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All Journal Journal of Biomedicine and Translational Research Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) JOMIS (Journal of Midwifery Science) Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Jurnal Ilmiah Kesehatan Jiwa
Innawati Jusup
Department Of Psychiatry, Faculty Of Medicine, Diponegoro University
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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The role of Zinc Intake in Serotonin and Cortisol Level in Patient with Depression Tanjung Ayu Sumekar; Innawati Jusup; Natalia Dewi Wardani; Titis Hadiati; Mohammad Sulchan; Alifiati Fitrikasari
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.13808

Abstract

Background: Low zinc levels affects the relationship between the glutamatergic and serotonergic systems in major depressive disorders that cause stress and inflammation. Decreased zinc in the hippocampus can activates the HPA axis associated with an increase in cortisol. Several studies documented the relationship between zinc and clinical depression, however further research including biological measurements is needed to support these studies.Objective: To observe the correlation between zinc intake with serotonin and cortisol serum in patient with depressionMethods: This was an observational study with cross sectional design. Subjects were patients with depression who came to Dr. Kariadi Hospital, Tugurejo Hospital, Diponegoro National Hospital and Permata Medika Hospital met the inclusion and exclusion criteria. The food frequency questionnaire (FFQ) was used to assess daily zinc intake. The levels of serum serotonin and cortisol were measured using ELISA technique.Results: Of the 53 subjects, there was significant correlation between zinc intake with serotonin serum level (p=0,038), however there was no correlation between zinc intake with cortisol serum level (p=0,845)Conclusion: The higher zinc intake the higher serotonin serum level, however there was no correlation between zinc intake with cortisol serum level in patients with depression. 
Perbedaan Kadar Gula Darah Sewaktu pada Pasien Skizofrenia yang Mendapat Terapi Antipsikotik Generasi Kedua Selama kurang dari Empat Bulan dan lebih dari Empat Bulan Rani Rahayu; Faizah Fulyani; Innawati Jusup; Alifiati Fitrikasari
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.196 KB) | DOI: 10.36408/mhjcm.v8i2.567

Abstract

ABSTRAK LATAR BELAKANG : Skizofrenia merupakan gangguan mental dengan mortalitas dua sampai tiga kali lipat lebih tinggi dibandingkan populasi umum. Antispikotik generasi kedua merupakan salah satu terapi untuk skizofenia, namun memiliki efek samping gangguan metabolik yang lebih tinggi dibandingkan antipsikotik golongan pertama, seperti peningkatan kadar gula darah. TUJUAN : Mengetahui perbedaan kadar gula darah sewaktu pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua selama kurang dari empat bulan dan lebih dari empat bulan. METODE : Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Sampel adalah data rekam medis 67 pasien skizofrenia di RSJD Amino Gondohutomo Semarang yang memenuhi kriteria inklusi. Subjek dibagi menjadi dua kelompok yaitu yang mendapatkan terapi kurang dari 4 bulan dan yang mendapatkan terapi selama lebih dari 4 bulan. Uji statistik menggunakan uji Mann Whitney untuk mengetahui perbedaan antara kedua kelompok. HASIL : Kadar gula darah sewaktu pada kelompok yang mendapat terapi antipsikotik generasi kedua selama kurang dari empat bulan lebih rendah (116 mg/dl) dibandingkan dengan yang mendapatkan terapi lebih dari empat bulan (118 mg/dl). Meskipun demikian, perbedaan tersebut tidak bermakna secara statistik (p>0.05). KESIMPULAN : Tidak terdapat perbedaan kadar gula darah sewaktu pada pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua kurang dari empat bulan dan lebih dari empat bulan. Kata Kunci : skizofrenia, antipsikotik, gula darah sewaktu
Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women Innawati Jusup; Lusiana Batubara; Dwi Ngestiningsih; Faizah Fulyani; Devina Afraditya Paveta; Putri Theresia Lemmo Ate Bancin
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.157

