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Treatment of bilateral ankylosis of the temporomandibular joint with temporalis superficial fascia interpositional flap Yusuf, Harmas Yazid; Kasim, Alwin; Karasutisna, Tis
Padjadjaran Journal of Dentistry Vol 19, No 1 (2007): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Ankylosis of the temporomandibular joint (TMJ) involves fusion of the mandibular condyle to the base of the skull. Trauma and infection are the leading causes of ankylosis. A case of true bilateral ankylosis of the temporomandibular joint is presented. A 21-year-old male patient had a multiple bone fractures history at the age of 13 due to a sports injury. A TMJ injury might not be detected at that time resulting in a progressive restriction of his mouth opening. He presented with almost complete lack of mobility of the mandible. Surgical treatment was a resection of the ankylotic bone mass, interposition temporalis superficial fascia flaps, and early mobilization and aggressive physiotherapy. The functional results showed good remarks.

Prevalence of dentigerous cysts due to impaction of mandibular third molar teeth Nuraini, Hanifah; Yusuf, Harmas Yazid; Hardianto, Andri
Padjadjaran Journal of Dentistry Vol 25, No 1 (2013): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Dentigerous cyst is an odontogenic cyst that surrounds the crown of an impacted tooth, caused by fluid accumulation between the reduced enamel epithelium and the enamel surface, usually associated with mandibular third molars. The purpose of this study was to find out the prevalence of dentigerous cyst caused by impaction of mandibular third molar at the oral and maxillofacial surgery department of Hasan Sadikin hospital Bandung. This study was a descriptive survey study. Samples were taken from the data of patientâs medical record from July 2006 until June 2011. The result of this study showed the number of oromaxillofacial cyst cases in the period was as much as 316 (0.78%). Dentigerous cyst was the most common odontogenic cyst (48,64%). Dentigerous cyst most commonly caused by impaction of the mandibular third molar (13,89%). The amount of male and female patients with dentigerous cyst was the same (50% each). The most age group that suffered dentigerous cyst due to impaction of the mandibular third molars was the age group of 41-50 years (40%). The most chosen therapy was enucleation (100%). From the results of this study can be concluded that dentigerous cyst due to impaction of mandibular third molars was the most common case, with the same frequency found in both male and female, the most age group of impacted was the age group of 41-50 years old, and the most chosen therapy was enucleation.

Polymorphic Relationship of rs7526700, rs2278651, and rs611386 Of SLC30A1 Mothers’ Gene with Mothers’ High Levels of Zinc Chairunas1, Sjarif Hidajat Effendi2, Harmas Yazid Yusuf3, Eriska Riyanti4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i1.45

The most common facial malformation in all populations and ethnic groups is Cleft lip and palate (CB/L). Various factors cause nonsyndromic cleft lip and palate abnormalities (CB/L NS) such as interactions between environmental and genetic factors, so that CB/L embryopathy is not clear. Deficiency of Zn with certain severity in pregnant women can be a risk factor for CB/L. The purpose of this study was to analyze the relationship of polymorphism of rs7526700, rs2278651, and rs611386 of the gene SCL30A1 mother with a group of deficiency events of Zinc maternal. The type of this research is an observational study through cross sectional approach with the research subjects are mothers and newborns diagnosed with CB/L NS in the Perinatology Department of Dr. Hasan Sadikin Hospital Bandung and other Network Hospitals. The research was conducted in September 2016 to June 2017 with 34 groups samples. Data were analyzed using fisher’s exact test and correlation test. The results showed that the majority of mothers who became the research respondents aged 25-29 years were 34% and the majority of infants who became the respondents were female as much as 60%, and most types of lip and palate disorders experienced by infants who became the respondents was Unilateral CB/L which is as much as 66%. Furthermore, the results of statistical tests indicated that there was no significant relationship between polymorphism of rs7526700, rs2278651, and rs611386SLC30A1 maternal gene with levels of Zinc maternal

Incidence of Mandibular Fractures as A Complication of Lower Third Molar Extraction: A Rapid Review Farras Syakira Reiza; Endang Sjamsudin; Harmas Yazid Yusuf
Jurnal Kesehatan Gigi Vol 8, No 2 (2021): Desember 2021
Publisher : Jurusan Keperawatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v8i2.6900

