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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kebidanan Jurnal Pendidikan Matematika ALIBKIN (Jurnal Bimbingan Konseling) JURNAL DERIVAT: JURNAL MATEMATIKA DAN PENDIDIKAN MATEMATIKA JURNAL PENDIDIKAN MIPA E-JURNAL JUSITI : Jurnal Sistem Informasi dan Teknologi Informasi Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Math-UMB.EDU LINEAR: Journal of Mathematics Education Indonesian Journal of Biomedicine and Clinical Sciences Kreano, Jurnal Matematika Kreatif Inovatif
Budi Mulyono
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Social Sciences Other

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High Glucose, but Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells Ikhlas Muhammad Jenie; Budi Mulyono; Soedjono Aswin; Sri Kadarsih Soejono
International Journal of Public Health Science (IJPHS) Vol 4, No 3: September 2015
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.289 KB) | DOI: 10.11591/ijphs.v4i3.4735

Abstract

Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases. Platelet hyperreactivity has been frequently found in patient with diabetes mellitus. To examine whether testosterone and high glucose modify platelet aggregation through endothelial cells, we did an in vitro study using endothelial cells culture from human umbilical vein (HUVEC). Treatments were performed in HUVEC sub culture as either normoglucose (5.6 mM) or high glucose (22.4 mM) medium, with or without testosterone (0, 1, 10, 100 nM), for 24 hours. HUVEC were trypsinized, resuspended, and then incubated with platelet rich plasma from healthy male donors with ratio 1:104 for 3 minutes. Platelet aggregation measured by turbidimetry methode. This study showed that testosterone did not significantly influence platelet aggregation through endothelial cells in normoglucose (p = 0.144) or high glucose (p = 0.916) medium. There was no main effect of testosterone (p = 0.73) as well as no interaction between testosterone and glucose (p = 0.69), but there was a main effect of glucose (p = 0.004), to platelet aggregation through endothelial cells. In conclusion, high glucose, but not testosterone, inhibits platelet aggregation mediated by endothelial cells.
Peningkatan Sikap Positif Terhadap Personal Growth Dengan Bimbingan Kelompok Teknik Role Playing Budi Mulyono; Muswardi Rosra; Moch Johan Pratama
ALIBKIN (Jurnal Bimbingan Konseling) Vol 7, No 2 (2019): ALIBKIN
Publisher : ALIBKIN (Jurnal Bimbingan Konseling)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (699.744 KB)

Abstract

The purpose of the research is to increase a  positive attitude towards psychological well-being, especially the dimension of personal growth. The method used in this study is quasi-experimental design of  untreated  design with dependent pre-test and posttest.  The research subjects used an experimental group of 10 people. The results of the statistical analysis showed that the value (Sig) was 0.000 0.05, so Ho was rejected and Ha was accepted, The conclusion is that attitudes towards personal growth can be increased using the role playing group guidance services in the experimental group.Tujuan penelitian untuk meningkatkan sikap positif  terhadap kesejahteraan psikologis khususnya dimensi personal growth. Metode yang digunakan dalam penelitian ini adalah quasi eksperimen design with dependent pre-test and posttest. Subjek penelitian menggunakan  kelompok eksperimen sebanyak 10 orang. Hasil analisis statistik menunjukan nilai (Sig) 0,000 0,05, maka Ho ditolak dan Ha diterima, Kesimpulannya adalah sikap terhadap personal growth dapat ditingkatkan menggunakan layanan bimbingan kelompok teknik role playing pada kelompok eksperimen.Kata kunci: bimbingan dan konseling, role playing, personal growth
PEMBELAJARAN MATEMATIKA POKOK BAHASAN RATA-RATA HITUNG MENGGUNAKAN PENDEKATAN PMRI DI KELAS VII Aditin Putria; Ratu Ilma Indra Putri; Budi Mulyono
Jurnal Pendidikan Matematika Vol 9, No 2 (2015)
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22342/jpm.9.2.2430.148 - 161

