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All Journal Media Gizi Mikro Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JOURNAL OF CIVIL ENGINEERING, BUILDING AND TRANSPORTATION Jurnal Jamu Indonesia Jurnal Tumbuhan Obat Indonesia
Danang Ardiyanto
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Health Professions Medicine & Pharmacology Public Health Other

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PENINGKATAN NILAI HEMOGLOBIN, MCV, MCH, DAN FERITIN PADA KASUS ANEMIA DEFISIENSI BESI DENGAN RAMUAN JAMU DI KLINIK SAINTIFIKASI JAMU HORTUS MEDICUS Tofan Aries Mana; Danang Ardiyanto; Saryanto Saryanto
Media Gizi Mikro Indonesia Vol 8 No 2 (2017): Media Gizi Mikro Indonesia Juni 2017
Publisher : Balai Penelitian dan Pengembangan Kesehatan Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.155 KB) | DOI: 10.22435/mgmi.v8i2.604

Abstract

ABSTRAK Latar belakang. Anemia defisiensi besi merupakan masalah defisiensi nutrien yang banyak terjadi di seluruh dunia terutama di negara berkembang termasuk Indonesia. Permasalahan anemia ini disebabkan oleh kurangnya zat besi di dalam tubuh. Jamu memiliki potensi sebagai alternatif untuk mengatasi permasalahan anemia defisiensi besi. Tujuan. Tujuan penelitian ini adalah mengetahui perubahan parameter subjek dengan anemia setelah diberi jamu di Klinik Saintifikasi Jamu. Penelitian ini diharapkan menjadi solusi untuk anemia defisiensi besi selain penggunaan tablet penambah darah. Metode. Penelitian ini menggunakan desain quasi experimental pre-post test design. Sebanyak 35 subjek diintervensi selama 28 hari dengan jamu yang terdiri dari 5 gram daun bayam merah, 10 gram herba tapak liman dan 15 gram rimpang temulawak. Khasiat jamu dinilai dari perubahan rerata nilai Hb, serum feritin, dan TIBC. Keamanan ramuan dinilai berdasarkan kadar SGPT, SGOT, ureum, dan kreatinin sebelum dan sesudah intervensi. Hasil. Adanya kenaikan nilai Hb yang signifikan (p=0,000) pada akhir intervensi bila dibandingkan awal intervensi menjadi 11,09. Serum feritin, MCV, MCH mengalami kenaikan yang signifikan (p=0,000) pada hari ke-28. Kadar TIBC turun menjadi 336,51 μg/dL sehingga ada perbedaaan yang signifikan (p=0,000) pada hari ke-28. Nilai SGPT (18,77 μ/L) dan SGOT (18,89 μ/L) subjek pada hari ke-28 masih dalam rentang normal. Nilai ureum (22,90 μ/L) dan kreatinin (0,75 μ/L) pada hari ke-28 masih berada pada nilai normal. Kesimpulan. Ramuan Jamu dapat meningkatkan nilai Hb, MCV, MCH, dan feritin pada pasien di Klinik Saintifikasi Jamu
Analisis Ramuan Jamu Antihipertensi di Rumah Riset Jamu Hortus Medicus Tawangmangu Periode Januari-Juni 2017 Danang Ardiyanto; Tyas Friska Dewi
Jurnal Jamu Indonesia Vol. 4 No. 2 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1068.437 KB) | DOI: 10.29244/jji.v4i2.128

