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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Sriwijaya Journal of Surgery Sriwijaya Journal of Ophthalmology Bioscientia Medicina : Journal of Biomedicine and Translational Research
Erial Bahar
Department of Anatomy, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Short Chain Fatty Acid (SCFA) Gut Biota and Interleukin 6 (IL-6) Related to the Severity of Systemic Lupus Erithematosus (SLE) at Dr. Mohammad Hoesin General Hospital Palembang Edwin Nugraha Fitriawan; Eddy Mart Salim; Erial Bahar; Nova Kurniati; Yuniza; Syamsu Indra; Norman Djamaludin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.527

Abstract

Background. SLE is an autoimmune disease characterized by the presence of autoantibodies in the nucleus, deposition of immune complexes, and can attack various body tissues. Gut biota in this case short-chain fatty acids (SCFA) play a role in the inflammatory process in the SLE, while the levels of IL- 6 can also be associated with a response to inflammation which will be seen in the degree of SLE activity. This study aims to determine the correlation of SCFA Gut biota and IL - 6 with SLE degree activity. Methods. This study is a cross-sectional study with a correlation test design, conducted from November 2021-January 2022 at RSMH Palembang with the research subjects being all SLE patients seeking treatment at the Allergy-Immunology Division of RSMH Palembang with categories of mild and moderate-severe SLE activity degree. Examination of SCFA Gut biota using stool samples and serum IL-6 levels were associated with SLE activity degree. Statistical analysis of the correlation test with Spearman for numerical data not normally distributed, and continued with linear regression test to assess the multivariate analysis in this study. Results. The sample consisted of 32 patients, every 16 patients with mild and moderate-severe SLE activity degrees. The correlation between SCFA Gut biota with SLE activity degree was found to have a correlation coefficient of r=-0.777 with p=0.000. Correlation between IL-6 with SLE activity degree obtained a correlation coefficient of r=0.910 with p=0.000, while the correlation test between IL-6 and SCFA Gut biota obtained r=-0.633 with a value of p=0.000. Multivariate analysis found that 70.5% of SCFA Gut biota and IL-6 affected SLE activity degree. Conclusion. SCFA Gut biota and IL-6 had a significant correlation in statistical tests with the SLE activity degree.
The Role of Nutritional Status on SARS-CoV-2 IgG Levels After COVID-19 Vaccination in Palembang Ditta Puspa Anggraini; Eddy Mart Salim; Nur Riviati; Erial Bahar; Syamsu Indra; Nova Kurniati; Ahmad Rasyid; Yuniza
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.569

Abstract

Background: The elderly and geriatric population is the population most at risk for complications of COVID-19. Preliminary data show that individuals aged >59 years are estimated to experience five times more severe COVID-19 symptom onset than those aged 30 to 59 years. Nutritional status is believed to play a role in the body's ability to produce antibodies after COVID-19 vaccination. Methods: A cross-sectional analytic observational study to determine the role of nutritional status on levels of IgG SARS-CoV-2 after COVID-19 Vaccination in Palembang. IgG levels were assessed by the ECLIA method. Data analysis was carried out univariate and bivariate. Results: The mean quantitative IgG of SARS-CoV-2 in underweight nutritional status was higher with a value of 5757.42±2594.08 U/mL and with the lowest mean quantitative IgG SARS-CoV-2 in overweight nutritional status with a value of 2998.13±4386.95 U/mL. Conclusion: Nutritional status did not play a role in SARS-CoV-2 IgG levels after the COVID-19 vaccination in Palembang.
Factors Related to the Incidence of Dysphagia in Patients Using Tracheal Cannula at Dr. Mohammad Hoesin General Hospital Palembang Puspa Zuleika; Mariance; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.574

