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All Journal Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Heart Science Journal Indonesian Andrology and Biomedical Journal
Andrianto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine Airlangga University - RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Characteristics of Peripartum Cardiomyopathy (PPCM) pregnancy and preeclampsia in Dr Soetomo Hospital, Surabaya, Indonesia, 2014-2016 Dibya Arfianda; Budi Wicaksono; Khanisyah Erza Gumilar; Andrianto Andrianto
Majalah Obstetri dan Ginekologi Vol. 27 No. 1 (2019): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.898 KB) | DOI: 10.20473/mog.V27I12019.40-44

Abstract

Objectives: to present data on the characteristics of pregnancy with PPCM and PE. Management of patients with PPCM is almost the same as for patients with acute or chronic heart failure, which uses drug therapy. PPCM and preeclampsia (PE) are two related diseases, although not directly. Both have similar pathophysiological mechanisms.Case Report: We present 25 pregnancy cases with PPCM at Dr. Soetomo Hospital within 3 years. Data were collected from January 2014 to December 2016, consisting of 5 PPCM cases and the other 20 cases were PPCM with PE cases.Conclusion: Pregnancy with PPCM-PE has higher morbidity than PPCM only. The diagnosis of PPCM should be established immediately if heart failure symptoms are found in the third trimester and the patient has risk factors, such as age >30 years, multigravida, obesity, and multiple pregnancy.
Implikasi Klinis Gambaran Elektrokardiogram Low-voltage Andrianto Andrianto; Putri Rachmawati Dewi
Jurnal Kardiologi Indonesia Vol. 37, No. 4 Oktober - Desember 2016
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v37i4.585

Abstract

Low-voltage on the surface electrocardiogram (ECG) is classically defined as peak-to-peak QRS voltage less than 5 mm in all limb leads and less than 10 mm in all precordial leads. There are many causes of low QRS voltage (LQRSV), and they can be differentiated into those due to the deficient heart’s generated potentials (cardiac causes) and those due to the attenuating influences of the pericardial space and pericardium, or the passive body volume conductor, enveloping the heart (extracardiac causes). In some patients, LQRSV voltage may only represent a normal variant. The ECG challenge for this issue is to examine the physiological, anatomical and electrical equipment problems of low-voltage, or low-amplitude, ECG and to suggest methods for troubleshooting the low-voltage ECG to ensure reliable cardiac monitoring.
Perioperative Antithrombotic Management Andrianto Andrianto; Amelia Arindanie
Jurnal Kardiologi Indonesia Vol 38 No 3 (2017): July - September 2017
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.783

Abstract

The management of antithrombotic therapy in the perioperative setting is a common problem, balancing haemorrhagic risk with thrombotic risk. High-quality evidence is lacking regarding the optimal approach for patients on oral anticoagulants or antiplatelet agents. The two main issues that need to be considered in perioperative antithrombotic management is the patient’s risk of a thromboembolic event when therapy is interrupted and the risk of bleeding associated with the surgery or procedure. An assessment of these factors will determine the optimal perioperative anticoagulant management ap­proach. The overall objective of this review is to provide a practical approach relating to perioperative management which can be used in everyday clinical practice. Abstrak Masalah tatalaksana terapi antitrombotik perioperatif yaitu menyeimbangkan risiko perdarahan dan risiko trombosis masih sering dijumpai sehari-hari. Bukti klinis yang kuat mengenai tatalaksana yang optimal dari terapi antikoagulan atau antiplatelet masih sangat sedikit. Dua hal yang perlu dipikirkan dalam tatalaksana terapi antitrombotik perioperatif adalah risiko kejadian tromboemboli ketika terapi antitrombotik dihentikan dan risiko perdarahan akibat tindakan pembedahan yang dilakukan. Penilaian faktor-faktor tersebut akan menentukan pendekatan yang optimal dari tatalaksana antikoagulan perioperatif. Tinjauan pustaka ini bertujuan memberikan pendekatan praktis tentang tatalaksana antitrombotik perioperatif yang dapat dipakai dalam praktik klinis sehari-hari.
Gene Expression of SOX2, OCT4, and Nanog by Small Molecule Compound VC6TFZ on Peripheral Blood Mononuclear Cell Rizka Amalia; Budi Susetyo Pikir; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1759