Abstract

Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis 
The Correlation between Perceived Social Support with Suicide Ideation Prima Kusumastuti; Innawati Jusup; Alifiati Fitrikasari; Titis Hadiati
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.10540

Abstract

Background: Based on data from WHO in 2015, it shows that the death rate due to suicide in the world was recorded to have increased by 23.2% compared to 2009. Research in 2016 shows that the largest age range who experienced suicide was from 15-29 years. Many things are predicted to be a protective factor against suicide, including social support. Research on suicide protection factors is useful in preventing the increasing number of suicides.Objective: To analyze the correlation between perceived social support with suicidal ideationMethods: This research is a quantitative study with cross sectional design. Samples were taken from vocational school and academy in Semarang, who met the inclusion and exclusion criterias. The sample selection was carried out by the simple random sampling method. This research used the Indonesian version of the SSI (Scale of Suicide Ideation) and the MSPSS (Multidimentional Scale of Perceived Social Support) questionnaires.Results: It was found that the prevalence of high suicidal ideation score was 50.8% while the low suicidal ideation score was 49.2%. There was a significant correlation between suicidal ideation with perceived of family support (p = 0.002) and peer support (p = 0.050). Meanwhile, there was no significant correlation between the suicidal ideation and the support from significant others (p = 0.154). Conclusion: There was a correlation between perceived of family and peer support with suicidal ideation
English language Andrew - Johan; Regina Oktavia; Lusiana Batubara; Dwi Ngestiningsih; Innawati Jusup
JOMIS (Journal of Midwifery Science) Vol 5 No 2 (2021): JOMIS (Journal Of Midwifery Science)
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jomis.v5i2.1697

Abstract

Background: Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) are increased in tissue damage. Ashitaba contains many compounds that can reduce serum SGOT and SGPT levels. Objective: This study was proposed to prove that giving Ashitaba extract could reduce serum SGOT and SGPT levels in rats exposed to burn injury. Methods: This study used a posttest only control group design with 20 rats as samples. All research samples were treated with second-degree burns and were divided into 2 different groups, the treatment group (given Ashitaba extract 300 mg /kg BW) and the control group. The blood serum was analyzed for SGOT and SGPT test on the 2nd, 8th, and 14th days. For statistical analysis, the Wilcoxon test used to analyze the levels of serum SGOT and SGPT. Results: There was no significant difference in serum SGOT and SGPT levels between the control and treatment groups on the 2nd, 8th, and 14th days Conclusion: Ashitaba extract could not reduce serum SGOT and SGPT levels in rats exposed to burn injury.
Systemic Lupus Erythematosus Berhubungan dengan Depresi Ichdinavia Harsaya; Innawati Jusup
Jurnal Ilmiah Kesehatan Jiwa Vol 2 No 1 (2020): April 2020, Jurnal Ilmiah Kesehatan Jiwa
Publisher : RSJD Dr. Amino Gondohutomo Provinsi Jawa Tengah