Abstract

Salah satu penyakit tidak menular yang memiliki prevalensi tinggi di dunia adalah hipertensi. Selain menggunakan pengobatan konvensional, penatalaksanaan hipertensi dapat ditangani dengan jamu. Penelitian bertujuan memeroleh gambaran penggunaan, persentase keberhasilan terapi dan jenis kelamin serta frekuensi terapi, dengan keberhasilan terapi ramuan jamu antihipertensi di Rumah Riset Jamu (RRJ) Hortus Medicus. Desain penelitian menggunakan potong lintang dengan rancangan observasional deskriptif. Observasi dilakukan pada data sekunder berupa rekam medik. Ramuan antihipertensi yang digunakan di RRJ periode Januari-Juni 2017 adalah ramuan I terdiri dari tanaman obat Apium graveolens‚ Centella asiatica‚ Orthosiphon stamineus dan Imperata cylindrica dengan 70 resep (70%). Ramuan II terdiri dari Apium graveolens‚ Centella asiatica‚ Orthosiphon stamineus‚ dan Imperata cylindrica dan Sonchus arvensis dengan 20 resep (20%). Ramuan III terdiri dari Apium graveolens‚ Centella asiatica dan Orthosiphon stamineus dengan 10 resep (10%). Persentase keberhasilan terapi ramuan jamu 1‚ 2‚ dan 3 berturut-turut adalah 80%‚ 60%‚ dan 50%. Faktor-faktor yang mempengaruhi keberhasilan terapi adalah jenis kelamin dan frekuensi terapi. Jenis kelamin tidak memiliki korelasi yang signifikan dengan keberhasilan terapi hipertensi dengan nilai p=0‚705 (p>0‚05)‚ dengan nilai Odds Ratio (OR) sebesar 1‚151. Faktor frekuensi terapi juga tidak memiliki korelasi yang signifikan dengan keberhasilan terapi hipertensi dengan nilai p=0‚420 (p>0‚05)‚ dengan nilai Odds Ratio (OR) sebesar 3‚421.
UJI TOKSISITAS AKUT DAN SUB KRONIS RAMUAN JAMU UNTUK FIBRO ADENOMA MAMMAE (FAM) Saryanto Saryanto; Danang Ardiyanto
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.658 KB) | DOI: 10.31942/jiffk.v0i0.1342

Abstract

ABSTRACT Mammary fibroadenomas (FAM) is the mammary gland benign tumor and has a high incidence rate in women aged 20-30 years. The purposes of this study are to assess the acute and subchronic toxicity of the herbs for FAM. The herb for FAM is a mixture of several simplisia (Curcuma zedoaria Rosch. rhizome; Loranthus parasiticus; Curcuma mangga Val. rhizome and Mammeria mimosa tuber) with a (10 g: 10 g: 5 g: 8 g: 7 g) ratio. Acute toxicity assay performed on the male and female Spraque-Dawley (SD) rats (aged 2-3 months with 200-250 g body weight). Forty-eight rats divided into four treatment groups (control group and three treatment groups of herbs for FAM). A decoction of herbs for FAM treated once a day orally. Toxicity clinical symptoms and lethal doses (LD50) observed for 7-14 days. Subchronic toxicity assay was also conducted in the male and female SD rats (aged 1.5-2 months with 150-200 g body weight). The three-dose series of herbs for FAM treated to the rats orally once daily for 90 days. The results of acute and subchronic toxicity assays found the quasi LD50 value of herbs for FAM is 5.000 mg/kg BW. This herb is safe for use in the medium term as an herbal medicine for FAM. Key words: FAM, acute, subchronic, toxicity assay
EFEK FORMULA JAMU ANTI ANEMIA TERHADAP KADAR HEMOGLOBIN PASIEN ANEMIA DI RUMAH RISET JAMU “HORTUS MEDICUS” TAWANGMANGU Danang Ardiyanto; PR Widhi Astana; Agus Triyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.488 KB) | DOI: 10.31942/jiffk.v0i0.1192

Abstract

ABSTRAKJamu untuk pasien anemia dapat menjadi suatu terobosan dalam menjawab masalah anemia di Indonesia. Sebuah penelitian studi klinik telah dilakukan di Klinik Saintifikasi Jamu “Hortus Medicus” Balai Besar Litbang Tanaman Obat dan Obat Tradisional Tawangmangu untuk menilai kenaikan kadar hemoglobin darah pada pasien anemia yang diterapi formula jamu anti anemia. Sebanyak 35 subjek secara sukarela mengikuti penelitian ini mendapatkan terapi formula jamu selama 1 bulan. Formula jamu merupakan infusa yang terdiri dari 5 gram daun bayam merah (Amaranthus tricolor L.), 10 gram herba tapak liman (Elephantopus scaber L) dan 15 gram rimpang temulawak(Curcuma xanthorrhiza) diminum 3 kali sehari. Hemoglobin diukur pada awal(hari ke-0), hari ke-14, dan hari ke 28. Menggunakan pengukuran hari ke-0 sebagai pembanding, dengan tingkat kepercayaan 95% terdapat peningkatan Hemoglobin pada hari-14 dan hari ke-28 secara signifikan.Kata Kunci: Formula jamu, hemoglobin, anemia.
EFEK RAMUAN JAMU INSOMNIA TERHADAP KUALITAS HIDUP PASIEN INSOMNIA DI KLINIK “HORTUS MEDICUS” TAWANGMANGU Peristiwan Ridha; Danang Ardiyanto; Agus Triyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.193 KB) | DOI: 10.31942/jiffk.v0i0.1193

