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All Journal E-Jurnal Medika Udayana Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE Sriwijaya Journal of Surgery Arkus
Mulawan Umar
Oncology Surgery Division, Department Of Surgery, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Penggunaan Kontrasepsi Hormonal pada Penderita Kanker Payudara yang dirawat di RSUP Mohammad Hoesin Palembang Muttaqien, Faisal; Umar, Mulawan
Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2017): vol.7 no.2
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v7i2.1373

Abstract

Kanker payudara merupakan kanker padat dengan insidensi tertinggi setelah kanker serviks di Indonesia. Ada banyak faktor risiko kanker payudara, salah satunya adalah penggunaan kontrasepsi hormonal. Tujuan dari penelitian deskriptif ini untuk mengetahui karakteristik penggunaan kontrasepsi hormonal pada pasien kanker payudara di Rumah Sakit Umum Mohammad Hoesin. Data diperoleh dari pasien yang dirawat di Rumah Sakit Mohammad Hoesin dengan diagnosis kanker payudara pada bulan Mei sampai Juni 2015 (94 kasus). Diagnosis ditegakkan berdasarkan temuan patologi anatomi yang didapat dari biopsi atau mastektomi. Informasi tentang penggunaan kontrasepsi hormonal dan karakteristik peserta didapatkan melalui wawancara langsung. Hasil penelitian menunjukkan bahwa berdasarkan data kontrasepsi hormonal, sebagian besar penderita kanker payudara pernah menggunakan kontrasepsi hormonal yaitu sebanyak 56,38%. Jenis kontrasepsi yang paling banyak digunakan yaitu injeksi 3 bulanan (36,17%). Penderita yang mengkonsumsi kontrasepsi pil sebesar 25,53%. Penggunainjeksi 1 bulanan hanya sebesar 6,3% dan kontrasepsi implan sebesar 9,57%. Penderita kanker payudara yang menggunakan kontrasepsi hormonal sebagian besar lamanya ? 5 tahun, yaitu pada kontrasepsi pil (62,5%), kontrasepsi injeksi 1 bulanan (83,3%), kontrasepsi injeksi 3 bulanan (58,82%). Pada kontrasepsi implan kelompok pengguna dengan lama ? 5 tahun sama dengan kelompok pengguna lebih dari 10 tahun (44,44%). Kesimpulannya sebagian besar pasien dengan kanker payudara menggunakan kontrasepsi hormonal (56,38%) dan yang paling umum digunakan adalah injeksi tiga bulan/Medroxyprogesteron acetat (36,17%). Mayoritas pasien menggunakan kontrasepsi hormonal kurang dari 5 tahun, kecuali pasien yang menggunakan alat kontrasepsi implan.
Neoadjuvan Chemotheraphy Responses to Local Advanced Breast Cancer Patients at Dr Moh Hoesin Hospital Palembang Giovanno, Aldo; Mgs. Irsan Saleh; Nur Qodir; Mulawan Umar
Sriwijaya Journal of Medicine Vol. 3 No. 3 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i3.131

Abstract

Neoadjuvant Chemotherapy Responses on Locally Advanced Breast Cancer Patients in General Hospital of Mohammad Hoesin Palembang. Breast cancer is a malignancy which invaded breast tissue in the form of ductal or lobular. One most therapy which given is neoadjuvant chemotherapy. Neoadjuvant Chemotherapy can reduce tumor size so that surgery can be performed with good for breast removal with Modification of Radical Mastectomy (MRM) and Breast Conservative Therapy (BCT). This purposes from this research is to find out neoadjuvant chemotherapy response in Locally Advanced Breast Cancer Patients which is received chemotherapy treatment in RSUP dr Mohammad Hoesin Palembang. This observational descriptive study was conducted at RSUP Mohammad Hoesin Palembang in period between October until November 2019. The sample of this study was locally advanced breast Cancer patients who underwent chemotherapy that met the inclusion and exclusion criteria. The data were obtained by interviews and observed medical record from the patients which were then analyzed by univariate analysis using SPSS version 25. In this study there were 34 locally advanced breast cancer patients who fulfilled the inclusion and exclusion criteria. 24 of 34 patients (70,6%) received positive response and 10 of 34 patients (29,4%) received negative response. Many factors can determine the success of chemotherapy neoadjuvant one of them is a status of molecular subtype from breast cancer patients that must be managed with hormonal therapy and the provision of appropriate chemotherapy regimens also determine the success rate of neoadjuvan therapy in local breast cancer patients.
Gambaran Risiko Hormonal Pasien Kanker Payudara di RSMH Palembang Arekcsueng Hutahaean; Nur Qodir; Mariatul Fadilah; Mulawan Umar; Eddy Roflin
E-Jurnal Medika Udayana Vol 10 No 8 (2021): Vol 10 No 08(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i8.P07