Abstract

Background: The need for tracheostomy increases during the coronavirus diseases 2019 (COVID-19) pandemic. However, some studies suggest that tracheostomy causes dysphagia which can lead to other health problems such as pneumonia, choking, weight loss, malnutrition, and dehydration with serious side effects. This study aims to determine the factors associated with the incidence of dysphagia in patients using a tracheal cannula. Methods: This study is an observational study using a cross-sectional design. Data collection was carried out using medical record data on 58 patients who used a tracheal cannula recorded in the medical record data for the FEES examination at Dr. Mohammad Hoesin General Hospital Palembang from January 2019 to September 2021. The data were analyzed by descriptive statistics, chi-square, and multiple logistic regression. Results: Of 58 patients who used a tracheal cannula, it was found that 75.9% had dysphagia. The results of the comparison test showed that the factors associated with the incidence of dysphagia were gender (p=0.001), nutritional status (p=0.013), incision location (p=0.043), and primary disease (p=0.021). Factors that were not associated with the incidence of dysphagia were age (p=0.933), tracheostomy indication (p=0.741), and the type of tracheal cannula (p=1,000). Patients are male, with low and high tracheal cannula incision locations, and have a primary neurological disease. The probability or chance of dysphagia is 79.8%. Conclusion: Tracheostomy can cause dysphagia which is influenced by gender, location of tracheal cannula incision, and primary disease.
Relationship between the Number of CD4+ and CD8+ Cells in Patients with COVID-19 (Coronavirus Disease 2019) at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Hidayatullah; Zen Ahmad; Phey Liana; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.585

Abstract

Background: The pathogenesis of COVID-19 involves complex immunological processes that can predispose to disease severity. In COVID-19 patients, there will be changes in the number of CD4 + and CD8 + cells which are part of lymphocyte cells in the specific immune system. This study aims to see the relationship between CD4+ and CD8+ cell counts in COVID- 19 patients at Dr. Mohammad Hoesin Hospital Palembang, Indonesia. Methods: This research is an observational study with a case series approach. A total of 30 study subjects who were COVID-19 patients participated in this study. The number of CD4+ and CD8+ cells was assessed, then correlation analysis was performed with the Spearman test, p<0.05. Results: The correlation between CD4+ and CD8+ has a value of R = 0.875 and p<0.01. This shows that CD4+ and CD8+ have a strong positive correlation and are statistically significant. Conclusion: The increase in the number of CD4+ cells will be followed by an increase in the number of CD8+ cells in COVID-19 patients at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia.
Factors that Influence the Speed of Occurence of Senile Cataracts in South Sumatra Imaniar Kesuma; Anang Tribowo; Erial Bahar
Sriwijaya Journal of Medicine Vol. 3 No. 2 (2020): Vol 3, No 2, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i2.73

Abstract

Introduction. Cataracts are any condition of opacity in the lens that can occur due to the hydration (fluid addition) of the lens, the lens protein denaturation or the consequences of both. Factors that can affect the development rate of the opacity of the lens such as diabetes mellitus, hypertension, certain medications, the B ultraviolet rays from sunlight, toxic effects of smoking, alcohol, less vitamin E, and chronic inflammation in the eyeball.Methods. The type of research is observational analytical with a cross-sectional design. This study was held in August to December in 2019 in Eye hospital in South Sumatra with sampling as many as 234 patients from the medical record. Data is processed using SPSS. The Chi-square test is conducted to determine the relationship of factors that affect the rate of senile cataract in Eye Hospital in South Sumatera Province. Results. From 234 patients, as many as 177 patients (75.6%) with mature cataract and 57 patients (24.4%) with immature cataract. There is no meaningful relation between senile cataract and hypertension (p = 0,068; OR = 1,084; 95% CI = 0,589-1,995). There is no meaningful relation between senile cataract and diabetes mellitus (p = 1.808; OR = 1,876; 95% CI = 0,741-4,747). There is no meaningful relation between senile cataract and gender (p = 0.51; OR = 0,933; 95% CI = 0,514-1,696). There is no meaningful relation between the senile cataract and age (p = 0,784; OR = 1,319; 95% CI; 0,714-2,437).Conclusion. There is no significant relationship between senile cataract occurence, hypertension, diabetes mellitus, gender and age.
Correlation of Absolute Lymphocyte Count with Severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang Zen Ahmad; Yulia Nugraha Karsita; Phey Liana; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.601

