Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Biotechnology BERITA BIOLOGI Proceedings of the International Conference on Applied Science and Health Jurnal Dunia Kesmas BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA)
Nastiti Wijayanti
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
The Immunomodulatory Activity of Leaves Extract of Gaharu Gyrinops versteegii (Gilg.) Domke on Macrophage Cell of Mice (Mus musculus L.) in vitro Assyafiya Salwa; Tri Rini Nuringtyas; Lisna Hidayati; Nastiti Wijayanti
BERITA BIOLOGI Vol 21, No 2 (2022): Berita Biologi
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v21i2.4136

Abstract

The immune response is divided into innate immune response and adaptive immune response. Macrophages are one of the immunity cells that work both in innate and adaptive immune response. The activities of secondary metabolites present in agarwood-producing plants allow the potential for natural immunomodulators so that the purpose of this study was to determine the potential G. versteegii extract leaves as immunomodulator and to examine the effect of G. versteegii leaves extract toward macrophage cells of mice (Mus musculus L.). The steps to be carried out in this study were the preparation of G. versteegii leaves extract with multi-level extraction, collection of M. musculus, cytotoxicity test with MTT assay, phagocytosis activity test of macrophages calculated by light microscopy (400X), and Griess assay for NO production of macrophages. The cytotoxicity test resulted an IC50 value of G. versteegii leaves extract was 183.45 µg/mL and the Imboost® as comparison solution is 20.12 µg/mL. This value used to determine the concentration of extract for phagocytosis activity test and NO production of macrophages test. The results showed that G. versteegii leaves extract has the potential as an immunomodulator and extract with 20 µg/mL concentration has the highest effect on phagocytosis activity and NO production. 
Co-Authors Abdul Rahman Siregar Abrory Agus Cahya Pramana Aditya Nur Subchan Andi Mahendra Arif Luthfi Nurul Huda Aris Haryanto Assyafiya Salwa Dyah Widiastuti Eka Ramadhani Fajar Priyambada Gian Aditya Pertiwi Hendy Eka Putra Hera Nirwati Ibnu Agus Ariyanto Lisna Hidayati Mei Ria Santi Michael Kann Nenny Sri Mulyani Ni Wayan Erly Sintya Dewi Nur Rofika Ayu Shinta Amalia Nurhaida Widiani Purnomo Hadi Raden Aditya Aryandi Setiawibawa S. Sutaryo Sitti Rahmah Umniyati Titis Widowati Tri Rini Nuringtyas Tri Wibawa Yundari, Yundari