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All Journal MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JFIOnline Jurnal Farmasi Higea Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Jurnal Sains dan Kesehatan
Mareta Rindang Andarsari
Departement Of Pharmacy Practice, Faculty Of Pharmacy, Airlangga University, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Efek Kronis Minuman Berenergi pada Ginjal Suharjono, .; Izzah, Zamrotul; Andarsari, Mareta Rindang; Budiatin, Aniek Setya; Rahmadi, Mahardian
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Penggunaan minuman berenergi telah meluas di masyarakat hingga menjadikannya sebagai bagian dari gaya hidup sehari-hari. Perubahan pola hidup seperti kurang minum air putih dan sering mengkonsumsi minuman berenergi memicu terjadinya penyakit ginjal kronik. Penelitian ini dilakukan untuk menentukan pengaruh penggunaan beberapa jenis minuman berenergi dalam jangka waktu tertentu terhadap fungsi ginjal tikus berdasarkan parameter hematologi, urinalisis dan histopatologi ginjal. Tikus dibagi menjadi 4 kelompok dan mendapatkan 3 jenis minuman berenergi (ED1, ED2 dan ED3) dan air sebagai kontrol selama 30 hari. Sehari setelah pemberian minuman bernergi berakhir, tikus dimasukkan dalam kandang metabolik untuk menampung urin 24 jam. Kemudian tikus dianastesi dan diambil darah dan dikorbankan dan kemudian diambil organ ginjal untuk pemeriksaan histopatologi. Hasil urinalisis menunjukkan penurunan ekskresi kreatinin urin diiringi peningkatan rasio albumin terhadap kreatinin di urin. Pemeriksaan hematologi menunjukkan peningkatan kadar serum kreatinin, sedangkan pemeriksaan histopatologi ginjal menunjukkan abnormalitas pada medulla ginjal.
Efek Kronis Minuman Berenergi pada Ginjal Suharjono, .; Izzah, Zamrotul; Andarsari, Mareta Rindang; Budiatin, Aniek Setya; Rahmadi, Mahardian
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (767.533 KB) | DOI: 10.35617/jfi.v7i4.259

Abstract

Abstrak Penggunaan minuman berenergi telah meluas di masyarakat hingga menjadikannya sebagai bagian dari gaya hidup sehari-hari. Perubahan pola hidup seperti kurang minum air putih dan sering mengkonsumsi minuman berenergi memicu terjadinya penyakit ginjal kronik. Penelitian ini dilakukan untuk menentukan pengaruh penggunaan beberapa jenis minuman berenergi dalam jangka waktu tertentu terhadap fungsi ginjal tikus berdasarkan parameter hematologi, urinalisis dan histopatologi ginjal. Tikus dibagi menjadi 4 kelompok dan mendapatkan 3 jenis minuman berenergi (ED1, ED2 dan ED3) dan air sebagai kontrol selama 30 hari. Sehari setelah pemberian minuman bernergi berakhir, tikus dimasukkan dalam kandang metabolik untuk menampung urin 24 jam. Kemudian tikus dianastesi dan diambil darah dan dikorbankan dan kemudian diambil organ ginjal untuk pemeriksaan histopatologi. Hasil urinalisis menunjukkan penurunan ekskresi kreatinin urin diiringi peningkatan rasio albumin terhadap kreatinin di urin. Pemeriksaan hematologi menunjukkan peningkatan kadar serum kreatinin, sedangkan pemeriksaan histopatologi ginjal menunjukkan abnormalitas pada medulla ginjal.
Effect of Mannitol Hydration as Renoprotective on Cisplatin Induced Nephrotoxicity (CIN) in Head and Neck Cancer Patients Mareta Rindang, Andarsari; Yunita Dyah, Kusumaningrum; Rosy Nurlita, Hapsari; Dwi Hari, Susilo; Dewi Wara, Shinta
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16958

