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All Journal e-CliniC JURNAL BIOMEDIK Universa Medicina
Herry E. J. Pandaleke
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profil kandidosis intertriginosa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari - Desember 2013 Polii, Saranita Vikani Gabriele; Pandaleke, Herry E. J.; Kapantow, Marlyn G.
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.11010

Abstract

Abstract:Intertriginous candidosis is a fungal infection of the skin caused by Candida, especially Candida albicans, in the skin fold areas. This study was aimed to obtain the profile of intertriginous candidosis at Dermatovenereology clinic of Prof. Dr. R. D. Kandou Hospital Manado from January 2013 to December 2013. This was a descriptive retrospective study using medical record data of new and old patients diagnosed as intertriginous candidosis based on number of cases, age group, sex, occupation, location, precipitating factors, and type of treatment. The results showed that of the 4099 total patients there were 40 patients (0.98%) with intertriginous candidosis. It is most common in females (70%), aged 45-64 years (42.5%), worked as civilized employee (32.5%), location on the groin (32.43%), precipitating factor sweaty/damp environment (32.5%), and topical antifungal (65%).Keywords: intertriginous candidosis Abstrak: Kandidosis intertriginosa adalah infeksi jamur kulit yang disebabkan oleh jamur Candida, cenderung oleh spesies Candida albicans pada daerah-daerah lipatan kulit. Penelitian ini bertujuan untuk mengetahui profil kandidosis intertriginosa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013 – Desember 2013. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien baru dan lama dengan diagnosis kandidosis intertriginosa yang berobat di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013 – Desember 2013 berdasarkan jumlah kasus, kelompok usia, jenis kelamin, pekerjaan, lokasi, faktor pencetus, dan jenis pengobatan. Hasil penelitian menunjukkan bahwa terdapat 40 pasien (0,98%) kandidosis intertriginosa dari keseluruhan total 4099 pasien. Persentase tertinggi ditemukan pada perempuan (70%), kelompok usia 45-64 tahun (42,5%), pekerjaan pasien PNS (32,5%), lokasi lipatan kulit pada lipat paha (32,43%), faktor pencetus berkeringat/lingkungan lembab (32,5%), dan terapi antifungi topikal (65%). Kata kunci: kandidosis intertriginosa
PROFIL SKABIES DIPOLIKLINIK KULIT DAN KELAMIN BLU RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI – DESEMBER 2012 Gunawan, I Made Erik Sastra; Kandou, Renate T.; Pandaleke, Herry E. J.
e-CliniC Vol 2, No 1 (2014): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.2.1.2014.3606

Abstract

Abstract: Scabies is a skin disease caused by sentization of Sarcoptes scabiei var. hominis and its products. Scabies affects skin and highly contagious in humans and animals, affects all races and classes in all over the world. Risk factors of this disease is low socioeconomic, individual’s poor hygiene, dirty environment, unhealthy behaviour, and high population density. The purpose of this study was to evaluate the profile of scabies patients in Dermatovenereology clinic of Prof. Dr. R. D. Kandou Hospital Manado during the period from January – December 2012. The Method used in this study was descriptive retrospective. The result showed that among 41 scabies patients (3.74%), the highest rate was from age group between 15 – 24 years (29.26%), male (63.41%), most occupation was students (48.78%), most location affected was generalized (80.48%) and most therapy used was anti-scabies combined with antihistamine (60.98%) Keywords: scabies, profile   Abstract: Skabies adalah penyakit kulit yang di sebabkan oleh sensitisasi terhadap sarcoptes scabiei varietas hominis dan produknya. Skabies menyerang kulit dan mudah menular dari manusia ke manusia, dari hewan ke manusia atau sebaliknya, dapat mengenai semua ras dan golongan di seluruh dunia. Faktor risiko penyakit  ini adalah sosial ekonomi yang rendah, higiene perorangan yang jelek, lingkungan yang tidak bersih, perilaku yang tidak sehat, serta kepadatan penduduk. Tujuan penelitian untuk mengetahui profil pasien skabies di poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari  – Desember 2012. Metode penelitian ini bersifat deskriptif retrospektif. Hasil penelitian memperlihatkan dari 41 penderita skabies (3,74%) terbanyak dari kelompok umur 15 – 24 tahun (29,26%), jenis kelamin laki – laki (63,41%), pekerjaan sebagai pelajar (48,78%), lokasi secara generalisata (80,48%) dan terapi antiskabies yang di kombinasikan dengan antialergi (60,98%). Kata kunci: skabies, profil
PROFIL DERMATOFITOSIS DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI – DESEMBER 2012 Bertus, N. Viter P.; Pandaleke, Herry E. J.; Kapantow, Grace M.
e-CliniC Vol 3, No 2 (2015): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v3i2.8862

