Claim Missing Document
Check
Articles

Found 12 Documents
Search

LONGAN PEEL EXTRACT (DIMOCARPUS LONGAN L.) AS AN ANTIOXIDANT AGAINST OXIDATIVE STRESS IN WISTAR RATS INDUCED BY TOXIC DOSES OF PARACETAMOL Aulia Sandriani; Faizah Fulyani; Donna Hermawati; Santoso Santoso; Eva Annisaa
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.311 KB) | DOI: 10.14710/dmj.v9i2.27098

Abstract

Background: Oxidative stress is an imbalance between free radicals and antioxidants, characterized by increase in malodialdehyde (MDA) levels. Stress oxidative caused by paracetamol overdose consumption and can be a serious problem for the structure and liver cell function. Oxidative stress prevented and controlled by antioxidant. Longan peel has phenolic and flavonoid which can potentially be sources of natural antioxidants. This study aimed to prove the longan peel extract had an antioxidant effect that could affect the oxidative stress in rats induced by toxic doses of paracetamol. Method: : Experimental research with control group design. Group P1, P2, and P3 were treatment group induced by paracetamol with a toxic dose of 2000 mg/kgBW and given extracts of longan peel (Dimocarpus longan L.) with multilevel doses, that were 25 mg/kgBW, 50 mg/kgBW, and 75 mg/kgBW wistar rat. Then, blood samples from each group were collected and measured plasma MDA levels and the animals were terminated, then their livers were taken for measurement of liver SOD enzyme activity. Result: One Way ANNOVA test showed a significant difference in plasma MDA (p=0,000) in the whole group of wistar rats. Significant differences were also shown on the examination of plasma MDA levels in the K1-K2, K2-P1, K2-P2, and K2-P3 groups (p<0,05). Conclusion: Longan peel extract had the effect of reducing plasma MDA levels of wistar rats induced by toxic doses of paracetamol compared to the control group.Keywords: Paracetamol, longan peel extract, MDA.
The Effect of Carbonated, Isotonic, and Yoghurt Drinks to the Hardness of Bulk Fill Composite Resin Tyagita Haning Ratnasari; Nadia Hardini; Yoghi Bagus Prabowo; Faizah Fulyani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.31349

Abstract

Background: Composite resin often used as a restoration material due to its advantages in the aesthetic field. The bulk-fill type is one of the composite resin that can be applied directly into cavities as deep as 4 mm, so that restoration procedure becomes easy and effective. Hence, exposure to various acidic drinks can reduce the hardness of composite resins and eventually lead to failure of the tooth restoration process.Objective: This research aimed to evaluate the effects of several commercial acidic drinks, (carbonated, isotonic, and yogurt) on the hardness of bulk-fill composite resins.Method: This research was an experimental study with a post-test control group design. Twenty-four specimens were made with the size 10 x 4 mm using the metal mold rings. Specimens were divided into 4 groups for artificial saliva (served as a control), carbonated, isotonic, and yogurt. Specimens were immersed in storage agents for 5 seconds followed by artificial saliva for 5 seconds. This cycle was repeated 20 times for 14 days. The bulk-fill composite resin hardness was measured using a Micro Vickers Hardness Tester with a load of 100 grams for 10 seconds. Statistical analysis was performed using One Way ANOVA and Post Hoc LSDResults: Data were normally distributed and homogeneous with p > 0.05. The One Way ANOVA test showed the biggest difference in bulk fill composite resin between 4 groups (p < 0.001). The Post Hoc LSD test showed significant differences between all groups (p < 0.001)Conclusion: Carbonated, isotonic, and yogurt drink significantly decreased surface microhardness of bulk-fill composites resin but the carbonated drinks greatly reduce the hardness value since it has the lowest pH of 2.3.
HUBUNGAN ANTARA NILAI BONE MINERAL DENSITY DENGAN SKOR KUALITAS HIDUP PADA LANSIA Hernanda Haudzan Hakim; Lusiana Batubara; Faizah Fulyani
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.618 KB) | DOI: 10.14710/dmj.v8i1.23331

