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All Journal Medicina E-Jurnal Medika Udayana Sari Pediatri Molecular and Cellular Biomedical Sciences (MCBS) ISM (Intisari Sains Medis) : Jurnal Kedokteran
Dewi Sutriani Mahalini
Department Of Child Health, Medical Faculty, Udayana University
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children I Gusti Ngurah Made Suwarba; Ni Putu Yunik Novayanti; I Gusti Lanang Sidiartha; Dewi Sutriani Mahalini
Molecular and Cellular Biomedical Sciences Vol 3, No 1 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (846.409 KB) | DOI: 10.21705/mcbs.v3i1.38

Abstract

Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand. Valproic acid increase the synthesis of serum GABAergic in the other hand vitamin B6 is required as cofactor for gamma-amino butyric acid (GABA) formation. The dosage and duration of valproic acid therapy might be correlated with vitamin B6 serum level. The aim of this study is to know the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy in children with epilepsy.Materials and Methods: This is a cross sectional study to investigate the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy. The level of vitamin B6 serum was determined by checking vitamin B6 active form in serum, pyridoxal 5’-phospate (PLP).Results: In this study, 37 epilepsy children with valproic acid duration therapy more than 3 months was enrolled. Fifty six percent epilepsy children were male, commonly on children age 1-5 years old. Spearman correlation coefficient test showed a significant weak negative correlation between vitamin B6 serum level and dosage of valproic acid (r=–0.35; p=0.03), and very weak negative correlation with valproic acid duration therapy (r=-0.08; p=0.59), however it was not significant. Conclusion: There was a significant weak negative correlation between vitamin B6 serum level and very weak negative correlation with valproic acid duration therapy, but not significant in children with epilepsy.Keywords: correlation, valproic acid, vitamin B6
Karakteristik diare pada anak di RSUP Sanglah Denpasar tahun 2017 I Dewa Made Satrianjaya; Ni Nyoman Metriani Nesa; Dewi Sutriani Mahalini
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (779.152 KB) | DOI: 10.15562/ism.v10i2.194

Abstract

Background: Diarrhea is one of the most common diseases affecting children around the world. In Indonesia, the national rate of diarrhea prevalence is 9% where 16.7% of cases occur at 1-4 years old and 16.5% of cases at under one year old. In addition, dehydration causes most mortalities. Aim: This study aims to determine the characteristics of diarrhea in children in Sanglah General Hospital, Denpasar. Method: Thisstudyis a cross-sectional study design using secondary data from the register data in the Pediatric Division of Sanglah General Hospital Denpasar from January to November 2017. Of the 170 data, there were 165 survival samples. Characteristics of diarrhea in children are described using tables, pie charts, and graphs.Result: Most of the sample were males (56.5%), infants (40%), patients from Denpasar (55.3%) and those with good nutritional status (60%). The mean age of the patient was 26.6 months, the mean body weight was 10.6 kg, and the mean height was 79.8 cm. Most of them were diagnosed with acute diarrhea (98%), where the most common cause is a viral infection (75%). The most common comorbid diseases are congenital heart disease and neurological disease (10.6%). Most patients have only mild dehydration (57%). Long term treatment of diarrhea patient in child wards mostly for 2-3 days.Conclusion: Diarrheain children in Sanglah Denpasar Hospital period January-November 2017 most suffered by men and babies, mostly from Denpasar. Most of them have acute diarrhea that is mainly caused by a viral infection.
PROFIL STATUS NUTRISI ANAK PALSI SEREBRAL DI POLIKLINIK RUMAH SAKIT UMUM PUSAT SANGLAH, DENPASAR, BALI Pratiwi, I Gusti Ayu Putu Eka; Sidiartha, I Gusti Lanang; Mahalini, Dewi Sutriani
E-Jurnal Medika Udayana Vol 12 No 3 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i03.P01

Abstract

Pendahuluan: Anak dengan palsi serebral (PS) memiliki risiko tinggi mengalami malnutrisi. Malnutrisi yang terjadi menyebabkan gangguan pertumbuhan, penurunan fungsi otak, pengurangan potensi perkembangan, gangguan kekebalan tubuh, gangguan penyembuhan luka, dan menurunkan kekuatan dari otot-otot pernapasan sehingga akan memudahkan untuk terjadinya infeksi. Suatu penelitian yang menggambarkan status nutrisi anak PS yang dapat memetakan kondisi nutrisi anak PS penting untuk dilakukan sehingga dapat dipergunakan untuk tata laksana selanjutnya yang lebih baik. Tujuan: untuk mengetahui profil status nutrisi anak dengan palsi serebral (PS) di RSUP Sanglah, Denpasar, Bali. Metode: penelitian ini merupakan penelitian deskriptif potong lintang menggunakan sampel anak dengan PS. Kriteria inklusi: pasien PS < 18 tahun yang berkunjung ke Poliklinik Anak RSUP Sanglah pada periode 1 Maret 2022 sampai 30 Agustus 2022. Kriteria eksklusi: usia < 1 tahun dan orangtua tidak bersedia menandatangani informed consent. Sampel dianalisis secara deskriptif untuk melihat profil status nutrisinya. Hasil: penelitian ini mendapatkan sebanyak 60 sampel penelitian dengan median usia 3,79 (rentang 1-17,89) tahun. yang terdiri dari 26 (43,3%) laki-laki dan 34 (56,7%) perempuan. Sebanyak 21 (35%) anak didapatkan dengan gizi baik, 13 (21,7%) anak dengan gizi kurang, 21 (35%) anak dengan gizi buruk, 2 (3,3%) anak berisiko gizi lebih, 2 (3,3%) anak gizi lebih, dan 1 (1,7%) anak obes. Severely stunted terdapat pada 27 (45%) anak, stunted sebanyak 12 (20%) anak, dan normal terdapat pada 21 (35%) anak. Simpulan: kejadian malnutrisi akut dan kronis cukup tinggi pada pasien anak dengan PS di RSUP Sanglah, Denpasar, Bali.
KARAKTERISTIK RUJUKAN PASIEN ANAK PADA ERA JAMINAN KESEHATAN NASIONAL DI PUSKESMAS DENPASAR TIMUR TAHUN 2021 Putri, Ni Kadek Dwi Pramana; Wati, Dyah Kanya; Mahalini, Dewi Sutriani
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P09

