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All Journal Jurnal Berkala Epidemiologi Health Notions Jurnal Aisyah : Jurnal Ilmu Kesehatan AKSONA Neurona Jurnal Widya Medika
Sudibyo, Devi Ariani
Department Of Neurology, Faculty Of Medicine, Universitas Airlangga Dr. Soetomo General Academic Hospital, Surabaya
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Profile of Pharmacological Treatment in Trigeminal Neuralgia Patients in The Period of January 2018-December 2018 Marlon Yutimma Roestam Moenaf; Maftuchah Rochmanti; Devi Ariani Sudibyo
Health Notions Vol 4, No 9 (2020): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn40905

Abstract

Trigeminal neuralgia is a condition that affects the trigeminal nerve, that manifests in a series of stabbing like pain, and often described like electricity. Its treatment guideline is to prioritize pharmacotherapy until patient is well. The gold standard treatment for trigeminal neuralgia is pharmacotherapy of Carbamazepine. However, carbamazepine is proven to cause allergic reaction to some patients. This research aims to describe the pharmacotherapy that is given to patients. The regiments of pharmacotherapy in trigeminal neuralgia shows that CBZ is the main pharmacotherapy given, as it is the gold standard treatment. GBP is the is the second most pharmacotherapy given and a concoction medication of Paracetamol, Diazepam and Amitriptyline being the third most favored therapy. Neurotropic B Vitamins plays a big role, as a support in the therapy to maintain the health of the overall nervous system. The pain scale data shows that almost all patients have significant pain relieve. The therapy of trigeminal neuralgia in this study shows that CBZ is most favored as it is the gold standard, however not all AEDs are accessible. Almost all patients have significant pain relieve eventhough not using gold standard treatment. Keywords: trigeminal neuralgia; pharmacotherapy
Injeksi Cairan Dekstrosa Hipertonik (Proloterapi) pada Osteoarthritis Lutut Kronis Muhammad Reza Fathoni; Devi Ariani Sudibyo
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.762 KB) | DOI: 10.20473/aksona.v1i2.143

Abstract

Pendahuluan: Proloterapi juga dikenal sebagai terapi injeksi regeneratif atau skleroterapi adalah terapi yang menggunakan zat kimia atau biologi untuk kondisi nyeri muskuloskeletal kronis, termasuk osteoartritis lutut. Osteoartritis(OA) lutut adalah bentuk paling umum dari osteoarthritis kronis di seluruh dunia serta merupakan penyebab utama nyeri dan kecacatan dalam beberapa tahun terakhir, hasilbeberapa uji klinis yang dipublikasikan telah menunjukkan efek positif proloterapi pada osteoartritis lutut. Kasus: Wanita,51 tahun dengan nyeri lutut kanan sejak 1 tahun lalu, semakin memberat dalam 3 bulan. Numeric Rating Scale (NRS) adalah 7. Didapatkan tenderness, krepitasi, dan range of movement (ROM) normal tanpa adanya deformitaslutut kanan. Dari pemeriksaan radiologis didapatkan osteoarthritis femorotibial joint grade 1 dan osteoarthritis femoropatellar joint kanan. Injeksi dekstrosa hipertonik 25% dilakukan setiap 2 minggu. Sebelumnya pasien mendapat injeksi steroid intraartikuler (triamsinolon) namun nyeri kembali muncul setelah tiga minggu. Nilai Numeric Rating Scale (NRS) menurun menjadi 4 setelah dilakukan injeksi dekstrosa hipertonik yang keempat. Kesimpulan: Injeksi dekstrosa hipertonik (proloterapi) dapat dijadikan sebagai modalitas terapi alternatif yang menghasilkan perubahan klinis pada osteoarthritis lutut dengan resiko minimal, biaya terjangkau dan penggunaan yang mudah.  
Azathioptrine in Refractory Tolosa-Hunt Syndrome: Two Case Report Devi Ariani Sudibyo; Mohammad Saiful Ardhi
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.809 KB) | DOI: 10.20473/aksona.v2i1.186