Abstract

Latar belakang : Seiring dengan bertambahnya usia, lansia mengalami penurunan nilai bone mineral density, sehingga menimbulkan berbagai macam keluhan. Keluhan yang ditimbulkan antara lain adalah perubahan bentuk tubuh, nyeri kronik dan patah tulang. Keluhan-keluhan tersebut dapat mempengaruhi aktivitas lansia sehari-hari terutama pada aspek fisik, psikologis, sosial dan lingkungan, sehingga diperkirakan penurunan nilai bone mineral density ini juga akan berdampak pada kualitas hidup lansia. Tujuan : Mengetahui hubungan antara nilai bone mineral density dengan skor kualitas hidup pada lansia. Metode : Penelitian ini merupakan penelitian observasional analitik dengan pendekatan belah lintang. Sampel dalam penelitian ini adalah 42 lansia wanita di berbagai posyandu lansia di Kota Semarang seperti Posyandu Lansia Cinde, Posyandu Lansia Tegalsari, Posyandu Lansia Mahoni, Posyandu Lansia Genuk, dan Posyandu Lansia Dewi Sartika. Pengambilan data bone mineral density dilakukan di Rumah Sakit Telogorejo Kota Semarang dengan menggunakan alat bone densitometry, sedangkan penilaian terhadap skor kualitas hidup dilakukan dengan menggunakan kuesinoer WHOQOL. Penelitian dilakukan selama periode Juni-September 2018. Hubungan antara bone mineral density dengan kualitas hidup diteliti dengan menggunakan analisis bivariat. Hasil : Rerata nilai bone mineral density pada lansia adalah 0,907±0,15 g/cm2 dan rerata skor kualitas hidup total adalah 294,79±43,60. Uji Shapiro-Wilk menunjukan sebaran data yang normal, sehingga dilakukan analisis korelasi menggunakan uji pearson. Hasil analisis menunjukan tidak terdapat korelasi bermakna (p>0,05) antara nilai bone mineral density dengan skor kualitas hidup pada lansia. Simpulan : Tidak ada hubungan antara nilai bone mineral density dengan kualitas hidup lansia secara keseluruhanKata kunci : Bone Mineral Density, Kualitas Hidup, WHOQOL.
Perbedaan Kadar Gula Darah Sewaktu pada Pasien Skizofrenia yang Mendapat Terapi Antipsikotik Generasi Kedua Selama kurang dari Empat Bulan dan lebih dari Empat Bulan Rani Rahayu; Faizah Fulyani; Innawati Jusup; Alifiati Fitrikasari
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.196 KB) | DOI: 10.36408/mhjcm.v8i2.567

Abstract

ABSTRAK LATAR BELAKANG : Skizofrenia merupakan gangguan mental dengan mortalitas dua sampai tiga kali lipat lebih tinggi dibandingkan populasi umum. Antispikotik generasi kedua merupakan salah satu terapi untuk skizofenia, namun memiliki efek samping gangguan metabolik yang lebih tinggi dibandingkan antipsikotik golongan pertama, seperti peningkatan kadar gula darah. TUJUAN : Mengetahui perbedaan kadar gula darah sewaktu pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua selama kurang dari empat bulan dan lebih dari empat bulan. METODE : Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Sampel adalah data rekam medis 67 pasien skizofrenia di RSJD Amino Gondohutomo Semarang yang memenuhi kriteria inklusi. Subjek dibagi menjadi dua kelompok yaitu yang mendapatkan terapi kurang dari 4 bulan dan yang mendapatkan terapi selama lebih dari 4 bulan. Uji statistik menggunakan uji Mann Whitney untuk mengetahui perbedaan antara kedua kelompok. HASIL : Kadar gula darah sewaktu pada kelompok yang mendapat terapi antipsikotik generasi kedua selama kurang dari empat bulan lebih rendah (116 mg/dl) dibandingkan dengan yang mendapatkan terapi lebih dari empat bulan (118 mg/dl). Meskipun demikian, perbedaan tersebut tidak bermakna secara statistik (p>0.05). KESIMPULAN : Tidak terdapat perbedaan kadar gula darah sewaktu pada pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua kurang dari empat bulan dan lebih dari empat bulan. Kata Kunci : skizofrenia, antipsikotik, gula darah sewaktu
Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women Innawati Jusup; Lusiana Batubara; Dwi Ngestiningsih; Faizah Fulyani; Devina Afraditya Paveta; Putri Theresia Lemmo Ate Bancin
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.157

Abstract

Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis 
The Effect of Espresso and Drip Brewing Coffee Methode to The Hardness of Bulk-Fill Composite Resin Rahmadani Widya Atmani; Diah Ajeng Purbaningrum; Faizah Fulyani; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.31162

Abstract

Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin.
THE EFFECT OF CARBONATED, ISOTONIC AND YOGHURT DRINKS IMMERSION ON THE ROUGHNESS OF BULK-FILL COMPOSITE RESIN Ayu Khoirun Nisa; Diah Ajeng Purbaningrum; Lusiana Batubara; Faizah Fulyani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30521

