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All Journal Indonesian Journal of Biotechnology Jurnal Skolastik Keperawatan (e-Journal) Paediatrica Indonesiana GIZI INDONESIA Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Mohammad Juffrie
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Efficacy of Fucoidan on Gastric Ulcer Mohammad Juffrie; Ina Rosalina; Wahyu Damayanti; Ali Djumhana; A. Ariani; Harjono Ahmad
Indonesian Journal of Biotechnology Vol 11, No 2 (2006)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.732 KB) | DOI: 10.22146/ijbiotech.7565

Abstract

Hyperacidity causes gastric injury, and in severe situations, ulcer could develop. The growth factors known asthe basic fibroblast growth factor (bFGF) and the epidermal growth factor (EGF) have been recognized to promoteulcer healing. Fucoidan is extracted from a brown seaweed of Okinawa called Mozuku or Cladosiphon okamuranus.Fucoidan is effective for the healing of gastric ulcers by inducing epithelial cells to produce growth factors. The aimof this study is to explore the efficacy of fucoidan in patient who suffered by gastric ulcer. A randomized control trialdouble blind was conducted to 33 eligible samples. By using four-blocks random samples were divided into fucoidanand placebo groups. 100 mg of fucoidan was given to the fucoidan group and 100 mg of glucose was given to theplacebo group. Due to ethical reasons, for both groups were given a proton pump inhibitor. There was no differencein the age category between the fucoidan group (mean: 46.23 ± 14.8 years) and the placebo group (mean: 46.18 ± 18.4years) (p: 0.28). There was also no difference in sex between the fucoidan group (female: 10/33; male 7/33) and theplacebo group (female: 7/33; male: 9/33); p: 0.38. According to the SAKITA and MIWA criterias 32 patients fulfilledA1 which indicate active severe ulcer, and 1 patient fulfilled A2 which indicate active moderate ulcer. Most of theulcers were gastric ulcer. There was a significant improvement of the grade of ulcer in fucoidan group (94%) (16/17)compared to placebo group (37.5%) (6/16,p: 0.005). There was a significant reduction of abdominal pain after 5 daysin the fucoidan group, compared to the placebo group (p: 0.04). Vomiting tends to decrease in day 6 of the fucoidangroup however its proportion is similar with that of the placebo group (p: 0.9). Fucoidan is effective for ulcer healingand reducing ulcer symptoms.Key words : fucoidan, gastric ulcer, anti-peptic activity
PENGARUH ASAP ROKOK TERHADAP KUALITAS HIDUP TOTAL PENDERITA RINITIS ALERGI PERSISTEN Roy David Sarumpaet; Mohammad Juffrie; Suprihati .; Indwiani Astuti
Jurnal Skolastik Keperawatan Vol 2 No 1 (2016): Januari-Juni
Publisher : Fakultas Ilmu Keperawatan Universitas Advent Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35974/jsk.v2i1.235

Abstract

ABSTRAK Pendahuluan: Pengaruh asap rokok pada penderita Rinitis Alergi Persisten (RAP) yang prevalensinya semakin meningkat di Indonesia belum mendapat perhatian untuk diteliti, meskipun jumlah penduduk yang merokok semakin bertambah. Tujuan: Menganalisis hubungan asap rokok “side-stream” (SS)  dengan  perubahan kualitas hidup (KH) total penderita Rinitis Alergi Persisten (RAP).  Metode: Penelitian ini adalah dengan desain kasus kontrol, dimana 63  penderita RAP  sedang-berat yang dibuktikan dengan tes alergi dibagi menjadi kelompok perlakuan (32) dan kontrol (31) secara acak. 32 penderita RAP dipaparkan dengan asap rokok (SS) dari 5 batang rokok selama 2 jam dalam  suatu  ruangan. Seluruh responden diminta mengisi kuesioner kualitas hidup dari Juniper’s RQLQ. Hasil: KH total antara kelompok perlakuan dengan kontrol tidak berbeda bermakna. KH total yang terpapar asap rokok setiap hari  berbeda bermakna. Diskusi: Asap rokok yang dipaparkan pada penderita RAP tidak menyebabkan perubahan kualitas hidup.ABSTRACT Introduction: The effect of cigarette smoke on Persistent Allergic Rhinitis patients (RAP) prevalence is increasing in Indonesia. Although the number of people who smoke is increasing yet  it has not received attention for examination. Objective: To analyze the relationship between cigarette smoking "side-stream" (SS) with the change in total quality of life (TQL) among patients with Persistent Allergic Rhinitis (PAR). Method: This study is a case-control design, in which 63 patients with moderate-severe RAP evidenced by allergy tests are divided into treatment groups (32) and control (31) randomly. RAP 32 patients were exposed to cigarette smoke (SS) from 5 cigarettes for 2 hours in a room. All respondents were asked to fill out questionnaires quality of life of Juniper's RQLQ. Results: KH total between treatment groups was not significantly different with control. KH total exposed to secondhand smoke every day significantly different. Discussion: Cigarette smoke described in patients with RAP does not lead to changes in the quality of life.
The accuracy of clinical diagnosis for dehydration according to the integrated management of childhood illness Siswanto Marudut; Yati Soenarto; Mohammad Juffrie
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.271 KB) | DOI: 10.14238/pi46.5.2006.225-8