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Abstract

Sistemik Lupus Eritomatosus atau SLE merupakan suatu penyakit autoimun sistemik kronik yang ditandai dengan terbentuknya berbagai macam antibodi yang membentuk kompleks imun yang menyebabkan terjadinya kerusakan jaringan. Manifestasi klinis pada SLE beragam, mulai dari kelelahan, penurunan berat badan, demam, dapat juga bermanifestasi di kulit, paru, ginjal, gastrointestinal dan neuropsikiatri. Stres pada mental merupakan faktor pencetus paling dominan, dan gejala yang paling umum dari manifestasi klinis neuropsikiatri SLE adalah gangguan mood atau depresi dan disfungsi kognitif. Pasien dengan riwayat SLE yang mengalami depresi kami sajikan dalam kasus ini. Penelitian ini bertujuan untuk mengetahui hubungan antara Systema Lupus Erythematosus dengan Depresi. Penelusuran dilakukan dengan database Pubmed, Cochrane, Springer. Penelusuran dibatasi menggunakan penyaringan publikasi jurnal pembatasan terbitan 5 tahun terakhir, subjek penelitian manusia. Hasil penelusuran dari jurnal tersebut didapatkan bahwa salah satu manifestasi klinis pada SLE adalah Neuropsikiatri dan gejala yang paling umum dari manifestasi klinis neuropsikiatri SLE adalah gangguan mood atau depresi. Terapi Immunosupresif umumnya digunakan untuk pengelolaan pasien dengan SLE, dan farmakoterapi yang melibatkan obat – obatan psikotropika dan psikoterapi diberikan pada pasien dengan NPSLE. Systema lupus Erytemathosus atau SLE berhubungan dengan Depresi baik itu sebagai penyebab ataupun dapat juga sebagai komorbid. Pengobatan Depresi dengan SLE mengunakan antidepresan. Kata kunci: depresi, SLE, terapi SYSTEMIC LUPUS ERYTHEMATOSUS IS RELATED TO DEPRESSION ABSTRACT Systemic Lupus Erythomatosus or SLE is a chronic systemic autoimmune disease characterized by the formation of various kinds of antibodies that form immune complexes that cause tissue damage. Clinical manifestations in SLE vary, ranging from fatigue, weight loss, fever, can also manifest in the skin, lungs, kidneys, gastrointestinal and neuropsychiatric. Mental stress is the most dominant trigger factor, and the most common symptoms of clinical manifestations of neuropsychiatric SLE are mood disorders or depression and cognitive dysfunction. We present patients with a history of SLE who are depressed in this case. This study aims to determine the relationship between Systema Lupus Erythematosus and Depression. Searches were carried out with the Pubmed, Cochrane, Springer database. Searches were limited using filtering of journal publications for the limitation of the last 5 years, the subject of human research Search results from the journal found that one of the clinical manifestations of SLE is Neuropsychiatry and the most common symptom of clinical manifestations of SLE neuropsychiatry is mood disorders or depression. Immunosuppressive therapy is generally used for the management of patients with SLE, and pharmacotherapy involving psychotropic drugs and psychotherapy is given to patients with NPSLE. Systema lupus Erytemathosus or SLE is associated with depression either as a cause or as a comorbid. Treatment for depression with SLE uses antidepressants. Keywords: depression, SLE, therapy
Pasien Depresi dengan Gangguan Kepribadian Borderline yang Mendapatkan Terapi Psikofarmaka dan Psikoterapi Psikodinamik Tommy Raharja; Innawati Jusup
Jurnal Ilmiah Kesehatan Jiwa Vol 3 No 1 (2021): April 2021: Jurnal Ilmiah Kesehatan Jiwa
Publisher : RSJD Dr. Amino Gondohutomo Provinsi Jawa Tengah

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Abstract

Depresi adalah gangguan kesehatan mental yang ditandai dengan suasana hati yang tertekan, kehilangan minat atau kesenangan, penurunan energi, perasaan bersalah atau rendah diri, gangguan tidur atau nafsu makan dan konsentrasi yang buruk. Saat ini, diperkirakan 350 juta orang terkena depresi di seluruh dunia. Borderline Personality Disorder (BPD) ditandai pola mendalam ketidakstabilan hubungan interpersonal, citra diri, dan ditandai impulsivitas. Prevalensi BPD ± 2%. Kasus depresi dengan BPD yang terjadi pada seorang perempuan berusia 21 tahun ini mendapat terapi berupa Fluoxetine 1x20mg, Clobazam 1x10mg, dan Psikoterapi Psikodinamik.Tujuan penelitian untuk menambah gambaran lebih banyak tentang penanganan depresi dengan BPD. Penelusuran dilakukan dengan database PubMed, Cochrane, Tripdatabase, Medscape menggunakan kata kunci pencarian Depression AND Borderline AND Psychotherapy AND Pharmacotherapy. Penelusuran dibatasi menggunakan penyaringan jurnal terbitan 10 tahun terakhir, subjek penelitian manusia. Hasil penelusuran menunjukkan bahwa SSRI dengan Psikoterapi Psikodinamik merupakan penanganan yang cukup efektif untuk menangani depresi dengan BPD. Target terapi dari farmakoterapi adalah untuk mencapai kondisi remisi sempurna pada pasien. Strategi dari terapi BPD adalah mengatasi kesulitan hubungan interpersonal. Sebagian besar intervensi psikologis spesifik BPD melibatkan terapi multimodal. SSRI dengan Psikoterapi Psikodinamik adalah penangangan yang cukup efektif dan dapat dipertimbangkan untuk menangani depresi dengan BPD.
HUBUNGAN GANGGUAN KOGNITIF DENGAN DEPRESI DAN AKTIVITAS PENYAKIT PASIEN LUPUS ERITEMATOSUS SISTEMIK Liko Maryudhiyanto; Bantar Suntoko; Soesmeyka Savitri; Innawati Jusup; Rihadini; Titis Hadiati
Majalah Kesehatan FKUB Vol. 9 No. 3 (2022): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2022.009.03.1

