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All Journal Folia Medica Indonesiana Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Aisyah : Jurnal Ilmu Kesehatan Narra J AKSONA Neurona Trends in Infection and Global Health
Paulus Sugianto
Departemen Neurologi FK Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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PENGUKURAN TINGKAH LAKU PADA MODEL NYERI NEUROPATIK PERIFER: TIKUS DENGAN CCI (CHRONIC CONSTRICTION INJURY) Hanik Badriyah Hidayati; Paulus Sugianto; Junaidi Khotib; Chrismawan Ardianto; Kuntoro Kuntoro; Mohammad Hasan Machfoed
NEURONA Vol 35 No 3 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i3.15

Abstract

BEHAVIORAL ASSESMENT OF THE PERIPHERAL NEUROPATHIC PAIN MODEL: RAT WITH CCI (CHRONIC CONSTRICTION INJURY)ABSTRACTNeuropathic pain occurs in 20% of patients with chronic pain. This mainly due to the lack of effective treatment and the presence of drug’s side effects. Animal models have been broadly utilized in validating the therapeutic target and the development of analgesic drugs. Chronic constriction injury (CCI) is a model of peripheral neuropathic pain characterized by allodynia and hyperalgesia. Chronic constriction injury model is produced by loose ligation of the sciatic nerve resulting in nerve damage, thus sensitizes and lowers pain threshold. The pain threshold test is performed by providing a pressure and thermal sensory stimulus that results in observable withdrawal behavior. This article discusses several methods in assessing pain-related behavior on the CCI neuropathic pain model.Keywords: Behavioral, chronic constriction injury, mechanical, neuropathic painABSTRAKNyeri neuropatik terjadi pada seperlima pasien dengan nyeri kronik. Hal ini disebabkan karena terapi nyeri neuropatik masih kurang efektif dan adanya efek samping obat. Model hewan terbukti bermanfaat untuk validasi target dan perkembangan obat analgesik. Chronic constriction injury (CCI) merupakan model nyeri neuropatik perifer dengan karakteristik alodinia dan hiperalgesia. Model CCI dibuat dengan memberikan ligasi longgar pada saraf skiatik yang menyebabkan kerusakan saraf, sehingga terjadi sensitisasi dan ambang nyeri menurun. Tes ambang nyeri dilakukan dengan memberikan stimulus sensorik berupa tekanan dan panas yang akan menghasilkan tingkah laku withdrawal yang bisa diobservasi. Artikel ini membahas penilaian tingkah laku nyeri pada model nyeri neuropatik CCI.Kata kunci: Chronic constriction injury, mekanik, nyeri neuropatik, tingkah laku
HUBUNGAN FAKTOR SOSIODEMOGRAFI TERHADAP SKOR QUALITY OF LIFE IN EPILEPSY INVENTORY-10 PASIEN EPILEPSI DEWASA DI RSUD DR. SOETOMO Dwiastri Iris Sarwastuti; Paulus Sugianto; Hanik Badriyah Hidayati; Azimatul Karimah
NEURONA Vol 38 No 3 (2021)
Publisher : PERDOSNI

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Abstract

Introduction: Several socio-demographic factors, such as age, sex, marital status, level of education, and employment status can determine adult epilepsy patients’ quality of life, which Quality of Life quantitively presents in Epilepsy Inventory-10 (QOLIE-10) score. Aim: This study was to understand the correlation between age, sex, marital status, level of education, and employment status on adult epilepsy patients’ QOLIE-10 score at Soetomo General Hospital. Methods: Analytical observational study using accidental sampling of adult epilepsy patients at Soetomo General Hospital in June 2019-December 2019 was implemented. Several socio-demographic factors were obtained, including age, sex, marital status, level of education, employment status, and their QOLIE-10 score calculation. Correlation analysis against the QOLIE-10 score was carried out, including the Spearman test for socio-demographic factors of age and level of education; and the Mann-Whitney test for socio-demographic factors of gender and marital status, and employment status. Results: Obtained a total of 47 samples with the most common characteristics such as aged 18-25 years (29.8%), male (53.2%), married (57.4%), had the last educational level in senior high school (68.1%), and unemployed (68.1%). Correlation analysis showed an insignificant relationship between age, sex, marital status, recent education, and employment status on the QOLIE-10 score of adult epilepsy patients (p≥0.05). Discussion: Age, sex, marital status, recent education, and employment status did not show a significant relationship to the QOLIE-10 score of adult epilepsy patients. Keywords: epilepsy, QOLIE-10
MANAJEMEN NON-OPERATIF ABSES SEREBELLUM Putri Irsalina; Paulus Sugianto
NEURONA Vol 38 No 3 (2021)
Publisher : PERDOSNI

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Abstract

A brain abscess is a severe infection that needs to be treated early. The increased mortality for brain abscesses is caused by modern diagnostic imaging and antibiotics that can penetrate into the central nervous system and abscesses. A cerebellar abscess was reported, with the chief complaint of chronic progressive headache. Head contrast magnetic resonance imaging (MRI) results show the presence of a right cerebellar abscess with a source of infection with otitis media and mastoiditis. Prover antibiotics and contrast head MRI evaluation show resolution of abscess diameter. Keywords: Cerebral abscess, cerebellar abscess, otitis media
Coinciding SARS-CoV-2 infection in HIV patients with cerebral toxoplasma Dika Chandra Bintari; Paulus Sugianto
Trends in Infection and Global Health Vol 1, No 2 (2021): December 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i2.23478