Abstract

Background: Composite resins are dental restorative materials that are widely used and have high aesthetic value compared to other materials. However, acidic environmental conditions can degrade the composite resins, resulting in increased surface roughness of the resin, and consequently lead to an increased risk of caries.Objective: the purpose of this study was to evaluate the effect of immersion in acidic drinks on the surface roughness of composite resins,Method: In this study 24 samples of bulk fillTM  composite resins were used. Samples were divided into four groups. Each sample was immersed for 5 seconds in either artificial saliva (control), carbonated beverage, isotonic, or yogurt, and followed by 5 seconds immersion in saliva. This cycle was repeated for 20 times for 14 consecutive days. The roughness of composite resin before and after 14 days immersion was measured by using a profilometer. Microscopic structures were analyzed by Scanning electron Microscope (SEM). Statistical analysis was used paired t-test, Anova and Post Hoc LSD.Results: Data from each sample group was normally distributed- with p > 0.05. The paired t-test for each group showed a p-value < 0.05, which indicates there was a significant difference between surface roughness before and after immersion. ANOVA analysis revealed that there was a difference in the surface roughness between groups LSD test, showed that there was difference in the surface roughness between artificial saliva with carbonated drink, isotonic drink with carbonated drink, yoghurt drink with carbonated drink (p<0.0001), between artificial saliva group with yoghurt drink, yoghurt drink with carbonated drink, yoghurt drink with isotonic drink (p <0.05) which means there was a significant difference between group. Meanwhile, the isotonic drinks with artificial saliva obtained results (p>0.05), which means there is no significant difference.Conclusion: Exposure of carbonated drinks, yoghurt drinks, and isotonic drinks can significantly increase the roughness of the surface Bulk Fill resin composite compared to exposure of artificial saliva.Keywords: Composite resin, Bulk Fill, Surface Roughness, Acid
HUBUNGAN ANTARA KADAR VITAMIN D DENGAN KEKUATAN GENGGAMAN TANGAN LANSIA Muhammad Rizky Caniago; Dwi Ngestiningsih; Faizah Fulyani
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.493 KB) | DOI: 10.14710/dmj.v8i1.23339

Abstract

Latar Belakang: Meningkatnya jumlah lansia di Indoneisa berdampak pada peningkatan masalah kesehatan. Pada lansia terjadi penurunan morfologi dan fungsi organ pada sistem musculoskeletal yaitu penurunan kekuatan otot (Sarkopenia). Kejadian sarkopenia sering ditemukan bersamaan dengan status defisiensi vitamin D. Tujuan: Mengetahui hubungan antara kadar vitamin D plasma dengan kekuatan genggaman tangan lansia. Metode: Penelitian observasional analitik dengan rancangan belah lintang, dilaksanakan di beberapa posyandu lansia kota Semarang. Subjek penelitian adalah lansia yang berusia ≥ 60 tahun. Subjek yang memenuhi kriteria diukur kekuatan genggaman tanganmya dengan menggunakan Jamar hand-dynamometer (3 kali pengukuran). Kadar vitamin D (25(OH)D) plasma diukur dengan menggunakan metode ELISA. Uji hipotesis yang digunakan adalah uji hipotesis korelasi Pearson. Hasil: Subjek pada penelitiana ini adalah lansia wanita yang berjumlah 47 orang. Usia subjek antara 60-80 tahun, dengan median 64 tahun. Body Mass Index (BMI) subjek adalah 23.60 (18.90-34.63) kg/m2. Pada penelitian ini didapatkan data kadar vitamin D (25(OH)D) plasma dengan rerata 17.31±4.65 ng/mL; kekuatan genggaman tangan 16.73±3.87 Kg dan kadar kalsium 9.45±0.55 mg/dL. Uji korelasi Pearson menunjukkan hasil yang signifikan dengan nilai p = 0,047 dan r = 0.291. Kesimpulan: Adanya hubungan signifikan positif lemah antara kadar vitamin D (25(OH) plasma dengan kekuatan genggaman tangan pada lansia.Kata Kunci: Lansia, kekuatan genggaman tangan, kadar vitamin D plasma, hubungan
Kadar MDA (Malondialdehyde) dan Aktivitas SOD (Superoxide Dismutase) pada Tikus Defisiensi Vitamin D dan Kalsium: Malondialdehyde (MDA) Levels and SOD (Superoxide Dismutase) Activity in Vitamin D and Calcium Deficiency Rat Untari; Gemala Anjani; Faizah Fulyani; Reza Achmad Maulana
JURNAL GIZI DAN KESEHATAN Vol. 17 No. 1 (2025): JURNAL GIZI DAN KESEHATAN
Publisher : UNIVERSITAS NGUDI WALUYO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jgk.v17i1.732