Abstract

Penelitian ini merupakan penelitian deskriptif yang menggambarkan hasil belajar siswa pada pembelajaran Matematika pokok bahasan rata-rata hitung menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI) di kelas VII.A SMP Negeri 1 Pangkalpinang. Proses pembelajaran, hasil belajar, dan penilaian hasil belajar yang dilakukan berpedoman pada  kurikulum 2013. Hasil dan pembahasan menunjukkan (1) keaktifan siswa dalam proses belajar 65% berkategori baik, berdasarkan observasi aktivitas siswa saat proses menunjukkan siswa mendengarkan atau memperhatikan penjelasan guru dan teman dengan aktif, menyelesaikan masalah, membandingkan jawaban atau berdiskusi dengan teman, berani mengkomunikasikan ide, serta bertanya atau menanggapi pertanyaan teman/guru;(2) hasil belajar pada ranah sikap selama proses, pengetahuan, dan keterampilan unjuk kerja dari 33 orang siswa menunjukkan ketuntasan dengan persentase 100%. Hasil belajar pada ranah sikap selama proses pembelajaran menunjukkan siswa mencapai ketuntasan untuk sikap jujur dan tanggungjawab dalam kelompok dengan predikat Baik (B). Hasil belajar keterampilan unjuk kerja dinilai menggunakan instrumen skala penilaian (rating scale). Hasil belajar 33 siswa pada ranah pengetahuan menggunakan tes formatif sebagai instrumen penilaian pengetahuan memberikan umpan balik bagi usaha perbaikan kualitas pembelajaran di kelas, didukung dengan bahan ajar yang menghasilkan tiga strategi siswa dalam menyelesaikan masalah terkait rata-rata yaitu menggunakan rumus rata-rata, leveling, dan ‘tebak dan cek’ (guess and check). Kata-kata kunci : Rata-rata hitung, PMRI, Kurikulum 2013, Hasil belajar. DOI: http://dx.doi.org/10.22342/jpm.9.2.2430.148 - 161
Perancangan dan Implementasi Aplikasi Distribusi Bantuan UMKM Kabupaten Sigi Syahrullah Syahrullah; Budi Mulyono; Hajra Rasmita
E-JURNAL JUSITI : Jurnal Sistem Informasi dan Teknologi Informasi Vol 6 No 2 (2017): e-jurnal JUSITI
Publisher : Universitas Dipa Makassar

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Abstract

Penelitian ini membahas tentang  permasalahan dalam proses verifikasi kelayakan  distribusi bantuan UMKM dari Dinas Koperasi dan UMKM Kabupaten Sigi, yang disebabkan oleh kesalahan pada saat proses pendataan dan adanya unsur subyektifitas dalam penentuan penerima dana. Selain itu masalah yang terjadi adalah pemberian bantuan yang berulang-ulang dan ada yang mendapatkan bantuan belum selesai masa pemberian bantuan selanjutnya. Hal ini akan mengakibatkan terjadinya ketidak akuratan dalam penyaluran dana bantuan ke UMKM. Tujuan penelitian ini adalah untuk merancang dan meinplemenasikan aplikasi distribuis bantuan UMKM oleh Dinas. Metod Perancangan yang digunakan dalam penelitian ini adalah Prototype. Hasil penelitian ini menemukan bahwa aplikasi dapat memberikan informasi mengenai daftar penerima bantuan UMKM di Kabupaten Sigi, dapat melakukan verifikasi penerima UMKM yang sudah pernah menerima bantuan di tahun yang sama. Berdasarkan  hasil pengujian yang telah dilakukan dapat disimpulkan bahwa aplikasi secara fungsional mengeluarkan hasil sesuai dengan yang diharapkan dan dinyatakan valid
DARAH AMAN DAN PENDONOR DARAH SUKARELA (Safe Blood and Voluntary Non-Remunerated Blood Donors) Teguh Triyono; Veronica Fridawati; Usi Sukorini; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1253

Abstract

Safe blood was collected from safe, low risk donors with a related absence of infectious disease screening as well. WHO has statedthat to guarantee its safety, blood should only be collected from voluntary non-remunerated blood donors (VNBD) coming from a lowriskpopulation. The aim of this study was to know the blood donors’ profile in Fatmawati Hospital (FH), Jakarta and Dr. SardjitoHospital (SH), Yogyakarta by comparison The research was carried out by cross sectional study and data were obtained from the donor’sinformation records 2011-2013. The data were further descriptively analyzed and presented in tables and graphs. The Student’s t-testwas used to analyze the difference of percentage mean for VNBD per-month between two hospitals with p<0.05. Based on the blooddonor types, it was shown that most of the blood donors consisted of replacement persons. The mean of monthly VNBD percentage wassignificantly higher in FH than in SH. There was an increased VNBD percentage i.e. 32, 35, 54 (FH) and 12, 18, 22 (SH) respectively,within the year 2011, 2012 and 2013.
METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS COLONIZATION AND SCREENING METHOD EFFECTIVENESS FOR PATIENTS ADMITTED TO THE INTENSIVE CARE Andaru Dahesihdewi; Budi Mulyono; Iwan Dwiprahasto; Supra Wimbarti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1149

