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Pengembangan Obat Kanker dari Daun Kelor (Moringa Oleifera) Silmi Hizba Hunafa; Yuke Andriane; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6638

Abstract

Abstract. Colon cancer ranks third most common in the world with the second highest mortality rate. Colon cancer therapy, one of which can be through chemotherapy using doxorubicin. Single use of doxorubicin has significant side effects. One effort to reduce side effects and increase its effectiveness is to combine doxorubicin with Moringa leaves (Moringa oleifera). Moringa leaves contain many active ingredients such as flavonoids, D-allose, and eugenol. Another effort that can be made to increase the effectiveness of drugs is by developing nanoparticles. The literature review method was carried out by searching the literature through national and international literature searches as well as data on articles and scientific journals that focused on colon cancer, doxorubicin, the mechanism of action of doxorubicin, the content of Moringa leaves, the anti-cancer effects of Moringa leaves. The results of this study are: There is a cytotoxic effect produced by Moringa leaves (Moringa oleifera) against colon cancer cells and there is a synergistic effect between the combination of doxorubicin and Moringa leaves (Moringa oleifera) against colon cancer cells. Abstrak. Kanker kolon menempati urutan ketiga tersering di dunia dengan tingkat kematian tertinggi kedua. Terapi kanker kolon salah satunya dapat melalui kemoterapi menggunakan doxorubicin. Penggunaan tunggal doxorubicin memiliki efek samping yang signifikan. Salah satu upaya untuk mengurangi efek samping dan meningkatkan efektivitasnya adalah dengan mengkombinasikan doxorubicin dengan daun kelor (Moringa oleifera). Daun kelor memiliki banyak kandungan bahan aktif seperti flavonoid, D-allose, dan eugenol. Upaya lain yang dapat dilakukan untuk meningkatkan efektivitas obat adalah dengan pengembangan nanopartikel. Metode literatur review ini dilakukan dengan pencarian literatur melalui pencarian literatur nasional maupun internasional serta data artikel dan jurnal ilmiah yang berfokus pada kanker kolon, doxorubicin, mekanisme aksi doxorubicin, kandungan daun kelor, efek anti-kanker daun kelor. Hasil dari penelitian ini adalah: Terdapat efek sitotoksik yang dihasilkan daun kelor (moringa oleifera) terhadap sel kanker kolon dan terdapat efek sinergis antara kombinasi doxorubicin dengan daun kelor (Moringa oleifera) terhadap sel kanker kolon.
Empowering Cihideung Village Farmers in Using Rose Flowers as Pharmaceutical Raw Materials Santun Bhekti Rahimah; Herry S. Sastramihardja; MIranti Kania Dewi; Siti Annisa Devi Trusda; Yuke Andriane
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 4 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i4.4070

Abstract

Roses (Rosa Damascene Mill) are the most prominent crops of the Cihideung Village community. During the COVID-19 pandemic, flower farmers needed help with marketing, so many of the roses were unused. These empowerment activities aim to increase the public's knowledge and capacity to use roses as a pharmaceutical. The activities are carried out offline in the form of workshops. The raw materials are fresh rose flowers, tools, ingredients for making rose water infusions, soap, and oil. Analysis of outcome was assessed using questionnaires before and after the workshop as well as observation of the enthusiasm of participants during the activity. The results showed an improvement in the knowledge and skills of the public regarding the use of roses. The community also provided guides for the improvement of their capacity independently and access to the technical video through YouTube. Activity publications are delivered in digital media as a promotion. The full support of the provincial government and local villages will strengthen the synergy and sustainability of these activities, and hopefully, in the future, this knowledge can improve and become an independent enterprise of the community of Cihideung Villages.
Training for the Elderly to Improve Skills in Preventing and Managing Chronic Diseases Andriane, Yuke; Bhekti Rahimah, Santun; Kania Dewi, Miranti; Annisa Devi Trusda, Siti; Awaliya Yulianto, Fajar
International Journal Of Community Service Vol. 4 No. 3 (2024): August 2024 (Indonesia - Malaysia)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v4i3.278