Abstract

A massive and notorious impact of coronavirus disease 2019 (COVID-19) pandemic has affected communities worldwide, urging extra preventive measure, especially for individuals with comorbidities including those who are suffering from human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). We reported a case of a 45-year-old man with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HIV infection as well as toxoplasmosis. The patient presented to the hospital with decreased consciousness and stiffness on both hands and feet accompanied with loss of appetite, fever, and coughing. Since 2014, he had been diagnosed with HIV and undergone combined antiretroviral therapies. Toxoplasmosis was revealed by multislice computed tomography (MSCT) showing multiple rim-like lesion in cortex-subcortex of left temporal lobe along with surrounding perifocal oedema. Furthermore, the finding was corroborated by the contrasted image exhibiting rim enhancement patterns. The patient was also RT-PCR confirmed Covid-19. Following examinations, the patient received pyrimethamine with a loading dose of 200 mg. The management was continued with oral intake of pyrimethamine, clindamycin, folic acid, and vitamin B6 for maintenance dose. This case report suggests that HIV patient suffering from COVID-19 can be treated with antiretroviral therapies since the specific antivirus for SARS-CoV-2 has not yet available. We believe that this case report could contribute to more understanding on the development of clinical management for COVID-19 in HIV-positive patients.
Correlation between Blood and Cerebrospinal Fluid (CSF) Neutrophil-Lymphocyte Ratio With Bacterial Meningitis Prognosis Patient Paulus Sugianto; Abdulloh Machin; Devi Ariani Sudibyo; Muhammad Hamdan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.743 KB) | DOI: 10.30604/jika.v8i2.1993

Abstract

Bacterial Meningitis is a bacterial infection of the central nervous system’s protective membranes called the meninges. Bacterial Meningitis has a high disability and case fatality rate. This inflammatory process not only manifests in CSF but also systemically. The neutrophil-lymphocyte ratio(NLR) can be a predicting factor of severity and prognosis in systemic inflammation. Only a few studies in Indonesia evaluate the neutrophil-lymphocyte ratio as a predictor of mortality in adult bacterial meningitis. This study also aimed to compare neutrophil-lymphocyte ratio in LCS and systemic as a predictor of mortality in patients with adult bacterial meningitis. This is an analytic cross-sectional study in Dr. Soetomo's general hospital—a total sample of 44 bacterial meningitis patients from the inpatient ward of Dr. Soetomo General Hospital Surabaya. The blood Neutrophil- Lymphocyte ratio, Glasgow Coma Scale upon admission, and  Absolute lymphocyte count were significant with bacterial meningitis outcome with p-value less than 0.05. Early detection of bacterial meningitis patient prognosis could alert the healthcare provider to give careful monitoring and aggressive treatment. Abstrak: Meningitis bacterial adalah inflamasi akibat bakteri di selaput otak dan sumsum tulang belakang bernama meningen. Meningitis merupakan penyakit dengan angka kematian dan angka kecacatan yang cukup tinggi walaupun sudah memberikan pengobatan yang tepat. Proses inflamasi ini terjadi tidak hanya pada system saraf pusat namun juga terjadi di seluruh tubuh. Rasio neutrophil-limfosit pada darah selama ini dapat menjadi tanda derajat keparahan dan prognosis pada kasus inflamasi sistemik. Hanya beberapa penelitian yang mencari tentang hubungan rasio limfosit dan neutrophil pada cairan serebrospinal apakah dapat menunjukan derajat keparahan pada infeksi meningitis bakteri. Dalam penelitian ini juga ingin mencari rasio limfosit dan neutrophil darah apakah selaras dengan rasio di dalam cairan serebro spinalis. Penelitian ini merupakan studi reptrospektif kroseksional analitik. Total sampel dari populasi ini adalah 44 yang memenuhi kriteria inklusi dan ekslusi. Secara Statistik didapatkan rasio neutrophil-limfosit darah, tingkat Glassgow Coma Scale saat masuk, dan nilai limfosit absolut signifikan dalam menentukan prognosis pasien dengan meningitis bakteri dewasa (P kurang dari 0.05 ).
Co-Authors Agustinus Ruma Chrismawan Ardianto Deby Wahyuning Hadi Devi Ariani Sudibyo Dika Chandra Bintari Dwiastri Iris Sarwastuti Edfina Rahmarini Fatih Nugraha Abdillah Fidiana Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Imas R. Palupi Isnin Anang Marhana Junaidi Khotib Karimah, Azimatul Kuntoro Kuntoro Lu Jordy Luhur Machin, Abdulloh Mayori Rachmawati Mohammad Hasan Machfoed Muhammad Hamdan Muhammad Ikbal Priya Nugraha Putri Irsalina Rachmi Kurniawati Rio Tasti Surpa Tamara Audrey Kadarusman Wardhani, Indrayuni Lukitra Wendy Amelia Sihombing