Pendahuluan: Pencabutan gigi molar ketiga merupakan salah satu prosedur kedokteran gigi yang sering dilakukan, tetapi bukan berarti resiko dan komplikasinya jarang terjadi. Salah satu komplikasi pencabutan gigi molar ketiga adalah fraktur mandibula. Penelitian ini bertujuan untuk mengetahui insidensi fraktur mandibula sebagai komplikasi pencabutan gigi molar ketiga rahang bawah. Metode: Rapid review ini dilakukan pada Desember 2020-Februari 2021 terhadap artikel berbahasa inggris yang melaporkan insidensi fraktur mandibula akibat pencabutan gigi molar ketiga rahang bawah. Pencarian artikel mengacu pada bagan PRISMA yang dilakukan melalui PubMed, ScienceDirect, dan Google Scholar tanpa membatasi tahun pencarian. Artikel terpilih memenuhi kriteria sesuai dengan kerangka PICO. Penapisan artikel dilakukan dengan memeriksa duplikasi, membaca judul dan abstrak, serta membaca isi keseluruhan teks. Hasil: Sebanyak delapan artikel dengan desain studi observasional dicakup dalam penelitian ini. Insidensi fraktur mandibula sebagai komplikasi pencabutan gigi molar ketiga berkisar antara 0,0046%-3,03%. Fraktur lebih banyak ditemukan pada laki-laki (n=42) daripada perempuan (n=20), pada usia rata-rata di atas 39 tahun, pada gigi-geligi lengkap (n=31) daripada tidak lengkap (n=3), pada gigi impaksi tulang penuh (n=47) daripada impaksi tulang sebagian (n=14), dan pada angulasi gigi horizontal (n=22) atau vertikal (n=20) daripada mesioangular (n=13) atau distoangular (n=6). Simpulan: Fraktur mandibula akibat pencabutan gigi molar ketiga rahang bawah jarang terjadi. Peningkatan kasus ditemukan pada pasien laki-laki, berusia di atas 39 tahun, memiliki gigi-geligi lengkap, gigi impaksi tulang penuh, dan angulasi gigi horizontal atau vertikal. Infeksi pre operatif dan kista merupakan keadaan patologis yang lebih sering ditemukan pada pasien fraktur.

Craniofacial Fibrous Dysplasia in Pediatric Patients with McCune-Albright Syndrome: A Scoping Review Salsabila, Anisah Rifda; Yusuf, Harmas Yazid; Hadikrishna, Indra
Journal of Indonesian Dental Association Vol 8 No 1 (2025): May
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v8i1.1286

Pendahuluan: Fibrous dysplasia (FD) adalah kelainan tulang langka non-neoplastik yang dikarakterisasikan dengan proliferasi berlebih pada proses pembentukan tulang oleh sel mesenkim. FD dapat timbul sebagai salah satu gejala klinis dari sindroma McCune-Albright (MAS). MAS memiliki triad gejala klinis khas yang terdiri dari FD, makula café-au-lait, dan hiperfungsi endokrinopati. FD dan MAS disebabkan oleh mutasi genetik post-zigotik, sehingga pasien akan lahir dengan penyakit FD. Penelitian ini bertujuan untuk memetakan dan menganalisis pengaruh gejala klinis lain dari MAS terhadap lesi FD kraniofasial pada pasien anak. Metode: Penelitian dilaksanakan menggunakan metode scoping review. Pencarian artikel dilakukan pada database Scopus dan PubMed. Kriteria inklusi: artikel yang membahas mengenai karakteristik lesi FD kraniofasial yang berkaitan dengan MAS pada pasien anak, dipublikasikan dalam jangka tahun 2016-2023, dipublikasikan melalui jurnal internasional, full text, dan free article. Penyaringan sumber literatur dilaksanakan sesuai dengan protokol PRISMA-ScR. Hasil: Delapan artikel ditetapkan sebagai kriteria inklusi. Pengaruh dari uncontrolled GH excess terhadap patogenesis lesi FD dibahas pada seluruh artikel, diantaranya adalah meningkatnya risiko gangguan penglihatan/pendengaran (tujuh artikel), tampilan makrosefali (lima artikel), meningkatnya risiko regrowth pasca operasi (empat artikel), ekspansi lesi FD (empat artikel), dan meningkatnya morbiditas lesi FD (satu artikel). Pembahasan mengenai PP serta koeksistensinya dengan gejala uncontrolled GH excess dibahas pada satu artikel. Hipofosfatemia dibahas pada lima artikel. Simpulan: GH excess dan PP merupakan jenis hiperfungsi endokrinopati yang dapat memperparah patogenesis dan gejala klinis lesi FD. Pada pasien MAS dengan jumlah (skeletal burden) lesi FD yang masif kondisi hipofosfatemia akan meningkatkan risiko fraktur tulang dan rasa nyeri pada lesi FD.

