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All Journal JURNAL GIZI INDONESIA Biomedika Smart Medical Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Narra J Gema Lingkungan Kesehatan Jurnal Info Kesehatan Indonesian Basic and Experimental Health Sciences
Arief Nurudhin
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Correlation of D- Dimer and Neutrophil Lymphocyte Ratio (NLR) Levels on COVID-19 Mortality Nurhayatun, Evi; Ayu Safira, Meilani; Nurudhin, Arief
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1207

Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by a novel coronavirus or a new type of corona virus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). D-dimer and Neutrophil Lymphocyte Ratio are parameters that can be used as a predictor of mortality in COVID-19, so this study aims to determine the relationship between D-dimer levels and NLR with mortality in COVID-19 patients. The study used an analytic observational method with a cross sectional approach from medical record data at UNS Hospital. The population in this study were COVID-19 patients at UNS Hospital who had their D-dimer and NLR levels checked in the period November 2020-January 2021. The sample was taken using a simple random sampling technique. Bivariate data analysis with Spearman Rank Correlation Test. Obtained 72 samples. 46 male patients and 26 female patients with the highest age range of 40-59 years as many as 34 patients. Patients who experienced mortality as many as 24 people while the rest survived. Spearman's Rank test obtained p-values of D-dimer and neutrophil lymphocyte ratio (NLR) with mortality of COVID-19 patients 0.009 and <0.001, respectively. While the correlation coefficients for D-dimer and NLR on mortality were 0.308 and 0.515, respectively. There is a relationship between D-dimer and NLR levels with mortality in COVID-19 patients with a positive correlation.
Umbilical Cord Mesenchymal Stem Cells Secretome in Osteoarthritis Patients: A Case Report Nurudhin, Arief; Prabowo, Nurhasan Agung; Wedhiningsih, Yulyani; Sunarso, Indrayana
Gema Lingkungan Kesehatan Vol. 23 No. 4 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/

Abstract

We report a case study of a 58-year-old lady diagnosed with symptomatic knee osteoarthritis (OA) who received umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome via intra-articular injections once weekly for a total of five weeks. This treatment significantly reduced pain compared to the control, using a Visual Analog Scale, with pain scores reducing from 7/10 to 3/10. Moreover, the patient showed marked functional capacity improvement, as indicated by a Western Ontario and McMaster Universities Osteoarthritis Index score from 65 to 30. Her Kellgren-Lawrence grade also improved radiographically from 4 to 2 indicating either an initiation of cartilage regeneration or a reduction in degenerative change. These favorable results position the UC-MSC secretome as a novel and safe treatment for knee osteoarthritis, making it a potent non-invasive replacement therapy to classical treatments. The researchers advise that these findings must be confirmed in bigger, controlled trials before the therapeutic effects of UC-MSC secretome can be established in broader patient populations.
The Effect of TNF-α and FIB-4 Score on Diastolic Dysfunction in Child Pugh C Liver Cirrhosis Karim, Muhammad Yusuf; Pramana, Triyanta Yuli; Sulastomo, Heru; Nurudhin, Arief; Pamungkasari, Eti Poncorini
Gema Lingkungan Kesehatan Vol. 23 No. 4 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i4.384

Abstract

Liver cirrhosis is a major global health concern, often complicated by cardiac dysfunction such as diastolic heart failure. Tumor necrosis factor-alpha (TNF-α) and FIB-4 score are widely used biomarkers in cirrhotic patients, but their predictive value for cardiac complications remains unclear. To determine the effect of TNF-α and FIB-4 scores on the severity of diastolic dysfunction in patients with Child-Pugh C liver cirrhosis. This analytical cross-sectional study included 40 Child-Pugh C cirrhotic patients. Serum TNF-α levels were measured using ELISA. Diastolic function was evaluated using echocardiography. Ordinal logistic regression was used to analyze the association between TNF-α, FIB-4, and diastolic dysfunction grades. The majority of participants had moderate (65.0%) or severe (35.0%) chronic inflammation based on TNF-α levels, with a median TNF-α of 45.52 pg/mL. Significant liver fibrosis (FIB-4 >3.25) was observed in 82.5% of participants. Grade I diastolic dysfunction was the most prevalent (52.5%). TNF-α levels were significantly associated with the degree of diastolic dysfunction (p=0.042), whereas FIB-4 scores showed no significant correlation (p=0.533). Elevated TNF-α is strongly associated with worsening diastolic dysfunction in Child-Pugh C cirrhosis, suggesting its role in systemic inflammation and myocardial injury. In contrast, the FIB-4 index may not reflect cardiac involvement in advanced cirrhosis. TNF-α may serve as a potential biomarker for cardiovascular risk stratification in cirrhotic patients, supporting early intervention and integrated care approaches.
Efek Secretome Sel Punca Mesenkimal Terhadap Ekspresi Interleukin 17 Dan Tumor Necrosis Factor Alpha Wulandari, Evi Liliek; Nurudhin, Arief; Arifin, Arifin; Adnan, Zainal Arifin
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.48954