Abstract

Background: Cisplatin is a cytostatic agent used as treatments in head and neck cancer patients.Nephrotoxicity is one of cisplatin major side effects. This study aimed to evaluate the renoprotectiveeffect of mannitol-hydration administration in head and neck cancer patients who receive cisplatinchemotherapy. Methods: This was a cohort observational study to analyze the renal function of head andneck cancer patients who receives cisplatin before and after mannitol-hydration administration in IRNASurgery and Soekardja Room of Chemotherapy at RSUD Dr. Soetomo Surabaya during June – September2018. The data obtained were BUN, SCr, and eClCr Cockroft-Gault of each cycle. Result: A total of 52patients were evaluated. The average value of creatinine serum, creatinine clearance, and BUN at each cyclewere fluctuate. However, the average value of creatinine serum and BUN were within the normal limit.The result of statistical analysis using paired t-test in those parameters at each cycle were not statisticallysignificant (p > 0,05) after mannitol administration except during first cycle to second cycle the SCr increasedsignificantly and eClCr was decreased significantly (p-value 0,024; 0,006, CI 95% respectively ). At fourthcycle the eClCr also decreased significantly (p value 0,008, CI 95%). Conclusion: The renoprotective effectof mannitol in head and neck cancer patients who receive cisplatin chemotherapy is sufficiently adequatewhich can maintain the value of BUN and creatinine serum of patients at each cycle within the normal limit.
Pengetahuan Profesi Tenaga Kefarmasian Terhadap Terapi dan Rawat Luka Pasien Kanker Mareta Rindang Andarsari; Pharmasinta Putri Hapsari; Marcha Debby Saraswati; Yudistira Nurrizky Grahitaning Putra Rohmaana; Didik Hasmono; Budi Suprapti
Majalah Farmasetika Vol. 6, Supl. 1, Tahun 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v6i0.37017

Abstract

Penderita kanker dengan modalitas terapi kanker dapat mengalami efek samping obat dan luka kanker. Penyelesaian permasalahan dan peningkatan faktor keselamatan pasien terkait penggunaan obat, serta kualitas hidup yang membaik dipengaruhi oleh kerjasama antara tenaga kesehatan, salah satunya tenaga kesehatan farmasi. Pengetahuan tenaga kefarmasian terkait pengobatan dan perawatan yang diberikan pada pasien kanker sangat dibutuhkan untuk menunjang praktek kolaborasi. Tingkat pengetahuan tenaga kefarmasian penting diketahui untuk upaya penguatan sistem pelayanan kesehatan. Penelitian ini bertujuan untuk mengetahui pengetahuan tenaga kesehatan farmasi terhadap terapi dan rawat luka pasien kanker. Penelitian ini adalah penelitian deskriptif, non-random sampling dengan metode accidental sampling. Penelitian dilakukan pada bulan November 2020, pengumpulan data menggunakan survei online. Total 99 orang tenaga kefarmasian yang terdiri dari apoteker dan tenaga teknis kefarmasian mengisi kuesioner tersebut. Selanjutnya dilakukan penilaian pengetahuan pada setiap butir pertanyaan. Sejumlah 71,72% tenaga kefarmasian memiliki pengetahuan yang baik terhadap hal umum terkait terapi dan rawat luka kanker. Lebih dari sembilan puluh persen tenaga kefarmasian dapat menjawab dengan tepat terkait tujuan terapi kanker, penanggulangan efek samping obat, dan keadaan yang diperhatikan saat perawatan luka. Apoteker memiliki pengetahuan yang baik sebesar 74,39% dan tenaga teknis kefarmasian sebesar 58,82%. Tenaga kefarmasian memiliki pengetahuan yang baik terkait perihal dasar terapi kanker dan rawat luka pasien kanker. Apoteker memiliki pengetahuan yang baik terutama perihal efek samping obat dibandingkan tenaga teknis kefarmasian.
Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia) Mareta Rindang Andarsari; Didik Hasmono; Samirah Samirah; Suharjono Suharjono; Dea Ayu Nabilah; Paulus Sugianto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 4 No. 2 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.691 KB) | DOI: 10.20473/jfiki.v4i22017.80-83

