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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Media Penelitian dan Pengembangan Kesehatan ASPIRATOR Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Ilmu Ternak Veteriner Majalah Kedokteran The Indonesian Biomedical Journal Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Media Ilmu Kesehatan Majalah Kedokteran Andalas jurnal Teknik Industri - Unisi Riset Informasi Kesehatan Jurnal Kedokteran Meditek Jurnal Intelek Dan Cendikiawan Nusantara Indonesian Journal of Biomedicine and Clinical Sciences
Heri Wibowo
Department Of Parasitology, Faculty Of Medicine, Universitas Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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The effect of dadih in BALB/c mice on pro-inflammatory and anti-inflammatory cytokine productions Ria Kodariah; Hadits Lissentiya Armal; Heri Wibowo; Andi Yasmon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.193 KB) | DOI: 10.19106/JMedSci005104201902

Abstract

The normal microflora formed as commensal bacteria have roles in maintaining homeostasis in the intestine tract. The reduction in the amount and on the diversity of the commensal bacteria lead to gastrointestinal dysbiosis which increase number of pathogens, induce inflammatory and can drive to colorectal cancer. Probiotics can be used to prevent, regulate, and modulate immune response by triggering the development of pathogen-specific memory. Currently, many foreign probiotic products are available in the market that cause the domestic products are less well known. Dadih is an original probiotic’s products originally from West Sumatra, Indonesia. It is made from fermented buffalo milk containing lactic acid bacteria (LAB). The objective of the study was to investigate the effect of dadih pro-inflammatory and anti-inflammatory cytokine production. The study was conducted using male BALB/c mice aged 6-8 weeks with body weight (BW) 20-30 g. Mice were given dadih at doses of 112 mg/20g BW for eight weeks. The results indicated that LAB bacteria in dadih are coccus, Gram-positive bacteria with 3x107 colony-forming units (CFU) and dominated by Lactococcus lactis subsp. lactis. In addition, the increase of both the anti-inflammatory cytokines (IL-10) and pro-inflammatory cytokines (TNF-α and IL-1β) was observed. In conclusion, the dadih can be used to maintain the immune system of mice.
Vitamin D suppresses inflammatory responses in insulin resistance Rona Kartika; Heri Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.01 KB) | DOI: 10.19106/JMedSci005202202009

Abstract

 Vitamin D has been known as a vitamin for bone health and mineral homeostasis. However, since the discovery of vitamin D receptor (VDR) in various types of cell, that statement has changed. Immune cells are known to express VDR and enzyme 1α-hydroxylase that could convert vitamin D into its active form, 1.25 dihydroxyvitamin D. In immune cells, vitamin D works as an immunomodulator which affects various levels of immune response. The net effects of vitamin D are increasing mucosal immunity, but dampening the adaptive immune system. Vitamin D deficiency is commonly found in people with diabetes mellitus (DM) and obesity. It is also associated with increased insulin resistance and poor glucose control. This review will explain how vitamin D as immunomodulator dampens insulin resistance. In immune cells from subjects with insulin resistance, administration of vitamin D could reduce the expression of pro-inflammatory cytokines through the NF-κB and MAPK pathways, thus the levels of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6 are decreased. The same thing happens in preadipocytes and mature adipocytes cells. In these cells, vitamin D suppresses the expression of pro-inflammatory mediators such as IL-6 and MCP-1. Although in the invitro studies, the administration of vitamin D showed a promising effect in modulating the immune system, the clinical effect of vitamin D supplementation in reducing insulin resistance in individuals with type 2 DM (T2DM) and prediabetes is still inconclusive 
Co-Authors Agus Aulung Agus Aulung Alida Rosita Harahap Ambar Hardjanti Ananta Putri Oktafianti Andi Yasmon Anis Shafa Anna Rozaliyani Annisa Mulia Anasis April Hari Wardhana Arleni Bustami Armedy Ronny Hasugian Ceisar Pawenang Aji Cicilia Febriani Hayuningrum Cityta Putri Kwarta Din Syafruddin Dini Aulia Cahya Dyah Haryuningtyas Sawitri Elita Donanti Emiliana Tjitra Endang Pratiwi Eti Herani Hanny Siti Nuraeni Helena Ullyartha Pangaribuan Hendri Astuty Ibnu Agus Ariyanto Inge Sutanto Iris Rengganis Irma Safitri Ismail E Prayitno Isna Indrawati Kustina, Amelia Maya Ulfah Melani Anggraini Monica Puspa Sari Muammar Khadaffi Muammar Khaddafi Muhammad I. Kahtan Muharam Natadisastra Nadar Sukri Ndaru Andri Damayanti Ni Ken Ritchie Ni Ken Ritchie Nora Harminarti Nurhadi Eko Firmansyah Oky Satiagraha Patra Patiah Perdana Heriyoko Puji Budi Setia Asih, Puji Budi Puspita Eka Wuyung Rayyan Firdaus Ria Kodariah Ria Syafitri Evi G Rizal Subahar Rizal Subahar Rona Kartika Rona Kartika Sari, Monica Puspa Sheila Nurrahmah Siti Aqila Zahra Nst Suradi Suradi Suriyani Tan Sylvia Sance Marantina Talitha Vania Salsabella Taniawati Supali Taniawati Supali Taniawati Supali Taniawati Supali Utami, Diah Dwi Viya Aurelia Salsabila Wahyu Pangestuti Lestari Widiastuti Widiastuti Yolazenia Yolazenia Yordan Khaedir Zulhasril Zulhasril