Abstract

Peripheral blood mononuclear cells are a potential source of cells to be induced into pluripotent stem cells because the collection procedure is easy, minimally invasive, and can be stored in a frozen form. Small molecule compound VC6TFZ consisting of valproic acid (VPA), CHIR990210 (CHIR), 616452, Tranylcypromine, Farsokline, 3-deazaneplanocin (DZnep) and TTNPB has been shown to induce pluripotency in mouse fibroblasts, but this has not been proven in peripheral blood cells. This chemical reprogramming strategy has the potential to be used in producing the desired functional cell types for clinical applications. This study aims to determine whether the small molecule compound VC6TFZ can induce pluripotency of peripheral blood mononuclear cells to become induced pluripotent stem cells. Mononuclear cells were isolated from peripheral venous blood by density gradient centrifugation method. The cells are grouped into 4 groups. Group 1 was the control group, which was not exposed to the small molecule. Groups 2-4 were experimental groups exposed to different doses of the small molecule VC6TFZ. Identification of induced pluripotent stem cells was carried out by identifying colony morphology and pluripotent gene expression of Octamer-binding transcription factor-4 (OCT4), Sex-determining region Y-box 2 (SOX2), and Nanog using Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Colonies with a round shape, large, cobble stone like, and clear boundaries resembling pluripotent stem cell colonies appeared on the 9th day of the induction process. OCT4 and Nanog gene expression were significantly increased in the treatment group compared to the control.
Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome Endah Indriastuti; Yetti Hernaningsih; Yulia Nadar Indrasari; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1609

Abstract

Acute Coronary Syndrome (ACS) includes ST-Elevation Myocardial Infarction (STEMI), non-ST Elevation MyocardialInfarction (NSTEMI), and Unstable Angina (UA). Platelet plays an essential role in ACS pathogenesis. Immature PlateletFraction (IPF) and platelet indices can predict platelet activations. Platelet indices consist of platelet count, Mean PlateletVolume (MPV), Platelet Distribution Width (PDW), plateletcrit (Pct). This study aimed to analyze the differences of IPF andplatelet indices among ACS patients. This study was an observational analytical cross-sectional study conducted inDr. Soetomo Hospital during May-September 2019. The subjects consisted of 30-STEMI, 25-NSTEMI, and 24-UA patients.The EDTA-samples were measured for platelet indices and IPF using Sysmex XN-1000. The differences between IPF andplatelet indices among STEMI, NSTEMI, and UA patients were analyzed using Kruskal-Wallis and Mann-Whitney test. The IPFvalues were significantly higher in STEMI patients than NSTEMI and UA patients. The IPF values of NSTEMI patients werehigher than UA patients. The MPV, PDW, and P-LCR were significantly higher in STEMI and NSTEMI compared to UA. TheMPV, PDW, and P-LCR values of NSTEMI patients were significantly higher than UA patients. The significant differencesbetween STEMI and NSTEMI toward UA might be caused by the more severe thrombotic conditions in myocardial infarctionpatients than UA. The IPF values were significantly different among each type of ACS patients gave an opportunity using thisparameter to differentiate the ACS types. The MPV, PDW, and P-LCR were significantly higher in myocardial infarctionpatients than UA patients, which also allowed them to use those parameters to differentiate both conditions.
Poor Outcome of Right Bundle Branch Block Coexist with ST-Elevation Myocardial Infarction Arifta Devi Anggraeni; Andrianto Andrianto; Ivana Purnama Dewi; Eka Prasetya Budi Mulia; Anudya Kartika Ratri
Heart Science Journal Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2022.003.01.7

