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All Journal Jurnal e-Biomedik JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Jurnal Kedokteran Klinik The Studies of Social Sciences Jurnal Kesehatan Tambusai Grimsa Journal of Science Engineering and Technology
Aaltje Manampiring
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Grimsa Journal of Science Engineering and Technology

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Efficacy of Purple Chrysanthemum Ethanol Extract in Inhibiting Staphylococcus aureus and Escherichia coli Growth Paukiran, Degol; Budiarso, Fona; Manampiring, Aaltje; Fatimawali, Fatimawali; Kepel, Billy Johnson; Bodhi , Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.63

Abstract

Staphylococcus aureus, a Gram-positive bacterium, and Escherichia coli, a Gram-negative bacterium, are known to cause both enteric and systemic infections in humans. The improper use of antibiotics has often been associated with the emergence of antibiotic resistance. Purple chrysanthemum (Chrysanthemum morifolium) has shown significant potential as an alternative treatment, owing to its strong antioxidant, anti-inflammatory, and antibacterial properties. These properties are attributed to the presence of bioactive compounds such as polyphenols, flavones, essential oils, and other phytochemicals. This study aimed to identify secondary metabolites and evaluate the antibacterial activity of ethanol extracts from purple chrysanthemum (Chrysanthemum morifolium). The extraction process was conducted using Ultrasonic-Assisted Extraction (UAE), and the antibacterial activity was assessed using the disc diffusion method at extract concentrations of 12.5%, 25%, and 50%, with ciprofloxacin serving as the positive control. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, phenolics, and steroids in the ethanol extract of purple chrysanthemum. Importantly, all ethanol extracts demonstrated antibacterial activity. The highest inhibition zones were observed at a 50% concentration, with S. aureus showing an inhibition zone of 12.35 ± 0.4 mm, while E. coli exhibited an inhibition zone of 15.08 ± 0.22 mm.
Investigating the Anti-Inflammatory Potential of Ethanol Extracts from Purple Chrysanthemum Flowers Sumakul, Gilbert Samuel; Fatimawali, Fatimawali; Bodhi, Widdhi; Budiarso, Fona Hermina Dwiana; Kepel, Billy Johnson; Manampiring, Aaltje
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.69

Abstract

Indonesia has high biodiversity, with around 9,600 species of flora possessing medicinal properties. One such plant is the purple chrysanthemum (Chrysanthemum morifolium), which is rich in bioactive compounds with anti-inflammatory potential. The purple chrysanthemum is used in traditional medicine to treat various diseases and has demonstrated significant anti-inflammatory activity in vitro. Given the high prevalence of inflammatory diseases in Indonesia and the side effects associated with conventional drugs, this plant is considered a promising alternative therapy that may be safer and more effective. The aim of this study was to identify the phytochemical compounds and evaluate the anti-inflammatory activity of an ethanol extract from purple chrysanthemum flowers (Chrysanthemum morifolium) in vitro. The extract was prepared using 96% ethanol, and its anti-inflammatory activity was assessed using the red blood cell membrane stabilization method. Blood samples were collected from Wistar rats. The inhibitory concentration (IC50) values of the extract and Diclofenac Sodium were 203.08 ppm and 224.04 ppm, respectively. These findings indicate that the ethanol extract of purple chrysanthemums exhibits anti-inflammatory activity
Co-Authors Astrid Noviera Iksan Billy J. Kepel Billy Kepel Bodhi , Widdhi Budiarso, Fona Hermina Dwiana Ekawati Tallei, Trina Engka, Joice Nancy A. Fatimawali . Fona Budiarso Gerungan, Yizreel Y. Hedison Polii Herlina I. S. Wungouw Hidayat, Muh. I. Kepel, Billy Johnson Lampus, Christania Lidya Togelang Lumanto, Priscilla R. Olivia C. Mulalinda Paukiran, Degol Paulina yamlean Prasetio, Nathanael F. PRILLY MONANGIN Ratu, Belinda D. P. M. Ratulangi, Andrew Johanes Sarah Mariana Pattuju Sumakul, Gilbert Samuel Sundah, Job P. A. Terence Kanzil Widdhi Bodhi Widhi Bodhi Wulan Tuerah