Abstract

Abstract: Dermatophytosis is a disorder of tissues with keratinized epithelia (eg. stratum corneum of epidermis, hairs, and nails) caused by fungi of dermatophyta. Based on its location, dermatophytosis is divided into: tinea capitis, tinea barbe, tinea cruris, tinea pedis et manum, tinea unguium, and tinea corporis. This study aimed to obtain the profile of dermatophytosis at the Dermatovenerology Clinic of Prof. Dr. R. D. Kandou Hospital Manado, during the period of January-December 2012. This was a retrospective descriptive study. Data of dermatophytosis classification, age, gender, occupation, and therapy classification were obtained from the medical record of that Dermatovenerology Clinic. The results showed that of 65 dermatophytosis cases (1.61% of all skin disease cases in 2012), the most frequent found was tinea cruris (55.38%), with age range 45-64 years old (49.24%), female (67.70%), pensioner (25.42%), and the most frequent therapy was a combination therapy (83.08%).Keywords: dermatophytosis, dermatophyta, tineaAbstrak: Dermatofitosis adalah penyakit pada jaringan yang mengandung zat tanduk (misalnya: stratum korneum pada epidermis, rambut, dan kuku), yang disebabkan oleh golongan jamur dermatofita. Berddasarkan lokasinya, dermatofitosis dibagi atas: tinea kapitis, tinea barbe, tinea kruris, tinea pedis et manum, tinea unguium, dan tinea korporis. Penelitian ini bertujuan untuk mendapatkan profil dermatofitosis di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2012. Penelitian ini menggunakan metode deskriptif retrospektif. Data mengenai klasifikasi dermatofitosis, umur, jenis kelamin, pekerjaan, dan terapi diperoleh dari rekam medik Poliklinik Kulit dan Kelamin. Hasil penelitian menunjukkan bahwa dari 65 kasus dermatofitosis (1,61% dari seluruh kasus penyakit kulit pada tahun 2012), yang terbanyak ialah tinea kruris (55,38%), kelompok umur 45-64 tahun (49,24%), jenis kelamin perempuan (67,70%), pensiunan (25,42%), dan terapi yang terbanyak digunakan ialah terapi kombinasi (83,08%).Kata kunci: dermatofitosis, dermatofita, tinea
Efektivitas Pemeriksaan Serologis Sifilis Baguna, Tirsa; Niode, Nurdjannah J.; Pandaleke, Herry E. J.
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.9.1.2021.32118