Abstract

BACKGROUND: The incidence of new-onset right bundle branch block (RBBB) coexistence with ST-elevation myocardial infarction (STEMI) has been associated with higher in-hospital mortality compared with those without RBBB.CASES: We present three cases of new-onset RBBB coexist with STEMI. Case I: a 64 years old male presented Killip I STEMI inferior-anterior with RBBB as new-onset. Rescue percutaneous coronary intervention (PCI) after failed thrombolytic was performed. New-onset atrial fibrillation (AF) with rapid ventricular response worsened his hemodynamic profile, leading to cardiogenic shock. Case II: an 80 years old male presented Killip IV late-onset anterior STEMI with new-onset RBBB. Cardiogenic shock got worsened after PCI stent. Case III: a 65 years old male presented Killip II extensive anterior STEMI with new-onset RBBB who underwent a primary PCI stent. Recurrent ventricular tachycardia (VT), worsening cardiogenic shock, and transient AV block occurred after PCI. The right bundle branch blood supply is mainly provided by a septal branch of left descending artery (LAD). Therefore, it may indicate proximal LAD occlusion and extensive infarction. Thus, catastrophic events may occur, which including acute heart failure, AV block, malignant ventricular arrhythmia, new-onset AF, and mostly cardiogenic shock, despite initiate reperfusion was performed without delay once the diagnosis is confirmed.  CONCLUSION: New RBBB suggests poor short-term prognosis due to its complication. Higher mortality is mostly linked to worsening cardiogenic shock.
Correlation Between Diabetes Mellitus and Clinical Outcome of Patients with Acute Coronary Syndrome Underwent Percutaneus Coronary Intervention Therapy in Dr Soetomo Surabaya Hospital Alanna Sari Pratikto; I Gde Rurus Suryawan; Andrianto; Purwo Sri Rejeki
Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.509 KB) | DOI: 10.20473/iabj.v1i2.31

Abstract

Introduction: Coronary heart diseases continue to be the rising cause of mortality amongst Indonesian population, alongside with the increasing number of diabetic patients. The first line management of ACS is percutaneous coronary intervention (PCI), however previous have shown that diabetic patients have worse outcomes after therapy compared to non-diabetic patients. This study aims to compare the clinical outcomes between acute coronary syndrome (ACS) patients with diabetes and those without diabetes following percutaneus coronary intervention therapy. Methods: This study used cross sectional observational approach collecting records of ACS patients that underwent percutaneous coronary intervention in RSUD Dr Soetomo Surabaya from January 2018 to December 2019. Data regarding a patient’s age, gender, diabetic status, location of lesion, revascularization status, and clinical outcome were collected. Those with missing or incomplete data were excluded from the study. A total of 55 patients were included and analyzed, Results: amongst 55 patients that underwent PCI observed, 23 were diabetic and 32 were non-diabetic. Study has shown that diabetic patients have higher mortality rate compared to those without diabetes (6 patients vs. 1 patient, p=0,072) however based on the result analysis the p value of >0,05 showed no significant relationship between patients’ diabetic status and the clinical outcome following PCI therapy. Study has also shown that diabetic patients are more likely to undergo staged PCI (56,5%), than total revascularization PCI. Conclusion: Study has found that diabetic ACS has a higher mortality rate compared to those without diabetes, however analitycal studies found no significant relationship between the two variables. Further studies should be performed with higher number of patients to accurately investigate the relationship between diabetes melitus and PCI outcomes.
Non-HDL Cholesterol and LDL Cholesterol as Main Risk Factors for Coronary Heart Disease: Meta-Analysis Ravell Hansen Untono; Jusak Nugraha; I. Gde Rurus Suryawan; Andrianto Andrianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.2006

Abstract

Coronary heart disease is a highly frequent illness in both developed and developing nations. Non-HDL cholesterol (n-HDL-c) and LDL cholesterol (LDL-c) stages are biomarkers that doctors frequently utilize to assess the risk of Coronary Heart Disease (CHD). This study was a systematic review and meta-analysis to assess the association between n-HDL-c and LDL-c as major risk factors for CHD. Cochrane, PubMed, and Science Direct searches were conducted using the keywords "LDL cholesterol," "non-HDL cholesterol," and "coronary heart disease." Any research that describes the analysis of LDL-c and n-HDL-c as key risk factors for CHD and all studies involving patients diagnosed with CHD are included in the literature. A total of seven papers were involved in the qualitative analysis (systematic review), while five studies were included in the quantitative analysis (meta-analysis). The English-language research includes two RCTs, four case-control studies, and one cohort study, with a total of 68,713 individuals. LDL-c parameters were obtained (MD = 8.45; 95 percent CI = 7.03-9.87 p=0.001) and n-HDLc (p=0.001) (MD = 35.57; 95 percent CI = 33.27-37.88). n-HDL-c may be a more significant parameter of CHD risk because it has a higher MD value.
microRNA-1 Induces Transdifferentiation of Peripheral Blood CD34+ Cells into Cardiomyocytes-like Cells Budi Susetio Pikir; Andrianto Andrianto; I Gde Rurus Suryawan; Hanestya Oky Hermawan; Dian Paramita Kartikasari; Primasitha Maharany Harsoyo
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1888

