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All Journal Nusantara Hasana Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Maya Ganda Ratna
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Perbandingan Ceftriaxone dan Ciprofloxacin dalam Tata Laksana Infeksi Saluran Kemih: Tinjauan Pustaka Maya Ganda Ratna; Sinta Nurmalasari; Meta Tri Yana; Alvina Christy Maretta; Mariani Mariani; Fiola Yonandes; Alfiya Farah Anindhita
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8152

Abstract

Urinary tract infection (UTI) is a common bacterial infection that requires appropriate antibiotic management to prevent complications and antimicrobial resistance. Ceftriaxone and ciprofloxacin are commonly used antibiotics with different clinical indications in UTI treatment. This literature review aims to compare the role of ceftriaxone and ciprofloxacin in the management of urinary tract infections. A narrative literature review was conducted using articles published within the last ten years from PubMed, ScienceDirect, and Google Scholar databases. The review focuses on clinical effectiveness, resistance patterns, and therapeutic considerations. The findings indicate that ceftriaxone is primarily used in moderate to severe or complicated UTIs, particularly in hospitalized patients, whereas ciprofloxacin is more frequently used in uncomplicated UTIs in outpatient settings. However, increasing bacterial resistance and safety concerns limit the empirical use of ciprofloxacin. These findings emphasize the importance of rational antibiotic selection based on clinical conditions and local resistance patterns.  
Integrasi Presisi Profil Molekuler Radiologis dan Klinis dalam Diagnosis dan Penatalaksanaan Congenital Megacalyces Rian Hendriyana Dwi Imanta; Fairuz Rafi Fadlurrahman; Maya Ganda Ratna; Giska Tri Putri
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8158

Abstract

Congenital Megacalyces is a rare anomaly of the renal pelvis-calyceal system characterized by non-obstructive calyx dilatation due to renal medulla hypoplasia. This condition is often misinterpreted as hydronephrosis, leading to unnecessary surgical interventions. Advances in genomic technology and precision imaging have opened up opportunities to understand the molecular basis and anatomical structure of this anomaly more deeply. A literature review was conducted through PubMed, ScienceDirect, and Google Scholar, covering publications that discuss the relationship between genomics, imaging, and clinical management of congenital kidney abnormalities. The integration of Next Generation Sequencing (NGS), 3D MRI reconstruction imaging, and AI-based radiomics analysis has proven to enhance diagnostic accuracy, differentiate between obstructive and non-obstructive abnormalities, and assist in determining appropriate conservative therapies. Case studies demonstrate the association between SETBP1 mutations and the development of bilateral megacalyces, as well as the effectiveness of long-term monitoring based on multimodal data. The integration of genetic, imaging, and clinical data is a strategic step toward precision medicine in the management of Congenital Megacalyces. This approach improves diagnostic accuracy, reduces unnecessary invasive interventions, and supports individualized therapy based on genetic and anatomical risk factors.
PERAN POTENSIAL BIOMARKER MOLEKULER DALAM MENILAI EFEKTIVITAS KLINIS INTERVENSI PROBIOTIK PADA PENYAKIT SALURAN PENCERNAAN Gasela Zalianti Balqis; Jesika Cahya Ningrum; Giska Tri Putri; Maya Ganda Ratna
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1842

Abstract

Gastrointestinal diseases represent a significant global health burden and require complex management. Current assessments of probiotic efficacy often rely on subjective patient reports, which can be potentially biased. This review aims to explore the potential of molecular biomarkers to provide objective measures of therapeutic response. A narrative review was conducted through PubMed, Google Scholar, and Cochrane databases. The literature was screened using the PICO framework, focusing on gastrointestinal diseases, probiotic interventions, and molecular biomarker outcomes. Probiotic therapy effectively modulates the gut-brain axis and restores microbiota homeostasis. Specific biomarkers such as fecal calprotectin (inflammation), malondialdehyde (oxidative stress), and zonulin and occludin (barrier integrity) have been shown to be robust indicators for patient monitoring. Changes in these biomarkers significantly correlate with improvements in clinical symptoms, such as pain reduction and normalization of stool consistency. The integration of molecular biomarkers provides an objective, evidence-based framework for evaluating the efficacy of probiotic therapy, supporting the transition to precision medicine in gastroenterology.
Co-Authors Alfiya Farah Anindhita Alvina Christy Maretta Fairuz Rafi Fadlurrahman Fiola Yonandes Gasela Zalianti Balqis Giska Tri Putri Jesika Cahya Ningrum Mariani Mariani Meta Tri Yana Rian Hendriyana Dwi Imanta Sinta Nurmalasari