantoso, Albertin Jane; Yusuf, Harmas Yazid; Sylvyana, Melita
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

ABSTRACTBackground: Ameloblastoma is the most common odontogenic tumor. Ameloblastoma is a borderline tumor because it is a benign but locally aggressive tumor with a high recurrence rate if the excision is not complete. The principle of treatment for ameloblastoma is excision all the tumor. This article aimed to conduct a retrospective study to analyze the characteristics of ameloblastoma in patients at Oral and Maxillofacial Surgery Hasan Sadikin Hospital Oral Surgery between the period of January 2018-December 2019Method: This is a retrospective study with 37 patients diagnosed with ameloblastoma during 2018-2019. We took data from each patient such as gender, age, radiological features, histopathological diagnosis of the location of ameloblastoma, management, defects, reconstruction. Result: A total of 22 patients were diagnosed with plexiform ameloblastoma, 12 cases of follicular ameloblastoma, 3 cases of mixed plexiform and follicular ameloblastoma. 31 patients were treated radically, while 6 patients were treated conservatively. Radical treatment is more often used to reduce recurrence rates, whereas conservative measures are indicated in children and adolescents, as well as adult patients with unilocular ameloblastoma types. Conclusion: The most characteristic of ameloblastoma is plexiform ameloblastoma in the mandible. Ameloblastoma is usually performed radically and reconstructed with an AO plate.

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