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All Journal Jurnal Ilmu Ternak Veteriner WARTAZOA Indonesian Bulletin of Animal and Veterinary Sciences Jurnal Sumberdaya Hayati Jurnal Medik Veteriner
Susan Maphilindawati Noor
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Veterinary

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 1 
Brucellosis: An Unrecognized Zoonotic Disease in Indonesia Noor, Susan Maphilindawati
Indonesian Bulletin of Animal and Veterinary Sciences Vol 16, No 1 (2006)
Publisher : Indonesian Animal Sciences Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (787.624 KB) | DOI: 10.14334/wartazoa.v16i1.867

Abstract

Brucellosis, a bacterial zoonosis, is a disease caused by members of the genus Brucella . In Indonesia, brucellosis has known as a contagious reproductive disease in animals, however, only certain people know that brucellosis can be transmitted to human . Bovine brucellosis is characterised by one or more of the following signs : abortion, retained placenta . orchitis, epididymitis and, rarely, arthritis, with excretion of the organisms in uterine discharges and in milk . The Brucella organism is transmitted to human most commonly by ingestion of untreated milk or milk products or through the mucous membranes and wound of the skin . The severity of human disease varies, depending largely upon the infecting strain . Brucella abortus, B . melitensis. B . suis and B. canis are highly pathogenic for humans . Clinical symptoms of human brucellosis may include an intermittent fever, headaches, weakness, arthalgia, myalgia and weight loss . Occasional complications include arthritis, endocarditis, hepatitis granuloma, meningitis, orchitis dan osteomyelitis have also been reported . Brucellosis can also produce spontaneous abortion in pregnant woman . Diagnosis is based on the isolation of the organism and serology . Antibiotics are usually the mainstay of treatment and long-term treatment may be required . Brucellosis can be controlled by comprehensive campaigns to eradicate the disease by vaccination programme followed by test and slaughter of domestic animals which exhibit positive serologic reactions to brucellae.   Key words : Brucellosis, zoonosis, diagnose, control
The mucosal and systemic immune responses in chickens orally immunised with Campylobacter jejuni antigen entrapped in poly-lactide-co-glycolide microparticles Noor, Susan Maphilindawati
Indonesian Journal of Animal and Veterinary Sciences Vol 3, No 4 (1998)
Publisher : Indonesian Animal Sciences Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.249 KB) | DOI: 10.14334/jitv.v3i4.127

Abstract

An oral immunisation in chickens with antigen entrapping in biodegradable microparticles was evaluated in order to achieve optimal antibody responses following oral vaccination. This study was adapted to Campylobacter jejuni antigen in chickens to observe its stimulation both mucosal and systemic immune responses. A group of 5 embryonated chicken eggs was immunised with heat-killed C. jejuni entrapped in poly-lactide-co-glycolide (PLG) microparticles at day 17 of incubation deposited into the amniotic fluid. Seven days after hatching the chickens were oral boostered, these was design to as Group A. In the Group B, each embryonated egg was immunised with soluble C. jejuni as in the same as Group A. Immune responses of post vaccination were observed at day-14, the humoral immunity was evaluated with an ELISA and whereas mucosal antibody response was detected by fluorescent histology. The serum IgG and IgA antibody responses, and also the bile and intestinal scrapping IgA antibody responses to campylobacter in Group A were significantly higher than those of the soluble antigen of Group B (P<0.05). Total number of immunoglobulin-containing cells for IgG, IgM, and IgA isotypes in the ileum in Group A chickens were also significantly higher than those of Group B (P<0.05) but was not in the duodenum and spleen. Key words : Campylobacter jejuni, poly-lactide-co-glycolide microparticles, oral immunisation, chickens
Study in ovo immunisation with flagellin and whole cell protein antigens of Campylobacter jejuni in chickens Noor, Susan Maphilindawati; Husband, Alan J
Indonesian Journal of Animal and Veterinary Sciences Vol 5, No 2 (2000)
Publisher : Indonesian Animal Sciences Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.048 KB) | DOI: 10.14334/jitv.v5i2.208

Abstract

In ovo immunisation of chickens with flagellin and whole cell protein antigens of Campylobacter jejuni was examined to determine Campylobacter infection. Four groups of embryonated chicken eggs (10 eggs per group) were immunised in ovo at day 17 of incubation and booster was given at 7 days post-hatch. Group I was immunised in ovo and oral booster with whole cell protein of C. jejuni, group II was immunised in ovo and oral booster with C. jejuni flagellin protein, group III was immunised in ovo and intraperitoneal booster with whole cell, and group IV was treated as control. The humoral immune responses were determined by enzyme-linked immunosorbent assay (ELISA) and the mucosal immune responses were examined by a direct fluorescent histology antibody technique. Immunised chickens of Group I, II, and III shown to have higher antibody titers than  those of control chickens (group IV). The titres of anti-campylobacter antibodies of all isotypes in serum, bile, and intestinal scrapping after challenge were not significantly different in all groups. In addition, when immunised chickens were orally challenged with a homologous strain of viable C. jejuni organism, the chickens remained infected throughout the experiment based on cloacal swabs and caecal contents. These findings indicated that although in ovo immunisation resulted in increasing of the mucosal and humoral immune responses in chickens, it is not strong enough to protect the Campylobacter colonisation in the intestinal tract.   Key words : In ovo immunisation, Campylobacter jejuni, whole cell, flagellar, chickens
Aktivitas Antibakteri Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta) Terhadap Bakteri Penyebab Jerawat Irianti, Ewith Ratih; Ramadhan, Firdaus; Noor, Susan Maphilindawati; Syafriana, Vilya; Ramadhani, Lidia Anggita
Jurnal Sumberdaya Hayati Vol. 11 No. 3 (2025): 2025
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.11.3.116-121