Abstract

Background Acute diarrheal disease causes over 5 milion deathsworldwide in children under 5 years old, mostly because of failureto detect and treat dehydration properly and immediately.Objective To determine the validity of clinical diagnosis of dehy-dration according to Integrated Management of Childhood Illness(IMCI) as a diagnostic test for dehydration in children under fiveyears old.Methods A prospective observational study was done for clinicaldiagnosis in dehydration. Children aged 2 months-5 years old withdiarrhea and or vomiting who visited the primary health centers inYogyakarta were enrolled. Clinical diagnosis was made by atrained IMCI nurses. Dehydration was defined as the presence ofdecreasing consciousness, very sunken eyes, slow reaction whenoffered a drink, and decreased skin elasticity. Ninety-five per-cents confidence intervals (CI) were calculated, and the signifi-cance was assessed by X 2 .Results There were 148 children aged 2 months to 5 years oldenrolled this study. Clinical dehydration used according to IMCIproduced sensitivity of 91% (95% CI 83;98), specificity of 82%(95% CI 75;89), positive predictive value (PPV) of 70% (95% CI58;77), negative predictive value (NPV) of 94% (95% CI 90;98),positive likehood ratio of 5.17 (95% CI 3.37;7.94), and negativelikehood ratio of 0.11 (95% CI 0.04;0.27).Conclusion Clinical diagnosis for dehydration according to IMCIis sufficiently accurate as a diagnostic test for dehydration in chil-dren under 5 years old
VIROLOGICAL AND IMMUNOLOGICAL RESPONSE TO ANTIRETROVIRAL TREATMENT IN HIV-INFECTED PATIENTS (Respons Virologis dan Imunologis terhadap Pengobatan Anti-Retroviral di Pasien Terinfeksi HIV) Umi S. Intansari; Yunika Puspa Dewi; Mohammad Juffrie; Marsetyawan HNE Soesatyo; Yanri W Subronto; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1187

Abstract

Infeksi HIV/AIDS masih menjadi tantangan global. Pengobatan antiretroviral (ART) berperan dalam menurunkan replikasi virus,menurunkan tingkat kematian infeksi oportunistik dan meningkatkan kualitas hidup orang yang hidup dengan HIV/AIDS. Meskipundemikian data terkait respons virologis dan imunologis termasuk aktivasi imun masih sangat terbatas. Penelitian ini bertujuan untukmengetahui respons virologis dan imunologis pasien HIV setelah 6 bulan memulai pengobatan ARV. Subjek dari penelitian observasionalprospektif ini adalah 44 pasien HIV yang belum pernah mendapat pengobatan ARV, yang berobat di RSUP Dr. Sardjito Yogyakarta danRSUP Dr. Kariadi, Semarang. Sampel darah EDTA sebanyak 6 mL diambil pra dan pasca 6 bulan pengobatan ARV untuk pemeriksaanjumlah sel T CD4+, kadar RNA HIV dan persentase sel T CD8+/38+. Kadar RNA HIV turun secara bermakna sejalan dengan persentasesel T CD8+/38+, sementara jumlah sel T CD4+ meningkat bermakna. Sebanyak 79,5% pasien mengalami pemulihan sel T CD4 optimal(>50 sel/μL) dan kadar RNA HIV turun lebih dari 1 log10 kopi/mL pada 93% pasien. Pasien dengan respons tidak sesuai antara virologisdan imunologis didapatkan sebanyak 13,6%. Kadar HIV bernasab positif dengan persentase sel T CD8+/38+ (r=0,58, p<0,0001) danbernasab negatif dengan jumlah sel T CD4+ (r=–0,470 (p<0,0001). Berdasarkan telitian ini, sebagian besar pasien mempunyai responsvirologis dan imunonologis yang sesuai 6 bulan setelah ART. Sebanyak 20,45% pasien tidak berespons atau mengalami ketidaksesuaianrespons virologis dan imunologis dan memerlukan penilaian dan pengobatan secara terus menerus.
PENGEMBANGAN FORMULA SIRUP ZINK DARI EKSTRAK IKAN BILIH (Mystacoleucus- padangensis) SEBAGAI ALTERNATIF SUPLEMENTASI ZINK ORGANIK PADA ANAK PENDEK (STUNTED) USIA 12-36 BULAN Eva Yuniritha; Mohammad Juffrie; Djauhar Ismail; Suwijiyo Pramono
GIZI INDONESIA Vol 38, No 1 (2015): Maret 2015
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v38i1.167

