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All Journal Dentika Dental Journal Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Jurnal of Syiah Kuala Dentistry Society

Winny Yohana, Winny

Bagian Oral Biologi Fakultas Kedokteran Gigi Universitas Padjadjaran

Author-ID : 3064867

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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MANAGEMENT OF TONSILLOLITH PALATINE: PENATALAKSANAAN BATU TONSILA PALATINA Yohana, Winny
Dentika: Dental Journal Vol. 21 No. 01 (2018): Dentika Dental Journal
Publisher : TALENTA

Tonsillolith Palatine are stones that logded in tonsillar palatine crypt, tonsillolith are stones that caused by an accumulation of sulfur-producing bacteria, fungus, desquamated cells, food debris, and mucus that collect in the tonsillar crypts. Tonsillolith also known as tonsil stones, tonsillar concretion, or lith. Tonsilloliths have been recorded weighing from 0,3g to 4g. It may be difficult to remove, but are usually not harmful. Tonsillolith can be unilateral or bilateral. Occurs in young adult and are rare in children. Etiologi is unknown, it has been shown that the calcification develop with mass of desquamated epithelium cells, serum, food debris and bacterial colony. This case reports a patient with tonsillolith palatine. A -55 years-old female came to a private clinic, she complained difficult to swallow, sore throat, itching in right tonsillar, a foreign body-like sensation. On clinical examination, a superficial tonsillolith may be seen as white hard mass within the right tonsillar, tonsillar slightly inflammation. The tonsillolith size is 2x3x1mm. Treatment is usually removal of the tonsilliths by excavator and although mouthwash, clindamycin 300mg three times a day, diclofenac sodium 50mg three times a day, gargling helps wound healing. After tonsillith excavated , a week later the wound healing is well. Her right tonsil palatine looks healthy, wound healing is normal no sore throat, prognosis is good. Healing will be perfect when eating soft food. Successful treatment depends on good cooperation between the patient and the doctor. Keywords: tonsillolith palatine, sore throat, excavated

Peningkatan Ketebalan Epitel Mukosa Bukal setelah Aplikasi Ekstrak Daun Sirih Winny Yohana; Ame Suciati; Myrna Rachmawati
Majalah Kedokteran Gigi Indonesia Vol 1, No 1 (2015): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Daun sirih termasuk tanaman herbal yang digunakan untuk bahan alternatif pengobatan, karena kandungannya yang berkhasiat sebagai antimikroba, antiplak, antioksidan, dan mudah didapat serta ekonomis. Penelitian bertujuan untuk mengetahui ketebalan epitel mukosa mulut tikus Wistar setelah aplikasi ekstrak daun sirih. Penelitian bersifateksperimental pada tiga kelompok yang masing-masing terdiri 9 ekor tikus Wistar. Kelompok pertama sebagai kontrol, kelompok kedua dan ketiga diberikan aplikasi ekstrak daun sirih 15 hari dan 35 hari. Tikus dikorbankan sesuai waktu yang ditentukan lalu dibuat sedian histologis dan pewarnaan HE untuk pengamatan ketebalan epitel. Data ukuranepitel diuji menggunakan uji parametric uji T independen. Hasil penelitian menunjukkan peningkatan ketebalan epitel yang bermakna dicapai oleh kelompok ketiga (±15,61 μm, p=0,002), sedangkan pada kelompok pertama dan kedua tidak terdapat peningkatan ketebalan epitel (p=0,261). Aplikasi ekstrak daun sirih dapat meningkatkan ketebalan epitel mukosa bukal tikus wistar. Increase in Buccal Mucous Epithelium Thickness after Application of Betel Leaf Extract. Betel leaf (Piper Betle Linn) is a herbal ingredient. It is widely used because of its antibacterial power, anti-inflamatory and antioxidant properties. It is readily available in affordable price. The aim of this study is to determine of buccal mucous epithelium thickness of Wistar rats after the application of betel leaf extract. This was an experimental laboratory research which was performed in three groups of Wistar rats. The first group was the control group. The second and third group were those given betel leaf extract for 15 and 35 days. Each group contained nine rats. The rats were sacrificed at the time determined and made histological slide with HE staining for observation of epithelial thickness. The data of the size of epithelium were tested using independent parametric T test. The result shows a significant increase in buccal mucous epithelium thickness on the third group (15,61μm, p=0,002). Conversely, there is no increase in buccal mucous epithelium thickness on another group (p=0,261). In conclusion, the increase in buccal mucous epithelium thickness of Wistar rats occurred after the application of betel leaf extract.