Abstract

Introduction: Tolosa-Hunt syndrome (THS) is an inflammatory disease with painful ophthalmoplegia and unilateral periorbital headache as detailed by the International Classification of Headache Disorders, 3rd edition (ICHD-3). Azathioprine has been suggested as a second-line treatment in refractory THS when oral corticosteroid only gives a partial response. Case: Two cases of THS, 45-year-old and 41-year-old women with unilateral headache, drooping of the left upper eyelid, and diplopia. They presented with complete ophthalmoplegia and ophthalmic division of trigeminal nerve disturbance. Magnetic resonance imaging (MRI) showed thickening of the left cavernous sinus, suggesting THS, while the other was normal. Corticosteroid (prednisone 1-1,5 mg/day) was given orally for the first two weeks, and according to the Numeric Pain Rating Scale (NPRS), pain intensity was reduced from severe to moderate. As a second-line treatment, azathioprine (2 mg/kg/day) was given afterward, with a significant reduction in pain intensity and remission of ophthalmoplegia within seven days. Azathioprine was used as an immunosuppressive agent and was continued for another three months without any deterioration in neurological deficits. The levels of complement 3, 4 (C3, C4), and C-reactive protein (CRP) were normal in both patients, with a slight increase in erythrocyte sedimentation rate (ESR) and equivocal values on antinuclear antibody (ANA) results. Other differentials of THS were eliminated from history-taking, physical examination, and proper investigations. Conclusion: Azathioprine as a second-line treatment can be used instead of an oral corticosteroid for refractory cases of THS with fewer side effects. Complete remission of ophthalmoplegia and a significant reduction in pain intensity was obtained.
MIGRAIN RETINAL Devi Ariani Sudibyo; Isti Suharjanti; Imas Resa Palupi
NEURONA Vol 38 No 4 (2021)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Retinal migraine can affect serious complications in patients through persistent visual disturbances. It has been described as repeated monocular visual disturbances, including scintillations, scotoma, or blindness, accompanied by migraine headaches. Few journals and case reports discuss retinal migraine. We report a 23-year-old female presented with recurrent left headaches, which were preceded by visual disturbances in the form of scotoma, blurred vision and dark vision. Visual disturbances occurred in the left eye, lasting 5 to 15 minutes before headache. According to the 3rd edition of the International Classification of Headache Disorder (ICHD-3), the patient met the diagnostic criteria for retinal migraine. Flunarizine 10mg as a retinal migraine prophylactic medication gave good results. Keywords: flunarizine, headache, migraine, retinal, visual aura.
Correlation between Blood and Cerebrospinal Fluid (CSF) Neutrophil-Lymphocyte Ratio With Bacterial Meningitis Prognosis Patient Paulus Sugianto; Abdulloh Machin; Devi Ariani Sudibyo; Muhammad Hamdan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.743 KB) | DOI: 10.30604/jika.v8i2.1993