Abstract

ABSTRAK Salah satu indikator kemanfaatan suatu modalitas terapi dalam meringankan gejala suatu penyakit adalah kualitas hidup. Kualitas hidup yang tinggi akan meningkatkan tingkat kesembuhan dan menurunkan morbiditas penyakit. Perkembangan obat tradisional semakin meningkat beberapa tehun terakhir. Jamu sebagai salah satu obat tradisional yang telah digunakan secara turun-temurun di masyarakat perlu mendapat pembuktian secara ilmiah.  Salah satu penggunaan jamu adalah sebagai terapi insomnia. Efektivitas jamu untuk insomnia dalam memperbaiki kualitas hidup memerlukan penelitian lebih lanjut. Sebuah penelitian observasi klinik telah dilakukan di Klinik Saintifikasi Jamu “Hortus Medicus” Balai Besar Litbang Tanaman Obat dan Obat Tradisional Tawangmangu untuk menilai kualitas hidup pasien insomnia yang diterapi ramuan jamu. Sebanyak 30 subjek secara sukarela mengikuti penelitian ini mendapatkan terapi ramuan jamu insomnia selama 14 hari dan dilanjutkan observasi tidak minum jamu selama 28 hari. Ramuan jamu yang digunakan adalah infusa dari 3 tanaman obat yang diminum 1 kali sehari sebelum tidur. Kualitas hidup diukur menggunakan Short Form-36(SF-36) pada awal (hari ke-0), hari ke-14, dan hari ke-42. Analisis statistik dilakukan dengan uji t berpasangan. Menggunakan pengukuran hari ke-0 sebagai pembanding, dengan tingkat kepercayaan 95% terdapat peningkatan kualitas hidup pada hari-14 dan hari ke-42 secara signifikan. Kata Kunci: Ramuan jamu, kualitas hidup, insomnia
UJI KLINIK MULTISENTER PENGARUH FORMULA JAMU OSTEOARTHRITIS TERHADAP RASA NYERI DIBANDING PIROXICAM Danang Ardiyanto; Peristiwan R Widhi Astana
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.941 KB) | DOI: 10.31942/jiffk.v0i0.1344

Abstract

ABSTRACT Herb scientification program is expected to obtain scientific evidence of the use of herb through research-based services. The purpose of this study is to reveal the efficacy of pain relief herb for osteoarthritis (OA) compared to the standard drug piroxicam. This clinical study performed through multi-center clinical trial approach involving 30 physicians who have been trained in herbs scientification trainee in February to December 2014. The study design was an open clinical trial without blinding. 123 patients with OA who met the inclusion criteria included in this study and they divided into two groups (63 subjects treat with OA herb and 60 subjects treated with piroxicam (as a control group). The OA herb consists (Curcuma xanthorrhiza roxb rhizome (15 g), Phyllanthus urinaria herbs (7 g), Curcuma domesticae rhizoma (15 g), Foeniculum vulgare Mill seeds (3 g), Orthosiphon aristatus leaves (5 g), and Acalyptha india herb (5 g)). Data collected for four weeks in both groups of patients. This clinical study concludes that the treatment of OA herb for 28 days significantly decrease the pain in patients with osteoarthritis. OA herbs can reduce the patient's VAS scores were comparable to piroxicam (p> 0.05). Key words: Osteoarthritis, pain relief herb, VAS, piroxicam
EFEK PEMBERIAN KAPSUL EKSTRAK JAMU HIPERGLIKEMI TERHADAP KUALITAS HIDUP: The Effect of Hyperglycemic Herbal Extract Capsules on Quality of Life Ulfa Fitriani; Agus Triyono; Danang Ardiyanto; Zuraida Zulkarnain; Peristiwan Ridha Widhi Astana; Ulfatun Nisa; Fajar Novianto; Enggar Wijayanti
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.600