Neutrophil-to-Lymphocyte Ratio (NLR) as An Inflammation Degree Marker in Tongue Cancer Patient Syakira Husna Lathifah; Winny Yohana; Moch. Rodian
Jurnal Kesehatan Gigi Vol 8, No 2 (2021): Desember 2021
Publisher : Jurusan Keperawatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v8i2.7024

Tongue cancer is one of the most common malignancies of all oral malignancies. Cancer staging is induced by a systemic inflammatory response with one of the markers, one of them is neutrophil-lymphocyte ratio (NLR). This study aims to provide an overview of the NLR as a marker of the degree of inflammation in patients with tongue cancer. This systematic literature review was conducted online from January 2021 to March 2021 against articles reporting RNL as a marker of inflammatory action in patients with tongue cancer. The search for articles referred to Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) and conducted through PubMed, PMC, ScienceDirect, and EBSCOhost with the publication year 2015-2020. Selected articles met the criteria according to the PICO framework (Population, Intervention, Comparison, Outcome). Article screening is done by reading the title and abstract, checking for duplication, and reading the entire text. Sixteen in 841 research articles with observational study design were identified, the NLR cut-off value ranges from 2.04-2.95. Nine in ten research articles suggested a relationship between the NLR value and several clinicopathological characteristics of the patient. Twelve articles mentioned that there was the association of RNL with patient overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS). The NLR value can be an indicator of the degree of inflammation in patients with tongue cancer as assessed from the parameters of the clinicopathological assessment and can be a predictive factor for patient's prognosis or survival status.

Characteristics of Age and Oral Hygiene Status on Palatine Tonsil Size in Chronic Tonsillitis Patients Tias Ayu Karina; Winny Yohana; Moch. Rodian
Jurnal Kesehatan Gigi Vol 8, No 2 (2021): Desember 2021
Publisher : Jurusan Keperawatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v8i2.7023

Introduction: Tonsillitis is an inflammation of the palatine tonsils that caused by the invasion of microorganisms into the mucous membranes of the tonsils. Age is related to the tonsils immunological activity on the size of the palatine tonsils. Oral hygiene is one of determinant risk factor for chronic tonsillitis. This study aims to provide a characteristics of age and oral hygiene in determining the size of the palatine tonsils in chronic tonsillitis patients. Methods: This systematic literature review was conducted online from January to March 2021 against articles reporting on age, palatine tonsils size, and oral hygiene on chronic tonsillitis. The search for articles referred to Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) which conducted through PubMed, PMC, Science Direct, and Google Scholar with the with the publication year 2015-2020. Selected articles met the criteria according to the PICO framework (Population, Intervention, Comparison, Outcome). The articles were screened by checking for duplication, reading the titles and abstracts, and the full text articles. Results: Twelve in 16 research articles (75%) mentioned that there was a relation between age and enlargement of the size of the palatine tonsils in chronic tonsillitis patients, and one in 16 articles (6,25%) mentioned that there was no relation between age and tonsillar hypertrophy. Three articles (18,75%) mentioned the role and relationship of bacteria in the oral cavity related to the process of the occurrence of chronic tonsillitis. Two in 3 research articles (67%) mentioned that there was a relation between the oral hygiene status and enlargement of the size of the palatine tonsils in chronic tonsillitis patients. One in 3 articles (33%) mentioned that there was no relation. Conclusion: Ages 5-15 years had T3 tonsil size (70%), ages 13-15 years had T2 tonsil size (80%), ages 16-48 years had T2 tonsil size (76.30%) and ages 19-25 years had T3 tonsil size (53%). This means that all ages could be experience of tonsil enlargement in chronic tonsillitis. Adults had bad oral hygiene status (76.30%), meanwhile in children only 14.47% in chronic tonsillitis patients.

Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma Silvi Kintawati; Murnisari Darjan; Winny Yohana
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 4 (2017): December 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Adenoid cystic carcinoma is a malignant salivary gland tumor located in the head and neck region. Although complete surgical resection and complementary radiotherapy have been shown to improve long-term survival rates, the prognosis of adenoid cystic carcinoma remains poor. Ki-67 expression is considered a marker for the cellular proliferation rate, the detection of its expression usually being related to the aggressiveness and unfavorable prognosis of adenoid cystic carcinoma in the salivary gland. Purpose: This study was conducted to quantify the expression of Ki-67 in adenoid cystic carcinoma and to correlate the result with clinical parameters and histopathological grading in determining the prognosis. Methods: Twenty three cases of salivary gland adenoid cystic carcinoma were identified at the Department of Anatomical Pathology, Dr. Hasan Sadikin Hospital between 2013 and 2015. Clinical data such as age, gender, location of tumor and histopathological grading was also collected. The expression of Ki-67 was assessed by immunohistochemical means to determine the correlation of Ki-67 with clinical parameters and histopathological grading. Results: There were no significant differences between the expression of Ki-67 and clinical parameters, although a very strong correlation existed between the expression of Ki-67 and histopathological grading (p < 0.01). Conclusion: There were no correlation between the expression of Ki-67 and clinical parameters, although a correlation existed between the expression of Ki-67 and histopatological grading in salivary gland adenoid cystic carcinoma. Thus, clinical parameters were unusable in determining the prognosis of adenoid cystic carcinoma, although Ki-67 expression could be used for this purpose.

Variasi normal lidah manusia pada subras Deutro MelayuNormal variation of human tongue on Deutro Malay subrace Denta Asnatasia Nurmadhini; Winny Yohana; Marry Siti Mariam
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 1 (2019): April 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Lidah merupakan organ yang terdiri dari otot rangka dan dilapisi oleh membran mukosa. Organ ini merupakan salah satu indikator yang baik untuk diagnosis secara klinis dan karakteristiknya dapat dipengaruhi oleh ras. Tujuan penelitian adalah untuk mengetahui gambaran variasi normal lidah manusia pada subras Deutro Melayu sebagai suatu karakteristik lidah. Metode: Penelitian deskriptif dilakukan pada 96 mahasiswa Fakultas Kedokteran Gigi Universitas Padjadjaran angkatan 2014 yang terdiri dari 87 wanita dan 9 laki-laki. Sampel diambil dengan teknik purposive sampling. Penelitian dilakukan dengan mengamati lidah secara visual dalam keadaan protrusif dan tidak tegang. Lidah diamati berdasarkan bentuk dan tekstur permukaan kemudian difoto untuk dokumentasi. Analisis data dilakukan dengan distribusi frekuensi relatif. Hasil: Persentase bentuk lidah yang paling banyak ditemukan adalah persegi, membulat, persegi panjang, dan segitiga tajam, masing-masing sebanyak 46,87%; 44,79%; 5,20%; 3,12%; dan tidak ditemukan bentuk segitiga tumpul. Tekstur permukaan yang paling banyak muncul adalah tanpa fisura, diikuti oleh fisura vertikal sentral, vertikal lateral, sentral, dan horizontal sebanyak masing-masing 54,17%; 18,75%; 14,58%; 8,33%; dan 4,17%. Simpulan: Variasi normal bentuk lidah manusia yang paling sering ditemukan pada subras deutromelayu adalah persegi, sedangkan tekstur permukaan lidah paling banyak tanpa fisura.Kata kunci: Variasi normal, lidah, subras Deutro Melayu ABSTRACTIntroduction: Tongue is an organ consisted of skeletal muscle and covered by mucous membranes. This organ is a good indicator of clinical diagnosis, and its characteristics can be influenced by race. This study was aimed to describe the normal variation of the human tongue on Deutro Malay subrace as the tongue characteristics. Methods: A descriptive study was conducted on 96 students of Faculty of Dentistry Universitas Padjadjaran batch 2014, consisted of 87 women and 9 men. Samples were taken by purposive sampling technique. The research was carried out by observing the tongue visually in a protrusive and relax state. The tongue was observed based on the shape and surface texture then photographed for documentation. Data analysis was performed by relative frequency distribution. Results: The most found tongue shape was square, followed by rounded, rectangular, and sharp triangles, which were 46.87%; 44.79%; 5.20%; and 3.12% respectively, with no blunt triangle was found. The surface texture most appeared was without fissure, followed by a central vertical, vertical, central, and horizontal fissure, which were 54.17%; 18.75%; 14.58%; 8.33%; and 4.17% consecutively. Conclusion: The normal variation in the tongue shape of Deutro Malay subrace mostly found is square and the most surface texture is without fissure.Keywords: Normal variation, tongue, Deutro Malay subrace

