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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Global Pharma Technology Folia Medica Indonesiana
Budi Susetyo Pikir
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran –RSUD Dr. Soetomo. Kelompok Peneliti Sel Punca – Institut Penyakit Tropik, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Relationship Between Energy Drinks A and B with Blood Pressure and Pulse Rate Increase Among College Students Setiabudi, Narendra Arya; Pikir, Budi Susetyo; Lestari, Pudji; Purwanto, Bambang
Journal of Community Medicine and Public Health Research Vol. 5 No. 1 (2024): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v5i1.52676

Abstract

Energy drinks are popular among various groups of people, such as teenagers and working individuals. These beverages are consumed to provide additional energy and improve focus. This research investigates the relationship between energy drinks and blood pressure and heart rate in students of the Faculty of Medicine at Universitas Airlangga, Surabaya, Indonesia. The study used the open trial – randomized cross-over study method and collected primary data through experiments. The sample consisted of students from the Faculty of Medicine at Universitas Airlangga, aged 19 to 22 years, with a normal body mass index ranging from 18.5 to 24.9. The systolic, diastolic, and heart rate values were measured before and after consuming energy drinks. A total of 38 research samples were used, including 22 males (57.8%) and 16 females (42.1%). Energy drinks such as Kratingdaeng and Extra Joss showed a significant increase in blood pressure. However, no significant changes were observed in heart rate. The results of the Wilcoxon statistical test, comparing systolic and diastolic conditions before and after consuming Extra Joss, showed p<0.0001. A significance level of p<0.05 indicates a significant effect of energy drinks on the students. The Wilcoxon test for Kratingdaeng also yielded a p<0.0001. For the p-value through the Wilcoxon test on diastolic values before and after consuming Extra Joss and Kratingdaeng, the result was p<0.05. However, the Wilcoxon test for heart rate before and after consuming Kratingdaeng and Extra Joss had a at p<0.05. In the Mann-Whitney statistical test, a p<0.05 was found only in the post-systolic condition, while other conditions had at p≥0.05. In conclusion, energy drinks significantly affected blood pressure, but no significant changes were observed in heart rate.
Quercetin Stabilizes Atherosclerotic Plaques by Reducing Matrix Metalloproteinase-9 Expression and Enhancing M2 Macrophage Activity in Wistar Rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto; Utomo, Budi; Widjiati, Widjiati; Oktaviono, Yudi Her
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3790

Abstract

BACKGROUND: Quercetin has been shown to alleviate and prevent atherosclerosis. However, its role in stabilizing atherosclerotic plaques to prevent plaque rupture remains unclear. Therefore, this study was conducted to investigate the effects of quercetin on stabilizing atherosclerotic plaques.METHODS: Thirty-two Wistar rats were objected to a high-fat diet, along with an endothelial injury procedure conducted during the second week to create atherosclerotic plaque models. After six weeks, the subjects were randomly assigned to five groups consist of two control groups and three treatment groups treated with different quercetin dosages. Following the treatment, all subjects were euthanized to collect the left common carotid artery. The stability of the atherosclerotic plaques was evaluated by measuring the expression of matrix metalloproteinase-9 (MMP-9) using real-time polymerase chain reaction, assessing the activity of M1 and M2 macrophages along with the M1/M2 ratio using an enzyme-linked immunosorbent assay, and determining the maximum intima thickness through histopathological examination.RESULTS: Quercetin significantly reduced the expression of MMP-9, increased the activity of M2 macrophages, and lowered the M1/M2 ratio at doses of 10 and 50 mg/kg. However, there was no effect on M1 macrophage activity or maximum intima thickness. Path analysis indicated that quercetin primarily enhanced atherosclerotic plaque stability by reducing MMP-9 expression (p<0.001) and subsequently enhancing M2 macrophage activity (p=0.002).CONCLUSION: Quercetin administration significantly decreased the expression of MMP-9, enhanced the activity of M2 macrophages, and lowered the M1/M2 ratio at specific doses. These findings emphasize the significance of quercetin in stabilizing atherosclerotic plaques.KEYWORDS: atherosclerotic plaque, quercetin, stability, Wistar rats
Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation Putra, Rendra Mahardhika; Dharmadjati, Budi Bakti; Pikir, Budi Susetyo; , Irma Maghfirah; Isaridha, Ilma Alfia; Arnindita, Jannatin Nisa
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: • A genetic variable has been identified as an atrial fibrillation risk factor. • Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.
Quercetin Inhibits the Progression of Atherosclerosis by Enhancing the Activity of M2 Macrophages in Wistar Rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/pfc2jx21

Abstract

Quercetin, widely acknowledged as an exceptionally potent antioxidant, is known for its diverse array of bioactive properties that confer numerous health benefits. However, the specific effect of quercetin on atherosclerosis progression remains unclear and warrants further investigation. This experimental study used Wistar rats with a post-test-only control-group design. It aimed to analyze the effect of quercetin in inhibiting the progression of atherosclerosis. Twelve adult male rats were selected and used to construct an experimental model that mimics atherosclerotic plaque formation. The model was achieved by administering a high-fat diet with a caloric value of 414 kcal per 100 grams and performing an endothelial injury procedure during the second week of the study. After six weeks, the rats were divided into two groups of six: the control group continued on the high-fat diet, while the quercetin group maintained the same diet and received 10 mg/kg of quercetin via gavage. At the end of week eight, the progression of atherosclerotic plaques was evaluated by measuring the activity of M1 and M2 macrophages, as well as the carotid artery intima-media thickness and the degree of carotid arterial stenosis. Quercetin administration significantly increased the activity of M2 macrophages (p=0.002, mean difference 10.66, 95% CI 5.90 - 15.41); in contrast, no significant effect was found on the activity of M1 macrophages (p=0.562), carotid artery intima-media thickness (p=0.407), and the degree of carotid arterial stenosis (p=0.734). This study emphasizes quercetin's role in inhibiting atherosclerosis progression by enhancing the activity of M2 macrophages. Additional studies are necessary to explore various quercetin doses involving more atherosclerosis parameters.
Co-Authors , Irma Maghfirah Andrianto Annisa Trissatharra Arnindita, Jannatin Nisa Bambang Purwanto Budi Bakti Dharmadjati Budi Utomo David Setyo Budi Dharmadjati, Budi Bakti Fita Triastuti Hendri Susilo Ilma Alfia Isaridha Imam Mahbub Zam Zami Irma Maghfirah Isaridha, Ilma Alfia Jannatin Nisa Arnindita Laurentius Andre Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Mochammad Yusuf Alsagaff Mohammad Satya Bhisma Mulyanto Mulyanto Pakpahan, Cennikon Pudji Lestari Putra, Rendra Mahardhika Rendra Mahardhika Putra Rizka Amalia Romi Ermawan, Romi Setiabudi, Narendra Arya Sinta Dwi Juniar Suryantoro, Satriyo Dwi Widjiati Widjiati, Widjiati Wungu, Citrawati Dyah Kencono Yudi Her Oktaviono, Yudi Her