Abstract

Background: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage become crucial to reduce morbidity and mortality. Objective: This study was aimed to assess the use of antibiotics, prescribed for patients with bacterial meningitis in Neurology Department of Dr. Soetomo General Hospital Surabaya from January 2010 until June 2015. Methods: Retrospective study using medical record of inpatients obtained from January 1st 2010 until June 30th 2015. The inclusion criteria were inpatients with bacterial meningitis (diagnosed by physician using CT scan data, lumbal puncture and clinical signs and symptoms) and prescribed with antibiotics. Patients with antibiotics therapy less than 3 days and infection other than bacterials were excluded. Results: From 85 patients, male to female ratio was 1.66. Meningitis appear to be mostly occured in productive age, 39 (45.88%) in 15 - 29 years old and 40 (47.06%) in 30 - 60 years old. Number of antibiotics prescribed were 130 prescriptions, as single and combination therapy. The most prescribed antibiotic was cephalosporins (97 prescriptions), dominated by 2 g twice daily ceftriaxone with 86 (66.15%) from overall prescriptions. Followed by metronidazole and fluoroquinolons,11 (8.46%) and 8 (6.15%) respectively. In addition, there were 26 prescriptions of combination therapy, mostly ceftriaxone and metronidazole. Conclusion: Bacterial meningitis are mostly treated using ceftriaxone which is an appropriate drug of choice.
Assessment of Antibiotic Use in ICU Patients with Pneumonia Using ATC/DDD as a Quantitative Analysis Method Mareta Rindang Andarsari; Zedny Norachuriya; Sarah Mahmudatun Nabila; Toetik Aryani; Alfian Nur Rosyid
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.138-145

Abstract

Background: Pneumonia is an infection of the lung tissue which is mainly caused by bacteria. High utilization and inappropriate use of antibiotics increase resistant bacteria, morbidity, mortality, and treatment cost. Quantitative evaluation becomes one of the indicators to assess the use of antibiotics which is one indicator of the quality of the antimicrobial resistance control program. Objective: This study aimed to evaluate the use of antibiotics an effort to increase the rationality of the use of antibiotics. Methods: This study was a retrospective observational study with a sampling method of time-limited sampling in Universitas Airlangga hospital from January until December 2019. Quantitatively using Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD). Result: The samples obtained were 68 severe pneumonia patients who met the inclusion criteria. From the result of the study, there were 13 types of antibiotics used for pneumonia therapy, and the three most used were Levofloxacin, Ceftriaxone, and Meropenem, with a total of all antibiotics 73.64 DDD/100 patients-days. Most useful is parenteral Levofloxacin at 21.92 DDD/100 patient-days, Ceftriaxone at 20.45 DDD/100 patient-days and Meropenem at 14.29 DDD/100 patient-days. Conclusion: The DDD value indicates high antibiotic usage, but high antibiotic use does not imply unreasonable drug use, so we must undertake a qualitative review of antibiotic use.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID Andarsari, Mareta Rindang; Hanunnisa, Nadhifa; Lestari, Kristanti; Sholichah, Aminatush; Ratri, Dinda Monika Nusantara; Asmarawati, Tri Pudy
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.584

