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All Journal Jurnal Kedokteran Syiah Kuala The Indonesian Biomedical Journal Indonesian Journal of Chemistry Indonesian Journal of Jamu
Djoko Santoso
Departemen-SMF Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Public Health

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ACUTE KIDNEY INJURY (AKI) PADA KEHAMILAN Satriyo Dwi Suryantoro; Djoko Santoso; Sarah Firdausa
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.19284

Abstract

Acute Kidney Injury (AKI) in pregnancy remains a cause for fetomaternal morbidity and mortality, particularly in developing countries. Hypertensive complications of pregnancy (preeclampsia/eclampsia, HELLP syndrome) remains the leading cause of AKI in pregnancy. A set of systemic and renal physiological adaptive mechanisms occur during a normal gestation that will cause several changes in laboratory parameters of renal function, electrolytes, fluid and acid – base balance. Diagnosis of AKI in pregnancy is based on the serum creatinine increase and reduction of urine output. Management of AKI in pregnancy requires a multidisciplinary approach between nephrologists and obstetricians for optimizing care for both mother and child. In approaching AKI in pregnant woman, emphasis should be placed on making early and accurate diagnosis to allow prompt intervention and to facilitate recovery from AKI.
Anthropometry-based Body Fat Percentage Predicts High hs-CRP in Chronic Kidney Disease Patients Mochammad Thaha; Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Cahyo Wibisono Nugroho; Nurina Hasanatuludhhiyah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.397

Abstract

BACKGROUND: Obesity is an important cardiovascular risk factor and associated with low grade inflammation in chronic kidney disease (CKD) patients. This study aims to assess the association between body fat with serum high sensitivity C-reactive protein (hs-CRP) level in CKD patients.METHODS: A cross-sectional study was performed in 71 CKD patients. Anthropometric measurements included body weight, height, body mass index (BMI), body fat percentage (BFP), skinfold thickness (SKF) of triceps and biceps were performed by trained physician. BFP was calculated using Kwok’s Formula and hs-CRP was measured by Particle enhanced Turbidimetry.RESULTS: The averaged BMI of our subjects was 25.8±4.4. There was no significant difference in BMI between pre-dialysis and hemodialysis CKD patients. Positive correlation was found between BFP and hs-CRP (r=0.266; p<0.05), while there was no significant correlation between BMI and hs-CRP.CONCLUSION: Body fat percentage was associated with hs-CRP. Hence, it will be more beneficial to assess nutritional status in CKD using BFP rather than BMI alone since it was demonstrated to correlate with hs-CRP in our studyKEYWORDS: CKD, obesity, inflammation, body fat, hs-CRP
Could Complete Blood Count Parameters and Non-fasting Cholesterol Profile Describe Inflammation and Oxidative Stress in Chronic Kidney Disease? Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Berliana Hamidah; Haerani Rasyid; Zaky El Hakim; Maulana Muhtadin Suryansyah; Mohammad Yusuf Alsagaff; Djoko Santoso; Maulana Antiyan Empitu; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.451