Abstract

An increasing elderly population in the world has a broad impact on society. Elderly people have different characteristics and are vulnerable to physical and psychological health problems, one of which is chronic diseases such as hypertension, diabetes, and coronary heart disease. The elderly require special attention from their families, surrounding communities, and the local government. In response to this, the Unisba Faculty of Medicine organized a Community Service (PKM) activity called "Training for the Elderly to Improve Skills in Preventing and Managing of Chronic Diseases." This activity aims to enhance the knowledge and skills of the elderly in preventing and managing their diseases, which will help prevent complications and increase the quality of life of the elderly. This, in turn, will empower them to remain productive members of society. PKM activities occurred in Cihanjuang Village on July 22-23, 2022. The event was a collaboration of Unisba Medical Faculty, the Cihanjuang village government, and the Parongpong District. A PKM activity was conducted offline for two days with around 60 participants. The activity included comprehensive health education material, assistance and mentoring for elderly people in sports activities, examination and modification of risk factors for chronic diseases. Detection of disease through checking blood pressure, independent blood sugar monitoring at home, and anthropometric examination including body weight, height, upper arm circumference, and waist circumference. The result of these activity showed that the knowledge of elderly on chronic disease management increased by 19.79% based on analysis of pre-test and post-test. It also enhanced the skills of elderly people in early detection and modification of risk factors for chronic diseases. The measurement results indicate that 11.32% of participants are at risk based on BMI, 54,72% are classified as obese 1, and 33.96% are classified as obese 2. All of the participants had a risk of comorbidities based on BMI and waist circumference calculations, with some falling into the category of increased 9.43%, moderate 3.77%, severe 52.83%, and very severe 33.96%. This program will support the accelerated development of Active Alert Villages and Subdistricts as one of the performance targets in the community empowerment process to improve the community's welfare. Keywords: Elderly, chronic disease, co-morbidities, knowledge, skills, Cihanjuang
Prescription Writing Errors in Clinical Clerkship among Medical Students Indriyanti, Raden Anita; Yulianto, Fajar Awalia; Andriane, Yuke
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (59.885 KB) | DOI: 10.29313/gmhc.v7i1.4069

Abstract

Prescription is an instruction written by a medical practitioner to give a drug or device for a patient. The proper prescription will contribute to speedy recovery or healing process for the patient. Clinical clerkship must have an excellent competency to choose the right medication and prescribe the appropriate drugs or therapy. This study aims to analyze the common error in prescription's writing in clinical clerkship among medical students at their final examination to be a medical doctor. This study used the analytic method to 609 sheets of prescription from 180 clerkship students in their last try out on objective structured clinical examination (OSCE) at the Faculty of Medicine Universitas Islam Bandung in March 2018. Analyzed the component that every prescription should have, which consists of patient identity, superscription, inscription, subscription, and signatures. The result showed that more than half of the clerkship students made an error in subscription (50.25%) and signatures items (55.83%), while most of them had written down properly the patient identity (77.5%), superscription (83.74%), and inscription (78.98%). As a result, with more than half error in a prescription written in subscription and signature item, the failure of giving adequate therapy will cause a low recovery or healing process to the patients. Moreover, it may harm or cause death to the patients. In conclusion, more than half of medical students made common errors in prescription's writing. KESALAHAN PENULISAN RESEP PADA MAHASISWA KOASISTENSI FAKULTAS KEDOKTERANResep merupakan instruksi yang ditulis oleh tenaga medis untuk memberikan obat atau seperangkat alat kepada pasien. Peresepan yang tepat akan membawa proses pemulihan dan penyembuhan terhadap pasien. Mahasiswa kedokteran yang menjalankan masa koasisten harus memiliki kompetensi yang baik untuk memilih dan menuliskan terapi yang sesuai. Penelitian ini bertujuan menganalisis kesalahan umum dalam penulisan resep pada mahasiswa kedokteran yang akan menghadapi ujian akhir untuk menjadi seorang dokter. Penelitian ini menggunakan metode analitik terhadap 609 lembar resep dari 180 mahasiswa kedokteran yang sedang melaksanakan try out akhir objective structured clinical examination (OSCE) di Fakultas Kedokteran Universitas Islam Bandung pada Maret 2018. Dianalisis setiap komponen yang harus ada dalam penulisan resep, yaitu identitas pasien, superskripsi, inskripsi, subskripsi, dan signature. Hasil penelitian menunjukkan bahwa lebih dari setengah mahasiswa melakukan kesalahan pada item subskripsi (50,25%) dan signature (55,83%), sedangkan sebagian besar sudah menulis dengan baik pada item identitas pasien (77,5%), superskripsi (83,74%), dan inskripsi (78,98%). Akibatnya, dengan lebih dari setengah jumlah kesalahan dalam penulisan item subskripsi dan signature maka kegagalan dalam memberikan terapi yang adekuat dapat menyebabkan angka kesembuhan yang rendah, terlebih lagi dapat menimbulkan bahaya bahkan kematian terhadap pasien. Simpulan, lebih dari setengah mahasiswa kedokteran melakukan kesalahan umum dalam penulisan resep.
Hubungan Frekuensi Konsumsi Junk Food dengan Tingkat Kecemasan pada Mahasiswa Tingkat 2 Fakultas Kedokteran Universitas Islam Bandung M. Rizki Budiman; Sastramihardja, Herri S.; Andriane, Yuke
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10616