Abstract

BACKGROUND: Transdifferentiation is a method to provide cells sources for cellular cardiomyoplasty. CD34+ cells are potential cells sources because these cells can differentiate into cardiomyocytes through several mechanisms. MicroRNA (miR-1) is known to have the ability to inhibit the expression of histone deacetylase 4 (HDAC4). HDAC4 is a gene that essentially contributes in cardiomyocytes differentiation. However, the study reporting an evidence that miR-1 can induce transdifferentiation of CD34+ peripheral blood cells into mature cardiomyocytes is limited.METHODS: CD34+ cells were taken from peripheral blood and isolated using a magnetic-activated cell sorting (MACS) method in vitro. Mature mimics of miR-1 were transfected into isolated CD34+ cells and then incubated for 48 hours for quantification of HDAC4 mRNA using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). On the fifth day after miR-1 transfection, cardiomyocyte-like cells were identified based on their morphology and cardiac troponin expression using immunocytochemistry.RESULTS: Transfection of miR-1 in CD34+ isolated cells decreased HDAC4 gene expression by -0.54 fold at second day and caused a significant increase in percentage of cardiac troponin positive cells (median: 31.34; p<0.05) at fifth-day post-transfection. The efficiency of transdifferentiation was 32%. The miR-1 transfection had a significant negative relationship with HDAC4 gene expression (B=-1.000; p=0.001). HDAC4 gene expression had a negative and significant relationship with the percentage of cardiac troponin-positive cells (B=-0.701; p=0.001).CONCLUSION: This study suggests that miR-1 can induce transdifferentiation of peripheral blood CD34+ cells into cardiomyocytes-like cells by decreasing HDAC4 gene expression.KEYWORDS: transdifferentiation, microRNA-1, CD34, cardiomyocyte, HDAC4
Association Between Dietary Patterns of Salty Foods, Sweet Drinks, Fruit and Vegetables and The Prevalence of Hypertension in East Java: Multivariate Analysis of Indonesian Basic Health Surveys Data 2018 Andrianto; Mohammad Satya Bhisma; Fita Triastuti; Budi Susetyo Pikir; Annisa Trissatharra
Media Gizi Indonesia Vol. 18 No. 1 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension remains the main cause of mortality globally, including in Indonesia, with a prevalence rate of 34.1%. Various studies have reported an association between dietary patterns and the prevalence of hypertension. Therefore, further analysis is needed to determine preventive intervention strategies in each region. This study aimed to analyze the effect of dietary patterns on the prevalence of hypertension in East Java Province. The sample is the result of multistage random sampling from the census block of Basic Health Research (Riskesdas) report in the East Java Province collected from 2013 – 2018. The classical assumption test was carried out using the Kolmogorov-Smirnov method, bivariate test using the Pearson method, and multivariate test using the multiple linear regression method. There are three variables tested that have a p-value below the value of α <0.05, including eating salty foods once a day (p=0.021), drinking sweet drinks three times per month (p=0.008), and non-routine of fruits and vegetables consumption (p=0.003). Based on the r-value, the association between predictor variables and prevalence in order from the largest to the smallest of the habit of not consuming fruits and vegetables (r=-0.469), the habit of drinking sugary drinks three times per month (r=-0.425), and salty eating habits one time per day (r=-0.372). Multivariate multiple linear regression analysis showed that daily intake of salty foods (p=0.013) was associated with the prevalence of hypertension.
Co-Authors Alanna Sari Pratikto Amelia Arindanie Annisa Trissatharra Anudya Kartika Ratri Arifta Devi Anggraeni Budi Susetio Pikir Budi Susetyo Pikir Budi Wicaksono Dian Paramita Kartikasari Dibya Arfianda Eka Prasetya Budi Mulia Fita Triastuti Hanestya Oky Hermawan Hanestya Oky Hermawan Hermina Novida, Hermina Indriastuti, Endah Ivana Purnama Dewi Jusak Nugraha Khanisyah Erza Gumilar Meity Ardiana Mohammad Satya Bhisma Primasitha Maharany Harsoyo Putri Rachmawati Dewi Ravell Hansen Untono Rejeki, Purwo Sri Rizka Amalia Rurus Suryawan Shafiero Muhammad Elsya Putera Sony Wibisono Sony Wibisono Suryawan, I Gde Rurus Ula Nur Pramesti Karman Veithzal Rivai Zainal Yetti Hernaningsih Yulia Nadar Indrasari