Abstract

Abstract: High prevalence of syphilis can be reduced by doing screening. Tests used for screening and diagnosis of syphilis are serological tests of syphilis consisting of nontreponemal tests and treponemal tests. Nontreponemal tests consist of Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) meanwhile Treponemal tests consist of Treponema Pallidum Haemagglutination Assay (TPHA) and Treponema Pallidum Rapid (TP Rapid). This study was aimed to determine the effectiveness of syphilis serological tests. This was a literature review study using the keywords namely serology OR serological OR serologic AND syphilis in PubMed and ClinicalKey. The literatures were written in English and/or Indonesian, published in the last 10 years (2011-2020), and can be accessed in full text. The results obtained 25 literatures. High sensitivity was found in RPR of 9.1%-100%, VDRL of 44.4% -100%, and TP Rapid of 50.0%-100%. High specificity was found in TPHA of 99.7% and TP Rapid of 85.3% -100%. In conclusion, effective syphilis screening is performed with RPR and VDRL, while effective syphilis diagnostic is performed with TP Rapid and TPHA.Keywords: syphilis, serology tests, effectiveness of tests  Abstrak: Prevalensi kasus sifilis yang tinggi dapat diturunkan dengan adanya skrining. Pemeriksaan yang digunakan untuk skrining dan diagnosis sifilis ialah pemeriksaan serologis sifilis, terdiri atas pemeriksaan serologis non spesifik treponema dan pemeriksaan serologis spesifik treponema. Pemeriksaan serologis non spesifik treponema antara lain Rapid Plasma Reagin (RPR) dan Venereal Disease Research Laboratory (VDRL). Pemeriksaan serologis spesifik treponema antara lain Treponema Pallidum Haemagglutination Assay (TPHA) dan Treponema Pallidum Rapid (TP Rapid). Penelitian ini bertujuan untuk mengetahui efektivitas pemeriksaan serologis sifilis. Jenis penelitian ialah literature review menggunakan kata kunci serology OR serological OR serologic AND syphilis di PubMed dan ClinicalKey. Literatur yang digunakan memiliki bahasa Inggris dan/atau bahasa Indonesia, terbitan 10 tahun terakhir (2011-2020), dan dapat diakses teks lengkap. Sensitivitas tinggi ditemukan pada RPR sebesar 9,1%-100%, VDRL sebesar 44,4%-100%, dan TP Rapid sebesar 50,0%-100%. Spesifisitas tinggi ditemukan pada TPHA sebesar 99,7% dan TP Rapid sebesar 85,3%-100%. Simpulan penelitian ini ialah skrining sifilis efektif dilakukan dengan RPR dan VDRL, sedangkan diagnostik sifilis efektif dilakukan dengan TP Rapid dan TPHA.Kata kunci: sifilis, pmeriksaan serologis, efektivitas pemeriksaan
Comparative efficacy of topical 10% versus 5% tranexamic acid in treatment of women with melasma: a double-blind randomized controlled trial Mawu, Ferra Olivia; Kapantow, Marlyn Grace; Pandaleke, Herry E. J.; Cahyadi, Alexandro Ivan; Togelang, Lidya; Tampi, Joan Alexandra; Christopher, Paulus Mario
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.213-219

Abstract

BackgroundMelasma is a highly prevalent chronic pigmentary disorder. The pathogenesis is unknown but melasma often occurs in photo-exposed areas, e.g., cheeks, upper lip, chin, and forehead. Tranexamic acid (TA), a plasmin inhibitor, aids in the inhibition of UV-induced plasmin activity and melanogenesis, making it a favorable therapeutic option for melasma. Tranexamic acid may be administered through various routes, e.g., topical. This study aimed to compare the efficacy of topical 10% versus 5% TA in women with melasma. MethodsThis double-blind randomized controlled trial included 16 females with epidermal type melasma who were randomized into two groups to receive either topical 10% TA (n = 8) or 5% TA (n = 8) applied twice daily for eight weeks. Prior to intervention and at 8 weeks after intervention, the intensity and extension of melasma were assessed based on melasma area and severity index (MASI) score and pigmentation score. ResultsMean MASI and pigmentation scores in both treatment groups were similar at base-line (p>0.05). The reduction in MASI and pigmentation scores in the topical 10% TA and 5% TA groups was similar and statistically not significant after 4 and 8 weeks of treatment (p>0.05). There were no drug-related adverse reactions or complications. ConclusionThis study demonstrated that topical 10% TA and 5% TA were effective in treating women with melasma. The utilization of topical 5% TA for melasma is a promising alternative therapeutic option without the need to increase the concentration of the formulation.
Co-Authors Andravita F. Mitaart Baguna, Tirsa Cahyadi, Alexandro Ivan Caren C.a Pangow Christopher, Paulus Mario Damayanti Tangkidi, Damayanti Dotulong, Julieta D. P. Fahriah . Grace M. Kapantow Gunawan, Ellen I Made Erik Sastra Gunawan Judith Kapari Juliver S. Gabriel, Juliver S. Korompis, Charly M. M. Lidya Togelang Maharani, Ayu Makalew, Deivy A. Mariani V. Lasut Marlyn G. Kapantow Marlyn Grace Kapantow Mawu, Ferra Olivia N. Viter P. Bertus, N. Viter P. Nana N. Jayadi, Nana N. Niken Ernaningtyas, Niken Nurdjannah J. Niode Oktavia R. L. Sondakh, Oktavia R. L. Patricia I. Tiwow Pieter L. Suling Renate T. Kandou Rita S. Tanamal Samuel Rian Wowor Saranita Vikani Gabriele Polii, Saranita Vikani Gabriele Shienty Gaspersz Silvia Nathalia Susanti, Ratna I. Tampi, Joan Alexandra Thigita A. Pandaleke Wibawa, Anthony S. Yurike Sunaryo