Prevalence of dentigerous cysts due to impaction of mandibular third molar teeth Nuraini, Hanifah; Yusuf, Harmas Yazid; Hardianto, Andri
Padjadjaran Journal of Dentistry Vol 25, No 1 (2013): March 2013
Publisher : Universitas Padjadjaran

Dentigerous cyst is an odontogenic cyst that surrounds the crown of an impacted tooth, caused by fluid accumulation between the reduced enamel epithelium and the enamel surface, usually associated with mandibular third molars. The purpose of this study was to find out the prevalence of dentigerous cyst caused by impaction of mandibular third molar at the oral and maxillofacial surgery department of Hasan Sadikin hospital Bandung. This study was a descriptive survey study. Samples were taken from the data of patient’s medical record from July 2006 until June 2011. The result of this study showed the number of oromaxillofacial cyst cases in the period was as much as 316 (0.78%). Dentigerous cyst was the most common odontogenic cyst (48,64%). Dentigerous cyst most commonly caused by impaction of the mandibular third molar (13,89%). The amount of male and female patients with dentigerous cyst was the same (50% each). The most age group that suffered dentigerous cyst due to impaction of the mandibular third molars was the age group of 41-50 years (40%). The most chosen therapy was enucleation (100%). From the results of this study can be concluded that dentigerous cyst due to impaction of mandibular third molars was the most common case, with the same frequency found in both male and female, the most age group of impacted was the age group of 41-50 years old, and the most chosen therapy was enucleation.

Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity Patuti, Deece; Yusuf, Harmas Yazid; Hernowo, Bethy Suryawathy
Padjadjaran Journal of Dentistry Vol 22, No 2 (2010): July 2010
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol22no2.26873

Introduction: CD10 can also facilitate the ability of tumour metastasis by its ability to invade blood vessel walls.Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity. Methods: This study was preceded by collecting data on squamous cell carcinoma of the oral cavity in the medical record and paraffin blocks in the Anatomy Pathology section of 15 samples with enlarged regional lymph nodes and 15 samples without enlargement of regional lymph nodes. Then two preparations were made, the first preparation was stained with Hematoxylin Eosin (HE) to establish the diagnosis and determine the histopathological gradation, then count the number of eosinophils, and the other development was smeared with CD10. Outward immunohistochemistry uses the Labelled streptavidin biotin immunoperoxidase complex (LSAB) method using the Starr Trek Universal HRP Detection system. (Biocare Medical, USA). The primary antibody used was CD10 (Novocastra Laboratories Ltd, Newcastle upon Tyne, UK) with a dilution of 1:25 - 1: 50. Results: There was no statistically significant correlation between CD10 and enlargement of the lymph node regionally tested statistically using the Spearman rank test rs = -0.236, meaning that the increase in CD10 immunoexpression is inversely proportional to the enlargement of regional lymph node, but the correlation is not statistically significant The results of the analysis using the Spearman rank test found significance of p = 0.043 (significant) with a correlation strength of 37.2% Conclusion: There was no correlation between CD10 and enlargement of the lymph node regionally and correlation strength eosinophil distribution in squamous cell carcinoma of the oral cavity without regional lymph node enlargement.