Abstract

Background: The rRT-PCR examination is very effective as a diagnostic tool for COVID-19 but cannot be a full reference as an evaluation examination because rRT-PCR is able to capture the genetic material of the virus without ensuring that the virus is still alive or only dead particles. This study aims to explore the correlation between absolute lymphocyte values and the severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is an observational study involving 413 research subjects at Dr. Mohammad Hoesin General Hospital. Data analysis was carried out univariate and bivariate. Results: The absolute number of lymphocytes with the severity of COVID-19 has a negative correlation, with a strong correlation strength, which is expressed by the value of r = -0.617 and the degree of significance of p = 0.000. Conclusion: There is a correlation between absolute lymphocyte count and the severity of COVID-19 at Dr. Mohammad Hoesin General Hospital Palembang.
Comparison of the Success Rate of Radial Arterial Cannulation with Palpation Techniques and Ultrasound Guidance in Patients Undergoing Major Surgery with General Anesthesia Afriza Rizqi Zaini; Fredi Heru Irwanto; Mayang Indah Lestari; Erial Bahar; SNA Ratna Sari Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.630

Abstract

Background: Ultrasound-guided arterial cannulation has the potential to increase the total success rate and first attempt and reduce complications compared to conventional landmark palpation methods. This study aims to compare the success rate of radial artery cannula with palpation techniques and ultrasound guidance in patients undergoing major surgery under general anesthesia. Methods: This study is a randomized controlled trial singly. The inclusion criteria for this study were patients who underwent both emergency and elective surgery under general anesthesia, aged >18 years, with ASA I and II physical status. The study sample (60 people) was randomized by computer and divided into two groups (ultrasound guidance and palpation technique). The study will assess the success of the first insertion of the radial artery cannula in both groups. Data analysis was performed with SPSS 25 univariate and bivariate. Results: There is a significant relationship with the success of the first attempt at an ultrasound-guided cannula trial with a p-value of 0.045 with an odds ratio of 3.33 with a 95% confidence interval (0.998 – 11.139). Conclusion: Ultrasound-guided arterial cannulation has a better success rate and fewer complications than conventional palpation techniques.
Comparison of the Effectiveness of Levofloxacin Eye Drop 0.5% and Povidone-Iodine 2.5% Against Conjunctival Normal Flora Bacterial Colonies in Intraocular Preoperative Procedures Petty Purwanita; Okta Kurniawan Saputra; Erial Bahar; Nurmalia Purnama Sari
Sriwijaya Journal of Ophthalmology Vol. 6 No. 1 (2023): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.95

Abstract

Introduction: Endophthalmitis is the most severe ocular complication and often causes blindness. The incidence of endophthalmitis varies depending on the type of surgery performed, from 0.082% to 0.32%. The use of povidone-iodine and topical antibiotics on the conjunctiva has been reported to reduce the likelihood of postoperative infection. This study aimed to compare the effectiveness of levofloxacin ED 0.5% with povidone-iodine 2.5% in reducing the normal bacterial flora of the conjunctiva in intraocular preoperative procedures. Methods: Clinical trial experimental studies. A total of 34 research subjects participated in this study. The research subjects were grouped into treatment groups of 0.5% levofloxacin and 2.5% povidone-iodine. Analysis of differences in the number of bacterial colonies was carried out with the help of bivariate SPSS software. Results: Treatment with levofloxacin 0.5% eye drop was able to reduce the number of colonies by 78.11%, while treatment with povidone-iodine 2.5% was able to reduce the number of colonies by 68.57%. Conclusion: Levofloxacin 0.5% eye drop is superior in reducing the number of conjunctival bacterial colonies in intraocular preoperative procedures compared to 2.5% povidone-iodine.
The Effectiveness of Hyaluronic Acid Injection on Rat Tendon Repair Prognosis as a Model in Achilles Tendon Rupture Adi Mulya; Ismail Bastoni; Erial Bahar
Sriwijaya Journal of Surgery Vol. 3 No. 1 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v3i1.25