Abstract

Methicillin-resistant S.aureus (MRSA) menyebabkan banyak infeksi nosokomial (inos) dan penyebarannya menunjukkan mutu cleancare. Kejadian inos MRSA meningkatkan angka kesakitan, kematian, lama rawat inap, kebutuhan antibiotika dan meluasnya resistensi,readmisi serta biaya kesehatan. Penapisan kolonisasi MRSA di pasien yang akan dirawat intensif diperlukan untuk mencegah penyebarandan mengendalikan peresepan antibiotika. Pemeriksaannya diharapkan tepat guna untuk mendukung Sistem Jaminan KesehatanNasional. Penelitian dilaksanakan di Ruang Rawat Intensif RSUP Dr Sardjito Yogyakarta di seluruh pasien pada tahun 2015 saat masuksesuai patokan kesertaan dan non-kesertaan. Spesimen dari nares anterior dan kulit (aksila-inguinal), diambil dalam 1x24 jam, dinilaikepositifan MRSA menggunakan beberapa media identifikasi di Instalasi Laboratorium Klinik. Perbandingan analitik dan praktikabilitasmetode identifikasi dianalisis efektivitasnya. Kejadian kolonisasi S.aureus dan MRSA di pasien saat masuk perawatan Ruang Intensif23,4% dan 9,7%. Faktor kebahayaan dominan kolonisasi MRSA adalah riwayat perawatan RS. Nares anterior dominan sebagai tempatkolonisasi S.aureus (74,2%) dan MRSA (33,7%). Terdapat 7,7% kolonisasi lolos deteksi bila sampling hanya dilakukan di nares.Kesepakatan hasil pemeriksaan antar metode baik (indeks Kappa >0,8) dengan metode yang disarankan adalah penggunaan mediaselektif MRSA langsung atau urutan metode deteksi menggunakan Blood Agar, pengecatan Gram, uji aglutinasi, media khromogenikselektif MRSA. Metode penapisan dengan tingkat deteksi dan praktikabilitas yang baik bermanfaat mendukung pengendalian infeksidi ruang berkebahayaan tinggi.
STATUS PENGGUMPALAN (AGREGASI) TROMBOSIT SEBAGAI FAKTOR PROGNOSTIK TEJADINYA KELUARAN KLINIS STROK INFARK MENDADAK (STROK INFARK AKUT) Linda Rosita; Usi Sukorini; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1021

Abstract

The propriate management of acute infarction stroke will be able to reduce the morbidity and mortality of the disease. In diagnosingand managing the diseases, for the detection of the risk or prognostic factors information’s such as the history physical findings,confirmation and other supporting tests are needed. One of the supporting test is the laboratory examination i.e. platelet aggregationtest. Platelet aggregation is suggested having an important role in haemostasis especially to prevent excessive bleeding by forming plateletplug. Finally, further hyperactivity of platelet in terms of platelet hyper aggregation can create a thrombus and moreover lead to obstructthe vessels. The occlusion will give a negative outcome of an acute infarction stroke. The aim of this study is to know whether platelethyper aggregation has a contribution in the outcome of the disease or not by certain testing. A prospective cohort study was carried out,to compare between two groups of exposed and non-exposed group in Sardjito hospital Yogyakarta during the period of March up toearly July 2007. Eighty four subjects who met the inclusion and exclusion criteria were involved in this study. The exposed group was agroup of acute infarction stroke patient who were exposed to platelet hyper aggregation 48 (57%), on the other hand, patients who didnot have platelet hyper aggregation was separated as non-exposed group is 36 (43%). Inception of cohort was applied when the patientwas admitted to the emergency unit during 72 hours of the onset, before receiving antithrombotic drugs and had no previous history ofstroke. The patients were followed after 7 days hospitalization in the stroke unit and neurology unit and the outcome was measured byevaluating the score using Gadjah Mada stroke scale. The characteristics of the subjects were grouped by baseline data X2 test. Unvariedanalysis and multivariate analysis were taken to get the relative risk of having acute infarction stroke. In this case logistic regressionanalysis was used to know the relative risk (RR) measurement. Prognostic factors had influenced the outcome of acute infarction strokein patients who had a history of cardiovascular disease and aggregation status. The outcome of the platelet hyper aggregation grouphad a RR=2.15 (95% CI: 2.01–4.07) and the history of cardiovascular disease had a RR=1.78 (95% CI: 1.18–13.28).
KESAHIHAN DIAGNOSTIK HEMOGLOBIN RETIKULOSIT UNTUK DETEKSI DEFISIENSI ZAT BESI DI KEHAMILAN (Diagnostic Validity of Reticulocyte Hemoglobin for Iron Deficiency Detection in Pregnancy) Tri Ratnaningsih; Budi Mulyono; Sutaryo Sutaryo; Iwan Dwiprahasto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1282

