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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Global Pharma Technology Folia Medica Indonesiana
Budi Susetyo Pikir
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran –RSUD Dr. Soetomo. Kelompok Peneliti Sel Punca – Institut Penyakit Tropik, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Relationship Between Energy Drinks A and B with Blood Pressure and Pulse Rate Increase Among College Students Setiabudi, Narendra Arya; Pikir, Budi Susetyo; Lestari, Pudji; Purwanto, Bambang
Journal of Community Medicine and Public Health Research Vol. 5 No. 1 (2024): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v5i1.52676

Abstract

Energy drinks are popular among various groups of people, such as teenagers and working individuals. These beverages are consumed to provide additional energy and improve focus. This research investigates the relationship between energy drinks and blood pressure and heart rate in students of the Faculty of Medicine at Universitas Airlangga, Surabaya, Indonesia. The study used the open trial – randomized cross-over study method and collected primary data through experiments. The sample consisted of students from the Faculty of Medicine at Universitas Airlangga, aged 19 to 22 years, with a normal body mass index ranging from 18.5 to 24.9. The systolic, diastolic, and heart rate values were measured before and after consuming energy drinks. A total of 38 research samples were used, including 22 males (57.8%) and 16 females (42.1%). Energy drinks such as Kratingdaeng and Extra Joss showed a significant increase in blood pressure. However, no significant changes were observed in heart rate. The results of the Wilcoxon statistical test, comparing systolic and diastolic conditions before and after consuming Extra Joss, showed p<0.0001. A significance level of p<0.05 indicates a significant effect of energy drinks on the students. The Wilcoxon test for Kratingdaeng also yielded a p<0.0001. For the p-value through the Wilcoxon test on diastolic values before and after consuming Extra Joss and Kratingdaeng, the result was p<0.05. However, the Wilcoxon test for heart rate before and after consuming Kratingdaeng and Extra Joss had a at p<0.05. In the Mann-Whitney statistical test, a p<0.05 was found only in the post-systolic condition, while other conditions had at p≥0.05. In conclusion, energy drinks significantly affected blood pressure, but no significant changes were observed in heart rate.
Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation Putra, Rendra Mahardhika; Dharmadjati, Budi Bakti; Pikir, Budi Susetyo; , Irma Maghfirah; Isaridha, Ilma Alfia; Arnindita, Jannatin Nisa
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • A genetic variable has been identified as an atrial fibrillation risk factor. • Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.
Quercetin Inhibits the Progression of Atherosclerosis by Enhancing the Activity of M2 Macrophages in Wistar Rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.08

Abstract

Quercetin, widely acknowledged as an exceptionally potent antioxidant, is known for its diverse array of bioactive properties that confer numerous health benefits. However, the specific effect of quercetin on atherosclerosis progression remains unclear and warrants further investigation. This experimental study used Wistar rats with a post-test-only control-group design. It aimed to analyze the effect of quercetin in inhibiting the progression of atherosclerosis. Twelve adult male rats were selected and used to construct an experimental model that mimics atherosclerotic plaque formation. The model was achieved by administering a high-fat diet with a caloric value of 414 kcal per 100 grams and performing an endothelial injury procedure during the second week of the study. After six weeks, the rats were divided into two groups of six: the control group continued on the high-fat diet, while the quercetin group maintained the same diet and received 10 mg/kg of quercetin via gavage. At the end of week eight, the progression of atherosclerotic plaques was evaluated by measuring the activity of M1 and M2 macrophages, as well as the carotid artery intima-media thickness and the degree of carotid arterial stenosis. Quercetin administration significantly increased the activity of M2 macrophages (p=0.002, mean difference 10.66, 95% CI 5.90 - 15.41); in contrast, no significant effect was found on the activity of M1 macrophages (p=0.562), carotid artery intima-media thickness (p=0.407), and the degree of carotid arterial stenosis (p=0.734). This study emphasizes quercetin's role in inhibiting atherosclerosis progression by enhancing the activity of M2 macrophages. Additional studies are necessary to explore various quercetin doses involving more atherosclerosis parameters.
The endothelial injury technique using intravenous catheters: a new alternative method for developing atherosclerotic plaque models in Wistar rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto; Utomo, Budi; Widjiati , Widjiati; Oktaviono, Yudi Her
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.14

Abstract

Background: Developing an atherosclerotic plaque model is crucial in atherosclerosis research, as creating such a model remains a significant challenge. Objective: This study evaluates the endothelial injury technique using intravenous catheters as an alternative method for developing atherosclerotic plaque models in Wistar rats. Methods: This true experimental study employs a post-test-only control group design. Twenty-two adult male Wistar rats were randomly allocated into three groups: a control group, a treatment group that underwent a 6-week intervention, and another treatment group that underwent an 8-week intervention. The control group was fed a standard diet of 320 kcal per 100 grams, while both treatment groups received a high-fat diet of 414 kcal per 100 grams. In the second week, endothelial injury was induced in the left common carotid artery of both treatment groups using a 26G intravenous catheter. The parameters assessed in the atherosclerotic plaque model included matrix metalloprotease-9 expression, M1 macrophage activity, M2 macrophage activity, maximal intima thickness, and the degree of arterial stenosis. Result: The endothelial injury technique using intravenous catheters significantly impacted matrix metalloprotease-9 expression (p<0.001) in both the 6-week and 8-week treatment groups compared to the control group. In contrast, the treatment's effects on maximal intima thickness (p=0.003) and the degree of arterial stenosis (p=0.002) were statistically significant only after 8 weeks of intervention compared to the control group. Conclusion: The endothelial injury techniques using intravenous catheters can be considered an alternative method for developing atherosclerotic plaque models in Wistar rats. Although this new technique has several limitations, it holds promise for further development in future studies.
Co-Authors , Irma Maghfirah Andrianto Annisa Trissatharra Arnindita, Jannatin Nisa Bambang Purwanto Budi Bakti Dharmadjati Budi Utomo David Setyo Budi Dharmadjati, Budi Bakti Fita Triastuti Hendri Susilo Ilma Alfia Isaridha Imam Mahbub Zam Zami Irma Maghfirah Isaridha, Ilma Alfia Jannatin Nisa Arnindita Laurentius Andre Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Mochammad Yusuf Alsagaff Mohammad Satya Bhisma Mulyanto Mulyanto Pakpahan, Cennikon Pudji Lestari Putra, Rendra Mahardhika Rendra Mahardhika Putra Rizka Amalia Romi Ermawan, Romi Setiabudi, Narendra Arya Sinta Dwi Juniar Suryantoro, Satriyo Dwi Widjiati , Widjiati Wungu, Citrawati Dyah Kencono Yudi Her Oktaviono, Yudi Her