Abstract

Vitamin D and calcium deficiencies are often associated with increased oxidative stress. Oxidative stress conditions can cause cell damage and metabolic stress and induce degenerative diseases. Several parameters that are often used to measure oxidative stress are MDA (malondialdehyde) and SOD (superoxide dismutase) which can be found in blood or body tissue. This study aims to determine MDA levels and SOD activity in the livers of mice with vitamin D and calcium deficiency. This research used a pre-experimental design with a static group comparison design. A total of 12 male Wistar white rats (Rattus novergicus) were divided into two groups. The first group (K+) is a healthy control group without any treatment and the second group (K-) is a deficiency group given feed without vitamin D and calcium content (Modified AIN-93M (vitamin D and calcium depleted)). After 14 days of treatment, the MDA levels and SOD activity in the liver tissue were seen. MDA levels were measured using TBARS (Thiobarbituric Acid Reactive Substances) and SOD activity was measured using the Superoxide Dismutase (SOD) Activity Assay Kit. The results showed that MDA levels in the deficiency group (K-) were higher than in the control group (p<0.001) and SOD activity was lower than in the control group (p<0.001). MDA levels were higher and SOD activity was lower in the group of deficient mice (K-) compared to the group of healthy control mice (K+). Vitamin D and calcium deficiency conditions increase oxidative stress conditions in the liver of rat.   ABSTRAK Defisiensi vitamin D dan kalsium sering dihubungkan dengan peningkatan stress oksidatif. Kondisi stres oksidatif dapat menyebabkan kerusakan sel dan stress metabolik dapat menginduksi penyakit degenerative. Beberapa parameter yang sering digunakan untuk mengukur stres oksidatif yaitu MDA (malondialdehyde) dan SOD (superoxide dismutase) yang bisa ditemukan di darah atau jaringan tubuh. Penelitian ini bertujuan untuk mengetahui kadar MDA dan aktivitas SOD pada organ hati tikus dengan defisiensi vitamin D dan kalsium. Penelitian ini menggunakan rancangan pra-eksperimental (pre-experimental) dengan design static group comparison. Sebanyak 12 ekor tikus putih (Rattus novergicus) jantan galur Wistar dibagi menjadi dua kelompok. Kelompok pertama (K+) yaitu kelompok kontrol sehat tanpa diberikan perlakuan apapun dan kelompok kedua (K-) yaitu kelompok defisiensi dengan diberikan pakan tanpa kandungan vitamin D dan kalsium (AIN-93M Termodifikasi (vitamin D and calcium depleted)). Setelah 14 hari perlakuan, dilihat kadar MDA dan aktivitas SOD di jaringan organ hati. Pengukuran kadar MDA menggunakan TBARS (Thiobarbituric acid reactive substances) dan pengukuran aktivitas SOD dengan menggunakan Superoxide Dismutase (SOD) Activity Assay Kit. Hasil penelitian menunjukkan kadar MDA pada kelompok defisiensi (K-) lebih tinggi dibandingkan kelompok kontrol (p< 0.001) dan aktivitas SOD lebih rendah dibandingkan kelompok kontrol (p<0.001). Kadar MDA lebih tinggi dan aktivitas SOD lebih rendah pada kelompok tikus defisieni (K-) dibandingkan kelompok tikus kontrol sehat (K+). Kondisi defisiensi vitamin D dan kalsium meningkatkan kondisi stres oksidatif pada organ hati tikus.
Pengaruh Penyemprotan Larutan Asam Hipoklorit (HOCl) dengan Konsentrasi dan Durasi Berbeda terhadap Stabilitas Dimensi Hasil Cetakan Alginat Prajogo, Johanna Kezia; Fulyani, Faizah; Purnomo, Brigitta Natania Renata; Santoso, Oedijani
Acta Odontologica Indonesia Vol 1, No 1 (2025): June Edition
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.25989

Abstract

Background: Disinfection of alginate impressions is performed to prevent cross-infection. Alginate possesses properties of imbibition and syneresis which affect the dimensional stability of the impression. The disinfectant solution, hypochlorous acid (HOCl), is non-toxic, non-irritating, and non-corrosive at the appropriate concentrations. Hypochlorous acid has higher antimicrobial activity than sodium hypochlorite (NaOCl). Objective: This study aimed to determine the effect of spraying 0.01% and 0.02% HOCl with contact durations of 1 and 5 minutes on the dimensional stability of alginate impressions. Methods: This was a laboratory experimental study with a Post-Test Only Control Group Design. A total of 24 samples were divided into 4 treatment groups and 2 control groups. The dimensional stability of the alginate impressions was assessed by the difference in anteroposterior and mediolateral dimension measurements between the master model and the resulting gypsum casts, using a digital caliper. Measurements were taken 3 times by 3 different observers, followed by a two-way ANOVA statistical test. Results: The results of the two-way ANOVA test showed no significant difference between the groups with variations in concentration or contact duration. The largest dimensional difference was found in the control group sprayed with 5.25% NaOCl. Conclusion: Spraying alginate impressions with 0.01% and 0.02% HOCl with contact durations of 1 and 5 minutes does not affect the dimensional stability of the alginate impressions.