Abstract

Pendahuluan Systemic Lupus Erythematosus (SLE) adalah penyakit inflamasi autoimun kronis yang belum jelas penyebabnya dengan gambaran klinis yang luas serta tampilan perjalanan penyakit beragam. Sitokin tertentu seperti IL-17 dan TNFα sangat terkait dengan pathogenesis SLE. Sel punca mensekresikan sejumlah protein (secretome) termasuk growth factor, kemokin, sitokin, metabolit dan lipid bioaktif yang mengatur secara autokrin atau parakrin sambil merekayasa interaksi dengan lingkungan mikro sekitarnya. Penelitian ini bertujuan mengetahui pengaruh secretome sel punca mesenkimal terhadap ekspresi Interleukin 17 (IL-17) dan Tumor Necrosis Factor Alpha (TNF-α) pada mencit model lupus.Metode PenelitianPenelitian ini merupakan penelitian eksperimental dengan metode post test only control group design dengan randomisasi, sampel 21 mencit Balb/c betina, dibagi menjadi kelompok kontrol (injeksi NaCl 0,9% 0,5ml intraperitoneal), pristan (injeksi pristane 0,5ml intraperitoneal) dan pristan+secretome (injeksi pristan 0,5ml + secretome 0,45 ml intraperitoneal). Dilakukan pemeriksaan ekspresi IL-17 dan TNF- α jaringan ginjal ketiga kelompok. Analisa statistik menggunakan SPSS 22 for windows. Uji beda rerata antara kelompok menggunakan uji F Anova bila distribusi data normal dan bila signifikan akan dilanjutkan dengan LSD Post Hoc Test. P bermakna jika p<0,05.Hasil PenelitianHasil penelitian menunjukkan bahwa didapatkan hasil yang bermakna antara kelompok kontrol, pristan dan pristan+secretome baik pada kadar IL-17 (kontrol 6,9±1,95 ; pristan 9,9±2,27; pristan+secretome 6,1±1,95;  =0,016), dan TNF-α (kontrol 6,9±1,95; pristan 11,7±3,40; pristan+secretome 7,9±2,03; p=0,005).Kesimpulan Penelitian ini menunjukkan bahwa pemberian secretome sel punca mesenkimal berpengaruh menurunkan ekspresi IL-17 dan TNF- α pada mencit model lupus.Kata kunci : Secretome, Interleukin 17, Tumor Necrosis Factor Alpha, Lupus
Co-Authors Adnan, Zainal Arifin Adnan, Zainal Arifin Affandi, Andri Akrim Permitasari Arifin Arifin Ayu Safira, Meilani BAGUS WICAKSONO Bagus Wicaksono Damayani, Aritantri Eti Poncorini Pamungkasari Gazali, Itqan Indah Putri Maharani Karim, Muhammad Yusuf Maharani, Indah Putri Marwanta, Sri Nurhayatun, Evi Prabowo, Nurhasan A. Prabowo, Nurhasan Agung Rohman, Yulia Safitri, Ayu SI. Shanti Listyawati Shiddiqi, Toumi Sholehah, Laila Sidarta, Brigitte RA. Sulastomo, Heru Sunarso, Indrayana Toumi Shiddiqi Triyanta Yuli Pramana Wardhani, Lusi Oka Wedhiningsih, Yulyani Werdiningsih, Yulyani Wulandari, Evi Liliek Zainal Arifin Adnan