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All Journal JURNAL GIZI INDONESIA Nexus Kedokteran Klinik Biomedika Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Narra J Jurnal Info Kesehatan Indonesian Basic and Experimental Health Sciences
Arief Nurudhin
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Mesenchymal Stem Cell Secretome Improves Bone Quality in Autoimmune Rheumatic Patients (AIIRD): A Case Report Werdiningsih, Yulyani; Nurudhin, Arief; sunarso, indrayana
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp11-15

Abstract

ABSTRAK Autoimmune Inflammatory Rheumatic Disease (AIIRD) is a group of different disorders, which have similar clinical, laboratory and immunological manifestations. In East Asia, the top 3 diseases included in AIIRD are Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Sjogren's Syndrome. Glucocorticoids are still one of the therapeutic modalities for AIIIRD with their antiinflammatory and immunosuppressive effects. However, glucocorticoids have some side effects. One side effect of concern is decreased bone density. The condition of glucocorticoid induced osteoporosis (GIOP) is reported with increasing prevalence. The main effect of the use of glucocorticoids on bones is the presence of impaired bone formation regardless of the role of inflammation.  Secretome stem cells contain bioactives that exhibit diverse physiological functions such as immunomodulation, anti-inflammatory, angiogenesis, anti-apoptotic and anti-oxidation. Secretome can modulate cell differentiation by promoting osteogenesis and inhibiting adipogenesis. In this case report, it showed improvements in markers of bone damage, inflamation, and vitamin D levels after stem cell secretome administration in AIIRD patients with long-term corticosteroid use.
Effect of the Period of Glucocorticoid Administration on Bone Quality in Patients with Autoimmune Inflammatory Rheumatism Disease (AIIRD) Werdiningsih, Yulyani; Sunarso, indrayana; Nurudhin, Arief
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 2 (2025): APRIL
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss2pp52-58

Abstract

Introduction Inflammatory autoimmune rheumatic disease (AIIRD) such as rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome often requires long-term glucocorticoid therapy. Despite its effectiveness, glucocorticoids are recognized to cause decreased bone quality and increase the risk of osteoporosis. This study aims to evaluate the effect of the period of glucocorticoid administration on bone quality parameters in AIIRD patients. Methods This study was an observational analytical study with a cross-sectional design. A total of 28 female patients with AIIRD were divided into two groups based on the period of glucocorticoid administration: less than 24 months and more than 24 months. The parameters to be measured included bone mineral density (BMD), Collagen Type I C-Telopeptide (CTX), Vitamin D3 levels, and Calcium Ions. Data analysis was conducted using the Mann-Whitney test and the unpaired t-test with a significance level of p<0.05. Results There was no statistically significant difference between the two groups on all measured parameters. The mean BMD in the group of less than 24 months was 0.9471 kg/m², while in the group of more than 24 months it was 0.8920 kg/m² (p>0.05). The mean CTX also did not differ significantly between the two groups (0.2474 vs. 0.2508 ng/mL; p>0.05). Vitamin D3 and Calcium Ion levels showed similar results in the absence of significant differences (Vitamin D3: 15,596 vs. 16,255 ng/mL; Calcium Ion: 1,075 vs. 1,040 mmol/L; p>0.05). Conclusions The period of glucocorticoid administration does not show a significant effect on bone quality in AIIRD patients in this study. Nonetheless, regular monitoring and an individualized approach are still necessary to prevent bone complications in patients receiving long-term glucocorticoid therapy.
The Correlation of D- Dimer and Neutrophil Lymphocyte Ratio (NLR) Levels on COVID-19 Mortality Nurhayatun, Evi; Ayu Safira, Meilani; Nurudhin, Arief
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1207

Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by a novel coronavirus or a new type of corona virus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). D-dimer and Neutrophil Lymphocyte Ratio are parameters that can be used as a predictor of mortality in COVID-19, so this study aims to determine the relationship between D-dimer levels and NLR with mortality in COVID-19 patients. The study used an analytic observational method with a cross sectional approach from medical record data at UNS Hospital. The population in this study were COVID-19 patients at UNS Hospital who had their D-dimer and NLR levels checked in the period November 2020-January 2021. The sample was taken using a simple random sampling technique. Bivariate data analysis with Spearman Rank Correlation Test. Obtained 72 samples. 46 male patients and 26 female patients with the highest age range of 40-59 years as many as 34 patients. Patients who experienced mortality as many as 24 people while the rest survived. Spearman's Rank test obtained p-values of D-dimer and neutrophil lymphocyte ratio (NLR) with mortality of COVID-19 patients 0.009 and <0.001, respectively. While the correlation coefficients for D-dimer and NLR on mortality were 0.308 and 0.515, respectively. There is a relationship between D-dimer and NLR levels with mortality in COVID-19 patients with a positive correlation.
Co-Authors Adnan, Zainal Arifin Affandi, Andri Akrim Permitasari Ayu Safira, Meilani BAGUS WICAKSONO Bagus Wicaksono Damayani, Aritantri Gazali, Itqan Indah Putri Maharani Maharani, Indah Putri Marwanta, Sri Nurhayatun, Evi Prabowo, Nurhasan A. Prabowo, Nurhasan Agung Rohman, Yulia Safitri, Ayu SI. Shanti Listyawati Shiddiqi, Toumi Sholehah, Laila Sidarta, Brigitte RA. Sunarso, Indrayana Toumi Shiddiqi Wardhani, Lusi Oka Werdiningsih, Yulyani Zainal Arifin Adnan