Abstract

Jerawat adalah penyakit kulit yang disebabkan oleh beberapa faktor, salah satunya infeksi bakteri Staphylococcus epidermidis. Pengobatan dengan bahan alam sudah banyak dilakukan untuk mengurangi efek samping penggunaan obat anti-jerawat. Talas memiliki khasiat sebagai obat dan berpotensi sebagai antibakteri. Penelitian ini dilakukan untuk mengetahui aktivitas antibakteri ekstrak etanol 70% tangkai daun talas terhadap bakteri S. epidermidis dan senyawa bioaktif yang terkandung di dalamnya. Ekstrak dibuat dengan metode maserasi. Pengujian aktivitas antibakteri dengan metode difusi cakram dengan konsentrasi 0,5%; 1% ; 1,5%; 2%; dan 2,5% dengan klindamisin sebagai kontrol positif. Pengukuran zona bening atau diameter daya hambat (DDH) sebagai interpretasi data aktivitas antibakteri. Penapisan fitokimia meliputi alkaloid, flavonoid, saponin, terpenoid, steroid, dan tanin. Hasil pengujian aktivitas antibakteri menunjukkan terdapat zona bening pada semua konsentrasi kecuali 0,5%, dengan nilai rata-rata DDH masing-masing sebesar 17,33 mm; 20 mm; 25 mm; dan 27,67 mm. Nilai rata-rata DDH pada kontrol positif sebesar 47 mm. Berdasarkan penapisan fitokimia pada ekstrak etanol 70% tangkai daun talas memiliki hasil positif di semua uji. Ekstrak etanol 70% tangkai daun talas berpotensi sebagai antibakteri terhadap S. epidermidis dan memiliki senyawa-senyawa yang berpotensi sebagai bioaktif.
Genomic Characterization of Antimicrobial Resistance Genes in Pasteurella multocida Isolates from East Nusa Tenggara and Lampung, Indonesia Prihandani, Sri Suryatmiati; Wibawan, I Wayan Teguh; Noor, Susan Maphilindawati; Ekawasti, Fitrine; Khairullah, Aswin Rafif; Purba, Hastuti Handayani S.; Puarada, Alif Rahman Rohim; Safika, Safika
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.368-381

Abstract

Haemorrhagic Septicaemia (HS) is a devastating disease affecting cattle and water buffaloes in Indonesia, causing annual economic losses in livestock industries, particularly in Asia, Africa, and the Middle East. Pasteurella multocida, the causative agent of the disease, has shown increasing antimicrobial resistance, complicating treatment efforts. Therefore, this study aims to provide the first genomic analysis of P. multocida isolates from different Indonesian provinces, focusing on genes conferring resistance to beta-lactam antibiotics based on Whole Genome Sequencing (WGS) results. Genomic data can be used to confirm the results of phenotypic antibiotic resistance testing. P. multocida isolates analyzed in this study were sourced from the Indonesian Research Center for Veterinary Science (IRCVS) collection, which included 2 samples originating from different geographic locations within Indonesia. The samples were subjected to biochemical, molecular, and antimicrobial susceptibility testing. WGS was performed using Oxford Nanopore Technologies (ONT) with subsequent bioinformatics analysis for genome assembly and resistance profiling. Phenotypic analysis showed significant variations between the isolates. The NTT isolate showed resistance to Penicillin, while the Lampung 2952 remained susceptible in the disk antibiotic test. Genome sequencing revealed extensive resistance determinants, including β-lactamase genes (blaZ, blaR1) in the NTT isolate, correlating with its phenotypic resistance. The high-quality genome assemblies (N50: 17,225 bp for NTT; 12,662 bp for Lampung 2952) enabled comprehensive resistome characterization, identifying more than 22 resistance genes in each isolate, including novel variants not previously reported in Indonesian strains. Therefore, this study provides the first genomic and resistance analysis based on Whole Genomic Sequencing data of Indonesian P. multocida isolates. The results show the urgent need for enhanced surveillance and prudent antimicrobial use in livestock management.
Co-Authors Alan J Husband Firdaus Ramadhan, Firdaus Fitrine Ekawasti, Fitrine I wayan Teguh Wibawan Irianti, Ewith Ratih Khairullah, Aswin Rafif Puarada, Alif Rahman Rohim Purba, Hastuti Handayani S. Ramadhani, Lidia Anggita Safika S, Safika Sri Suryatmiati Prihandani