Abstract

Abstract. Anxiety is defined as the body's response to fear, which manifests as disturbances in feelings, thoughts, attitudes, and physiological changes. One of the factors that causes anxiety is consuming foods high in fat and sugar that are contained in junk food or fast food which is food that is easy to consume. This study aims to analyze relationship between frequency of junk food consumption and anxiety level in level 2 students at the Unisba Faculty of Medicine. This research is cross sectional study with sample size of 33 second year students of FK Unisba who met the inclusion criteria. Data was collected using the Food Frequency Questionnaire (FFQ) and Hamilton Anxiety Rating Scale (HAM-A). Data were analyzed using the Spearman statistical test. The research results showed that mostly respondents consumed junk food with a frequency of 1-3 times a month. It was also found that the entire research sample had anxiety with more than half of the respondents having mild levels of anxiety and 3 had severe anxiety. The Spearman test shows p value of 0,048 (< 0,05) and R value of 0,347. There is significant relationship between frequency of junk food consumption and level of anxiety with weak correlation strength. Abstrak. Kecemasan didefinisikan sebagai respon tubuh terhadap rasa takut, yang bermanifestasi sebagai gangguan perasaan, pemikiran, sikap, dan perubahan fisiologis. Salah satu faktor penyebab munculnya kecemasan adalah konsumsi makanan tinggi lemak dan gula yang terkandung dalam junk food atau makanan cepat saji yang merupakan makanan yang mudah dikonsumsi dan dibuat. Penelitian ini bertujuan untuk menganalisis hubungan antara frekuensi konsumsi junk food dengan tingkat kecemasan pada mahasiswa tingkat 2 Fakultas kedokteran Unisba. Penelitian ini merupakan penelitian cross sectional dengan jumlah sample sebanyak 33 orang mahasiswa tingkat 2 FK Unisba yang memenuhi kriteria inklusi. Data dikumpulkan menggunakan kuisioner Food Frequency Questionnaire (FFQ) dan Hamilton Anxiety Rating Scale (HAM-A). Data dianalisis dengan uji statistik spearman. Hasil penelitian didapatkan bahwa responden yang mengonsumsi junk food dengan frekuensi 1-3 kali perbulan sebanyak 12, 1 kali perminggu sebanyak 3, 2-4 kali perminggu sebanyak 11, 1 kali perhari sebanyak 2, 2-3 kali perhari sebanyak 2, 4 kali perhari sebanyak 3. Seluruh sample penelitian memiliki kecemasan dengan lebih dari setengah jumlah responden memiliki tingkat kecemasan ringan dan kecemasan berat 3 responden. Uji spearman menunjukkan nilai p sebesar 0,048 (<0,05) dan nilai R 0,347. Terdapat hubungan yang bermakna antara frekuensi konsumsi junk food dengan tingkat kecemasan dengan kekuatan korelasi lemah.
Perbandingan Kadar Gula Darah Puasa Antara Mahasiswa dengan Berat Badan Berlebih dan Mahasiswa dengan Berat Badan Normal Angkatan 2020 di Fakultas Kedokteran Universitas Islam Bandung Toni Praditya Irwansyah; Herri S. Sastramihardja; Yuke Andriane
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12063