Secretory Iga Sebagai Bagian Reaksi Sistem Imunitas Mukosa Oral Akibat Aplikasi Material Kurang Tepat Winny Yohana
Jurnal Material Kedokteran Gigi Vol 2 No 1 (2013): JMKG Vol 2 No 1 Maret 2013
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Oral health depends on the integrity of the mucosa. In the immune system, including skin, mucosa, respiratory tract is a leading of defense against infection. Microorganisms and dental materials in the oral cavity are foreign objects that can cause immune system reactions. The immune system coordinated by lymphocytes. The reaction of the immune system allows you to maintain the integrity of the body to an antigen, eliminating the aged cell (homeostasis), and to control death cell. The reaction of the immune system can occur naturally or specific. An important factor in the immunity of the oral cavity is a function of the integrity of the oral mucosa and salivary components. Secretory immunoglobulin A is the most important immunoglobulin in the saliva, and provide an important role to the protection of the oral mucosa from infection

Tekstur makanan: sebuah bagian dari food properties yang terlupakan dalam memelihara fungsi kognisi? (Food texture: a part of the food properties that ignorable for maintaining cognitive function?) Kartika Indah Sari; Winny Yohana
Makassar Dental Journal Vol. 4 No. 6 (2015): Vol 4 No 6 Desember 2015
Publisher : Makassar Dental Journal PDGI Makassar

Tekstur makanan adalah hasil dari respon tactile sense terhadap bentuk rangsangan fisik ketika terjadi kontak antara bagian di dalam rongga mulut dan makanan. Penelitian pada hewan dan manusia mengungkapkan bahwa aktivitas mastikasi mempengaruhi fungsi kognisi di hipokampus, suatu regio pada sistem saraf pusat yang penting untuk learning dan spasial memory. Artikel ini bertujuan membahas beberapa hasil penelitian terkini yang berkaitan dengan tekstur makanan, mastikasi dan fungsi kognisi. Aktivitas mastikasi merupakan aktivitas yang sangat kompleks yang merupakan kegiatan sensoris motoris. Gangguan terhadap fungsi mastikasi mempengaruhi morfologi hipokampal dan hipokampus melalui kemungkinan proses degenerasi, terutama pada manula. Penelitian-penelitian yang membahas topik ini masih terus berlangsung. Disimpulkan bahwa tekstur makanan yang padat atau keras dapat memelihara kemampuan learning dan memory, namun ingestion tekstur makanan lunak dalam jangka waktu yang lama kemungkinan akan mempengaruhi kemampuan learning dan memory melalui kemungkinan hubungan dengan neurogenesis hipokampal.

Possible bruksisme dan probable bruksisme pada penyandang sindrom down di Yayasan Persatuan Orang Tua Anak Dengan Down Syndrome (POTADS): studi cross-sectional Lathifah, Nabila Dara; Soewondo,, Willyanti; Yohana, Winny
Padjadjaran Journal of Dental Researchers and Students Vol 7, No 3 (2023): Oktober 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v7i3.48089

ABSTRAKPendahuluan: Sindrom Down (DS) merupakan suatu kelainan kongenital kromosom. Penyandang DS memiliki berbagai jenis kebiasaan buruk oral, salah satunya adalah bruksisme. Pendekatan non-instrumental untuk menilai bruksisme termasuk laporan diri dan pemeriksaan klinis. Tujuan penelitian ini adalah mengidentifikasi possible bruksisme dan probable bruksisme pada penyandang DS di Yayasan Persatuan Orang Tua Anak Down Syndrome (POTADS). Metode: Jenis penelitian dengan desain survei cross sectional. Subjek diperoleh dengan metode purposive sampling menghasilkan sebanyak 41 orang dari POTADS, terdiri dari 22 laki-laki dan 19 perempuan yang berhasil diuji. Pengambilan data dilakukan dengan menggunakan kuesioner untuk menilai possible bruksisme dan pemeriksaan klinis pada rongga mulut berupa kondisi gigi atrisi untuk menilai probable bruksisme. Hasil: Frekuensi possible bruksisme sebesar 68,30%; terdiri dari 14,64% sleep bruksisme (SB), 21,96% awake bruksisme (AB), dan 31,70% kombinasi. Frekuensi berdasarkan jenis kelamin menunjukkan 57,14% laki-laki dan 42,85% perempuan, sedangkan berdasarkan kelompok usia sebesar 64,28% pada anak-anak, 25% pada remaja, dan 10,71% pada dewasa. Frekuensi probable bruksisme adalah sebesar 31,70%. Simpulan: Possible bruksisme pada penyandang DS di Yayasan POTADS adalah 68,70%, dimana lebih tinggi dibandingkan frekuensi probable bruksisme yaitu 31,70%. Laki-laki dan usia anak-anak merupakan kelompok terbanyak yang mengalami bruksisme.KATA KUNCI: Sindrom down, kebiasaan buruk oral, bruksisme.Possible bruxism and probable bruxism in people with down syndrome at the Persatuan Orang Tua Dengan Down Syndrome (POTADS) Foundation: cross-sectional studyABSTRACT Introduction: Down syndrome (DS) is a chromosomal congenital disorder. People with DS have various types of oral bad habits, one of which is bruxism. Non-instrumental approaches to assessing bruxism include self-report and clinical examination. The purpose of this study was to identify bruxism among individuals with DS at the Persatuan Orang Tua Anak Dengan Down Syndrome (POTADS) Foundation. Methods: The type of research was a cross-sectional survey design. Subjects were obtained using the purposive sampling method, resulting in 41 people from POTADS, consisting of 22 men and 19 women, who were successfully tested. Data collection was carried out using a questionnaire to assess possible bruxism, as well as a clinical examination of the oral cavity to determine potential occurrence of bruxism by the observation of dental attrition conditions. Results: The frequency of possible bruxism was 68.30%, consisting of 14.64% sleep bruxism (SB), 21.96% awake bruxism (AB), and 31.70% combination bruxism. The frequency based on gender showed 57.14% male and 42.85% female, while based on age group, it was 64.28% in children, 25% in adolescents, and 10.71% in adults. The frequency of probable bruxism was 31.70%. Conclusions: Possible bruxism among individuals with DS at the POTADS Foundation is 68.70%, indicating a higher incidence compared to the frequency of probable bruxism, which is 31.70%. Males and children are the largest group who experience bruxismKEY WORDS: down syndrome, bad oral habit, bruxism.