Abstract

Entering the second trimester of pregnancy, more iron is required due to the increase in erythrocyte mass, plasma volume andthe development of fetus as well as chorion. Iron is needed the most in the third trimester. The existing hematological iron stageparameters can only detect iron deficiency in the latest stage. The aim of this study was to know the assessment validity of Ret-Heexamination as a new parameter to diagnose iron deficiency in pregnant women with anemia, as well as a screening tool for those interm pregnancy without anemia. The research design was cross sectional. The subjects were women in term pregnancy, gathered fromPKU Muhammadiyah Hospital, Bantul Yogyakarta from May to November 2013. A seven (7) mL blood sample was taken from thecubital vein of the subjects. Two mL of the sample was tested for routine hematological examination using an EDTA tube, while theRet-He was assessed using an automatic hematological instrument Sysmex XT-2000-i (Symex Corporation, Kobe, Japan). The serumof the remaining five (5) mL was used to check the serum iron and TIBC to obtain the saturation value (Tsat) using Cobas analyzerC501 (Roche Diagnostics, Germany), while the serum ferritin (SF) was examined using Minividas. The subjects were classified into two(2) groups based on the Hb levels, namely: anemia (Hb<11 g/dL) and those who did not (Hb≥11 g/dL). Furthermore, they were alsoclassified into two (2) groups based on transferrin saturation values: iron deficient (Tsat <9%) and normal (Tsat ≥9%). From 291subjects, 59 (20.3%) were found to have anemia and 232 (79.7%) did not. The cut off value of Ret-He to diagnose iron deficiency inpregnant women with anemia was 29.8 pg (82% sensitivity and 72% specificity). Meanwhile, the cut-off value of Ret-He for irondeficiency screening in pregnant women without anemia was 29.8 pg, with a sensitivity and specificity of 92% and 87% respectively.The Ret-He holds a good diagnostic validity to detect iron deficiency in pregnancy, with or without anemia.
KENASABAN FIBRINOGEN PLASMA DENGAN PENEBALAN ARTERI INTIMA-MEDIA KAROTIS KOMUNIS DI DIABETES MELITUS (Correlation Plasma Fibrinogen With Intima-Media Thickness of Carotid Artery in Diabetes Mellitus) Dwi Aryani; Budi Mulyono; Osman Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1250

Abstract

Diabetes mellitus is a global problem due to the increase of its prevalence, morbidity and mortality. Diabetes mellitus has chroniccomplications such as : micro vascular and macro vascular. The macro vascular complications reveal as atherosclerosis. The increase ofcarotid communist IMT was examined by using USG, which has become the standard for assessing atherosclerosis and recommended by theAmerican Heart Association. Fibrinogen levels have a role in atherosclerosis. This study was design cross-sectionals to know the associationbetween plasma fibrinogen with carotid communist IMT in patients with DM by special examination. The subjects were patients with DMcoming to Dr DR. Sardjito Yogyakarta and fulfil the inclusion as well as the exclusion criteria. The examination of fibrinogen was carried out by Claus’s method. The result showed positive correlation between plasma fibrinogen with carotid communist IMT in type 2 diabetes mellitus, r = 0.36 and p = 0.021. There is also positive correlation between age and carotid IMT with r = 0.314 and p = 0.048.
KORELASI ANTARA NEURON-SPECIFIC ENOLASE SERUM DAN GLASGOW COMA SCALE DI PASIEN CEDERA KEPALA Usi Sukorini; Isti Setijorini Wulandari; Budi Mulyono; Handoyo Pramusinto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1043