Abstract

Latar belakang: Rujukan adalah pelimpahan wewenang dan tanggung jawab mengenai masalah kesehatan dan kasus-kasus penyakit yang dilakukan secara timbal balik. Di era JKN, untuk meningkatkan pelayanan yang lebih bermutu karena adanya tindakan rujukan yang ditunjukkan pada kasus-kasus yang tergolong berisiko tinggi. Tujuan: Penelitian ini bertujuan untuk mengetahui karakteristik rujukan Puskesmas pada pasien anak di era jaminan kesehatan nasional di Puskesmas Denpasar Timur. Metode: Penelitian ini menggunakan metode deskriptif kuantitatif dengan pengambilan data dari rekam medis pasien dan dilakukan wawancara serta observasi singkat. Sampel pada penelitian ini adalah peserta rujukan pasien anak dari jaminan kesehatan nasional di Puskesmas Denpasar Timur periode 2021. Hasil: Hasil penelitian menunjukan sumber daya manusia Puskesmas Denpasar Timur sudah memenuhi standar ketenaga kesehatan. Fasilitas yang tersedia di puskesmas cukup memenuhi standar. Ketersediaan obat sudah sesuai dengan standar Formularium Nasional. Mayoritas pasien rujukan anak merupakan peserta BPJS Kesehatan dan penyakit yang paling banyak dirujuk yaitu gangguan tic. Simpulan: Pelaksanaan rujukan tingkat pertama peserta jaminan kesehatan nasional di Puskesmas Denpasar Timur dilakukan secara berjenjang dan dilakukan sesuai prosedur rujukan yang telah ditetapkan. Kata Kunci: Karakteristik, Rujukan, Puskesmas, JKN
KARAKTERISTIK FAKTOR RISIKO MENINGITIS BAKTERIAL PADA NEONATUS DI RSUP PROF. DR. I.G.N.G NGOERAH DENPASAR Sampe, Dhea Gracia Eliani; Mahalini, Dewi Sutriani; Witarini, Komang Ayu
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P16

Abstract

Bacterial meningitis in neonates is inflammation of the meninges in response to bacteria that can occur during the first 28 days of life. Bacterial meningitis is a serious problem causing neonatal deaths with various influencing factors. This research was conducted to obtain data regarding the characteristics of risk factors for bacterial meningitis in neonates at RSUP Prof. Dr. IGNG Ngoerah Denpasar. This study is retrospective, and data was taken from medical records of neonatal patients treated in the 2021-2022 period. Data are presented descriptively with sample determination using a total sampling technique. From a total of 45 samples that met the inclusion and exclusion criteria, it was found that most cases of neonatal bacterial meningitis occurred at premature gestational age <37 weeks (64.4%), 0-72 hours age group (64.4%), male gender. (51.1%), low birth weight <2500 grams (64.4%), history of asphyxia (51.1%), clinical respiratory distress (82.2%), clinical neonatal sepsis (100%), clinical jaundice neonatorum (68.9%), and use of ventilator/NIV/CPAP (82.2%). However, in this study, only distribution was obtained based on premature rupture of membranes (20%), intrauterine infection (35.6%), congenital abnormalities (26.7%), and neonates with clinical seizures (6.7%). Based on the research results, it can be concluded that the characteristic risk factors for neonates with bacterial meningitis, namely birth to mothers with preterm or premature gestational age, are more common in neonates aged 0-72 hours, which are associated with clinical EONS, male gender, LBW, history of asphyxia, clinical respiratory distress, clinical neonatal jaundice, and use of ventilator/NIV/CPAP. Keywords : Neonatal bacterial meningitis, characteristics, risk factors
Co-Authors Deborah Melati, Deborah Dyah Kanya Wati Eka Gunawijaya I Dewa Made Satrianjaya I Gusti Ayu Made Dwi Mas Istri I Gusti Ayu Putu Eka Pratiwi I Gusti Lanang Sidiartha I Gusti Ngurah Made Suwarba I Nyoman Budi Hartawan Ida Ayu Sri Wijayanti Ida Bagus Gede Suparyatha Komang Ayu Witarini Komang Kari Luh Putu Putri Sanjiwani Made Gede Dwi Lingga Utama Made Sebastian Dwi Putra Hardika Nanda Putri Chintia Ni Made Anggi Dwi Jayanti Ni Nyoman Metriani Nesa Ni Putu Yunik Novayanti Ni Putu Yunik Novayanti Novayanti, Ni Putu Yunik Putri, Ni Kadek Dwi Pramana Putu Asita Pungky Mithayayi Putu Ayu Widyanti Sampe, Dhea Gracia Eliani Sekarningrum, Putu A. Tri Yuliantini Wati, Dyah K.