Abstract

BACKGROUND: Establishment of inexpensive clinical laboratory tests to evaluate inflammation and oxidative stress is urgently needed in the limited resources settings. This study aims to investigate the potential of complete blood count (CBC) parameters and non-fasting cholesterol profile parameters to describe inflammation and oxidative stress in chronic kidney disease (CKD) patients.METHODS: Measurement of CBC, non-fasting cholesterol profile, high sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) were performed in 71 CKD patients grouped into hemodialysis (HD) and non-hemodialysis (non-HD). Correlation analysis were performed to assess the potential of CBC and cholesterol profile to describe the level of hs-CRP and MDA.RESULTS: In the HD group, total cholesterol was moderately associated with hs-CRP while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, monocyte/LDL-C ratio, neutrophil/HDL-C ratio, neutrophil/LDL-C ratio, platelet/HDL-C ratio and platelet/LDL-C ratio were strongly associated with hs-CRP. In the non-HD group,only neutrophil/total cholesterol ratio and platelet/total cholesterol ratio that were associated with hs-CRP. Total cholesterol, monocyte/LDL-C ratio, neutrophil/LDL-C ratio and platelet/LDL-C ratio were moderately associated with MDA while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were strongly associated respectively with MDA in HD group. In the non-HD group, total cholesterol/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were moderately associated with MDA in non-HD group while monocyte/HDL-C ratio was weakly associated with MDA.CONCLUSION: Some CBC parameters and non-fasting cholesterol profile such as cholesterol/HDL-C, monocyte/HDL-C, neutrophil/HDL-C and platelet/HDL-C ratio showed a potential to describe the inflammation and stress oxidative markers, given some strong associations with the level of hs-CRP and MDA. Further study is needed to assess whether this parameter represent long-term prognostic value among CKD patients.KEYWORDS: inflammation, oxidative stress, CRP, MDA, TAC, 8-OHdG, CBC, cholesterol
Determiner of Poor Sleep Quality in Chronic Kidney Disease Patients Links to Elevated Diastolic Blood Pressure, hs-CRP, and Blood-count-based Inflammatory Predictors Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Mochammad Thaha; Cahyo Wibisono Nugroho; Eka Arum Cahyaning Putri; Zaky El Hakim; Maulana Muhtadin Suryansyah; Rieza Rizqi Alda; Mohammad Yusuf Alsagaff; Mochammad Amin; Djoko Santoso; Yusuke Suzuki
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.452

Abstract

BACKGROUND: Sleep deprivation is strongly associated with cardiovascular disease (CVD) via sympathetic overstimulation and systemic inflammation in general population. However, the significance of poor sleep quality in chronic kidney disease (CKD) is still underexplored.METHODS: This study assessed the sleep quality of 39 with non-dialysis CKD (ND CKD) patients and 25 hemodialysis CKD (HD CKD) patients using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Poor sleeper was defined as individual with PSQI > 5.RESULTS: The prevalence of poor sleeper (30% vs. 60%, p=0.029) and the cummulative PSQI (ND CKD 4.5±4.4, HD CKD 8±6, p=0.038) are different between ND CKD and HD CKD groups. Among the ND CKD, there are association between short sleep duration (< 5 hours per day) with elevated diastolic blood pressure groups (r=0.421, p<0.05); habitual sleep efficiency with platelet-to-lymphocyte ratio (r= 0.532, p<0.0001); daytime dysfunction with increased hs-CRP (r=0.345, p=0.032) and neutrophil-to-lymphocyte ratio (r=0.320, p=0.046). In HD CKD group, a requirement to use sleep medication was associated with elevated highsensitivity C-reactive protein (hs-CRP) level (r=0.434, p=0.030) and decreased monocyte-to-lymphocyte ratio (r=- 0.410, p=0.042); daytime dysfunction was associated with serum hs-CRP (r=0.452, p=0.023).CONCLUSION: This study revealed that some features of poor sleep quality in CKD patients including low sleep efficiency, daytime dysfunction and requirement to use sleep medication were associated with increased diastolic blood pressure, hs-CRP and blood-count-based inflammatory predictors. Thus, this finding prompt to pay closer attention to sleep complaints in the management of CVD risk factors in CKD patients.KEYWORDS: sleep quality, chronic kidney disease, blood pressure, inflammation
Antioxidant Activity of Fungus Comb Extracts Isolated from Indo-Malayan Termite Macrotermes gilvus Hagen (Isoptera: Termitidae) Yanti Rachmayanti; Dikhi Firmansyah; Reza Ro&#039;isatul Umma; Decsa Medika Hertanto; I Ketut Sudiana; Djoko Santoso; Dodi Nandika; Lina Karlinasari; Arinana Arinana; Irmanida Batubara; Lucia Dhiantika Witasari
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.77227