Aktivitas antibakteri fraksi etanol Capsicum annuum L. (cabai merah rawit domba) terhadap Streptococcus mutans ATCC 25175: Studi eksperimental Garinanda, Yasmine Aliyah; Yohana, Winny; Pramesti, Hening Tjaturina
Padjadjaran Journal of Dental Researchers and Students Vol 8, No 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v8i2.55925

Pendahuluan: Karies gigi adalah infeksi bakteri pada rongga mulut yang mengakibatkan kerusakan lokal pada struktur gigi. Salah satu bakteri penyebab karies adalah Streptococcus mutans sehingga pengontrolan pertumbuhan bakteri ini diduga menurunkan risiko karies. Capsicum annuum L. (Cabai Merah Rawit Domba) diyakini memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk menentukan aktivitas antibakteri, konsentrasi hambat minimum (KHM) dan konsentrasi bakterisidal minimum (KBM) fraksi etanol C. annum (FECA) terhadap S. mutans ATCC 25175 secara in vitro. Metode: Jenis penelitian ini adalah eksperimental laboratoris menggunakan metode pengenceran seri dengan Chlorhexidine Gluconate 0,2% sebagai kontrol positif dan campuran media Brain Heart Infusion Broth dan suspensi S. mutans sebagai kontrol negatif. Data dianalisis dengan menggunakan uji statistik Mann-Whitney. Hasil: FECA pada konsentrasi 0.625-900 mg/ml tidak menghambat pertumbuhan S. mutans. Tidak terdapat perbedaan rata-rata absorbansi yang signifikan antara FECA pada konsentrasi 0.625-900 mg/ml dan kontrol negatif berdasarkan uji Mann Whitney. Terdapat pertumbuhan koloni S. mutans pada subkultur FECA pada konsentrasi 50-900 mg/ml di media Brain Heart Infusion Agar. Simpulan: Fraksi etanol C. annuum varietas Cabai Merah Rawit Domba Kabupaten Pangalengan tidak memiliki aktivitas antibakteri terhadap S. mutans ATCC 25175.

Co-Authors Ame Suciati Denta Asnatasia Nurmadhini Erna Herawati, Erna Garinanda, Yasmine Aliyah Hening Tjaturina Pramesti Huat, Tan Kien Kartika Indah Sari Lathifah, Nabila Dara Marry Siti Mariam Marunduri, Dwiana Lisany Moch. Rodian Moch. Rodian Murnisari Dardjan, Murnisari Murnisari Darjan Myrna Rachmawati Pandji, Alisha Zuchraini Rosiliwati Wihardja, Rosiliwati Silvi Kintawati Sivabalasundram, Sangary Sri Soewondo,, Willyanti Syakira Husna Lathifah Tias Ayu Karina Yurika Ambar Lita

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