Abstract

Bacterial Meningitis is a bacterial infection of the central nervous system’s protective membranes called the meninges. Bacterial Meningitis has a high disability and case fatality rate. This inflammatory process not only manifests in CSF but also systemically. The neutrophil-lymphocyte ratio(NLR) can be a predicting factor of severity and prognosis in systemic inflammation. Only a few studies in Indonesia evaluate the neutrophil-lymphocyte ratio as a predictor of mortality in adult bacterial meningitis. This study also aimed to compare neutrophil-lymphocyte ratio in LCS and systemic as a predictor of mortality in patients with adult bacterial meningitis. This is an analytic cross-sectional study in Dr. Soetomo's general hospital—a total sample of 44 bacterial meningitis patients from the inpatient ward of Dr. Soetomo General Hospital Surabaya. The blood Neutrophil- Lymphocyte ratio, Glasgow Coma Scale upon admission, and  Absolute lymphocyte count were significant with bacterial meningitis outcome with p-value less than 0.05. Early detection of bacterial meningitis patient prognosis could alert the healthcare provider to give careful monitoring and aggressive treatment. Abstrak: Meningitis bacterial adalah inflamasi akibat bakteri di selaput otak dan sumsum tulang belakang bernama meningen. Meningitis merupakan penyakit dengan angka kematian dan angka kecacatan yang cukup tinggi walaupun sudah memberikan pengobatan yang tepat. Proses inflamasi ini terjadi tidak hanya pada system saraf pusat namun juga terjadi di seluruh tubuh. Rasio neutrophil-limfosit pada darah selama ini dapat menjadi tanda derajat keparahan dan prognosis pada kasus inflamasi sistemik. Hanya beberapa penelitian yang mencari tentang hubungan rasio limfosit dan neutrophil pada cairan serebrospinal apakah dapat menunjukan derajat keparahan pada infeksi meningitis bakteri. Dalam penelitian ini juga ingin mencari rasio limfosit dan neutrophil darah apakah selaras dengan rasio di dalam cairan serebro spinalis. Penelitian ini merupakan studi reptrospektif kroseksional analitik. Total sampel dari populasi ini adalah 44 yang memenuhi kriteria inklusi dan ekslusi. Secara Statistik didapatkan rasio neutrophil-limfosit darah, tingkat Glassgow Coma Scale saat masuk, dan nilai limfosit absolut signifikan dalam menentukan prognosis pasien dengan meningitis bakteri dewasa (P kurang dari 0.05 ).
Pain Type and Quality of Life in Cervicogenic Headache Patients Sudibyo, Devi Ariani; Fathoni, M Reza; Puti, Nazla Ananda Rachmi
AKSONA Vol. 5 No. 1 (2025): JANUARY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i1.52075

Abstract

Highlight: Cervicogenic headache is the most incapacitating type, leading to significant physical impairment. Based on the data, there were 15 subjects in the nociceptive pain group and 15 subjects in the neuropathic pain group. There was a statistically significant correlation between the type of pain and the mental quality of life. In patients with cervicogenic headaches and neuropathic pain, there was a stronger relationship than those with nociceptive pain.   ABSTRACT Introduction: Cervicogenic headache is classified as a secondary headache under the International Classification of Headache Disorders, third edition (ICHD-3). Significant neuropathic and nociceptive pain components are believed to be present in this condition, which eventually lowers quality of life by causing problems like anxiety, depression, and sleep disruptions. Objective: This study aimed to correlate pain types with quality of life in those suffering from cervicogenic headaches. Methods: A cross-sectional observational study was conducted at the Neurology Outpatient Clinic of Dr. Soetomo General Academic Hospital in Surabaya from June to August 2020. Quality of life and pain types were evaluated using the painDETECT and SF-36 questionnaires. A painDETECT score of 12 or less indicated nociceptive pain, but a score of more than 12 indicated neuropathic pain. An SF-36 score below 50 indicated a poor quality of life. Conclusion:Patients with cervicogenic headaches and neuropathic pain exhibited a lower quality of life compared to those experiencing nociceptive pain. These findings emphasize the importance of evaluating pain types to support the maintenance of a good quality of life.  
Evaluasi Status Fungsional Pasien Stroke Iskemik Di Ruang Rawat Inap Saraf RSUD Dr. Soetomo Menggunakan Instrumen Functional Independence Measure (FIM) Inez Anabela Suprijadi Suprijadi; Florentina Sustini; I Putu Alit Pawana; Devi Ariani Sudibyo
JURNAL WIDYA MEDIKA Vol. 5 No. 1 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i1.1994