Abstract

Introduction: Rupture of the Achilles tendon has become an increasingly common case in the last two decades with an incidence of 18% per 100,000 population. The controversy about the best treatment arises because the results are determined by the method of tendon repair and postoperative functional rehabilitation. In recent years, there is a great deal of interest in hyaluronic acid which is found in certain amounts in the soft tissue extracellular matrix and joint fluid. Several experimental studies have shown the application of hyaluronic acid (HA) to heal tendons and stimulate tendon healing and reduce adhesion formation. This research is to find out the effectiveness of injecting hyaluronic acid in behavior changes in mice that have modified Achilles tendon rupture in 21 mice divided into three groups according to their treatment, namely intramuscular HA (IM), Intralesional HA (IL) and NaCl in laboratory animals Sriwijaya University Faculty of Medicine 2019 by seeing changes in behavior every 7 days 3 times. Results: The group with HA-IL treatment had the highest cure success rate, which was 7 (58.3%) good grades, 5 (41.7%) good grades and 2 (100%) very good grades and 5 (33.3%) good and 2 (50%) extraordinary (change behavior 1, 2 and 3, respectively). Then HA-IM 5 (41.7%) Good grades, 7 (58%) Good grades, and 5 (33.3%) and 2 (50%) exceptional grades (change behavior 1, 2 and 3, respectively) and NaCL only have a value of 5 (33.3%) both for behavior change 3. Conclusion: There is a difference in effectiveness between administration of hyaluronic acid and without administration of hyaluronic acid to behavioral changes in repair of the Achilles tendon.
Platelet/Lymphocyte Ratio Accuracy as Predictor of Neo-Adjuvant Chemotherapy Response in Locally Advanced Breast Cancer at Dr. Mohammad Hoesin General Hospital Palembang Abdur Rahman; Mulawan Umar; Erial Bahar
Sriwijaya Journal of Surgery Vol. 4 No. 1 (2021): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v4i1.54

Abstract

Background: Platelet/lymphocyte ratio (PLR) is considered as predictor for chemotherapy response in locally advanced breast cancer undergoing neo-adjuvant chemotherapy. This study aims to evaluate the relationship between the platelet/lymphocyte ratio and neo-adjuvant chemotherapy response in patients with locally advanced breast cancer at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is a prognostic test of the platelet/lymphocyte ratio accuracy to predict the response of neo-adjuvant chemotherapy in patients with locally advanced breast cancer. The study included 113 subjects. Results: From 113 patients, the PLR cut off point value was 206.83 with an under curve area (AUC) of 91.8%. The results of the PLR prognostic test were sensitivity of 98%, specificity of 87%, Positive Predictive Value of 95%, Negative Predictive Value of 93%, and 95% of accuracy. There was a significant relationship between PLR and chemotherapy response in patients with locally advanced breast cancer (p = 0.000). Conclusion: There was a significant relationship between PLR on chemotherapy response. PLR can be used as a predictor of neo-adjuvant chemotherapy response with a good degree of accuracy.
Co-Authors Abdur Rahman Abla Ghanie Abla Ghanie, Abla Adi Mulya Afriza Rizqi Zaini Ahmad Hifni Ahmad Hifni Ahmad Hifni Ahmad Rasyid Amir Hamzah Anang Tribowo Anggi Ciptawan Anjab Akmal Sya’roni Apriandini Mirdasari Putri Argo Ismoyo Ari Utama Ayus Astoni Ditta Puspa Anggraini Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Edwin Nugraha Fitriawan Efman EU Manawan Ferry Usnizar Fiona Widyasari Fredi Heru Irwanto Guntur Bayu Bima Pratama Harun Hudari Hidayatullah Ika Kartika Imam Supriyanto Imaniar Kesuma Indri Widya Sari Ismail Bastoni Lidiawati Handayani Lisa Apri Yanti Lisa Apri Yanti Listya Paramita M. Aprizal Putera Mariance Mayang Indah Lestari Mediarty Mufida Muzakkie Mulawan Umar Mulawan Umar Nelly Oktriyani Norman Djamaludin Nova Kuniati Nova Kurniati Nova Kurniati Noveldy Calzoum Bachry Nur Riviati, Nur Nurmalia Purnama Sari Okta Kurniawan Saputra Petty Purwanita Phey Liana Puspa Zuleika Puspa Zuleika, Puspa Raden Yudistira Dwi Ananda Rama Mandela Riezki Indrina Pratiwi Rizandiny Samuel Bertua Halomoan Manurung SNA Ratna Sari Devi Suroso Adi Nugroho Suyata Syamsu Indra Syamsu Indra Syamsu Indra Taufik Indrajaya Trijoso Permono Vidi Orba Busro Welly Salutondok Yoan Levia Magdi Yulia Farida Yahya Yulia Nugraha Karsita Yulianto kusnadi Yuniza Yuniza Zen Ahmad Zulkhair Ali