Abstract

Sirup zink ekstrak ikan bilih dibuat dari formulasi sirup dengan bahan dasar ikan bilih (mystacoleucus padangensis) yang mempunyai kandungan zink 27,8 mg/100 gram, lebih tinggi dibandingkan bahan pangan lain. Pemanfaatan ekstrak ikan bilih sebagai alternatif suplementasi zink organik untuk mengatasi defisiensi zink perlu diteliti dalam upaya percepatan penanggulangan masalah anak pendek (stunted) pada anak umur 12-36 bulan. Tujuan penelitian ini adalah mengembangkan formula sirup zink dari ekstrak ikan bilih (mystacoleuseus padangensis) sebagai alternatif suplementasi zink organik pada anak pendek (stunted). Penelitian eksperimental laboratorium ini dimulai dari ekstraksi ikan bilih dengan metode yang standar dilakukan di laboratorium Biologi dan Sediaan Cair Fakultas Farmasi Universitas Gadjah Mada Yogyakarta. Ekstrak ikan bilih mengandung kadar zink yang sangat tinggi (161,97 mg/100 gram), di formulasi menjadi formula sirup suspensi, dengan sediaan utama estrak Zink Citrat, Vitamin A dan protein, ditambah sirup simplek (64%), CMC-Na, Asam Citrat, perasa buah dan pewarna. Formula sirup suplementasi zink ini memenuhi syarat International Zinc Nutrition Consultative Group (IZiNCG), dengan 3 formulasi terbaik berdasarkan uji organoleptik, yaitu formula F 4.1, F 2.2 dan F 2.3. Formula sirup zink dari ektrak ikan bilih dapat dijadikan sebagai alternatif suplementasi zink organik untuk menanggulangi defisiensi zink pada anak pendek (stunted).ABSTRACT THE DEVELOPMENT OF ZINC SYRUP FORMULA FROM BILIH FISH EXTRACT (Mystacoleucus-padangensis) AS AN ALTERNATIVE FOR ZINC ORGANIC SUPPLEMENTATION IN STUNTED CHILDREN AGED 12-36 MONTH The extract of bilih fish (mystaleuseuspadangensis) zinc syrup is made from basic ingredient of bilih fish which contains 27,8 mg zinc/100 gram syrup. It is much higher than other food zinc source. The use of the extract of bilih fish as an alternative of organic zinc supplementation can be used for those who have zinc deficiency. Therefore, it is essential to be studied as an alternative intervention program for stunting in children aged 12-36 months. This objective of this study is to develop zinc formula syrup from the extract of bilih fish (mystaleuseuspadangensis) as an organic zinc supplementation for stunted children. This laboratory experimental research is begun by extracting the fish bilih using a standard method. The extract of bilih fish is formulated in the form of suspension syrup, at the laboratory of Biology and Liquid Preparation in the Faculty of Pharmacy, Gajah Mada University in Yogyakarta. The extract of bilih fish is very high in zinc content (161, 97 mg/100 gram), with main preparation of Zinc Citrate, Vitamin A and protein, added with simplex syrup (64%), CMC-Na, Citric Acid, fruit flavor and food color subtances. This supplement syrup formula is based on International Zinc Nutrition Consultative Group (IZiNCG), with 3 best formulas based on organoleptic test, formula F 4.1, F 2.2 and F 2.3. The zinc syrup formula from extract of bilih fish could be an alternative of organic zinc supplementation to address zinc deficiency in stunted children.Keywords: extract bilih, zinc supplementation, stunting
Co-Authors A. Ariani Ali Djumhana Budi Mulyono Djauhar Ismail Harjono Ahmad Ina Rosalina Indwiani Astuti Marsetyawan HNE Soesatyo Roy David Sarumpaet Siswanto Marudut Suprihati . Suwijiyo Pramono Umi S. Intansari Wahyu Damayanti Yanri W Subronto Yati Soenarto Yundari, Yundari Yunika Puspa Dewi