Abstract

Breast cancer is a multifactorial disease. Most of the breast cancer risk factors are hormonal risk factors that associated with the length of exposure to estrogen hormone. This study is aimed to know the description of hormonal risk factors of breast cancer patients in RSUP Dr. Mohammad Hoesin Palembang. This study is a descriptive-observational study with cross-sectional design. Samples in this study are medical records of breast cancer patients in RSUP Dr. Mohammad Hoesin Palembang during January 2019 – August 2020 that meet the inclusion and exclusion criteria. In this study, 97 breast cancer patients were included as participant. Most of the participants had menarche at the age of 12 – 14 (72.2%), menopause at the age of 45 – 54 (38.1%), first pregnancy at the age of 20 – 29 (48.5%), parity ? 3 times (46.4%), breastfed (76.3%), used hormonal contraception (71.1%), not used any menopausal hormone (96.9%), not consumed alcohol (100%) and normal nutritional status (56.7%).
Primary Prevention of Breast Cancer Mulawan Umar
Arkus Vol. 2 No. 1 (2016): ARKUS
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/arkus.v2i1.64

Abstract

Breast cancer is the most common cancer among women and with high mortality rate. There is evidence showing the influence of life style and environmental factors on the development of mammary gland cancer (high-fat diet, alcohol consumption, and lack of physical exercise). Primary prevention may contribute to a decrease in morbidity and mortality. The aim of this paper is to review current knowledge and reports regarding primary prevention of breast cancer.
Comparison of the Effectiveness of Full Negative Pressure with Half Negative Pressure on Suction Drain in Reducing Post-Modified Radical Mastectomy Seroma Gulraj Singh; Mulawan Umar; Nur Qodir
Sriwijaya Journal of Surgery Vol. 2 No. 2 (2019): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.332 KB) | DOI: 10.37275/sjs.v2i2.18

Abstract

Abstract Introduction: Modified radical mastectomy (MRM) is a breast cancer treatment option that is still operable. One of the postoperative complications that can be found is the formation of seroma. High negative suction drain is done to treat seroma after surgery but it can contribute to increase the length of stay in hospital. Methods: This study was a clinical randomized control trial (cRCT) conducted on 30 breast cancer patients in June - July 2019 at Moehammad Hoesin Hospital in Palembang. This study divided the two sample groups, each group consisting of 15 patients. One group was given half negative pressure on suction drain (experimental group) and the other used full negative pressure on suction drain (control group). Results: There was a significant difference (p <0.005) between the full and half negative pressure groups where there were more seroma events in the full vacuum group in 9 (60%) cases and half vacuum in 2 (30%) but there were no significant differences in long period of stay (p> 0.005). Conclusion: Half negative pressure is more effective in treating seroma than full negative pressure.
USIA, SUBTIPE MOLEKULAR, DAN LOKASI METASTASIS PADA PASIEN KANKER PAYUDARA DENGAN METASTASIS JAUH DI RSMH PALEMBANG Miranti, Gabrina; Qodir, Nur; ., Irfannuddin; Umar, Mulawan; ., Swanny
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P18

Abstract

About 90% of cancer-related deaths are caused by distant metastases. Age at diagnosis and molecular subtypes can be used to predict the event of distant metastases. This study aims to determine age and location preference for distant metastases based on tumor molecular subtypes in breast cancer patients. This study was a descriptive observational study with a cross-sectional design. The sample in this study were breast cancer patients with distant metastases, both de novo and recurrent metastases, at Dr. Mohammad Hoesin for the period January - December 2018 who were recorded in the medical record and met the research criteria. There were 93 patients with distant metastatic breast cancer (17 patients with de novo metastases; 76 recurrent metastases). In the de novo and recurrent metastatic groups, most of the patients were ?40-60 years (52.9% and 67.1%). The most common sites of metastases were the lungs (34.4%) and bone (25.8%). Luminal A subtype metastasized dominantly to lungs (45%), luminal B to bone (34.1%), HER2-enriched to lungs (50%), and TNBC to lungs (57.4%) and liver (28.6%). The highest percentage of breast cancer patients with distant metastases in Dr. Mohammad Hoesin Palembang was found in the age group ?40?60 years. The most common sites for metastases are lungs and bones. Most luminal A and HER2-enriched subtypes metastasized to lungs, luminal B to bone, and TNBC to lungs and liver. Keywords: Age, Subtype, Metastatis Site, Distant Metastatis Breast Cancer
Chemotherapy and Quality of Life in Breast Cancer Patients: A Case-Series Study in Palembang, Indonesia Eka Satyani Belina; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 8 No. 1 (2025): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v8i1.120