Abstract

Indonesian termites are one of the wealthiest biological resources considering their very high species diversity (300 species) and extensive geographical distribution in the Indonesian mainland. However, its potential as a source of bioactive compounds has not been fully explored. One of the endemic termite sub-families of Indonesian, Macrotermitinae (Isoptera: Termitidae), has a food source in the form of fungal nodules that grow and spread in a particular structure in the termite nest that is shaped like a mammalian brain called a fungus comb, which likely serves as a source of bioactive compounds. This study aims to analyze the potential of fungus comb from an Indonesian Macrotermitinae sub-family species as a source of antioxidants. Antioxidant activity was tested on four different extracts of fungus comb (EFC), namely hexane extract, ethyl acetate extract, methanol extract and water extract, using DPPH• (1,1-diphenyl-2-picrylhydrazyl) and ABTS•+ (2,2′-azino-di-[3-ethylbenzthiazolinesulphonate]) radicals. The results showed that the highest antioxidant activity was found in methanol extract, followed by ethyl acetate extract with IC50 values of 0.6 mg/mL and 0.75 mg/mL, respectively. TEAC (Trolox equivalent antioxidant capacity) analysis confirmed the high antioxidant activity of methanol extract.
Fingerprints, Antioxidant Activity, and Anti-Tyrosinase of Fungus Comb Extract Trisni Untari Dewi; Diva Putri Diposani; Eti Rohaeti; Dodi Nandika; Lina Karlinasari; Arinana Arinana; Djoko Santoso; Lucia Dhiantika Witasari; Yanti Rachmayanti; Irmanida Batubara
Jurnal Jamu Indonesia Vol. 8 No. 3 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i3.346

Abstract

Fungus comb is a structure made by termite colony Macrotermitinae with lots of potential because it contains secondary metabolites such as steroids, terpenoids, and saponins and compounds containing antioxidant and anti-tyrosinase properties. This study aimed to determine fungus comb extracts' fingerprint pattern, antioxidant capacity, and anti-tyrosinase activity. Thin layer chromatography (TLC) was used to determine fingerprint patterns. The resulting TLC pattern was processed with ImageJ and converted into a densitogram. The fungus comb was extracted with n-hexane and ethyl acetate. TLC results showed that fungus comb extracts contain steroids and terpenoids and have antioxidant properties. The antioxidant capacity assay was carried out with 2,2-diphenyl-1-picrylhydrazyl reagent. N-hexane extract had an antioxidant capacity value of 9.07 mg ascorbic acid equivalent (AAE)/g extract, while ethyl acetate extract had 6.04 mg AAE/g extract. Anti-tyrosinase activity assay was carried out with L-tyrosine and L-3,4-dihydroxyphenylalanine (L-DOPA) as substrates. N-hexane extract had a better anti-tyrosinase activity with IC50 of 1804 µg/mL for L-tyrosine and 6784 µg/mL for L-DOPA.
Co-Authors Aditia Wardana Arinana Arinana Berliana Hamidah Cahyo Wibisono Nugroho Chandra Irwanadi Mohani Decsa Medika Decsa Medika Hertanto Dikhi Firmansyah Diva Putri Diposani Dodi Nandika Eka Arum Cahyaning Putri Eti Rohaeti Firdausa, Sarah Haerani Rasyid Haerani Rasyid Ika Nindya Kadariswantiningsih Irmanida Batubara Lina Karlinasari Lucia Dhiantika Witasari Lucia Dhiantika Witasari Maulana Antiyan Empitu Maulana Muhtadin Suryansyah Maulana Muhtadin Suryansyah Mochammad Amin MOCHAMMAD THAHA Mohammad Yusuf Alsagaff Mohammad Yusuf Alsagaff Nur Sulastri Nurina Hasanatuludhhiyah Pranawa Pranawa Reza Ro&#039;isatul Umma Rieza Rizqi Alda Rieza Rizqi Alda S.Pd. M Kes I Ketut Sudiana . Soenarnatalina Melaniani Sri Mardjiati Mei Wulan Suryantoro, Satriyo Dwi Trisni Untari Dewi Vina Amalia Widodo Widodo Yanti Rachmayanti Yusuke Suzuki Yusuke Suzuki Zaky El Hakim Zaky El Hakim