Abstract

Lupus eritematosus sistemik (LES) adalah suatu penyakit inflamasi kronis yang mempengaruhi banyak organ termasuk sistem saraf pusat. Prevalensi gejala neuropsikiatri berupa gangguan kognitif pada pasien masih cukup tinggi. Gangguan kognitif pada domain memori, eksekutif, dan atensi akan menyebabkan pasien LES mengalami depresi. Pasien LES yang mengalami depresi akan menyebabkan hasil pengobatan yang buruk. Gangguan kognitif juga berhubungan dengan aktivitas penyakit LES. Tujuan penelitian ini menganalisis hubungan gangguan kognitif dengan depresi dan peningkatan aktivitas penyakit pasien LES. Metode penelitian ini observasi cross sectional. Subjek penelitian ialah 82 pasien LES di RSUP Dr. Kariadi, Semarang. Instrumen penelitian menggunakan Beck Depression Inventory II (BDI-II) untuk depresi, Montreal Cognitive Assessment (MocA-Ina) untuk gangguan kognitif, dan Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) untuk aktivitas penyakit. Hasil menunjukkan prevalensi gangguan kognitif pada subjek penelitian adalah 64,6% dengan domain memori paling sering terganggu. Prevalensi depresi sebesar 57,3%. Proporsi pasien gangguan kognitif dengan depresi lebih banyak (62,3%) dibandingkan tanpa depresi. Aktivitas penyakit berat memiliki prevalensi paling tinggi yakni 54,4%. Gejala aktivitas penyakit paling sering didapatkan ialah alopesia dan artirtis (65,9%). Tidak terdapat hubungan yang bermakna antara gangguan kognitif dengan depresi (p = 0,151). Terdapat hubungan yang bermakna antara gangguan kognitif dengan aktivitas penyakit LES (p = 0,009). Domain kognitif berhubungan dengan aktivitas penyakit LES (p = 0,02). Kesimpulan penelitian ini tidak terdapat hubungan yang bermakna antara gangguan kogntif terhadap depresi pada pasien LES dan terdapat hubungan yang bermakna antara gangguan kognitif dengan aktivitas penyakit pasien LES.
Co-Authors Alifiati Fitrikasari Andrew - Johan Bantar Suntoko Devina Afraditya Paveta Djuara P Lubis Fulyani, Faizah Ichdinavia Harsaya Liko Maryudhiyanto Linda Kartika Sari Lusiana Batubara Mohammad Sulchan Muchlis Achsan Udji Sofro Natalia Dewi Wardani Prima Kusumastuti Putri Theresia Lemmo Ate Bancin Rani Rahayu Regina Oktavia Rihadini Soesmeyka Savitri Tanjung Ayu Sumekar Titis Hadiati Titis Hadiati Tommy Raharja Tommy Raharja