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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Sains dan Teknologi Farmasi Indonesia
Ilma Nugrahani
Fakultas Farmasi Universitas Pancasila Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

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Journal : indonesian journal of pharmacy

 1 
The impact of hot melt granulation method on propranolol hydrochloride physicochemical properties Ilma Nugrahani; Hasan Rahmat; Joshita Djajadisastra
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.272 KB) | DOI: 10.14499/indonesianjpharm0iss0pp167-172

Abstract

Hot melt granulation is based on agglomeration by use of thermoplastic binder material that is solid at room temperature and softens and melts at higher temperature. By selecting a binder that is insoluble in water, melt granulation is a way of producing modified release granules, i.e. lipids/waxes to exhange the release of soluble drugs. The critical problem of this method is drugs instability because of heating. It has been studied the impact of hot melt granulation method on propranolol hydrochloride physicochemical properties. Physicochemical properties were evaluated including : water content titration – Karl Fischer, chemical structure analysis by Fourier Transforms Infrared Spectrophotometry (FTIR), and thermodynamic analysis by Differential Scanning Calorimetry (DSC). The results showed that hot melt granulation did not change the propranolol hydrochloride physicochemical structure but it changed anhydrate ß lactose to anhydrate a lactose. Key words : carnauba wax ; hot melt granulation; propranolol hydrochloride; physicochemical properties.
FTIR Method for Peptide Content Estimation and Degradation Kinetic Study of Canarium Nut Protein Rozana Oktaviary; Ilma Nugrahani; Slamet Ibrahim Surantaatmadja; Tutus Gusdinar Kartawinata; Cintya Nurul Apsari
Indonesian Journal of Pharmacy Vol 31 No 2, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss2pp78

Abstract

Quantitative analysis of bioactive peptide mostly conducted by measuring the activity. While the determination of peptide content in natural sources has been conducted using various instruments, vibrational spectroscopy remains underutilized. Here, we attempted new developed method in peptide quantification and degradation kinetic analysis using Fourier-Transform Infrared Spectroscopy. Bovine Serum Albumin was used as standard protein in method development and validation. Peptide content was estimated by converting peak area to concentration. The method was used to estimate peptide content in Canarium nut protein and its hydrolysates, which potentially hold biological activity. Kinetic study was conducted with microwave as an accelerator for hydrolysis, an apparatus rarely used in peptide study. Amide I band on wavenumber range of 1724.05-1619.91 cm-1 was selected for analysis, considering its selectivity and linearity. The method also met other validation requirement, including accuracy and precision. When applied in quantitative analysis, the method was able to calculate peptide content decrease in Canarium nut protein after hydrolysis using papain (38.24%), pepsin (33.67%) and alkaline reagent (28.53%). In kinetic study, microwave-assisted peptide degradation exhibited logarithmic profile with the equation of y=-0.148ln(x)+0.9591 and R² value of 0.963. Based on these results, FTIR is useful in estimating peptide content and in analyzing degradation kinetic profile. 
Identification of physical interaction between levodopa–benzerazide hydrochloride Ilma Nugrahani; Sukmadjaja Asyarie; Sundani Noerono Soewandhi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1353.355 KB) | DOI: 10.14499/indonesianjpharm0iss0pp96-104

Abstract

The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.
Co-Authors Abdillah, Muhammad Nur Aditya Aditya Andreanus Andaja Soemardji Andy Susbandiyah Ifada Astrini, Dwie Asyarie, Sukmadjaja Belda Nurmeyna Benny Permana Cintya Nurul Apsari Dea Dwi Puspita Debora Ronauli Dwie Astrini Hasan Rahmat Hasan Rahmat, Hasan Hidehiro Uekusa Humairoh, Rosnaini Irda Fidriany Joshita Djajadisastra Joshita Djajadisastra, Joshita Kartawinata, Tutus Gusdinar Marlia Singgih Wibowo Melvia Sundalian N.S, Sundani Ningsih, Listia Nurmeyna, Belda Okky D. Putra Okky Dwichandra Putra Pusparani Krisnamurthi Putra, Okky D. Rachmat Mauludin Ratna A. Utami Rozana Oktaviary Slamet Ibrahim - Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sundani Noerono Soewandhi Sundani Nurono Soewandhi Triyadi Hendra Wijaya Tutus Gusdinar Kartawinata Utami, Ratna A. Wibowo, Marlia Singgih Winni Nur Auli