Abstract

The outcome after head injury is mostly determined by Glasgow Coma Scale (GCS) and the degree of brain damage which reveals.CT scan is also important to assess its severity. However relatively it is not in a less costly manner and sometimes patients mobilisationare needed. Brain damage due to traumatic head injury refers to homeostasis unbalance, and it is the important causes of releasingbiochemical analyte from neuron via injured blood brain barrier to circulation. Neuron-specific enolase as a glycolytic enzyme in neuroncytoplasm might increase. Hopefully, measurement of NSE levels can provide information about the extent of the disease. The objectiveof the study is to test the correlation between the Neuron Specific Enolase (NSE) serum as a one of biochemical marker of brain injuryand the GCS. For this purpose, a cross sectional, analytical observasional study was carried out at the Emergency Departement andDepartement of Clinical Laboratory, Sardjito General Hospital, Yogyakarta, Indonesia. Fifty-one patients selected by an eligible criteriawere included in the study, which consist of severe, moderate and mild head injury. Blood samples were collected and serum NSE wasmeasured by immunoanalyzer using Electro Cheluminescence ImmunoAssay (ECLIA). Chi square test was used to test the differenceproportion of the group: NSE ≥ 21.7 ng/mL and NSE < 21.7 ng/mL according to measured variables, and Spearman correlation testwas used to correlate serum NSE and GCS, and other variables. In the study fifty-one patients with head injury were included, 74.5%of patients were males and 68.6% is in the age of 15–45 years old. The patients were further divided into two groups on the basis ofserum NSE ≥ 21.7 ng/mL and < 21.7 ng/mL; the former group was dominated by severe head injury patients (54.1%). In addition, aproportion of non survivors (66.6%) in group NSE ≥ 21.7 ng/mL was higher compared to those in NSE < 21.7 ng/mL group. Moreover,a large number of mild head injury (95.45%) and survivors (83.33%) had lower serum NSE (< 21.7 ng/mL). In the study, was found anegative correlation between serum NSE and GCS (r = -0.552; p = 0.00). Also, serum NSE were inversely correlated with blood kaliumand hemoglobin (r = -0.162; p = 0.027 dan r = -0.376; p = 0.009), in contrast with leucocytes count (r = 0.485; p = 0.001). Theconclusion so far there was a negative correlation between serum NSE and GCS. It is suggested that neuron-specific enolase can be veryuseful as a biochemical marker in assesssing the severity of head injury. Therefore, it is nessessary to carry out the prognostic study toknow to what extent it can predicting the outcomes.
Co-Authors Adika Zhulhi Arjana Aditin Putria Andaru Dahesihdewi Anita Desiani Chyrza Adhea Salsabila Durotun Afifah Dwi Aryani Echa Alda Melinia Efryanty Eftia Putri Anggriani Elsa Susanti Erina Ika Fadilla Hajra Rasmita Handoyo Pramusinto Hapizah Ifa Sari Ikhlas Muhammad Jenie Isti Setijorini Wulandari Iwan Dwiprahasto Izza Della Nur Rizki Linda Rosita Mareta Wulan Permatasari Marsetyawan HNE Soesatyo Meryansumayeka Meryansumayeka Moch Johan Pratama Mohammad Juffrie Muswardi Rosra Naila Az-zahra Ninik Pujiati Osman Sianipar Putri Aisyah Rafika Sari Ratu Ilma Indra Putri Siti Istiana Siti Nayla Fanisha Soedjono Aswin Somakim, Somakim Sri Kadarsih Soejono Supomo Supra Wimbarti Supratik Sutaryo Sutaryo Syahrullah Tandean Tommy Novenanto Teguh Triyono Tri Ratnaningsih Umi S. Intansari Usi Sukorini Veronica Fridawati Wening Andarsari Widya Asmara Yanri W Subronto Yeni Yowandari Yunika Puspa Dewi Zulkardi