Abstract

Demam tifoid merupakan penyakit infeksi yang disebabkan oleh bakteri yang salah satu pengobatannya dengan diberikan terapi antibiotik. Untuk mencapai keberhasilan terapi adalah dengan melakukan pemilihan antibiotik. Hal yang perlu diperhatikan dalam memilih antibiotik yaitu dengan melihat efektivitas biaya. Cara mengetahui antibiotik yang paling cost-effective adalah dengan cost-effectiveness analysis (CEA). Analisis ini dapat dihitung dengan nilai ACER (Average Cost-Effectiveness Ratio) yang dilihat dari biaya pengobatan langsung dan efektifitas terapi. Efektivitas terapi dapat dilihat dari data klinis dan laboratorium pasien meliputi suhu, nadi, RR dan leukosit pasien saat keluar dari rumah sakit. Hasil penelitian ini adalah nilai ACER kloramfenikol sebesar Rp1.700.501 (berdasarkan data suhu, nadi, dan RR) dan cefixime sebesar Rp. Rp2.335.650 (berdasarkan data suhu, nadi, RR dan leukosit) pada tahun 2020. Sedangkan cefixime memiliki nilai ACER pada tahun 2021 sebesar Rp4.852.897 (berdasarkan data suhu, nadi, dan RR) dan Rp5.349.785 (berdasarkan data suhu, nadi, RR dan leukosit). Kesimpulan dari penelitian ini adalah kloramfenikol dan sefiksim merupakan antibiotik yang cost-effective berdasarkan nilai ACER terendah untuk pasien rawat inap di Rumah Sakit Universitas Airlangga
Pharmacy Students’ Readiness for Offline Learning in The New Normal Transmission of COVID-19: A Cross-Sectional Study Budi Suprapti; Ratri, Dinda Monika Nusantara; Mareta Rindang Andarsari; Ritonga, Fany Devita; R.R. Endang Lukitaningsih; Enda Mora; Enok Nurliawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.34-41

Abstract

Background: Pharmacy students consist of undergraduate and professional pharmacy students. They are candidates for future pharmacist health workers who require practical experience. Offline learning with hands-on practice methods in health facilities supports their professional skills. Objective: This study aimed to determine pharmacy students' knowledge and attitude toward implementing offline learning methods during the new normal era. Methods: This study involved pharmacy students from Indonesia who were asked to participate in an e-questionnaire about the vaccination program, COVID-19 health protocols, pharmacist competence, and attitude toward implementing offline learning. The students' scores were based on their knowledge and attitude. Statistical analysis was performed to compare the scores between the two groups, and a correlation test was conducted to assess the relationship between the students' knowledge and attitudes. Results: A total of 652 pharmacy students were divided into two groups, undergraduate and professional pharmacy students, in a 3:1 ratio. About 74.6% of undergraduate students and 78.5% of professional pharmacy students had good and moderate knowledge. The level of knowledge was not different between the two groups (p=0.602; p>α). Professional pharmacy students were more ready to engage in offline learning compared to undergraduate students (p=0.001; p<α). However, there was a relatively low correlation between knowledge and attitudes, with r = 0.079 (p=0.043; p<α). Conclusion: Professional pharmacy students are more ready for offline learning methods than undergraduate students, particularly in hands-on field practice.
Quantitative and Qualitative Analysis of Antibiotics in the Intensive Care Unit (ICU) Mareta Rindang Andarsari; Lisa Ariyanti Zainu; Sri Rahayu Saleh; Aminatush Sholichah; Dewi Wara Shinta; Cahyo Wibisono Nugroho
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1128

Abstract

The high incidence of infection in the ICU requires frequent use of antibiotics, thereby increasing the risk of developing antibiotic resistance when used irrationally. To assess the quantity and quality of antibiotic use, the World Health Organization (WHO) recommends using the Anatomical Therapeutic Chemical (ATC) classification system or the Defined Daily Dose (DDD) method. In that study, 25 articles were analyzed, including 21 quantitative research articles and four qualitative research articles. These articles were obtained from three databases: PubMed Central (PMC), Research Gate, and Google Scholar. The most commonly used antibiotics in the ICU are ceftriaxone (1×2g, IV) with a DDD value of 358,139/100 bed-days, meropenem (3×2g, IV) with a DDD value of 289,747/100 bed-days, and piperacillin-tazobactam (4×4.5g, IV) with a DDD value of 164,816/100 bed-days. These values indicate the number of antibiotics used in relation to 100 days of sleep. In addition, evaluation of the quality of antibiotic use in the ICU revealed that it is generally characterized by irrational use. By conducting such research, healthcare professionals can optimize the use of antibiotics in the ICU, leading to more effective treatment outcomes while minimizing the development of antibiotic resistance. Keywords: Antibiotics, ATC/DDD, Gyssens, intensive care unit
Pemahaman Masyarakat tentang Desain dan Isi Informasi pada Etiket Obat serta Praktik Penggunaan Antibiotika Sirup Kering Ananda, Yussi; Noorrizka, Gusti; Nita, Yunita; Andarsari, Mareta Rindang; Yuda, Ana
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 2 (2024): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i2.7009