Abstract

Quality of Life (QoL) in diabetes mellitus (DM) has become highly emphasized in recent years as health care outcome. Hyperglicemic herbs potio, one of scientific herbs, has been proven to be safe and efficacious. The use of extract capsules as an innovative form of herbal medicine continues to be developed. The study aimed to examine the effect of giving hyperglicemic herbal extract capsules on the QoL of hyperglycemic patients at Rumah Riset Jamu (RRJ) Hortus Medicus. The method used was pre and post-test design with quasi-experimental. A total of 60 patients followed the study during September-November 2019. The hyperglycemic herbs formula consisting of 5 grams daun Salam, 5 grams sambiloto, 7 grams kayu manis and 10 grams temulawak which converted to the one extract capsule. For the daily doses are two capsules twice a day. The Metformin 500 mg single dose as a control of the study. Before this study and on day 28th, the patients had been examined the QoL using the short form-36 (SF-36). The data were analyzed using the Wilcoxon and Mann Whitney test. The results showed that there was a significant increase in total score of SF-36 (p=0,000) between before and after taking extract capsules, especially for the general health domain (p=0,002). The total score of SF-36 between extract capsules and Metformin groups was not significantly difference (p=0,323). Hyperglycemic herbal extract capsules improved the QoL of the hyperglycemic patients.
Seismic Performance Study of Multi-storey Building Structures with Nonlinear Time History Analysis Method Eka Faisal Nurhidayatullah; Danang Ardiyanto
JOURNAL OF CIVIL ENGINEERING BUILDING AND TRANSPORTATION Vol. 9 No. 1 (2025): JCEBT MARET
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jcebt.v9i1.12622

Abstract

Assessment of the structure of existing buildings is necessary, especially for multi-story buildings in risk category IV located in high seismicity areas such as Yogyakarta. If there are indications of weaknesses, immediate actions such as retrofitting and rehabilitation can be taken as disaster mitigation efforts. This study examines the seismic behavior and performance of buildings using the Nonlinear Time History Analysis method with modified real earthquake recordings through spectral matching processes to meet the target spectra. Deaggregation analysis shows that fault mechanism earthquakes with a magnitude range of 6.6-6.8 and a distance of 30-40 km are the most dangerous and potentially occurring. The selection of earthquake recordings based on deaggregation analysis results in five identical ground motions: Kobe, Imperial Valley, Friuli, and Northridge. Nonlinear time history analysis using these five ground motions, after spectral matching, shows that the largest base shear force and displacement along the x-axis of the building are influenced by the Imperial Valley earthquake, while along the y-axis by the Kobe earthquake. The performance of the structure against the Imperial Valley earthquake along the x-axis is at the Damage Control level, while the Kobe earthquake along the y-axis is at the Immediate Occupancy level. Plastic hinge analysis results indicate that most structural elements remain in good condition, with only a small potential for damage in the range of 2-5%. Shear walls have effectively functioned as energy dissipators, preventing damage to other structural elements, especially columns, and preventing the soft story effect. The Strong Column Weak Beam damage hierarchy pattern has been successfully achieved.
EFEK PEMBERIAN KAPSUL EKSTRAK JAMU HIPERGLIKEMI TERHADAP KUALITAS HIDUP: The Effect of Hyperglycemic Herbal Extract Capsules on Quality of Life Ulfa Fitriani; Agus Triyono; Danang Ardiyanto; Zuraida Zulkarnain; Peristiwan Ridha Widhi Astana; Ulfatun Nisa; Fajar Novianto; Enggar Wijayanti
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.600

Abstract

Quality of Life (QoL) in diabetes mellitus (DM) has become highly emphasized in recent years as health care outcome. Hyperglicemic herbs potio, one of scientific herbs, has been proven to be safe and efficacious. The use of extract capsules as an innovative form of herbal medicine continues to be developed. The study aimed to examine the effect of giving hyperglicemic herbal extract capsules on the QoL of hyperglycemic patients at Rumah Riset Jamu (RRJ) Hortus Medicus. The method used was pre and post-test design with quasi-experimental. A total of 60 patients followed the study during September-November 2019. The hyperglycemic herbs formula consisting of 5 grams daun Salam, 5 grams sambiloto, 7 grams kayu manis and 10 grams temulawak which converted to the one extract capsule. For the daily doses are two capsules twice a day. The Metformin 500 mg single dose as a control of the study. Before this study and on day 28th, the patients had been examined the QoL using the short form-36 (SF-36). The data were analyzed using the Wilcoxon and Mann Whitney test. The results showed that there was a significant increase in total score of SF-36 (p=0,000) between before and after taking extract capsules, especially for the general health domain (p=0,002). The total score of SF-36 between extract capsules and Metformin groups was not significantly difference (p=0,323). Hyperglycemic herbal extract capsules improved the QoL of the hyperglycemic patients.
Co-Authors Agus Triyono Eka Faisal Nurhidayatullah Enggar Wijayanti Fajar Novianto Peristiwan R Widhi Astana Peristiwan Ridha Peristiwan Ridha Widhi Astana PR Widhi Astana Saryanto Saryanto Tofan Aries Mana Tyas Friska Dewi Ulfa Fitriani Ulfatun Nisa Zuraida Zulkarnain