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Journal : ComEngApp : Computer Engineering and Applications Journal

Identification of Significant Proteins Associated with Diabetes Mellitus Using Network Analysis of Protein-Protein Interactions Usman, Muhammad Syafiuddin; Kusuma, Wisnu Ananta; Afendi, Farit Mochamad; Heryanto, Rudi
Computer Engineering and Applications Journal Vol 8 No 1 (2019)
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.82 KB) | DOI: 10.18495/comengapp.v8i1.283

Abstract

Computation approach to identify significance of proteins related with disease was proposed as one of the solutions from the problem of experimental method application which is generally high cost and time consuming. The case of study was conducted on Diabetes Melitus (DM) type 2 diseases. Identification of significant proteins was conducted by constructing protein-protein interactions network and then analyzing the network topology. Dataset was obtained from Online Mendelian Inheritance in Man (OMIM) and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) which provided protein data related with a disease and Protein-Protein Interaction (PPI), respectively. The results of topology analysis towards Protein-Protein Interaction (PPI) showed that there were 21 significant protein associated with DM where INS as a network center protein and AKTI, TCF7L2, KCNJ11, PPARG, GCG, INSR, IAPP, SOCS3 were proteins that had close relation directly with INS.
Co-Authors . Indahwati . Sutoro Aam Alamudi Abd. Rasyid Syamsuri Agus Mohamad Soleh Agus Santoso Aji Hamim Wigena Akbar Rizki Akbar Rizki Akbar Rizki Aki Hirai Anang Kurnia Anggraini Sukmawati Annisa Malik Apino, Ezi Aqmar, Nurzatil Bagus Sartono Budi Susetyo Budi Susetyo Budi Waryanto Budi Waryanto Budi Waryanto Cici Suhaeni Dairul Fuhron Dalimunthe, Amir Abduljabbar Dian Ayuningtyas Eka Setiawaty Erwandi Erwandi fatimah Fatimah Febie Tri Lestari Fitrianto, Anwar H S, Rahmat Handayani, Vitri Aprilla Handayani, Vitri Aprilla Hari Wijayanto Hari Wijayanto Hasibuan, Rafika Aufa Hasnita Hasnita Herdina Kuswari Heri Retnawati Hiroki Takahashi I Made Sumertajaya Ikhlasul Amalia Rahmi Indahwati Indahwati Indahwati Isnan Mulia Itasia Dina Sulvianti Izzati, Fatkhul Kensuke Nakamura Khairil Anwar Notodiputro Koesnandy H, Abialam Kusman Sadik Latifah Kosim Darusman M. Rafi Maya Deanti Maysarah Sabariah Kudadiri Md. Altaf-Ul-Amin . Melati Mochamad Ridwan Mochamad Ridwan, Mochamad Mohammad Masjkur Muchlishah Rosyadah Muhammad Ali Umar Mukhamad Najib Nadhif Nursyahban Nur Hikmah Nur Janah Nur Jannah Nurul Qomariasih Octaviani, Siti Nurfajar Panjaitan, Intan Juliana Pardede, Timbul Pika Silvianti Pika Silvianti Pika Silvianti Puspita, Novi Qomariasih, Nurul Rifqi Aulya Rahman Rizal Bakri Rossi Azmatul Barro Rosyada, Munaya Nikma Rosyadah, Muchlishah Rudi Heryanto Safitri, Wa Ode Rahmalia Septaningsih, Dewi Anggraini Septanti Kusuma Dwi Arini Septiani, Adeline Vinda Shigehiko Kanaya Sulistiyani . Syahrir, Nur Hilal A. Syahrir, Nur Hilal A. Usman, Muhammad Syafiuddin Widhiyanti Nugraheni Widya Putri Nurmawati Winata, Hilma Mutiara Wisnu Ananta Kusuma Zana Aprillia