Abstract

Abstract.Overweight is an accumulation of excess fat in the body which can disrupt overall health. This condition occurs because there is an imbalance between incoming energy and outgoing energy. Since 2014, more than 1.9 billion adults over the age of 18 have been overweight. According to WHO, overweight has become a world problem, especially in Indonesia as a developing country where there are changes in consumption patterns and lifestyles. Diabetes is a condition where blood sugar levels exceed 200mg/dL. One of the risk factors for diabetes is being overweight, but it does not rule out the possibility that even normal weight people suffer from diabetes because there are other factors that can influence blood glucose levels. This study aims to analyze the comparison of fasting blood sugar levels in 2020 FK UNISBA students who are overweight and those who are normal. This research is a cross-sectional study with a sample size of 65 people consisting of active students from the class of 2020 and meeting the inclusion and exclusion criteria. Data was collected by direct measurement using a glucometer and weight scale. Data were analyzed using the chi square test. The results of this study showed that almost half of the respondents were overweight, 49.2%. The highest percentage of fasting blood sugar levels was also found, namely respondents who had normal fasting blood sugar levels (70-100mg/dL) as many as 64.6%, and there were students with low fasting blood sugar levels as many as 35.4%. The chi square test shows a p value of 0.228 (>0.05). There was no significant difference between fasting blood sugar levels in overweight and normal students. Abstrak. Overweight merupakan suatu akumulasi lemak berlebih di dalam tubuh yang dapat mengganggu kesehatan secara keseluruhan. Kondisi ini terjadi karena adanya ketidakseimbangan antara energi yang masuk dengan energi yang keluar. Sejak 2014 sudah lebih dari 1,9 miliar orang dewasa di atas usia 18 tahun mengalami overweight. Menurut WHO overweight telah menjadi masalah dunia, khususnya di Indonesia sebagai negara berkembang dimana adanya perubahan pola konsumsi dan gaya hidup. Dibates merupakan kondisi kadar gula darah melebihi 200mg/dl. Salah satu faktor risiko dari diabetes adalah overweight. Penelitian ini bertujuan untuk menganalisis perbandingan kadar gula darah puasa pada mahasiswa yang memiliki berat badan berlebih dan yang normal. Penelitian ini merupakan penelitian analitik observasional desain cross sectional dengan jumlah sampel 65 orang yang memenuhi kriteria inklusi yaitu mahasiswa angkatan 2020 dan bersedia menjadi reponden, dan kriteria eksklusi yaitu sudah terdiganosis diabetes mellitus dan mahasiswa dengan underweight. Data dikumpulkan dengan cara pengukuran langsung di laboraturium dan pengukuran tinggi dan berat badan. Data dianalisis dengan uji chi square. Hasil penelitian ini didapatkan indeks masa tubuh dengan presentase terbanyak yaitu responden yang memiliki berat badan normal sebanyak 33 responden. Didapatkan juga kadar gula darah puasa dengan presentase terbanyak yaitu responden yang memiliki kadar gula darah puasa 70-100mg/dL sebanyak 42 responden. Uji chi square menunjukkan nilai p sebesar 0,228 (>0,05). Tidak terdapat perbedaan yang bermakna antara kadar gula darah puasa pada mahasiswa dengan berat badan berlebih dan yang normal.