Abstract

Menyajikan informasi obat dan konsisten pada etiket obat memiliki potensi untuk meningkatkan kepatuhan dan hasil terapi. Etiket obat harus memuat informasi penting yang dibutuhkan pasien untuk menjamin obat yang aman dan efektif. Diperlukan panduan pelabelan obat untuk mengurangi potensi kesalahan pengobatan. Penelitian ini bertujuan untuk melihat perbedaan sikap, pemahaman, dan praktik penggunaan obat oleh pasien yang mendapat sediaan sirup kering dengan 2 macam desain etiket, yaitu etiket yang umum digunakan di Indonesia dan etiket yang dikembangkan berdasarkan panduan dari beberapa negara, yaitu FIP, USP, dan ACSQHC. Dalam penelitian ini, diperoleh total 80 responden. Hasil yang diperoleh adalah tidak ada perbe- daaan sikap dari kedua kelompok responden mengenai desain etiket kecuali dalam hal kelengkapan isi informasi (P = 0,044). Pada variabel pengetahuan juga tidak terdapat perbedaan bermakna pada kedua kelompok responden, namun pada variabel praktik penggunaan terdapat perbedaan bermakna (P = 0,020) dimana kelompok responden satu mempunyai skor yang lebih tinggi dari kelompok dua yaitu masing-massing 2,68 ± 0,474 dan 2,28 ± 0,784. Kebenaran dalam mengukur dosis dapat dipengaruhi oleh keterampilan motorik seseorang, namun tetap dibutuhkan kelengkapan informasi yang dapat mengurangi potensi medication error, sehingga diperlukan panduan yang mengatur informasi minimal yang harus ada dalam etiket obat pada pelayanan resep di Indonesia. Presenting drug information and consistency on drug labels has the potential to improve compliance and therapeutic outcomes. Drug labels must contain important information needed by patients to ensure safe and effective drugs. Drug labeling guidelines are needed to reduce the potential for medication errors. This study aims to see the differences in attitudes, understanding, and practices of drug use by patients who receive dry syrup preparations with 2 types of label designs, namely labels commonly used in Indonesia and labels developed based on guidelines from several countries, namely FIP, USP, and ACSQHC. In this study, a total of 80 respondents were obtained. The results obtained that there was no difference in attitudes from the two groups of respondents regarding label design except in terms of the completeness of the information content (P = 0.044). In the understanding variable, there was also no significant difference in the two groups of respondents, but in the practice variable there was a significant difference (P = 0.020), where respondent group one had a higher score than group two, namely 2.68 ± 0.474 and 2.28 ± 0.784 respectively. The accuracy in measuring the dose can be influenced by a person's motor skills, but complete information is still needed to reduce the potential for medication errors, so a guideline is needed that regulates the minimum information that must be included in drug labels in prescription services in Indonesia. Submitted: 07-11-2024, Revised: 13-12-2024, Accepted: 17-12-2024, Published regularly: December 2024
Co-Authors Aminatush Sholichah Ananda, Yussi Asmarawati, Tri Pudy Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Cahyo Wibisono Nugroho Dea Ayu Nabilah Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Enda Mora Enok Nurliawati Hanunnisa, Nadhifa Lestari, Kristanti Lisa Ariyanti Zainu Mahardian Rahmadi Noorrizka, Gusti Paulus Sugianto Pharmasinta Putri Hapsari R.R. Endang Lukitaningsih Ritonga, Fany Devita Rosy Nurlita, Hapsari Rosyid, Alfian Nur Samirah Samirah Sarah Mahmudatun Nabila Sholichah, Aminatush Sri Rahayu Saleh Suharjono, Suharjono Susilo, Dwi Hari Toetik Aryani Yuda, Ana Yudistira Nurrizky Grahitaning Putra Rohmaana Yunita Nita Zamrotul Izzah Zedny Norachuriya