Abstract

Introduction: Stroke is a sudden and acute functional focal and global brain disorder that lasts more than 24 hours due to brain blood circulation disorders. Strokes can influence several aspects of life including ADL. Aim: To analyze the patients with ischemic stroke in Neurology Department of RSUD Dr. Soetomo by Functional Independence Measure (FIM) scale at the times of admission to hospital, discharge, and one month after follow-up. Methods: The design of study was cohort. Sample was 60 patients that suitable with the inclusion criteria and was selected by consecutive sampling. Patient’s age, sex, length of stay, nutritional intake, compliance of drugs intake, and the ability of physical activity were recorded. After that, motor assessment and daily activities skills were evaluated by FIM scale. Data was collected by interview and examination for 5 months. Data was analyzed by t-test. Results: A sum of 60 patients are studied. Most frequent genders are male (53,3%), age ranging from 60-69 years old (36,7%), length of stay mostly less than a week (88,3%), nutritional intake is mostly balanced (31,7%), most of the patients take their drugs regularly (66,7%), and most of the patients are only need supervision (45%). The FIM score at admission ranged between 54-71 (40%), at discharged ranged between 72-89 (46,7%), and after one month follow-up ranged between 72-89 (48,3%). There were significant change at p=0,001 between FIM Score at discharged and admission and also between FIM score after one month follow-up and discharged. Conclusion: All patients’ FIM scores were improved. There was a correlation between patient’s length of stay and FIM score at admission and also the ability of physical activity. Significant correlation was found between patient’s age and the ability of physical activity with the FIM score at discharge. Patient’s age, length of stay, and the ability of physical activity have significant correlation with The FIM score after one month follow-up.
PREVALENCE OF MENSTRUAL MIGRAINE AND THE EFFICACY OF SUMATRIPTAN ADMINISTRATION: Prevalensi Migrain Menstrual dan Efikasi dari Pemberian Sumatriptan Maridsky, Aldilla Afifie Putri; Sudibyo, Devi Ariani; Qurnianingsih, Ema; Dyah Kencono Wungu, Citrawati
Jurnal Berkala Epidemiologi Vol. 12 No. 1 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I12024.62-70

Abstract

Background: Menstrual migraine is a primary headache that often attacks women of reproductive age. This type of migraine has high severity and is resistant to treatment. Therefore, an effective treatment is needed to treat this menstrual migraine. Sumatriptan has been shown to have a better effect as an acute treatment for menstrual migraine patients. Purpose: This study aims to determine the prevalence and effectiveness of sumatriptan as a therapy for menstrual migraine. Methods: This research is based on a literature review following predetermined inclusion criteria. First, a literature search was carried out adhering to the PRISMA flow in 4 databases: Pubmed, Science Direct, ProQuest, and ClinicalTrial.co. Results: Based on keywords, 267 studies were found in the literature search. However, only three studies covering 845 participants met the predetermined inclusion criteria. The average age of menstrual migraine patients in the three studies was 37 years. These three studies of sumatriptan revealed a significant effect in providing a pain-free response in menstrual migraine patients. These three studies also showed that sumatriptan 100 mg has a higher level of effectiveness in providing a pain-free response in menstrual migraine sufferers and was preferably given during mild attacks. Conclusion: These three studies indicate that typically, women who suffer from menstrual migraines are of reproductive age. Additionally, this study shows that using sumatriptan as an acute therapy significantly helps provide a pain-free response in menstrual migraine patients.
Co-Authors Ardhi, Mohammad Saiful Dyah Kencono Wungu, Citrawati Fathoni, M Reza Fathoni, Muhammad Reza Florentina Sustini Imas Resa Palupi Inez Anabela Suprijadi Suprijadi Isti Suharjanti Machin, Abdulloh Maridsky, Aldilla Afifie Putri Marlon Yutimma Roestam Moenaf Muhammad Hamdan Muhammad Reza Fathoni Paulus Sugianto Pawana, I Putu Alit Puti, Nazla Ananda Rachmi Qurnianingsih, Ema Rochmanti, Maftuchah Rochmanti