Abstract

Introduction: Breast cancer is a prevalent malignancy affecting women worldwide, and its treatment, particularly chemotherapy, can significantly impact patients' quality of life (QoL). This study aimed to assess the QoL of breast cancer patients undergoing chemotherapy in Palembang, Indonesia, and to identify factors associated with their QoL. Methods: A cross-sectional study was conducted at the Oncology Unit of Dr. Mohammad Hoesin General Hospital in Palembang, Indonesia, from December 2024 to January 2025. A total of 150 breast cancer patients who met the inclusion criteria were enrolled in the study. Data were collected through medical records and the Functional Assessment of Cancer Therapy - Breast (FACT-B) questionnaire. The FACT-B assesses QoL in five domains: physical, social/family, emotional, functional, and breast cancer-specific concerns. Descriptive statistics, Spearman's correlation, and logistic regression were used to analyze the data. Results: The majority of the patients were aged 40-60 years (70%), had low educational levels (41.3%), were married (83.3%), had locally advanced disease (44%), and had completed chemotherapy (41.3%). The mean FACT-B total score was 76.8. A significant negative correlation was found between the intensity of chemotherapy and QoL (r = -0.306, p = 0.000). Logistic regression analysis revealed that patients who had completed chemotherapy had a significantly lower QoL than those who had not undergone chemotherapy (OR = 0.30, 95% CI = 0.15-0.60, p = 0.001). Conclusion: Chemotherapy significantly impacts the QoL of breast cancer patients in Palembang, Indonesia. Patients who have completed chemotherapy have a lower QoL than those who have not undergone chemotherapy. These findings highlight the importance of providing comprehensive supportive care to breast cancer patients undergoing chemotherapy to improve their QoL.
Dissecting the Triad of Distress: A Multivariate Analysis of Clinical, Surgical, and Sociodemographic Determinants of Quality of Life in Indonesian Breast Cancer Patients Undergoing Chemotherapy Muhammad Yufimar Riza Fadilah; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 8 No. 2 (2025): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v8i2.138

Abstract

Introduction: The assessment of health-related quality of life (HRQoL) is a paramount outcome in breast cancer survivorship, yet the interplay of disease-specific, treatment-related, and patient-level factors is not fully understood in Southeast Asian populations. This study aimed to comprehensively model the predictors of HRQoL and fatigue by simultaneously evaluating clinical, surgical, and sociodemographic variables among Indonesian breast cancer patients. Methods: A cross-sectional study was conducted with 102 female breast cancer patients undergoing chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Data on clinical variables (AJCC stage, chemotherapy cycles, treatment intent), surgical procedures (breast and axillary surgery type), and sociodemographic characteristics were collected. HRQoL was assessed using the validated Indonesian versions of the Functional Assessment of Cancer Therapy-General (FACT-G) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaires. Bivariate correlations and a hierarchical multivariate linear regression analysis were performed to identify significant independent predictors of FACIT-F scores. Results: The cohort was characterized by advanced disease (Stage III/IV: 62.7%) and aggressive surgical management (Mastectomy: 75.5%; Axillary Lymph Node Dissection: 68.6%). In the multivariate analysis, several factors emerged as significant independent predictors of poorer HRQoL. These included advanced cancer stage (β = -0.41, p < 0.001), having undergone a mastectomy versus breast-conserving surgery (β = -0.28, p = 0.002), having had an axillary lymph node dissection versus sentinel node biopsy (β = -0.25, p = 0.005), and a higher number of chemotherapy cycles (β = -0.19, p = 0.018). The final model explained a substantial portion of the variance in HRQoL (Adjusted R² = 0.58). In contrast, sociodemographic factors including age, income, and education were not significant predictors in the final model (p > 0.05). Conclusion: HRQoL in this cohort is not determined by a single factor but by a triad of distress: the biological burden of the disease (stage), the physical and psychological morbidity of surgical treatment, and the cumulative toxicity of chemotherapy. These treatment-related realities powerfully override the influence of sociodemographic characteristics. These findings mandate a paradigm shift towards an integrated supportive care model that proactively addresses surgical morbidity alongside systemic side effects from the point of diagnosis.
Co-Authors ., Irfannuddin ., Swanny Arekcsueng Hutahaean Darwin, Nopriansyah Eddy Roflin Eka Satyani Belina Giovanno, Aldo Gulraj Singh Mariatul Fadilah Mgs. Irsan Saleh Miranti, Gabrina Muhammad Yufimar Riza Fadilah Muttaqien, Faisal Nur Qodir Nur Qodir Qodir, Nur Qodir, Nur Theodorus