Correlation of odontogenic infection severity score with C-reactive protein levels on patients with odontogenic infection in Dr Hasan Sadikin General Hospital Bandung Prihandana, Ariyaka Niastya; Yusuf, Harmas Yazid; Nurwiadh, Agus; Lismayanti, Leni
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.21252

Introduction: Head and neck infections commonly caused by spreading odontogenic infection, which able to cause a local and systemic manifestation, from mild to severe complications according to its severity. Assessment of the severity of odontogenic infections is essential to determine the prognosis, assessed through local and systemic parameters. Laboratory examination used to examine the biological marker that indicates the ongoing infection. C-reactive protein (CRP) is a protein synthesised by hepatocytes in response to the body's inflammatory process, including odontogenic infection. This study was aimed to analyse the severity score of odontogenic infections using the CRP levels in patients with odontogenic infections. Methods: An analytic study with a cross-sectional approach was conducted on 30 patients of Dr Hasan Sadikin General Hospital Bandung diagnosed with odontogenic infections, determined by calculations according to Hosmer and Lemeshow. Assessment of the severity score in odontogenic infections and quantitative CRP levels with the Dimension tool was conducted afterwards. Correlation between odontogenic infection severity score and CRP levels was analysed using regression and correlation tests. Results: From 30 subjects, there was found 33.3% with mild severity score, 63.3% moderate score and 3.3% severe score. The mean of the CRP level was significantly increased according to the odontogenic severity scoring category. All research subjects who were examined showed that there was a very strong and significant correlation (p-value<0.05) between the severity of odontogenic infections and CRP levels in odontogenic infection patients with a correlation coefficient r=0.84 (p=0.001). Conclusion: There is a positive correlation between the CRP levels and the severity score of odontogenic infection. The higher the CRP levels, the odontogenic infection will be more severe. Therefore, the CRP level might be considered an additional biomarker in supporting the severity of odontogenic infection in clinical practice.

The Role of p53 Gene In Molecular Pathogenesis of Oral Squamous Cell Carcinoma Nabilla, Firyal; Hadikrishna, Indra; Yusuf, Harmas Yazid
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.9906

Introduction: Oral squamous cell carcinoma is the most common malignant tumor in oral and originates from the epithelial tissue. Carcinoma formation is a genetic process that triggers changes in cell morphology and behavior. Abnormalities in cell cycle control, regulated by p53 among these factors. This study was conducted to examine the role of p53 and p53-related proteins in the formation of oral squamous cell carcinoma. Review: p53 is a component of the genome associated with the development of cancer in humans. Several studies have suggested that p53 is an important antitumor weapon. In the cell cycle, p53 is recognized if there is a cell mutation or the presence of an oncogene, and delays the cell cycle to prevent cells from becoming cancerous. The level of p53 will increase and react by arresting the cell cycle, directing cells to repair or undergo apoptosis. If p53 does not function, the cell cycle carrying damaged genetic material continues and is unable to undergo apoptosis. As a result, cells continue to proliferate with genetic abnormalities that can lead to malignancy. Conclusion: Loss of p53 function can cause random mutations, chromosomal changes, and aneuploidy, which drive the growth of cancer cells to a malignant state. Analysis of changes at the molecular level can be a major diagnostic tool to guide treatment and identify changes associated with oral squamous cell carcinoma.

Treatment of bilateral ankylosis of the temporomandibular joint with temporalis superficial fascia interpositional flap Yusuf, Harmas Yazid; Kasim, Alwin; Karasutisna, Tis
Padjadjaran Journal of Dentistry Vol 19, No 1 (2007): March 2007
Publisher : Universitas Padjadjaran

Ankylosis of the temporomandibular joint (TMJ) involves fusion of the mandibular condyle to the base of the skull. Trauma and infection are the leading causes of ankylosis. A case of true bilateral ankylosis of the temporomandibular joint is presented. A 21-year-old male patient had a multiple bone fractures history at the age of 13 due to a sports injury. A TMJ injury might not be detected at that time resulting in a progressive restriction of his mouth opening. He presented with almost complete lack of mobility of the mandible. Surgical treatment was a resection of the ankylotic bone mass, interposition temporalis superficial fascia flaps, and early mobilization and aggressive physiotherapy. The functional results showed good remarks.

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